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Books > Academic & Education > Professional & Technical > Biochemistry

Handbook of Stem Cells, Volume 1 ; Volume 2 - Embryonic Stem Cells; Adult & Fetal Stem Cells (Hardcover, 2nd Revised edition):... Handbook of Stem Cells, Volume 1 ; Volume 2 - Embryonic Stem Cells; Adult & Fetal Stem Cells (Hardcover, 2nd Revised edition)
Anthony Atala, Robert P. Lanza
R7,386 Discovery Miles 73 860 Within 6 - 13 working days

New discoveries in the field of stem cells increasingly dominate the news and scientific literature revealing an avalanche of new knowledge and research tools that are producing therapies for cancer, heart disease, diabetes, and a wide variety of other diseases that afflict humanity. The Handbook of Stem Cells integrates this exciting area of life science, combining in two volumes the requisites for a general understanding of adult and embryonic stem cells. Organized in two volumes entitled Pluripotent Stem Cells & Cell Biology and Adult & Fetal Stem Cells, this work contains contributions from the world s experts in stem cell research to provide a description of the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations as well as a the latest information of what is known about each specific organ system.
* Provides comprehensive coverage on this highly topical subject
* Contains contributions by the foremost authorities and premiere names in the field of stem cell research
*Companion website - http: //booksite.elsevier.com/9780123859426/- containsover 250 color figures in presentation format"

Molecular Biology Techniques - A Classroom Laboratory Manual (Paperback, 3rd Revised edition): Sue Carson, Heather Miller, D.... Molecular Biology Techniques - A Classroom Laboratory Manual (Paperback, 3rd Revised edition)
Sue Carson, Heather Miller, D. Scott Witherow
R1,350 Discovery Miles 13 500 Within 7 - 11 working days

This manual is an indispensable tool for introducing advanced undergraduates and beginning graduate students to the techniques of recombinant DNA technology, or gene cloning and expression. The techniques used in basic research and biotechnology laboratories are covered in detail. Students gain hands-on experience from start to finish in subcloning a gene into an expression vector, through purification of the recombinant protein.
The second edition has been completely re-written, with new laboratory exercises and all new illustrations and text, designed for a typical 15-week semester, rather than a 4-week intensive course. The project approach to experiments was maintained: students still follow a cloning project through to completion, culminating in the purification of recombinant protein. It takes advantage of the enhanced green fluorescent protein-students can actually visualize positive clones following IPTG induction.
*Cover basic concepts and techniques used in molecular biology research labs
*Student-tested labs proven successful in a real classroom laboratories
*Exercises simulate a cloning project that would be performed in a real research lab
*"Project" approach to experiments gives students an overview of the entire process
*Prep-list appendix contains necessary recipes and catalog numbers, providing staff with detailed instructions"

A Human Chorionic Gonadotropin (HGC) (Hardcover): Larry Cole, Laurence Cole A Human Chorionic Gonadotropin (HGC) (Hardcover)
Larry Cole, Laurence Cole
R1,840 R1,238 Discovery Miles 12 380 Save R602 (33%) Within 7 - 11 working days

Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs.

The book describes the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, andexamines hCG, hyperglycosylated hCG and hCG free ss-subunit, 3 separate and independent molecules with totally sovereign physiological functions.

It provides comprehensive information on hCG from basic science to clinical medicine

Written by specialists in the field"

Regenerative Biology and Medicine (Paperback, 2nd Revised edition): David L. Stocum Regenerative Biology and Medicine (Paperback, 2nd Revised edition)
David L. Stocum
R1,568 Discovery Miles 15 680 Within 7 - 11 working days

Since the publication of the first edition of Regenerative Biology and Medicine in 2006, steady advances have been made in understanding the origin and characteristics of stem cells in epithelia, skeletal muscle, and bone, and in the niche signals that regulate the activities of these cells. Simultaneously, breakthroughs including the creation of iPSCs and transdifferentiation have created a momentum for regenerative biology with implications in regenerative biology that are far-reaching.

This book highlights these advances in the field to embrace a vast audience of investigators in chemistry, computer science, informatics, physics and mathematics as well as graduate students, clinical physicians, and biologists who are realizing the importance of the fields of regenerative biology and medicine in practice. Organized in three parts - biology of regeneration, regenerative medicine, and perspectives - this second edition creates a framework for integrating old and new data in this progressive field.
Includes coverage odskin, hair, teeth, cornea, and central neural tissuesProvides description of regenetive medicine indigestive, respiratory, urogenital, musculoskeletal, and cardiovascular systemsIncludes amphibians as powerful research models with discussion ofappendage regeneration in amphibians and mammals"

Principles and Practice of Clinical Research (Hardcover, 3rd Revised edition): John I. Gallin, Frederick P. Ognibene Principles and Practice of Clinical Research (Hardcover, 3rd Revised edition)
John I. Gallin, Frederick P. Ognibene
R1,651 Discovery Miles 16 510 Within 7 - 11 working days

The third edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers.
Incorporates new chapters on Managing Conflicts of Interest in Human Subjects Research, Clinical Research from the Patient's Perspective, The Clinical Researcher and the Media, Data Management in Clinical Research, Evaluation of a Protocol Budget, Clinical Research from the Industry Perspective, and Genetics in Clinical ResearchAddresses the vast opportunities for translation of basic science observations to the bedside through clinical researchDelves into data management and addresses how to collect data and use it for discoveryContains valuable, up-to-date information on how to obtain funding from the federal government

The Dictionary of Cell & Molecular Biology (Paperback, 5th Revised edition): John M Lackie The Dictionary of Cell & Molecular Biology (Paperback, 5th Revised edition)
John M Lackie
R1,891 Discovery Miles 18 910 Within 7 - 15 working days

An expanded, up-to-date resource for students and researchers, "The Dictionary of Cell & Molecular Biology, Fifth Edition," provides clear and concise definitions needed for laboratory study. With over 12,000 entries and a breadth of terms across bioscience, including plant molecular biology, microbiology and biotechnology, this revision reflects the changes in the research over the past few years. The latest edition of "The Dictionary of Cell and Molecular Biology" maintains its outstanding reputation as an authoritative, clear, and accessible reference with short, cross-referenced definitions of important technical terminology.
Thoroughly revised and expanded by over 20% with over 12,000 entries in cellular and molecular biologyIncludes expanded coverage of terms, including plant molecular biology, microbiology and biotechnology areasConsistently provides the most complete short definitions of technical terminology for anyone working in life sciences todayFeatures extensive cross-references Provides multiple definitions, notes on word origins, and other useful features

Nitric Oxide - Biology and Pathobiology (Hardcover, 2nd Revised edition): Louis J. Ignarro Nitric Oxide - Biology and Pathobiology (Hardcover, 2nd Revised edition)
Louis J. Ignarro
R4,344 Discovery Miles 43 440 Within 7 - 15 working days

Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide s role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology.
Edited by Nobel Laureate Louis J. Ignarro

Up-to-date therapeutic implications of nitric oxide research Authored by world experts on nitric oxide Detailed research of the biochemistry and synthesis of nitric oxide

Clinical and Translational Science - Principles of Human Research (Hardcover): David Robertson, Gordon H. Williams Clinical and Translational Science - Principles of Human Research (Hardcover)
David Robertson, Gordon H. Williams
R1,906 Discovery Miles 19 060 Within 7 - 11 working days

Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health.
This book is designed as the most authoritative and modern resource for the broad range of investigators in various medical specialties taking on the challenge of clinical research. Prepared with an international perspective, this resource begins with experimental design and investigative tools to set the scene for readers. It then moves on to human genetics and pharmacology with a focus on statistics, epidemiology, genomic information, drug discovery and development, and clinical trials. Finally, it turns to legal, social, and ethical issues of clinical research concluding with a discussion of future prospects to provide readers with a comprehensive view of the this developing area of science.
* Clinical research is one of the fastest growing fields in private practice and academic medicine with practical biological, physiological, cellular, and therapeutic applications
* Contributions from international leaders provide insight into background and future understanding for clinical and translational science
* Provides the structure for complete instruction and guidance on the subject from fundamental principles, approaches and infrastructure to human genetics, human pharmacology, research in special populations, the societal context ofhuman research, and the future of human research

Practical Guide to Clinical Computing Systems - Design, Operations, and Infrastructure (Hardcover): Thomas H. Payne Practical Guide to Clinical Computing Systems - Design, Operations, and Infrastructure (Hardcover)
Thomas H. Payne
R2,215 Discovery Miles 22 150 Within 7 - 15 working days

The development of clinical computing systems is a rapidly growing priority area of health information technology, spurred in large measure by robust funding at the federal and state levels. It is widely recognized as one of the key components for reducing costs and improving the quality of care. At the same time as more and more hospitals and clinics are installing clinical computing systems, major issues related to design, operations, and infrastructure remain to be resolved. This book tackles these critical topics, including system selection, configuration, installation, user support, interface engines, and long-term operation. It also familiarizes the reader with regulatory requirements, budgetary issues, and other aspects of this new electronic age of healthcare delivery.
It begins with an introduction to clinical computing and definition of key terminology. The next several chapters talk about system architecture and interface design, followed by detailed discussion of all aspects of operations. Attention is then given to the realities of leadership, planning, oversight, budgeting, and employee recruitment. This invaluable resource includes a special section that talks about career development for students and others interested in entering the field.
*Provides a complete overview of practical aspects
*Detailed guidance on the design and operation of clinical computing systems
*Discusses how clinical computing systems relate to health care organization committees and organizational structure
*Includes numerous real-life examples with expert insights on how to avoid pitfalls

Handbook of Evaluation Methods for Health Informatics (Paperback): Jytte Brender Handbook of Evaluation Methods for Health Informatics (Paperback)
Jytte Brender
R1,901 Discovery Miles 19 010 Within 7 - 15 working days

This Handbook provides a complete compendium of methods for evaluation of IT-based systems and solutions within healthcare. Emphasis is entirely on assessment of the IT-system within its organizational environment. The author provides a coherent and complete assessment of methods addressing interactions with and effects of technology at the organizational, psychological, and social levels.
It offers an explanation of the terminology and theoretical foundations underlying the methodological analysis presented here. The author carefully guides the reader through the process of identifying relevant methods corresponding to specific information needs and conditions for carrying out the evaluation study. The Handbook takes a critical view by focusing on assumptions for application, tacit built-in perspectives of the methods as well as their perils and pitfalls.
*Collects a number of evaluation methods of medical informatics
*Addresses metrics and measures
*Includes an extensive list of anotated references, case studies, and a list of useful Web sites

Bioindustry Ethics (Paperback): david l Finegold, Cecile Bensimon, Abdallah S. Daar, Margaret L. Eaton, Beatrice Godard, Bartha... Bioindustry Ethics (Paperback)
david l Finegold, Cecile Bensimon, Abdallah S. Daar, Margaret L. Eaton, Beatrice Godard, …
R1,043 Discovery Miles 10 430 Within 7 - 15 working days

This book is the first systematic, detailed treatment of the approaches to ethical issues taken by biotech and pharmaceutical companies. The application of genetic/genomic technologies raises a whole spectrum of ethical questions affecting global health that must be addressed. Topics covered in this comprehensive survey include considerations for bioprospecting in transgenics, genomics, drug discovery, and nutrigenomics, as well as how to improve stakeholder relations, design ethical clinical trials, avoid conflicts of interest, and establish ethics advisory boards. The expert authors represent multiple disciplines including law, medicine, bioinformatics, pharmaceutics, business, and ethics.

Transgenic Animal Technology - A Laboratory Handbook (Hardcover, 2nd Revised edition): Carl A. Pinkert Transgenic Animal Technology - A Laboratory Handbook (Hardcover, 2nd Revised edition)
Carl A. Pinkert
R2,471 Discovery Miles 24 710 Within 7 - 15 working days

A transgenic animal is one that is genetically modified to carry genes from another species. Transgenic species can be raised to carry potentially useful genes from a variety of species. While the topics of genetic engineering and cloning are controversial, the reality is that these technologies offer tremendous benefits to society - from offering a framework for developing and screening medical therapies, to enhancing the safety and nutrition of the food we eat.
Importance of Topic
One potential application of research into transgenic animal technology is the creation of domestic animals genetically designed to express a certain human disease and therefore serve as models for the study and treatment of human illnesses. Although many mouse models of human diseases are available today, such models in large domestic animals physiologically more similar to humans are sparse and critically needed. Further research in this field will undoubtedly uncover many more direct and indirect benefits of this technology.
Why This Title
Transgenic animal technologies and the ability to introduce functional genes into animals have revolutionized our ability to address complex biomedical and biological questions. This well-illustrated handbook covers the technical aspects of gene transfer from molecular methods to whole animal considerations for important laboratory and domestic animal species. It describes methodologies as employed by leading laboratories and is a key resource for researchers, as well as a tool for training technicians and students. This second edition incorporates updates on a variety of genetic engineering technologies ranging from microinjection and ES cell transfer to nuclear transfer in a broad range of animal modeling systems.
Contains a comprehensive collection of transgenic animal and gene transfer methods
Discusses background and introduction to techniques and animal systems
Teaches practical step-by-step protocols
New section on analysis"

Drosophila Cells in Culture (Hardcover): Guy Echalier Drosophila Cells in Culture (Hardcover)
Guy Echalier
R6,191 Discovery Miles 61 910 Within 7 - 15 working days

Currently "Drosophila" is a dominant experimental model in developmental biology and in gene regulation in eukaryotes. This volume summarizes some thirty years of experience in the handling of "in vitro" cultured "Drosophila" cells. Its main emphasis is on gene transfer methodology, cell responses to heat shock, hormonal regulation of genes, and on the expression and mobility of transposable elements.
Key Features
* Some thirty years of experience in handling "in vitro" cultured "Drosophila" cells
* Cell cultures which provide material for a multiplicity of biochemical approaches
* DNA-mediated gene transfer as an irreplaceable tool for analyzing basic mechanisms of regulation
* "Drosophila" cell lines which qualify them for use in biotechnology

Animal Migration, Orientation and Navigation (Hardcover): Sidney A. Gauthreaux Animal Migration, Orientation and Navigation (Hardcover)
Sidney A. Gauthreaux
R1,864 Discovery Miles 18 640 Within 7 - 11 working days

Animal Migration, Orientation, and Navigation presents the various aspects of animal migration, including the evolution of migration, climatic and meteorological influences, and bioenergetics. This book discusses the physiological control, sensory systems, orientation and navigation, and biological clocks and phenology aspects of animal migration. Organized into five chapters, this book begins with an overview of the migration strategies of animals in the context of a space continuum. This text then explains the influence of short- and long-term climatic cycles on the spectrum of migratory patterns in nature. Other chapters consider the energetic requirements of different migration strategies and the energy stores of the migrants. This book discusses as well the physiological basis of animal migration, with emphasis on endocrinal findings on the timing and energetic aspects of different migration strategies. The final chapter deals with the mechanisms used in direction finding by migrating animals. This book is a valuable resource for biologists and ecologists.

Handbook of Proteolytic Enzymes (Hardcover, 3rd Revised edition): Alan J. Barrett, Neil D. Rawlings, J. Fred Woessner, Guy... Handbook of Proteolytic Enzymes (Hardcover, 3rd Revised edition)
Alan J. Barrett, Neil D. Rawlings, J. Fred Woessner, Guy Salvesen
R10,951 Discovery Miles 109 510 Within 6 - 13 working days

Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold.
Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more.
* The only comprehensive book on proteolytic enzymes
* Includes 671 chapters, each written by experts in their field, on proteolytic enzymes from all groups of living organisms and the viruses, including those that are currently major targets of pharmaceutical research
* Accompanying CD-ROM provides fully searchable text, 2D structures of peptidases in color and links directly to PubMed and MEROPS databases
*Each chapter describes in detail the enzyme name, its history, activity and specificity, structural chemistry, preparation, biological aspects and distinguishing features
*Over 1000 peptidases included

Designing Science Presentations - A Visual Guide to Figures, Papers, Slides, Posters, and More (Paperback): Matt Carter Designing Science Presentations - A Visual Guide to Figures, Papers, Slides, Posters, and More (Paperback)
Matt Carter
R696 Discovery Miles 6 960 Within 7 - 11 working days

"Designing Science Presentations "guides researchers and graduate students of virtually any discipline in the creation of compelling science communication. Most scientists never receive formal training in the creation, delivery, and evaluation of such material, yet it is essential for publishing in high-quality journals, soliciting funding, attracting lab personnel, and advancing a career.

This clear, readable volume fills that gap and provides visually intensive guidance at every step-from the construction of original figures to the presentation and delivery of those figures in papers, slideshows, posters, and websites. It provides pragmatic advice on the preparation and delivery of exceptional scientific presentations; demonstrates hundreds of visually striking presentation techniques, giving readers inspiration for creating their own; and is structured so that readers can easily find answers to particular questions.
Clear heading for each section indicates its message, highlighted with graphic illustrations Two summary paragraphs that complement the visual images and clearly discuss the main pointNumerous examples of high-quality figures, page layouts, slides, posters, and web pages to help stimulate readers' ideas for their own presentationsNumerous "before and after" examples to illustrate the contrast between poor and outstanding presentations

Emergent Collective Properties, Networks and Information in Biology (Hardcover): J. Ricard Emergent Collective Properties, Networks and Information in Biology (Hardcover)
J. Ricard; Series edited by Giorgio Bernardi
R2,095 Discovery Miles 20 950 Within 7 - 11 working days

The concept of network as a mathematical description of a set of states, or events, linked according to a certain topology has been developed recently and has led to a novel approach of real world. This approach is no doubt important in the field of biology. In fact biological systems can be considered networks. Thus, for instance, an enzyme-catalysed reaction is a network that links, according to a certain topology, the various states of the protein and of its complexes with the substrates and products of the chemical reaction. Connections between neurons, social relations in animal and human populations are also examples of networks. Hence there is little doubt that the concept of network transgresses the boundaries between traditional scientific disciplines.
This book is aimed at discussing in physical terms these exciting new topics on simple protein model lattices, supramolecular protein edifices, multienzyme and gene networks.
*Physical and mathematical approach of biological phenomena.
*Offers biochemists and biologists the mathematical background required to understand the text.
*Associates in the same general formulation, the ideas of communication of a message and organization of a system.
*Provides a clear-cut definition and mathematical expression of the concepts of reduction, integration, emergence and complexity that were so far time-honoured and vague

Microarrays (Paperback): Hans-Joachim Muller, Thomas Roeder Microarrays (Paperback)
Hans-Joachim Muller, Thomas Roeder
R735 Discovery Miles 7 350 Within 7 - 11 working days

Microarrays is an invaluable laboratory manual for anyone conducting experiments in the field of molecular biology or medical biochemistry who needs to understand and use microarray technologies. These technologies are especially appropriate in genome analysis, diagnostics, and studies involving differential gene expression.
Providing straightforward explanations, the authors demonstrate proven methods for biochip application and an overview of presently available instruments, biochips, and software. Chapters cover the different requirements for DNA and protein chips, as well as spotters and scanners. The book also covers high throughput screening, patent research, and the minimum requirements for setting up or expanding a microarray laboratory.
- Covers microarray applications, technology, and execution
- Written in an approachable yet informative tone
- Includes more than 100 detailed figures and graphs
- Examines the history of microarrays and their future potential
- Defines key terms from related disciplines
- Contains a full chapter on the importance of database research and patents
- Describes how to develop or improve one's own microarray laboratory

Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy (Hardcover): G V Sherbert Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy (Hardcover)
G V Sherbert
R2,606 R2,471 Discovery Miles 24 710 Save R135 (5%) Within 8 - 13 working days

Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management.

This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment.

Provides afundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes

Aids the development of therapeutic treatments for cancer

Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research "

Analysis of Triplet Repeat Disorders (Hardcover): D.C. Rubinsztein, M.R Hayden Analysis of Triplet Repeat Disorders (Hardcover)
D.C. Rubinsztein, M.R Hayden
R3,668 Discovery Miles 36 680 Within 7 - 15 working days

The clinical picture of diseases, caused by trinucleotide repeats, such as fragile X syndrome, myotonic dystrophy, Huntington's disease and forms of spinocerebella ataxia, provide the starting point for this authoritative review volume.
The book proceeds to integrate the current understanding of the molecular pathologies of these diseases, their genotype-phenotype relationships, the mutational processes involved and the laboratory and clinical issues relating to genetic testing for these disorders.
Clinicians and researchers in genetics, neuroscience, pediatrics and psychiatry will all benefit from the comprehensive overviews contributed by recognized world experts.

Jeff's View - On Science and Scientists (Hardcover): Gottfried Schatz Jeff's View - On Science and Scientists (Hardcover)
Gottfried Schatz
R467 Discovery Miles 4 670 Within 7 - 15 working days

Jeff's Views provide witty, insightful, and thought-provoking looks into the life of a modern scientist. From starting off to letting go, Gottfried ("Jeff") Schatz leads us through the trials and triumphs of scientific life. With his tongue firmly in his cheek, and his humour always intact, the Austrian essayist leads us through the confusing and seemingly insurmountable hill that is the career path of European scientists. In addition to giving useful insights into how to get funding, give seminars, and still find time to make that leading edge scientific discovery, Jeff explores the philosophical dimensions of recent biological breakthroughs such as the sequencing of the human genome, the evolution of sensory receptors, and cellular suicide.
Gottfried Schatz is one of the world's leading scientists in the field of bioenergetics and mitochondria biology. Born in a small Austrian village, he started his scientific career at the University of Graz, and ended it as President of the Swiss Science and Technology Council. With stints as a violinist in Austrian opera houses, professorships in the USA and Switzerland, and numerous prestigious awards along the way, Jeff is a true European, whose unique, and often controversial, viewpoints are appreciated by scientists and politicians alike.
These essays look at science from a very personal angle - often critical, sometimes sad, but always with excitement, wonder, and admiration. It is hoped that they will make you look at science with a slightly different view.
*Witty, insightful, and thought-provoking looks into life of a modern scientist
*Provides useful insights on how to get funding, give seminars, and still find time to makethat scientific discovery
*Explores recent breakthroughs in science: genome sequencing, sensory receptor evolution, and cellular suicide

Writing Clinical Research Protocols - Ethical Considerations (Paperback): Evan DeRenzo, Joel Moss Writing Clinical Research Protocols - Ethical Considerations (Paperback)
Evan DeRenzo, Joel Moss
R1,396 Discovery Miles 13 960 Within 7 - 15 working days

This highly engaging guide for clinical researchers provides a foundation for improving skills in the understanding of ethical requirements in the design and conduct of clinical research. It includes practical information on ethical principles in clinical research, designing appropriate research studies, writing consent and assent documents, getting protocols approved, special populations, confidentiality issues, and the reporting of adverse events. A valuable appendix includes a listing of web resources about research ethics as well as a glossary. This will be an invaluable resource for basic scientists collaborating in clinical trials, physician investigators, clinical research fellows, research nurse coordinators, residents, and anyone who wants a better understanding of the clinical trials process.
* Walks investigators and trainees through identification of the ethical aspects of each section of a clinical research protocol
* Includes a chapter containing Case Histories
* Contains information on conducting clinical research within the pharmaceutical industry
* An appendix includes internet resources and world wide web addresses for important research ethics documents and regulations
* Chapter on 'Study Design and Methodology' purposely expanded to explicitly address biostatistical considerations

Modeling: Gateway to the Unknown - A Work by Rom Harre (Hardcover, New): Daniel Rothbart Modeling: Gateway to the Unknown - A Work by Rom Harre (Hardcover, New)
Daniel Rothbart
R1,407 Discovery Miles 14 070 Within 7 - 15 working days

Edited by Daniel Rothbart of George Mason University in Virginia, this book is a collection of Rom Harre's work on modeling in science (particularly physics and psychology). In over 28 authored books and 240 articles and book chapters, Rom Harre of Georgetown University in Washington, DC is a towering figure in philosophy, linguistics, and social psychology. He has inspired a generation of scholars, both for the ways in which his research is carried out and his profound insights. For Harre, the stunning discoveries of research demand a kind of thinking that is found in the construction and control of models. Iconic modeling is pivotal for representing real-world structures, explaining phenomena, manipulating instruments, constructing theories, and acquiring data.
This volume in the new Elsevier book series Studies in Multidisciplinarity includes major topics on the structure and function of models, the debates over scientific realism, explanation through analogical modeling, a metaphysics for physics, the rationale for experimentation, and modeling in social encounters.
* A multidisciplinary work of sweeping scope about the nature of science
* Revolutionary interpretation that challenges conventional wisdom about the character of scientific thinking
* Profound insights about fundamental challenges to contemporary physics
* Brilliant discoveries into the nature of social interaction and human identity
* Presents a rational conception of methods for acquiring knowledge of remote regions of the world
* Written by one of the great thinkers of our time.

Recent Advances in Psychology and Aging (Hardcover): Paul T. Costa, I. C. Siegler Recent Advances in Psychology and Aging (Hardcover)
Paul T. Costa, I. C. Siegler
R3,115 Discovery Miles 31 150 Within 7 - 15 working days

"Recent Events in the Psychology of Aging" documents the successful integration of aging into the mainstream of psychology. Leading psychologists present overviews of the key issues and research findings on mainstream topics. These include cognitive neuroscience, visual attention, learning, memory and cognition, as well as personality and happiness. The intersection of aging content with mainstream psychology is also prominent in the areas of emotions, personality, and social psychology as seen in the chapters on subjective well-being, emotional development, self-esteem and personality trajectories.
The seven chapters of this book offer information on such topics as: the seven sins of memory, categorizing the common breakdowns of memory in everyday life and the special breakdown of sins that increase with aging; problems with attention and learning; and offers answers to questions such as do emotions get blunted with age; do older people focus more on positive feelings; and the age old question of whether older people are happier than younger people is given in the chapter on the evolving concept of subjective well-being and the multifaceted nature of happiness. Questions about what occurs to one's self-esteem and personality are also masterfully discussed and the answers may be surprising. The concluding seventh chapter provides a cultural lens on the biopsychosocial study of aging.

Basic Biology and Clinical Impact of Immunosenescence (Hardcover, New): Graham Pawelec Basic Biology and Clinical Impact of Immunosenescence (Hardcover, New)
Graham Pawelec
R2,901 Discovery Miles 29 010 Within 7 - 15 working days

Ageing is of perennial interest as a universal feature in all human societies. The genetic background and biochemical bases of ageing processes are currently being revealed in unprecedented detail. It is emerging that one of the main hurdles to be overcome in achieving a long and healthy lifespan is the maintenance of a properly functioning immune system. The main cause of death in people who have achieved "successful ageing" (which mostly means not having succumbed to cancer or cardiovascular disease) is infectious disease, caused by immunosenescence. This book contains chapters by many of the leaders in the field of immune-related issues in ageing and remediation.

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