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Books > Academic & Education > Professional & Technical > Pharmacology

Principles of Clinical Pharmacology (Hardcover, 3rd Revised edition): Arthur J. Atkinson Jr., Shiew-Mei Huang, Juan J. L.... Principles of Clinical Pharmacology (Hardcover, 3rd Revised edition)
Arthur J. Atkinson Jr., Shiew-Mei Huang, Juan J. L. Lertora, Sanford P. Markey
R2,652 Discovery Miles 26 520 Within 7 - 15 working days

"Principles of Clinical Pharmacology" is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference covering the wide range of important topics impacting clinical pharmacology as the discipline plays an increasingly significant role in drug development and regulatory science.

The Third Edition has been endorsed by the American Society for Clinical Pharmacology and Therapeutics

* Includes new chapters on imaging and the pharmacogenetic basis of adverse drug reactions. * Offers an expanded regulatory section that addresses US and international issues and guidelines. * Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers and also illustrates the impact of gender on drug response. * Presents a broadened discussion of clinical trials from Phase 1 to incorporate Phases II and III.

The Law and Ethics of the Pharmaceutical Industry (Hardcover): M.N.G. Dukes The Law and Ethics of the Pharmaceutical Industry (Hardcover)
M.N.G. Dukes
R2,380 Discovery Miles 23 800 Within 7 - 11 working days

As one of the most massive and successful business sectors, the pharmaceutical industry is a potent force for good in the community, yet its behaviour is frequently questioned: could it serve society at large better than it has done in the recent past? Its own internal ethics, both in business and science, may need a careful reappraisal, as may the extent to which the law - administrative, civil and criminal - succeeds in guiding (and where neccessary contraining) it.
The rules of behavior that may be considered to apply to today's pharmaceutical industry have emerged over a very long period and the process goes on. Even the immensely detailed standards for quality, safety and efficacy laid down in drug law and regulation during the second half of the twentieth century have their limitations as tools for ensuring that the public interest is well served. In particular, national and regional regulatory agencies are heavily dependent on industrial data for their decision-making, their standards and competence vary, and even the existing network of agencies does not cover the entire world. What is more there are many areas of law and regulation affecting the industry, concerning for example the pricing of medicines, the conduct of clinical studies, the health protection of workers and concern for the environment. In some fields it is indeed hardly possible to maintain standards through regulation.
Professor N.M. Graham Dukes, a physician and lawyer with long term experience in industrial research management, academic study and international drug policy, provides here a powerfully documented analysis into the way this industry thinks, acts, and is viewed, and examines the current trends pointing to change.
*Provides a balanced picture of the current role of the pharmaceutical industry in society
*Includes indices of conventions, laws, and regulations; as well as judicial and disciplinary cases
*This is the only book addressing the legal implications of big pharma activities and ethical standards

Side Effects of Drugs Annual - A World-Wide Yearly Survey of New Data and Trends in Adverse Drug Reactions (Audio): Jeffrey K.... Side Effects of Drugs Annual - A World-Wide Yearly Survey of New Data and Trends in Adverse Drug Reactions (Audio)
Jeffrey K. Aronson
R3,633 Discovery Miles 36 330 Within 7 - 11 working days

Volume 28 in the series of Side Effects of Drugs Annuals (http: //www.elsevier.com/locate/series/seda) continues to serve its primary goal: to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists has reviewed new data and trends by selecting from the year's writing all that is truly new and informative, by critically interpreting it, and by pointing to whatever is unproven or misleading. The use of the book is enhanced by separate indexes, allowing the reader to access the text via drug name, adverse effect, or drug interaction.
The current annual includes an essay by the editor, Dr Jeffrey Aronson, entitled 'Classifying Drug Adverse Reactions in the 21st Century.' In it he describes how the modern approach to classifying adverse drug reactions takes into account the dose that causes the reaction, the time-course of the reaction, and the susceptibility factors that increase the individual patient's risk, and shows how this analysis can facilitate regulatory decision making.
*Provides a critical yearly survey of new data and trends
*Includes an essay that describes the modern approach to classifying adverse drug reactions
*Special reviews in this Annual include, among other topics: Antipsychotic drugs and now-onset diabetes mellitus, Treating asthma during pregnancy, and MMR vaccine and autism

Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs (Hardcover): Jeffrey K. Aronson Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs (Hardcover)
Jeffrey K. Aronson
R1,021 R299 Discovery Miles 2 990 Save R722 (71%) Within 7 - 11 working days

Elsevier now offers a series of derivative works based on the acclaimed "Meyler s Side Effect of Drugs, 15th Edition." These individual volumes are grouped by specialty to benefit the practicing biomedical researcher and/or clinician.
Opioids and analgesics are members of a diverse group of drugs used to relieve pain. They are frequently used in combination with prescription and nonprescription pain relievers, and misuse is prevalent. Pain medicine specialists and physicians or surgeons will find this volume useful in prescribing the appropriate drugs for pain therapy and for preventing misuse of the medication.
* The only drug guide that includes clinical case studies and expert analysis
* "UNIQUE " Features not only analgesics and anti-inflammatory drugs, but also all other drugs that act in an analgesic or anti-inflammatory manner
* Most complete cross referencing of drug-drug interactions available
* Latest content from the most highly regarded compilation of drug side effects: "Side Effects of Drugs Annual" serial"

Histopathology of Preclinical Toxicity Studies - Interpretation and Relevance in Drug Safety Evaluation (Hardcover, 4th Revised... Histopathology of Preclinical Toxicity Studies - Interpretation and Relevance in Drug Safety Evaluation (Hardcover, 4th Revised edition)
Peter Greaves
R2,769 Discovery Miles 27 690 Within 7 - 11 working days

The new 4th edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essential for those involved in drug safety evaluation, including pathologists, toxicologists and pharmacologists working in corporate, government, academic and research settings.

NEW TO THE FOURTH EDITION:

*This edition is in full color and featuresnearly 200 high-quality images

*Provides extended commentary on the relevance of pathological findingsand features a fully updatedbibliography containing sources for further reading

*Includes new content coverage on the commonly used transgenic animal models that are used in safety assessment, specific tumor types induced by drugs in rodents, and new drug-induced pathologies and lesions. "

PAKs, RAC/CDC42 (P21) - Activated Kinases - Towards the Cure of Cancer and Other PAK-Dependent Diseases (Hardcover, New):... PAKs, RAC/CDC42 (P21) - Activated Kinases - Towards the Cure of Cancer and Other PAK-Dependent Diseases (Hardcover, New)
Hiroshi Maruta
R1,550 Discovery Miles 15 500 Within 7 - 11 working days

This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases.

This book consists of 9 chapters which deal with different aspects of this kinase. These chapters are written by more than two dozen world-leading PAK experts. Each of these will provide updated biomedical information as well as future insight to a wide range of readers who are interested in this unique kinase and both its pathological and physiological roles as well as its functional evolution from its ancestral origins.
This publication will be the very first book ever published solely focused on PAK family kinases. Each chapter deals with the latest progress in PAK research written by a leading PAK expert with his or her own ideas and insight. Each chapter of this book has been written in such a way that clinical doctors who seek the effective cure of these formidable diseases, in addition to research scientists and biomedical students will value this book. This book describes in detail a number of PAK blockers which would be potentially useful for the therapy of these PAK-dependent diseases, and some of them are indeed available on the market inexpensively, without any side effect."

Clinical Pharmacology During Pregnancy (Hardcover, New): Donald R. Mattison Clinical Pharmacology During Pregnancy (Hardcover, New)
Donald R. Mattison
R1,040 Discovery Miles 10 400 Within 7 - 11 working days

"Clinical Pharmacology During Pregnancy" is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involved in the care of women during pregnancy. This book focuses on the impact of pregnancy on drug disposition and also includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy.

The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are covered, as are research issues, including clinical trial design and ethical considerations.
Uses an evidence-based approach for therapeutics during pregnancyIncludes a summary of specific medications by indication with up-to-date information on dosing and efficacy in pregnancy for the given indicationIncludes a companion website containing support materials for professional or continuing education courses in OB pharmacology

Handbook of Toxicology of Chemical Warfare Agents (Hardcover): Ramesh C. Gupta Handbook of Toxicology of Chemical Warfare Agents (Hardcover)
Ramesh C. Gupta
R3,695 Discovery Miles 36 950 Within 7 - 11 working days

This groundbreaking book covers every aspect of deadly toxic chemicals used as weapons of mass destruction and employed in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this one-of-a-kind handbook is prepared in a very user- friendly format that can easily be followed by students, teachers and researchers, as well as lay people. Stand-alone chapters on individual chemicals and major topics allow the reader to easily access required information without searching through the entire book.
This is the first book that offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors, biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, prophylactic, therapeutic and countermeasures, and the role of homeland security.
Presents a comprehensive look at all aspects of chemical warfare toxicology in one reference work. This saves researchers time in quickly accessing the very latest definitive details on toxicity of specific agents used in chemical warfare as opposed to searching through thousands of journal articles. Will include the most agent-specific information on the market.
Includes detailed coverage of the most exhaustive list of agents possibly used as chemical warfare agents in one source. Section 4: Agents That Can Be Used as Weapons of Mass Destruction ? 25 chapters long. Other books on the market only include a sample selection of specific agents. Offering all possible agents detailed under one cover makes this appealing to a wider audience and saves researchers time.

The Forward will be written by Dr. Tetsuo Satoh, Chiba University, Japan. He is one of the most respected, recognizable authorities on chemical warfare agents which will set the authoritative tone for the book.

Covers risk to humans, animals and the environment equally. Researchers involved in assessing the risks involved with a possible chemical warfare attack and those who are developing response plans to such attacks must look at not only the risks to human health but to our wildlife and environment as well. The holistic approach taken in this book ensures that the researchers have ready access to the details no matter which aspect of the effects of CWA's they might be concerned with.

Side Effects of Drugs Annual - A Worldwide Yearly Survey of New Data and Trends in Adverse Drug Reactions and Interactions... Side Effects of Drugs Annual - A Worldwide Yearly Survey of New Data and Trends in Adverse Drug Reactions and Interactions (Hardcover)
J.K. Aronson
R7,151 Discovery Miles 71 510 Within 7 - 15 working days

The Side Effects of Drugs Annual was first published in 1977. It has been published continuously since then, as a yearly update to the encyclopaedic volume Meyler's Side Effects of Drugs. Each new Annual provides clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists have contributed to the Annuals by selecting from each year's publications all that is truly new and informative, by critically interpreting it, and by pointing out whatever is misleading. The use of the book is enhanced by separate indexes, allowing the reader to enter the text via the drug name, adverse effect, or drug interaction. Special features of the Annuals are the Side Effects of Drugs Essay, usually written by a guest author, and the special reviews: short articles, within the different chapters, that give extra attention to topics of current interest. The Essay in Annual 27 is entitled 'The General Practice Research Database' (by Dr. H. Jick) and there is a Historical Essay entitled 'Louis Lewin - Meyler's Predecessor' (by Dr. J.K. Aronson). The special reviews in this volume include, among others: The effects of NSAIDs on blood pressure Risks of inhaled corticosteroids in children Leukotriene receptor antagonists and Churg-Strauss syndrome Amiodarone and thyroid disease Surveillance of adverse events following immunization Smallpox vaccination Safety aspects of folic acid Inhibitors of topoisomerase I and topoisomerase II Liver damage from kava kava

Bridging Hippocrates and Huang Ti, v. 1 - A Comparative Thesaurus of Traditional Chinese and Western Urology, Andrology and... Bridging Hippocrates and Huang Ti, v. 1 - A Comparative Thesaurus of Traditional Chinese and Western Urology, Andrology and Sexology (Hardcover, New)
P. Marandola, S. Musitelli, Wei Li Chen
R3,466 Discovery Miles 34 660 Within 7 - 15 working days

Western Medicine as seen today has a strong scientific basis in its development. The pathogenesis of most diseases and their symptomatology and physical signs are well studied and understood. The management of patients is based on firm understanding of these disease processes. In contrast, Traditional Chinese Medicine came about through the experience of many generations of practitioners over thousands of years. Undoubtedly, many of these treatments have proved to be effective in their own way, however, firm scientific basis is still lacking.


While most Western Medicine advocates control of disease by eradication of pathogens and surgical removal of diseased organs as in the case of cancer, Traditional Chinese Medicine seeks to improve resistance against disease. There is probably a great wealth of therapeutic value in Traditional Chinese Medicine, which has not been discovered or explored fully. By combining the knowledge of both Western and Traditional Chinese Medicine, one might be able to improve the results of efficacy of treatments and the survival of patients. The integration of Medicine from East and West will take time to evolve and will need interested physicians from different parts of the world to work closely together to realize such a possibility.


This book is an attempt to bridge the medical world of two great and ancient civilizations in their approach to the treatment of disease. It is informative with a detailed account of the history of medical development. It is highly recommended for those medical practitioners from both East and West who are interested to explore alternative medicine and research new areas of the medical frontier.

A Dictionary of Pharmacology and Allied Topics (Hardcover, 2nd Revised edition): D.R. Laurence, J. R. Carpenter A Dictionary of Pharmacology and Allied Topics (Hardcover, 2nd Revised edition)
D.R. Laurence, J. R. Carpenter
R5,470 Discovery Miles 54 700 Within 7 - 15 working days

This dictionary spans the practice of pharmacology, and of allied sciences insofar as they are related to it, with particular emphasis on the development, regulation and use of human medicine. It is offered to students as well as to professionals in pharmacology and allied sciences for "reference" and for "browsing," and as a bedside book and travelling companion. Its size (approximately 2000 entries) is appropriate for these uses.

Features of this dictionary:

- Provides definitions of terms in pharmacology, both basic and clinical

- Gives information on new medicine development and official regulations

- Covers allied topics, including statistics, ethics, scientific miscounduct, authorship, publication and law.

Approaches to Design and Synthesis of Antiparasitic Drugs (Hardcover): N. Anand, S. Sharma Approaches to Design and Synthesis of Antiparasitic Drugs (Hardcover)
N. Anand, S. Sharma
R5,945 Discovery Miles 59 450 Within 7 - 15 working days

This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

Antidiabetic Agents: Antidiabetic Agents (Hardcover): Bernard Testa, Urs A. Meyer Antidiabetic Agents: Antidiabetic Agents (Hardcover)
Bernard Testa, Urs A. Meyer
R3,050 Discovery Miles 30 500 Within 7 - 15 working days

Volume 27, the first thematic volume in the Series, provides an overview of present knowledge with regard to the pharmacological and clinical aspects of antidiabetic drugs. It aims to stimulate further consideration of possible concepts in the development of new antidiabetic drugs.

Biosensors, v. 3 - A Russian Perspective (Hardcover): A.P.F. Turner, Reinhard Renneberg Biosensors, v. 3 - A Russian Perspective (Hardcover)
A.P.F. Turner, Reinhard Renneberg
R4,151 Discovery Miles 41 510 Within 7 - 15 working days

Biosensors have captured the imagination of the world's scientific and commercial communities by combining interdisciplinary skills of biologists, physicists, chemists and engineers to provide innovative solutions to analytical problems. Biosensors are applicable to clinical diagnostics, food analysis, cell culture monitoring, environmental control and various military situations. Ever increasing demands for rapid and convenient analyses of a wide variety of materials in diverse locations has led to intense interest in the fusion of biology and electronics which mimics our principal concern: the effect of materials and environments on living systems. This series, "Advances in Biosensors", presents a compendium of research papers, in which authorities in the field of biosensors provide an up-to-date overview of their laboratory's contribution, summarizing the primary research as it has appeared, possibly scattered, in the journal and conference literature, and reflecting on their findings. The net result will be intense, yet highly readable accounts of the state of the art at this leading edge of analytical technology.

Pharmacological and Chemical Synonyms - A Collection of Names of Drugs, Pesticides and Other Compounds Drawn from the Medical... Pharmacological and Chemical Synonyms - A Collection of Names of Drugs, Pesticides and Other Compounds Drawn from the Medical Literature of the World (Hardcover, 10th Revised edition)
E.E.J. Marler
R8,514 Discovery Miles 85 140 Within 7 - 15 working days

Now in its tenth edition, this famous compilation of synonyms for drugs, pesticides and other substances of pharmacological or biochemical interest has become even more international and comprehensive in its scope. Electronic storage of the data has ensured that the book is fully up to date, while the highest degree of cross referencing between entries is guaranteed. The types of names presented are: chemical names, abbreviated chemical names, source names, pharmacological names, pesticide names, names derived from places, plants or persons, research code numbers, and proprietary names (trademarks).

For people working in the fields of biochemistry, pharmacology, pharmaceutics, and toxicology, as well as for medical editors and drug regulatory officers, this work will prove to be an indispensable source of information.

Neglected Factors in Pharmacology and Neuroscience Research - Biopharmaceutics, Animal Characteristics, Maintenance, Testing... Neglected Factors in Pharmacology and Neuroscience Research - Biopharmaceutics, Animal Characteristics, Maintenance, Testing Conditions (Paperback)
V. Claassen
R1,751 Discovery Miles 17 510 Within 7 - 15 working days

This text indicates those variables which in general may need a better control. Examples illustrate the impact that those variables may have on various characteristics. A series of representative studies are presented so that insight can be obtained about the effects of these parameters.

Advances in Atomic Spectroscopy, v. 1 (Hardcover): Joseph Sneddon Advances in Atomic Spectroscopy, v. 1 (Hardcover)
Joseph Sneddon
R2,657 Discovery Miles 26 570 Within 7 - 15 working days

This series describes selected advances in the area of atomic spectroscopy. It is promarily intended for the reader who has a background in atmoic spectroscopy; suitable to the novice and expert. Although a widely used and accepted method for metal and non-metal analysis in a variety of complex samples, "Advances in Atomic Spectroscopy" covers a wide range of materials. Each Chapter will completely cover an area of atomic spectroscopy where rapid development has occurred.

Advances in DNA Sequence-specific Agents, v. 1 - A Research Annual (Hardcover): Laurence Hurley Advances in DNA Sequence-specific Agents, v. 1 - A Research Annual (Hardcover)
Laurence Hurley
R2,449 Discovery Miles 24 490 Within 7 - 15 working days

This volume is aimed in general at scientists who have an interest in deciphering the molecular mechanisms for sequence recognition of DNA. The methods have general applicability to small molecules as well as oligomers and proteins, while the examples provide general principles involved in sequence recognition.

Advances in Biosensors 1992 (Hardcover): Anthony Turner Advances in Biosensors 1992 (Hardcover)
Anthony Turner
R4,163 Discovery Miles 41 630 Within 7 - 15 working days

Biosensors have captured the imagination of the world's scientific and commercial communities by combining interdisciplinary skills of biologists, physicists, chemists and engineers to provide innovative solutions to analytical problems. Biosensors area pplicable to clinical diagnostics, food analysis, cell culture monitoring, environmental control and various military situations. Ever increasing demands for rapid and convenient analyses of a wide variety of materials in diverse locations has led to intense interest in the fusion of biology and electronics which mimics our principal concern: the effect of materials and environments on living systems. This series "Advances in Biosensors" presents a unique compendium of research papers, in which eminent authorities in the field of biosensors provide an up-to-date overview of their laboratory's contribution, summarizing the primary research as it has appeared, possible scattered, in the journal and conference literature, and reflecting on their findings. The net result will be intense, yet highly readable accounts of the state of the art at this leading edge of analytical technology.

Pharmacogenomics - Challenges and Opportunities in Therapeutic Implementation (Hardcover): Yui-Wing Francis Lam, Larisa H.... Pharmacogenomics - Challenges and Opportunities in Therapeutic Implementation (Hardcover)
Yui-Wing Francis Lam, Larisa H. Cavallari
R1,601 Discovery Miles 16 010 Within 8 - 13 working days

"Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation" includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference.
Multi-contributed book and chapters are written by contributors who are experts in their fieldProvides perspectives from those involved in all aspects of pharmacogenomics-including academic, regulatory, economic, industry and medical-to illustrate how all of the pieces fit together and where the challenges may beIncludes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applicationsChapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research

A companion website offers an elaboration on key points and discussion questions and provides patient case scenarios that illustrate how pharmacogenomics may be applied to a clinical setting

Elsevier's Dictionary of Vitamins and Pharmacochemistry - in English, German, French and Portuguese (English & Foreign... Elsevier's Dictionary of Vitamins and Pharmacochemistry - in English, German, French and Portuguese (English & Foreign language, Hardcover)
Henry Philippsborn
R2,926 Discovery Miles 29 260 Within 7 - 11 working days

The dictionary will contain terms covering the following fields and subfields: Vitamin Technology: Vitamin biochemistry / Physiology; Origin of vitamins: natural, synthetic; Fat-soluble vitamins; Water-soluble vitamins; Vitamins as antioxidants; Vitamin deficiencies / Hypervitaminosis - Enzymes/Proteins: Biotechnology as applied biological science aimed at industrial exploitation - Hormones: Biochemistry; Physiology - Pharmaceutical Chemistry / Pharmaceutical Technology / Pharmaceutical Processes: Conception of the active principles; Structural analysis; Antibiotics and their way of action; Biochemistry; The Drug / The Medicament: Definition, origin, way of action; Biochemistry - Medical Aspects in the languages English, German, French and Portuguese.
*An important resource for pharmacologists, pharmaceutists and medical doctors
*Includes definitions in several prominent languages (English, German, French, Portuguese)
*Covers subfields of Vitamin Technology, Enzymes/Proteins, Hormones, Pharmaceutical Chemistry, Pharmaceutical Technology, Pharmaceutical Processes, and more

A Manual of Adverse Drug Interactions (Hardcover, 5th Revised edition): J.P. Griffin, P.F. D'Arcy A Manual of Adverse Drug Interactions (Hardcover, 5th Revised edition)
J.P. Griffin, P.F. D'Arcy; Foreword by Rosalinde Hurley
R5,832 Discovery Miles 58 320 Special order

For twenty years this book, now in its 5th edition, has provided information on adverse drug interactions that is unrivalled in coverage and scholarship.

Adverse drug reactions, many of them ascribable to interactions with other drugs or with chemical substances in food or the environment, are thought to cause or complicate one in twenty of hospital admissions.

The book is conveniently divided into two parts: Part 1 comments on drug interactions and their mechanisms, on a pharmacokinetic and pharmacodynamic level, while Part 2 consists of drug interaction tables, divided and subdivided into categories of disorders, and the drugs used in the treatment of these disorders.

If safety in drugs is to improve, education of prescribers is vitally important. This book, with its up-to-date and coordinated approach, serves that purpose well. The real threat, as the authors remind us, is the ignorance of practitioners, not the drug itself. The volume is therefore an essential addition to the shelves of those responsible for the prescription of drugs, in order to prevent a potential backlash when used in combination with other drugs or chemical substances.

Naturally Occurring Bioactive Compounds (Hardcover): Mahendra Rai, Maria Cecilia Carpinella Naturally Occurring Bioactive Compounds (Hardcover)
Mahendra Rai, Maria Cecilia Carpinella
R4,189 Discovery Miles 41 890 Special order

This timely book provides an overview of natural products/botanicals used for the management of insect-pest and diseases. It will help readers to update and widen their knowledge about natural products and their bio-activities against plant pathogens. The volume explores activity, chemistry, toxicity and geographic distribution of plants. Discussions concerning the methodology used for the detection of active principles, their mode of action and commercial prospects are of utmost importance and worthy of note.
* Focuses on recent achievements in natural bio-actives
* Global coverage of natural products / plants
* Targets the most important issues of natural botanicals/ biocides
* Includes innovative ideas with lucid explanations
* Contains specialized chapters, such as, natural control of multi-drug resistant organisms, anti-salmonella agents, natural house-dust-mite control agents, and naturally occurring anti-insect proteins, etc.
* Covers research on bioactives: From Lab to Field and Field to Market
* Includes eco-friendly and economically viable herbal technology

Target Validation in Drug Discovery (Hardcover, New): Brian W. Metcalf, Susan Dillon Target Validation in Drug Discovery (Hardcover, New)
Brian W. Metcalf, Susan Dillon
R1,473 Discovery Miles 14 730 Special order

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders (Hardcover): Robert A. McArthur, Franco Borsini Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders (Hardcover)
Robert A. McArthur, Franco Borsini
R1,351 Discovery Miles 13 510 Special order

"Psychiatric Disorders" is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. "Psychiatric Disorders "has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on "Animal and Translational Models for CNS Drug Discovery" is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery.

This is the first volume in the three volume-set, "Animal and Translational Models for CNS Drug Discovery" 978-0-12-373861-5, andis also available for purchase individually.
Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery processCritical evaluation of animal and translational models improving transition from drug discovery and clinical developmentEmphasizes what results mean to the overall drug discovery processExplores issues in clinical trial design and conductance in each therapeutic areaPsychiatric Disorders is available for purchase individually."

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