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The fourth edition of "Fundamental Neuroscience" reinvents itself as an engrossing and comprehensive presentation of the discipline of neuroscience, from molecules to cognition. Thorough but succinct, and lavishly illustrated, the book builds from an introductory section that includes fundamental neuroanatomy and goes on to cover cellular and molecular neuroscience, development, sensory systems, motor systems, regulatory systems, and behavioral and cognitive neuroscience. The book has been retooled to better serve its audience in the neuroscience and medical communities.
The chapters include more than 100 boxes describing clinical
conditions, techniques, and other special topics. Each chapter went
through a thorough review process, giving the book an evenness of
tone. The chapters are authored by outstanding working scientists
who are experts on the topics they cover.
"Development of the Nervous System" presents a broad and basic
treatment of the established and evolving principles of neural
development as exemplified by key experiments and observations from
past and recent times. The text is organized ontogenically. It
begins with the emergence of the neural primordium and takes a
chapter-by-chapter approach in succeeding events in neural
development: patterning and growth of the nervous system, neuronal
determination, axonal navigation and targeting, neuron survival and
death, synapse formation and developmental plasticity. Finally, in
the last chapter, with the construction phase nearing completion,
we examine the emergence of behavior. This new edition reflects the
complete modernization of the field that has been achieved through
the intensive application of molecular, genetic, and cell
biological approaches. It is richly illustrated with color
photographs and original drawings. Combined with the clear and
concise writing, the illustrations make this a bookthat is well
suited to students approaching this intriguing field for the first
Features - Thorough survey of the field of neural development - Concise but complete, suitable for a one semester course on upper level undergraduate or graduate level - Focus on fundamental principles of organogenesis in the nervous system - Integrates information from a variety of model systems, relating them to human nervous system development, including disorders of development - Systematically develops knowledge from the description of key experiments and results. - Organized ontologically - Carefully edited to be presented in one voice - New edition thoroughly updated and revised to include major new findings - All figures in full color, updated and revised - Specific attention on revising the chapter on cognitive and behavioral development to provide a foundation and outlook towards those very fast moving areas - Instructor website with figure bank andtest questions
Benefits - The only thorough textbook of Developmental Neuroscience on the market - Carefully structured and edited to map onto the syllabus of most developmental neuroscience courses - Priced to be affordable for undergraduates even in addition to broader textbooks - Carefully constructed instructor's website - Specifically designed to make teaching of complicated subjects easy and fun for instructors and students alike"
This is the fully revised and updated second edition of the very
sucessful introductory textbook on cognitive neuroscience. Written
by two leading experts in the field, thisbook takes a unique
thematic approach to introduce concepts of cognitive neurosciences,
guiding students along a clear path to understand the latest
findings whether or not they have a background in neuroscience. New
to this edition are "Frontiers in Cognitive Neuroscience" text
boxes; each one focuses on a leading researcher and their topic of
expertise. There is a new chapter on Genes and Molecules of
Cognition, and all other chapters have been thoroughly revised,
based on the most recent discoveries.
Rapid adoption and course preparation: A wide array of instructor support materials are available online including PowerPoint lecture slides, a test bank with answers, and eFlashcords on key concepts for each chapter. A textbook with an easy-to-understand thematic approach: in a way that is clear for students from a variety of academic backgrounds, the text introduces concepts such as working memory, selective attention, and social cognition.A step-by-step guide for introducing students to brain anatomy: color graphics have been carefully selected to illustrate all points and the research explained. Beautifully clear artist's drawings are used to 'build a brain' from top to bottom, simplifying the layout of the brain.
An easy-to-read, complete introduction to mind-brain science: all chapters begin from mind-brain functions and build a coherent picture of their brain basis. A single, widely accepted functional framework is used to capture the major phenomena. Learning Aids include a student support site with study guides and exercises, a new Mini-Atlas of the Brain and a full Glossary of technical terms and their definitions.Richly illustrated with hundreds of carefully selected color graphics to enhance understanding. "
Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, the outstanding and comprehensive classic text on neurochemistry, is now newly updated and revised in its Eighth Edition. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. It is also an excellent source of current information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text continues to be the standard reference and textbook for exploring the translational nature of neuroscience, bringing basic and clinical neuroscience together in one authoritative volume. Our book title reflects the expanded attention to these links between neurochemistry and neurologic disease.
This new edition continues to cover the basics of neurochemistry
as in the earlier editions, along with expanded and additional
coverage of new research from: Intracellular trafficking;Stem
cells, adult neurogenesis, regeneration;Lipid messengers;Expanded
coverage of all major neurodegenerative and psychiatric
disorders;Neurochemistry of addiction;Neurochemistry of
pain;Neurochemistry of hearing and balance;Neurobiology of learning
and memory;Sleep;Myelin structure, development, and disease;Autism;
The new edition features:
* Completely updated text with new authors and material, and many entirely new chapters * Over 400 fully revised figures in splendid color * 61 chapters covering the range of cellular, molecular and medical neuroscience * Translational science boxes emphasizing the connections between basic and clinical neuroscience * Companion website at http: //elsevierdirect.com/companions/9780123749475"
The second edition of this atlas maps the detailed architectonic
subdivisions of the cortical and subcortical areas in the macaque
monkey brain using high-resolution magnetic resonance (MR) images
and the corresponding histology sections in the same animal. This
edition of the atlas is unlike anything else available as it
includes the detailed cyto- and chemoarchitectonic delineations of
the brain areas in all three planes of sections (horizontal,
coronal, and sagittal) that are derived from the same animal. This
is a significant progress because in functional imaging studies,
such as fMRI, both the horizontal and sagittal planes of sections
are often the preferred planes given that multiple functionally
active regions can be visualized simultaneously in a single
horizontal or sagittal section. This combined MRI and histology
atlas is designed to provide an easy-to-use reference for
anatomical and physiological studies in macaque monkeys, and in
functional-imaging studies in human and non-human primates using
fMRI and PET.
The Mouse Brain in Stereotaxic Coordinates is the most widely used
and cited atlas of the mouse brain in print. It provides
researchers and students with both accurate stereotaxic coordinates
for laboratory use, and detailed delineations and indexing of
structures for reference. The Compact 3rd edition is both a major
revision and an expansion of previous compact editions. The 100
high resolution digital photographs of the coronal plane of section
from the third full edition now complement the coronal drawings.
The photographs of the sections and the intermediate sections are
also provided on the accompanying CD. In addition, the compact
version has a large introduction on stereotaxic surgery and the use
of the atlas in the lab, as well as a number of panoramic
simplified diagrams for student instruction. The Compact 3rd
edition is in 8.5 x 11 format and is spiral bound suitable for
positioning next to microscopes and cryotomes.
Magnetic resonance imaging (MRI) is a medical imaging technique
used to visualize detailed internal structure of the body. This
book discusses the recent developments in the field of MRI and its
application to the diagnosis of human brain disorders. In addition,
it reviews the newly emerging concepts and technology, based on the
multi-coherence imaging (MQCI). It explains how computer packages
can be used to generate images in diseased states and compare them
to in vivo results. This will help improve the diagnosis of brain
disorders based on the real-time events happening on atomic and
molecular quantum levels. This is important since quantum-based MRI
would enable clinicians to detect brain tumors at the very early
In the years since its first publication, "Paxinos and
Franklin's the Mouse Brain in Stereotaxic Coordinates" has received
virtually universal acceptance in neuroscience as the authoritative
source for stereotaxic coordinates and delineations. This atlas is
constructed in the style of "The Rat Brain in Stereotaxic
Coordinates," the most cited publication in neuroscience. The
completely revised and updated 4e of "Paxinos and Franklin's the
Mouse Brain in Stereotaxic Coordinates" features high-quality color
plates scanned by the renowned microscopy unit of the Allen
Institute for Brain Science. Constructed by the leaders in
neuroanatomical atlas development, the new edition will maintain
the position of the atlas as an indispensable resource for
scientists working on the mouse brain.
The "Atlas of the Spinal Cord" is the first comprehensive atlas
of rodent and primate spinal cords. This atlas features
histological images and labeled drawings of every segment from rat,
mouse, marmoset monkey, rhesus monkey, and human spinal cords.
Nissl-stained section images and matching drawings for each segment
are supplemented by up to four histochemical or immunohistochemical
images on a facing page. The neuron groups supplying major limb
muscles are identified in each species. Constructed by the
established leaders in neuroanatomical atlas development, this new
atlas will be the indispensible resource for scientists who work on
rodent or primate spinal cord.
Sleep is the natural state of bodily rest, common to all mammals
and birds and also seen in many reptiles, amphibians and fish. For
most species, regular sleep is essential for survival, yet the
specific purposes of sleep are still only partly clear and are the
subject of intense research. This volume is comprised of the
editors selection of the most relevant articles on sleep from the
"Encyclopedia of Neuroscience, " resulting in the first
comprehensive collection of introductory articles on the
neuroscience of sleep.Articles explore sleep s impact on neural
functioning, sleep disorders, the relation between sleep and other
clinical disorders, a look at sleep from a developmental
perspective, and more.
* Chapters offer impressive scope with topics addressing neural functioning, disorders, development, and more, carefully selected by one of the most preeminent sleep researchers
* Richly illustrated in full color with over 100 figures
* Contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge"
The previous two editions of the "Human Nervous System "have
been the standard reference for the anatomy of the central and
peripheral nervous system of the human. The work has attracted
nearly 2,000 citations, demonstrating that it has a major influence
in the field of neuroscience. The 3e is a complete and updated
revision, with newchapters covering genes and anatomy, gene
expression studies, and glia cells. The book continues to be an
excellent companion to the "Atlas of the Human Brain," and a common
nomenclature throughout the book is enforced. Physiological data,
functional concepts, and correlates to the neuroanatomy of the
major model systems (rat and mouse) as well as brain function round
out the new edition.
"The Mouse Nervous System" provides a comprehensive account of
the central nervous system of the mouse. The book is aimed at
molecular biologists who need a book that introduces them to the
anatomy of the mouse brain and spinal cord, but also takes them
into the relevant details of development and organization of the
area they have chosen to study. "The Mouse Nervous System" offers a
wealth of new information for experienced anatomists who work on
mice. The book serves as a valuable resource for researchers and
graduate students in neuroscience.
Embodied theories claim that semantic representations are
grounded in sensorimotor systems, but the contribution of
sensorimotor brain areas in representing meaning is still
controversial. One current debate is whether activity in
sensorimotor areas during language comprehension is automatic.
Numerous neuroimaging studies reveal activity in perception and
action areas during semantic processing that is automatic and
independent of context, but increasing findings show that
involvement of sensorimotor areas and the connectivity between
word-form areas and sensorimotor areas can be modulated by
contextual information. "Context Effects on Embodied Representation
of Language Concepts "focuses on these findings and discusses the
influences from word, phrase, and sentential contexts that
emphasize either dominant conceptual features or non-dominant
Fundamentals of Cognitive Neuroscience is a comprehensive and easy-to-follow guide to cognitive neuroscience. Winner of a 2013 Most Promising New Textbook Award from the Text and Academic Authors Association, this book was written by two leading experts in the field to be highly accessible to undergraduates with limited neuroscience training. It covers all aspects of the field-the neural framework, sight, sound, consciousness, learning/memory, problem solving, speech, executive control, emotions, socialization and development-in a student-friendly format with extensive pedagogy and ancillaries to aid both the student and professor. This introductory text takes a unique thematic approach, guiding students along a clear path to understand the latest findings whether or not they have a background in neuroscience. It includes case studies and everyday examples designed to help students understand the more challenging aspects of the material. It is richly illustrated with carefully selected color graphics to enhance understanding. Enhanced pedagogy highlights key concepts for the student and aids in teaching. Chapter outlines, study questions, glossary, and image collection are also available on the student's companion website. Ancillary support saves instructors time and facilitates learning; test questions, image collection, and lecture slides are available on the instructor's manual website. This book will be of interest to undergraduate students in Neuroscience, Psychology, and related disciplines that teach cognitive neuroscience.
The Rat Brain in Stereotaxic Coordinates, Compact Sixth Edition is
a smaller sized (8.5 x11inch), abridged version of the most
referenced work in neuroscience (over 35,000 citations for this
atlas). The compact edition provides the coronal plates and
diagrams of the current sixth edition in a smaller more convenient
spiral format and at a student friendly price. This book includes
an introduction for students to some of the major current concepts
in neuroanatomy: neuromeres and brain development. Students and
seasoned researchers will find herein the first major unified
nomenclature ontology tree based on development. The atlas features
161 coronal photographic plates and 161 juxtaposed diagrams. The
diagrams are in color, but the photographs are in black and white.
The full-sized sixth edition is in full color and also features the
sagittal and horizontal planes.
Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair.
This book discusses some of the more common neuro-inflammatory
diseases. Topics covered include multiple sclerosis, optic neuritis
and Susac syndrome.
This book presents the essentials of behavioral test methodology needed for effective study planning and high quality behavioral data collection on laboratory mice. The broad scope of behavioral testing in relation to the neurosciences is discussed, as are thefine details of varioustest situations. Mistakes made in past research are scrutinized and lessons are drawn about how to avoid them in future work. Diverse factors that can influence the results of behavioral experiments are discussed, ranging from the specific parameters employed in a test to the laboratory environment outside the test situation itself. Throughout the book, emphasis is placed on special issues that arise when testing genetically different mice, including inbred strains and mice with targeted mutations. This knowledge will assist an investigator who lacks formal training in behavioral psychology to build a behavioral testing lab and insure that its output meets current standards of good practice in behavioral neuroscience research.
The book will be a convenient manual of procedures for daily use
in studies of mouse behavior. It will be of interest even to
experienced behavioural researchers, but of particular value to
scientists just beginning work with mice, including undergraduate
and graduate students as well as postdoctoral investigators who
want to collect phenotypic data with knockout and other genetically
defined mice. Constructed from materials used in a long running
course on Advanced Animal Behavior at University of North
Carolina-Greensboro, the book is an ideal text for a course on
How do genes determine behavior? How much of behavior is nature
versus nurture? How do behaviors evolve? Anholt and Mackay, leading
scholars in the field of behavioral genetics, address these
questions and much more in this comprehensive textbook that defines
the emerging field of behavioral genetics. The provides a range of
examples, such as laboratory studies on flies and mice, field
observations on species as diverse as butterflies and meerkats, and
human behavioral disorders. The book blends classical and modern
genetic principles with neurobiological and ecological perspectives
to teach students how to find and map genes that affect behaviors,
as well as how the coordinated expression of ensembles of these
genes enables the nervous system to express complex behaviors in
response to changes in the environment. Principles of Behavioral
Genetics introduces us to the fascinating science that aims to
understand how our genes determine what makes us tick.
Now more than ever, doctors are being targeted by government
prosecutors and whistleblowers challenging the legality of their
relationships with drug and device companies. With reputations at
stake and the risk of civil and criminal liability, it is incumbent
upon doctors to protect themselves.
The Primer on the Autonomic Nervous System presents, in a readable
and accessible format, key information about how the autonomic
nervous system controls the body, particularly in response to
stress. It represents the largest collection of world-wide
autonomic nervous system authorities ever assembled in one book. It
is especially suitable for students, scientists and physicians
seeking key information about all aspects of autonomic physiology
and pathology in one convenient source. Providing up-to-date
knowledge about basic and clinical autonomic neuroscience in a
format designed to make learning easy and fun, this book is a
must-have for any neuroscientist s bookshelf
The authors of the most cited neuroscience publication, "The Rat Brain in Stereotaxic Coordinates," have written this introductory textbook for neuroscience students. The text is clear and concise, and offers an excellent introduction to the essential concepts of neuroscience.
Based on contemporary neuroscience research rather than old-style medical school neuroanatomy
Thorough treatment of motor and sensory systems
A detailed chapter on human cerebral cortex
The neuroscience of consciousness, memory, emotion, brain injury, and mental illness
A comprehensive chapter on brain development
A summary of the techniques of brain research
A detailed glossary of neuroscience terms
Illustrated with over 130 color photographs and diagrams
This book will inspire and inform students of neuroscience. It
is designed for beginning students in the health sciences,
including psychology, nursing, biology, and medicine.
Based on contemporary neuroscience research rather than the concepts of old-style medical school neuroanatomy
Thorough treatment of motor and sensory systems
A detailed chapter on human cerebral cortex
Discussion of the neuroscience of conscience, memory, cognitive function, brain injury, and mental illness
A comprehensive chapter on brain development
A summary of the techniques of brain research
A detailed glossary of neuroscience terms
Illustrated with over 100 color photographs and diagrams
The present proposal offers an outline of the planned major
Handbook on Mammalian Vocalization, which fills a clear niche
existing in the science book literature and on the market. The
Handbook is designed as a broad and comprehensive, but
well-balanced book, written from the neuroscience point of view in
the broad sense of this term. Only a few issues will be reduced,
which are extensively covered in other recent book publications.
The Handbook is planned in a unique way and will not directly
compete with other books on the market. This well-illustrated
Handbook will pay a particular attention to systematically
organized details but also to the explanatory style of the text and
internal cohesiveness of the content, so the successive chapters
will gradually develop a consistent story without losing the
inherent complexity. Studies from many species will be included,
however, rodents will dominate, as most of the brain investigations
were done on these species.
This completely revised edition of The Rat Brain in Stereotaxic
Coordinates, the second most cited book in science, represents a
dramatic update from the previous edition. Based on a single rat
brain, this edition features an entirely new coronal set of tissue
cut in regular 120 micron intervals with accompanying photographs
and drawings of coronal, horizontal and sagittal sections of this
new set. The use of the single brain allows for greater consistency
between sections, while advances in histochemistry techniques
provides increased refinement in the definition of brain areas,
making this the most accurate and detailed stereotaxic rat atlas
produced to date. The atlas will also include a CD-ROM featuring
all of the graphics and text. Every lab working with the rat as an
experimental animal model will want to use this book as their atlas
Leading authors review state-of-the-art in their field of
investigation and provide their views and perspectives for future
Central nervous system (CNS) diseases such as Alzheimer s disease, Parkinson s disease, and amyotrophic lateral sclerosis affect a large number of populations worldwide for which no suitable cure is currently available. In addition, stroke, nanoparticle intoxication, diabetes, hypertension, and psychostimulant abuse either alone or in combination are capable of inducing potential brain damage. Thus, there is an urgent need to expand our knowledge to find suitable therapeutic strategies to enhance neurorepair processes in such diseases.
This volume presents neuroprotection and novel therapeutic strategies developed in the last 5 years by 12 world leaders in the field. The term neuroprotection means rescuing neuronal and non-neuronal cells together. The cerebral endothelium that constitutes the anatomical and physiological site of the blood-brain barrier (BBB) is one of the most important non-neural cells in the CNS. Any distortion of the BBB leads to brain diseases and restoration of the barrier results in neuroprotection. Thus, the BBB appears to be the "gateway" for neurological diseases and neurorepair. However, to treat brain tumors or infarcts, new therapeutic strategies are needed to enhance brain drug delivery using nanotechnology. In addition, apart from conventional drugs, restoration of BBB function could also be achieved by means of antibodies directed against specific proteins, neurotransmitters or exogenous supplement of neurotrophic factors. Since co-morbidity factors e.g., hypertension, diabetes, and exposure of nanoparticles could complicate the pathogenesis of neurological disorders either an enhanced dose of the drug or nanodelivery of a combination of several drugs is needed to achieve neuroprotection.
This volume of "International Review of Neurobiology" is the
first to discuss novel therapeutic strategies in situations of
neurological disorders in combination with different co-morbidity
Reviews written by experts in such a way thatprovides basic knowledge for beginners and advanced information for researchers and experts.
New aspects of Neurodegenerative diseasessuch as;Alzheimer s Disease, Parkinson s Disease, Amyotrophic Lateral Sclerosis are presented with thelatest therapeutic measures.
Exacerbation of brain pathology in hypertension or diabetes is discussed for the first time."
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