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New discoveries in the field of stem cells increasingly dominate
the news and scientific literature revealing an avalanche of new
knowledge and research tools that are producing therapies for
cancer, heart disease, diabetes, and a wide variety of other
diseases that afflict humanity. The Handbook of Stem Cells
integrates this exciting area of life science, combining in two
volumes the requisites for a general understanding of adult and
embryonic stem cells. Organized in two volumes entitled Pluripotent
Stem Cells & Cell Biology and Adult & Fetal Stem Cells,
this work contains contributions from the world s experts in stem
cell research to provide a description of the tools, methods, and
experimental protocols needed to study and characterize stem cells
and progenitor populations as well as a the latest information of
what is known about each specific organ system.
This manual is an indispensable tool for introducing advanced
undergraduates and beginning graduate students to the techniques of
recombinant DNA technology, or gene cloning and expression. The
techniques used in basic research and biotechnology laboratories
are covered in detail. Students gain hands-on experience from start
to finish in subcloning a gene into an expression vector, through
purification of the recombinant protein.
Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs.
The book describes the detailed biology, clinical chemistry, and
clinical perspectives of hCG and associated molecules, andexamines
hCG, hyperglycosylated hCG and hCG free ss-subunit, 3 separate and
independent molecules with totally sovereign physiological
It provides comprehensive information on hCG from basic science to clinical medicine
Written by specialists in the field"
Since the publication of the first edition of Regenerative Biology and Medicine in 2006, steady advances have been made in understanding the origin and characteristics of stem cells in epithelia, skeletal muscle, and bone, and in the niche signals that regulate the activities of these cells. Simultaneously, breakthroughs including the creation of iPSCs and transdifferentiation have created a momentum for regenerative biology with implications in regenerative biology that are far-reaching.
This book highlights these advances in the field to embrace a
vast audience of investigators in chemistry, computer science,
informatics, physics and mathematics as well as graduate students,
clinical physicians, and biologists who are realizing the
importance of the fields of regenerative biology and medicine in
practice. Organized in three parts - biology of regeneration,
regenerative medicine, and perspectives - this second edition
creates a framework for integrating old and new data in this
The third edition of this innovative work again provides a unique
perspective on the clinical discovery process by providing input
from experts within the NIH on the principles and practice of
clinical research. Molecular medicine, genomics, and proteomics
have opened vast opportunities for translation of basic science
observations to the bedside through clinical research. As an
introductory reference it gives clinical investigators in all
fields an awareness of the tools required to ensure research
protocols are well designed and comply with the rigorous regulatory
requirements necessary to maximize the safety of research subjects.
Complete with sections on the history of clinical research and
ethics, copious figures and charts, and sample documents it serves
as an excellent companion text for any course on clinical research
and as a must-have reference for seasoned researchers.
An expanded, up-to-date resource for students and researchers, "The
Dictionary of Cell & Molecular Biology, Fifth Edition,"
provides clear and concise definitions needed for laboratory study.
With over 12,000 entries and a breadth of terms across bioscience,
including plant molecular biology, microbiology and biotechnology,
this revision reflects the changes in the research over the past
few years. The latest edition of "The Dictionary of Cell and
Molecular Biology" maintains its outstanding reputation as an
authoritative, clear, and accessible reference with short,
cross-referenced definitions of important technical terminology.
Nitric oxide (NO) is a gas naturally found in the body that
conveys information between cells. In the last decade researchers
have found that NO is a signaling molecule of key importance for
the cardiovascular system, regulating blood pressure and blood flow
to different organs. In addition, discoveries surrounding nitric
oxide s role as a principal neurotransmitter moderating erectile
function, a pathophysiological negotiator and messenger in
inflammation, and a weapon against infections have increased
research attention across the fields of biochemistry, chemistry,
molecular biology, gene therapy, cell biology, immunology,
pharmacology, neuroscience, and physiology.
Up-to-date therapeutic implications of nitric oxide research Authored by world experts on nitric oxide Detailed research of the biochemistry and synthesis of nitric oxide
Clinical or translational science is the field of study devoted to
investigating human health and disease, interventions and outcomes
for the purposes of developing new treatment approaches, devices,
and modalities to improve health. New molecular tools and
diagnostic technologies based on clinical and translational
research have lead to a better understanding of human disease and
the application of new therapeutics for enhanced health.
The development of clinical computing systems is a rapidly growing
priority area of health information technology, spurred in large
measure by robust funding at the federal and state levels. It is
widely recognized as one of the key components for reducing costs
and improving the quality of care. At the same time as more and
more hospitals and clinics are installing clinical computing
systems, major issues related to design, operations, and
infrastructure remain to be resolved. This book tackles these
critical topics, including system selection, configuration,
installation, user support, interface engines, and long-term
operation. It also familiarizes the reader with regulatory
requirements, budgetary issues, and other aspects of this new
electronic age of healthcare delivery.
This Handbook provides a complete compendium of methods for
evaluation of IT-based systems and solutions within healthcare.
Emphasis is entirely on assessment of the IT-system within its
organizational environment. The author provides a coherent and
complete assessment of methods addressing interactions with and
effects of technology at the organizational, psychological, and
This book is the first systematic, detailed treatment of the approaches to ethical issues taken by biotech and pharmaceutical companies. The application of genetic/genomic technologies raises a whole spectrum of ethical questions affecting global health that must be addressed. Topics covered in this comprehensive survey include considerations for bioprospecting in transgenics, genomics, drug discovery, and nutrigenomics, as well as how to improve stakeholder relations, design ethical clinical trials, avoid conflicts of interest, and establish ethics advisory boards. The expert authors represent multiple disciplines including law, medicine, bioinformatics, pharmaceutics, business, and ethics.
Currently "Drosophila" is a dominant experimental model in
developmental biology and in gene regulation in eukaryotes. This
volume summarizes some thirty years of experience in the handling
of "in vitro" cultured "Drosophila" cells. Its main emphasis is on
gene transfer methodology, cell responses to heat shock, hormonal
regulation of genes, and on the expression and mobility of
Animal Migration, Orientation, and Navigation presents the various aspects of animal migration, including the evolution of migration, climatic and meteorological influences, and bioenergetics. This book discusses the physiological control, sensory systems, orientation and navigation, and biological clocks and phenology aspects of animal migration. Organized into five chapters, this book begins with an overview of the migration strategies of animals in the context of a space continuum. This text then explains the influence of short- and long-term climatic cycles on the spectrum of migratory patterns in nature. Other chapters consider the energetic requirements of different migration strategies and the energy stores of the migrants. This book discusses as well the physiological basis of animal migration, with emphasis on endocrinal findings on the timing and energetic aspects of different migration strategies. The final chapter deals with the mechanisms used in direction finding by migrating animals. This book is a valuable resource for biologists and ecologists.
Extensively revised and updated, the new edition of the highly
regarded Handbook of Proteolytic Enzymes is an essential reference
for biochemists, biotechnologists and molecular biologists. Edited
by world-renowned experts in the field, this comprehensive work
provides detailed information on all known proteolytic enzymes to
date. This two-volume set unveils new developments on proteolytic
enzymes which are being investigatedin pharmaceutical research for
such diseases as HIV, Hepatitis C, and the common cold.
"Designing Science Presentations "guides researchers and graduate students of virtually any discipline in the creation of compelling science communication. Most scientists never receive formal training in the creation, delivery, and evaluation of such material, yet it is essential for publishing in high-quality journals, soliciting funding, attracting lab personnel, and advancing a career.
This clear, readable volume fills that gap and provides visually
intensive guidance at every step-from the construction of original
figures to the presentation and delivery of those figures in
papers, slideshows, posters, and websites. It provides pragmatic
advice on the preparation and delivery of exceptional scientific
presentations; demonstrates hundreds of visually striking
presentation techniques, giving readers inspiration for creating
their own; and is structured so that readers can easily find
answers to particular questions.
The concept of network as a mathematical description of a set of
states, or events, linked according to a certain topology has been
developed recently and has led to a novel approach of real world.
This approach is no doubt important in the field of biology. In
fact biological systems can be considered networks. Thus, for
instance, an enzyme-catalysed reaction is a network that links,
according to a certain topology, the various states of the protein
and of its complexes with the substrates and products of the
chemical reaction. Connections between neurons, social relations in
animal and human populations are also examples of networks. Hence
there is little doubt that the concept of network transgresses the
boundaries between traditional scientific disciplines.
Microarrays is an invaluable laboratory manual for anyone
conducting experiments in the field of molecular biology or medical
biochemistry who needs to understand and use microarray
technologies. These technologies are especially appropriate in
genome analysis, diagnostics, and studies involving differential
Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management.
This book reviews the latest developments providing insights
into the signalling processes involved in morphogenesis and
pathogenesis with emphasis on using the elements of the signalling
cascades as targets for therapeutic deployment.
Provides afundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes
Aids the development of therapeutic treatments for cancer
Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research "
The clinical picture of diseases, caused by trinucleotide repeats,
such as fragile X syndrome, myotonic dystrophy, Huntington's
disease and forms of spinocerebella ataxia, provide the starting
point for this authoritative review volume.
Jeff's Views provide witty, insightful, and thought-provoking looks
into the life of a modern scientist. From starting off to letting
go, Gottfried ("Jeff") Schatz leads us through the trials and
triumphs of scientific life. With his tongue firmly in his cheek,
and his humour always intact, the Austrian essayist leads us
through the confusing and seemingly insurmountable hill that is the
career path of European scientists. In addition to giving useful
insights into how to get funding, give seminars, and still find
time to make that leading edge scientific discovery, Jeff explores
the philosophical dimensions of recent biological breakthroughs
such as the sequencing of the human genome, the evolution of
sensory receptors, and cellular suicide.
This highly engaging guide for clinical researchers provides a
foundation for improving skills in the understanding of ethical
requirements in the design and conduct of clinical research. It
includes practical information on ethical principles in clinical
research, designing appropriate research studies, writing consent
and assent documents, getting protocols approved, special
populations, confidentiality issues, and the reporting of adverse
events. A valuable appendix includes a listing of web resources
about research ethics as well as a glossary. This will be an
invaluable resource for basic scientists collaborating in clinical
trials, physician investigators, clinical research fellows,
research nurse coordinators, residents, and anyone who wants a
better understanding of the clinical trials process.
Edited by Daniel Rothbart of George Mason University in Virginia,
this book is a collection of Rom Harre's work on modeling in
science (particularly physics and psychology). In over 28 authored
books and 240 articles and book chapters, Rom Harre of Georgetown
University in Washington, DC is a towering figure in philosophy,
linguistics, and social psychology. He has inspired a generation of
scholars, both for the ways in which his research is carried out
and his profound insights. For Harre, the stunning discoveries of
research demand a kind of thinking that is found in the
construction and control of models. Iconic modeling is pivotal for
representing real-world structures, explaining phenomena,
manipulating instruments, constructing theories, and acquiring
"Recent Events in the Psychology of Aging" documents the successful
integration of aging into the mainstream of psychology. Leading
psychologists present overviews of the key issues and research
findings on mainstream topics. These include cognitive
neuroscience, visual attention, learning, memory and cognition, as
well as personality and happiness. The intersection of aging
content with mainstream psychology is also prominent in the areas
of emotions, personality, and social psychology as seen in the
chapters on subjective well-being, emotional development,
self-esteem and personality trajectories.
Ageing is of perennial interest as a universal feature in all human societies. The genetic background and biochemical bases of ageing processes are currently being revealed in unprecedented detail. It is emerging that one of the main hurdles to be overcome in achieving a long and healthy lifespan is the maintenance of a properly functioning immune system. The main cause of death in people who have achieved "successful ageing" (which mostly means not having succumbed to cancer or cardiovascular disease) is infectious disease, caused by immunosenescence. This book contains chapters by many of the leaders in the field of immune-related issues in ageing and remediation.
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