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"Women and Health "is a comprehensive reference that addresses health issues affecting women of all ages - from adolescence through maturity. It goes far beyond other books on this topic, which concentrate only on reproductive health, and has a truly international perspective. It covers key issues ranging from osteoporosis to breast cancer and other cancers, domestic violence, sexually transmitted diseases, occupational hazards, eating disorders, heart disease and other chronic illnesses, substance abuse, and societal and behavioral influences on health.
In this second edition of "Women and Health," chapters
thoughtfully explore the current state of women s health and health
care, including the influences of sex and gender on the occurrence
of a wide variety of diseases and conditions. All chapters have
been extensively updated and emphasize the epidemiology of the
condition - the etiology, occurrence, primary and secondary
prevention (screening), risk factors, surveillance, changing trends
over time, and critical analysis of the diagnostic and treatment
options and controversies. Treatment sections in each chapter have
been expanded to create a stronger dialogue between epidemiologists
and women's health practitioners.
This Third Edition of Medical Cell Biology focuses on the
scientific aspects of cell biology important to medical students,
dental students, veterinary students, and prehealth undergraduates.
Maintaining a primary focus on eukaryotic cell biology, the text
explains general cell biology principles in the context of organ
systems and human and animal disease.
Basic Medical Endocrinology, Fourth Edition provides up-to-date
coverage of rapidly unfolding advances in the understanding of
hormones involved in regulating most aspects of bodily functions.
The discussion focuses on molecular and cellular aspects of hormone
production and action firmly rooted in the context of integrative
physiology. Topics are approached from the perspective of a
physiologist with over 40 years of teaching experience.
PLATELETS is the definitive current source of state-of-the-art
knowledge about platelets and covers the entire field of platelet
biology, pathophysiology, and clinical medicine. Recently there has
been a rapid expansion of knowledge in both basic biology and the
clinical approach to platelet-related diseases including thrombosis
and hemorrhage. Novel platelet function tests, drugs, blood bank
storage methods, and gene therapies have been incorporated into
patient care or are in development. This book draws all this
information into a single, comprehensive and authoritative
Integrates the entire field of platelet biology, pathophysiology, and clinical medicine
Full color reference comprising 64 chapters, 1400 pages, and 16,000 references
Contributions from 126 world leaders in their fields New chapters on topics such as the regulation of platelet life span, platelet microRNAs, GPVI and CLEC-2, monitoring of antiplatelet therapy, novel antiplatelet therapy, and making platelets "ex vivo"
"Statistics in Medicine, Third Edition" makes medical statistics
easy to understand by students, practicing physicians, and
researchers. The book begins with databases from clinical medicine
and uses such data to give multiple worked-out illustrations of
every method. The text opens with how to plan studies from
conception to publication and what to do with your data, and
follows with step-by-step instructions for biostatistical methods
from the simplest levels (averages, bar charts) progressively to
the more sophisticated methods now being seen in medical articles
(multiple regression, noninferiority testing). Examples are given
from almost every medical specialty and from dentistry, nursing,
pharmacy, and health care management. A preliminary guide is given
to tailor sections of the text to various lengths of biostatistical
*User-friendly format includes medical examples, step-by-step methods, and check-yourself exercises appealing to readers with little or no statistical background, across medical and biomedical disciplines
*Facilitates stand-alone methods rather than a required sequence of reading and references to prior text.
* Covers trial randomization, treatment ethics in medical research, imputation of missing data, evidence-based medical decisions, how to interpret medical articles, noninferiority testing, meta-analysis, screening number needed to treat, and epidemiology.
* Fills the gap left in all other medical statistics books between the reader s knowledge of how to go about research and the book s coverage of how to analyze results of that research.
"New in this Edition: "
* New chapters on planning research, managing data and analysis, Bayesian statistics, measuring association and agreement, and questionnaires and surveys.
* New sections on what tests and descriptive statistics to choose, false discovery rate, interim analysis, bootstrapping, Bland-Altman plots, Markov chain Monte Carlo (MCMC), and Deming regression.
* Expanded coverage on probability, statistical methods and tests relatively new to medical research, ROC curves, experimental design, and survival analysis.
*35 Databases in Excel format used in the book and can be downloaded and transferred into whatever format is needed along with PowerPoint slides of figures, tables, and graphs from the book included on the companion site, http: //www.elsevierdirect.com/companion.jsp?ISBN=9780123848642
*Medical subject index offers additional search capabilities."
Molecular Tools and Infectious Disease Epidemiology examines the opportunities and methodologic challenges in the application of modern molecular genetic and biologic techniques to infectious disease epidemiology. The application of these techniques dramatically improves the measurement of disease and putative risk factors, increasing our ability to detect and track outbreaks, identify risk factors and detect new infectious agents. However, integration of these techniques into epidemiologic studies also poses new challenges in the design, conduct, and analysis. This book presents the key points of consideration when integrating molecular biology and epidemiology; discusses how using molecular tools in epidemiologic research affects program design and conduct; considers the ethical concerns that arise in molecular epidemiologic studies; and provides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field. The book is recommended for graduate and advanced undergraduate students studying infectious disease epidemiology and molecular epidemiology; and for the epidemiologist wishing to integrate molecular techniques into his or her studies.
The field of gender-specific medicine examines how normal human
biology and physiology differs between men and women and how the
diagnosis and treatment of disease differs as a function of gender.
This revealing research covers various conditions that
predominantly occur in men as well conditions that predominantly
occur in women. Among the areas of greatest difference are
cardiovascular disease, mood disorders, the immune system, lung
cancer as a consequence of smoking, osteoporosis, diabetes,
obesity, and infectious diseases.
Longer bibliographies and suggested reviews/papers of particular relevance and importance will be added at the end of each section.
Each author will be asked to include recent meta-analysis of data
Each chapter will progress translationally from the basic science to the clinical applications of gender-specific therapies, drugs, or treatments
Section on drug metabolism will be eliminated but the subject will be incorporated into each relevant chapter
Section on aging will be eliminated but age will be considered as a variable in each of the separate chapters "
Understanding the complex factors contributing to the growing
childhood obesity epidemic is vital not only for the improved
health of the world's future generations, but for the healthcare
system. The impact of childhood obesity reaches beyond the
individual family and into the public arenas of social systems and
government policy and programs. "Global Perspectives on Childhood
Obesity" explores these with an approach that considers the current
state of childhood obesity around the world as well as future
projections, the most highly cited factors contributing to
childhood obesity, what it means for the future both for children
and society, and suggestions for steps to address and potentially
prevent childhood obesity.
Nutritional oncology is an increasingly active interdisciplinary
field where cancer is investigated as both a systemic and local
disease originating with the changes in the genome and progressing
through a multi-step process which may be influenced at many points
in its natural history by nutritional factors that could impact the
prevention of cancer, the quality of life of cancer patients, and
the risk of cancer recurrence in the rapidly increasing population
of cancer survivors.
A classic nephrology reference for over 25years, "Seldin &
Giebisch s" The Kidney, is the acknowledged authority on renal
physiology and pathophysiology. In this 5th edition, such new and
powerful disciplines as genetics and cell biology have been
deployed to deepen and widen further the explanatory framework. Not
only have previous chapters been extensively updated, but new
chapters have been added to incorporate additional disciplines.
Individual chapters, for example, now provide detailed treatment of
the significance of cilia; the role of stem cells is now given
special consideration. Finally, there has been a significant
expansion of the section of pathophysiology, incorporating the
newer findings of cell biology and genetics. If you research the
development of normal renal function or the mechanisms underlying
renal disease, "Seldin & Giebisch s" The Kidney is your number
one source for information.
This original six chapter book will briefly review and integrate
the basic concepts behind water distribution and movement in the
body. This fills a knowledge gap that most medical and
undergraduate physiology students acquire when these topics are
studied separately. As of now, there is no textbook that fully
integrates renal, cardiovascular and water physiology in a clear
understandable manner. The book is intended primarily for medical
students and undergraduate physiology students. Chapters include:
1) Water and its Distribution; 2) Water Dynamics; 3) Fluid Handling
by the Heart and Blood Vessels; 4) Fluid Handling by the Kidneys;
5) Water and Oxygen Delivery; 6) Integration in the Response to
Hemorrhage, Volume Depletion, and Water Redistribution.
Presentsa complex and detailed topicin an original way that will allow students to understand more complex textbooks and explanations"
Comparative Anatomy and Histology: A Mouse and Human Atlas is
aimed atthe new mouse investigator as well asmedical and
veterinarypathologists who need to expand their knowledge base into
comparative anatomy and histology. It guides the reader through
normal mouse anatomy and histology using direct comparison to the
human. The side by side comparison of mouse and human tissues
highlight the unique biology of the mouse, which has great impact
on thevalidation of mouse modelsof human disease.
The major objective of this book is to review in detail health
problems occurring with significant frequency in aging adults which
are proposed to be treated or ameliorated using nutriceuticals as
foods and dietary supplements as well as other complementary and
alternative therapies. Chapters primarily focusing on nutrients
have been excluded to maintain a focus on complementary and
alternative medicine (CAM).
I. Non-Nutritional Components in Diet and Supplements,
Nutriceuticals and their Role in Health Promotion in the Mature
A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte.
Individuals active in muscle investigation--as well as those new
to the field--will find this work useful, as will students of
muscle biology. In the case of hte former, many wish to grasp
issues at the margins of their own expertise (e.g. clinical matters
at one end; molecular matters at the other), adn this book is
designed to assist them. Students, postdoctoral fellows, course
directors and other faculty will find this book of interest. Beyond
this, many clinicians in training (e.g. cardiology fellows) will
The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry.
"Heart Development and Regeneration, " written by experts in the field, provides essential information on topics ranging from the evolution and lineage origins of the developing cardiovascular system to cardiac regenerative medicine. A reference for clinicians, medical researchers, students, and teachers, this publication offers broad coverage of the most recent advances.
Volume One discusses heart evolution, contributing cell lineages; model systems; cardiac growth; morphology and asymmetry; heart patterning; epicardial, vascular, and lymphatic development; and congenital heart diseases.
Volume Two includes chapters on transcription factors and
transcriptional control circuits in cardiac development and
disease; epigenetic modifiers including microRNAs, genome-wide
mutagenesis, imaging, and proteomics approaches; and the theory and
practice of stem cells and cardiac regeneration.
Authored by world experts in heart development and disease
New research on epigenetic modifiers in cardiac development
Comprehensive coverage of stem cells and prospects for cardiac regeneration
Up-to-date research on transcriptional and proteomic circuits in cardiac disease
Full-color, detailed illustrations
One major example of the synergy of bioactive foods and extracts is their role as an antioxidant and the related remediation of cardiovascular disease. There is compelling evidence tosuggest that oxidative stress is implicated in the physiology of several major cardiovascular diseases including heart failure and increased free radical formation and reduced antioxidant defences. Studies indicate bioactive foods reduce the incidence of these conditions, suggestive of a potential cardioprotective role of antioxidant nutrients.
BioactiveFood as Dietary Interventions for Cardiovascular
Diseaseinvestigates the role of foods, herbs and novel extracts in
moderating the pathology leading to cardiovascular disease. It
reviews existing literature, and presents new hypotheses and
conclusions on the effects of different bioactive components of the
At present, human society is facing a health care crisis that is affecting patients worldwide. In the United States, it is generally believed that the major problem is lack of affordable access to health care (i.e. health insurance). This book takes an unprecedented approach to address this issue by proposing that the major problem is not lack of affordable access to health care per se, but lack of access to better, safer, and more affordable medicines. The latter problem is present not only in the United States and the developing world but also in countries with socialized health care systems, such as Europe and the rest of the industrialized world. This book provides a comparative analysis of the health care systems throughout the world and also examines the biotechnology and pharmaceutical industries.
Exposure to space flight has been shown to results in changes in
many physiological systems, including the musculoskeletal system,
the cardiovascular system, the immune system, and the
neurovestibular system. These changes could negatively impact the
ability of humans to undertake long-term habitation and exploration
of space. However, there are limits to the studies that can be done
with humans in space. Both ground-based and space flight animal
model systems are currently used for these studies as an
alternative. This volume covers the latest developments in the use
of animal models to study the effects of the space flight
environment on human physiological systems.
Molecular medicine is the application of gene or DNA based knowledge to the modern practice of medicine. This book provides contemporary insights into how the genetic revolution is influencing medical thinking and practice on a broad front including clinical medicine, innovative therapies and forensic medicine. Extensively revised just after the completion of the Human Genome Project, it provides the latest in molecular medicine developments. It is the only book in Molecular Medicine that has undergone 3 editions, in which current practice as well as future developments are identified, and includes extensive tables, well presented figures resources for further understanding.
The Liver in Biology and Disease was conceived as a sequel in the
series "Principles of Medical Biology," whose general aim continues
to be the integration of human biology and molecular cell biology
into modern molecular medicine. It is a volume molded by the
Information Revolution which few will deny has forced the teaching
faculties in our medical schools to curtail and prune the teaching
load and focus on fundamentals and principles. With this intention
in mind, a volume of this nature takes into account the close
dependence of progress in the medical sciences on bioinformatics
(gene and protein analysis) or more precisely, computational
biology and of course, the Internet. In general, it follows the
pattern of its predecessors.
Structured to be a companion to the recently published Handbook of
Transfusion Medicine, the Handbook of Pediatric Transfusion
Medicine is dedicated to pediatric hematology-oncology and
transfusion medicine, a field which remains ambiguous and which has
generated few comprehensive texts. This book stands alone as one of
the few texts that addresses transfusion issues specific to
pediatric medicine. Written in an eminently readable style, this
authoritative handbook is a requirement for any pediatric physician
In this volume of ASPA, devoted to developmental biology research,
9 authors from different fields of developmental biology present
their investigations on various developing plant and animal models.
An "a priori" concern in mind that weightlessness might have
negative effects on developmental processes, it is encouraging to
know that the overall development of various organisms tested so
far is essentially correct under spaceflight conditions, leading to
viable individuals with viable offspring. On the other hand,
particular studies on specifically neurophysiological aspects in
developing organisms reveal important flight or postflight
disturbances; however it is encouraging to know that they appear to
be transient only.
Genetic recombination is a process of combining genes that leads to
the generation of cell variants that possess different
characteristics. This process is important to the evolution of a
species and to embryonic growth and differentiation. However, this
process can also lead to the development of abnormal, cancerous
cells. This book reviews the role of genetic recombination in the
generation of various cancers and how genetic alterations have been
or could be employed to elicit clinically useful information.
For many years, it has been known that when rats and mice are given a reduced amount of food, their life span is increased and they remain healthy and vigorous at advanced ages.
What is the reason for this change in the usual pattern of
aging? The evidence is overwhelming that the life extension results
from a slowing of aging processes. And the factor responsible is
the decrease in caloric intake. The obvious question: How does this
factor work? A good question - and the reason that research on the
anti-aging action of caloric restriction is today one of the most
studied research areas in biological gerontology. For it is felt
that if the biological mechanisms of the anti-aging action of
caloric restriction can be uncovered, we would gain an
understanding of the basic nature of aging processes, which would,
in turn, yield possible interventions in human aging. This book
aims to provide the growing number of researchers in this field
(faculty, postdoctoral trainees, and graduate students) with a
detailed knowledge of what is known about caloric restriction
within the frame of gerontology, as well as insights on future of
Apoptosis, or programmed cell death, is an adaptive form of cell death that plays a critical role in turnover of mitotic cells and various tissues in the adult, including epithelial cells, fibroblasts and various endocrine cells. Programmed cell death also plays a major role in development in organizing the body plan and molding intricate cellular structures such as nerve cell circuits in the brain. Rapidly progressing research into the molecular and biochemical underpinnings of the programmed cell death process are revealing novel genetic programs and molecular interactions that coordinate a process that results in death and removal of cells without an immune response and in the absence of the adverse effects on neighboring cells.
"Programmed Cell Death, Volume I," critically details the molecular, biochemical and cellular mechanisms of apoptosis. This volume covers programmed cell death in a variety of tissues and organ systems highlighting the interesting families of proteins involved in promoting or preventing apoptosis. These include the caspase and calpain families of proteases, Bcl-2 family members, and inhibitors of apoptosis proteins. Each chapter is written by an internationally recognized expert in a particular aspect of programmed cell death.
This book will provide the reader with a comprehensive
understanding of the cascade of events leading from an apoptotic
signal, such as trophic factor withdrawal or increased oxidative
stress, to cell death. Importantly, this volume also covers
signaling mechanisms designed to prevent apoptosis. Such
anti-apoptotic signaling cascades involve neurotrophic factors and
stress response pathways. "Programmed Cell Death, Volume I,"
provides the molecular and cellular foundation for http:
//www.elsevier.com/locate/isbn/0444507302Programmed Cell Death,
Volume II in which the roles of aberrant regulation of apoptosis in
human diseases ranging from cancer to Alzheimer's disease are
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