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"Principles of Clinical Pharmacology" is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference covering the wide range of important topics impacting clinical pharmacology as the discipline plays an increasingly significant role in drug development and regulatory science.
The Third Edition has been endorsed by the American Society for
Clinical Pharmacology and Therapeutics
* Includes new chapters on imaging and the pharmacogenetic basis of adverse drug reactions. * Offers an expanded regulatory section that addresses US and international issues and guidelines. * Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers and also illustrates the impact of gender on drug response. * Presents a broadened discussion of clinical trials from Phase 1 to incorporate Phases II and III.
As one of the most massive and successful business sectors, the
pharmaceutical industry is a potent force for good in the
community, yet its behaviour is frequently questioned: could it
serve society at large better than it has done in the recent past?
Its own internal ethics, both in business and science, may need a
careful reappraisal, as may the extent to which the law -
administrative, civil and criminal - succeeds in guiding (and where
neccessary contraining) it.
Volume 28 in the series of Side Effects of Drugs Annuals (http:
//www.elsevier.com/locate/series/seda) continues to serve its
primary goal: to provide clinicians and medical investigators with
a reliable and critical yearly survey of new data and trends in the
area of Adverse Drug Reactions and Interactions. An international
team of specialists has reviewed new data and trends by selecting
from the year's writing all that is truly new and informative, by
critically interpreting it, and by pointing to whatever is unproven
or misleading. The use of the book is enhanced by separate indexes,
allowing the reader to access the text via drug name, adverse
effect, or drug interaction.
Elsevier now offers a series of derivative works based on the
acclaimed "Meyler s Side Effect of Drugs, 15th Edition." These
individual volumes are grouped by specialty to benefit the
practicing biomedical researcher and/or clinician.
The new 4th edition of Histopathology of Preclinical Toxicity
Studies is now completely in full color and continues to describe
the pathology found in drug safety studies in laboratory animals
with an evidence-based discussion of the relevance of these
findings to the clinical investigation of new drugs for humans.
Organized according to organ systems, this revision features a
thoroughly updated bibliography and discusses new drug-induced
pathologies and applicable species comparisons to aid in the
preclinical safety assessment of new medicines. This updated
reference is essential for those involved in drug safety
evaluation, including pathologists, toxicologists and
pharmacologists working in corporate, government, academic and
NEW TO THE FOURTH EDITION:
*This edition is in full color and featuresnearly 200 high-quality images
*Provides extended commentary on the relevance of pathological findingsand features a fully updatedbibliography containing sources for further reading
*Includes new content coverage on the commonly used transgenic animal models that are used in safety assessment, specific tumor types induced by drugs in rodents, and new drug-induced pathologies and lesions. "
This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university students, but also a variety of patients who suffer from PAK-dependent diseases and clinical doctors who try to cure or delay these PAK-dependent diseases.
This book consists of 9 chapters which deal with different
aspects of this kinase. These chapters are written by more than two
dozen world-leading PAK experts. Each of these will provide updated
biomedical information as well as future insight to a wide range of
readers who are interested in this unique kinase and both its
pathological and physiological roles as well as its functional
evolution from its ancestral origins.
"Clinical Pharmacology During Pregnancy" is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involved in the care of women during pregnancy. This book focuses on the impact of pregnancy on drug disposition and also includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy.
The broad range of this book encompasses analgesics,
antiasthmatics, antidepressants, heart and circulatory drugs,
vitamins and herbal supplements, and more. Topics in chemotherapy
and substance abuse are covered, as are research issues, including
clinical trial design and ethical considerations.
This groundbreaking book covers every aspect of deadly toxic
chemicals used as weapons of mass destruction and employed in
conflicts, warfare and terrorism. Including findings from
experimental as well as clinical studies, this one-of-a-kind
handbook is prepared in a very user- friendly format that can
easily be followed by students, teachers and researchers, as well
as lay people. Stand-alone chapters on individual chemicals and
major topics allow the reader to easily access required information
without searching through the entire book.
The Forward will be written by Dr. Tetsuo Satoh, Chiba University, Japan. He is one of the most respected, recognizable authorities on chemical warfare agents which will set the authoritative tone for the book.
Covers risk to humans, animals and the environment equally.
Researchers involved in assessing the risks involved with a
possible chemical warfare attack and those who are developing
response plans to such attacks must look at not only the risks to
human health but to our wildlife and environment as well. The
holistic approach taken in this book ensures that the researchers
have ready access to the details no matter which aspect of the
effects of CWA's they might be concerned with.
The Side Effects of Drugs Annual was first published in 1977. It has been published continuously since then, as a yearly update to the encyclopaedic volume Meyler's Side Effects of Drugs. Each new Annual provides clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists have contributed to the Annuals by selecting from each year's publications all that is truly new and informative, by critically interpreting it, and by pointing out whatever is misleading. The use of the book is enhanced by separate indexes, allowing the reader to enter the text via the drug name, adverse effect, or drug interaction. Special features of the Annuals are the Side Effects of Drugs Essay, usually written by a guest author, and the special reviews: short articles, within the different chapters, that give extra attention to topics of current interest. The Essay in Annual 27 is entitled 'The General Practice Research Database' (by Dr. H. Jick) and there is a Historical Essay entitled 'Louis Lewin - Meyler's Predecessor' (by Dr. J.K. Aronson). The special reviews in this volume include, among others: The effects of NSAIDs on blood pressure Risks of inhaled corticosteroids in children Leukotriene receptor antagonists and Churg-Strauss syndrome Amiodarone and thyroid disease Surveillance of adverse events following immunization Smallpox vaccination Safety aspects of folic acid Inhibitors of topoisomerase I and topoisomerase II Liver damage from kava kava
Western Medicine as seen today has a strong scientific basis in its development. The pathogenesis of most diseases and their symptomatology and physical signs are well studied and understood. The management of patients is based on firm understanding of these disease processes. In contrast, Traditional Chinese Medicine came about through the experience of many generations of practitioners over thousands of years. Undoubtedly, many of these treatments have proved to be effective in their own way, however, firm scientific basis is still lacking.
This dictionary spans the practice of pharmacology, and of allied sciences insofar as they are related to it, with particular emphasis on the development, regulation and use of human medicine. It is offered to students as well as to professionals in pharmacology and allied sciences for "reference" and for "browsing," and as a bedside book and travelling companion. Its size (approximately 2000 entries) is appropriate for these uses.
Features of this dictionary:
- Provides definitions of terms in pharmacology, both basic and clinical
- Gives information on new medicine development and official regulations
- Covers allied topics, including statistics, ethics, scientific
miscounduct, authorship, publication and law.
This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.
Volume 27, the first thematic volume in the Series, provides an overview of present knowledge with regard to the pharmacological and clinical aspects of antidiabetic drugs. It aims to stimulate further consideration of possible concepts in the development of new antidiabetic drugs.
Biosensors have captured the imagination of the world's scientific and commercial communities by combining interdisciplinary skills of biologists, physicists, chemists and engineers to provide innovative solutions to analytical problems. Biosensors are applicable to clinical diagnostics, food analysis, cell culture monitoring, environmental control and various military situations. Ever increasing demands for rapid and convenient analyses of a wide variety of materials in diverse locations has led to intense interest in the fusion of biology and electronics which mimics our principal concern: the effect of materials and environments on living systems. This series, "Advances in Biosensors", presents a compendium of research papers, in which authorities in the field of biosensors provide an up-to-date overview of their laboratory's contribution, summarizing the primary research as it has appeared, possibly scattered, in the journal and conference literature, and reflecting on their findings. The net result will be intense, yet highly readable accounts of the state of the art at this leading edge of analytical technology.
Now in its tenth edition, this famous compilation of synonyms for drugs, pesticides and other substances of pharmacological or biochemical interest has become even more international and comprehensive in its scope. Electronic storage of the data has ensured that the book is fully up to date, while the highest degree of cross referencing between entries is guaranteed. The types of names presented are: chemical names, abbreviated chemical names, source names, pharmacological names, pesticide names, names derived from places, plants or persons, research code numbers, and proprietary names (trademarks).
For people working in the fields of biochemistry, pharmacology, pharmaceutics, and toxicology, as well as for medical editors and drug regulatory officers, this work will prove to be an indispensable source of information.
This text indicates those variables which in general may need a better control. Examples illustrate the impact that those variables may have on various characteristics. A series of representative studies are presented so that insight can be obtained about the effects of these parameters.
This series describes selected advances in the area of atomic
spectroscopy. It is promarily intended for the reader who has a
background in atmoic spectroscopy; suitable to the novice and
expert. Although a widely used and accepted method for metal and
non-metal analysis in a variety of complex samples, "Advances in
Atomic Spectroscopy" covers a wide range of materials. Each Chapter
will completely cover an area of atomic spectroscopy where rapid
development has occurred.
This volume is aimed in general at scientists who have an interest
in deciphering the molecular mechanisms for sequence recognition of
DNA. The methods have general applicability to small molecules as
well as oligomers and proteins, while the examples provide general
principles involved in sequence recognition.
Biosensors have captured the imagination of the world's scientific and commercial communities by combining interdisciplinary skills of biologists, physicists, chemists and engineers to provide innovative solutions to analytical problems. Biosensors area pplicable to clinical diagnostics, food analysis, cell culture monitoring, environmental control and various military situations. Ever increasing demands for rapid and convenient analyses of a wide variety of materials in diverse locations has led to intense interest in the fusion of biology and electronics which mimics our principal concern: the effect of materials and environments on living systems. This series "Advances in Biosensors" presents a unique compendium of research papers, in which eminent authorities in the field of biosensors provide an up-to-date overview of their laboratory's contribution, summarizing the primary research as it has appeared, possible scattered, in the journal and conference literature, and reflecting on their findings. The net result will be intense, yet highly readable accounts of the state of the art at this leading edge of analytical technology.
"Pharmacogenomics: Challenges and Opportunities in Therapeutic
Implementation" includes discussions and viewpoints from the
academic, regulatory, pharmaceutical, clinical, socio-ethical and
economic perspectives. Each chapter presents an overview of the
potential or opportunity within the areas discussed and also
outlines foreseeable challenges and limitations in moving
pharmacogenomics into drug development and direct therapeutic
applications. This edited book contains review questions for a more
in-depth analysis of the implications of pharmacogenomics and
discussion points to generate ideas on best to move the field
forward. Clinical pearls and case studies are used to illustrate
real-life experiences and both successful and unsuccessful
applications. Tables, figures, and annotations are included
throughout the book to facilitate understanding and further
A companion website offers an elaboration on key points and discussion questions and provides patient case scenarios that illustrate how pharmacogenomics may be applied to a clinical setting
The dictionary will contain terms covering the following fields and
subfields: Vitamin Technology: Vitamin biochemistry / Physiology;
Origin of vitamins: natural, synthetic; Fat-soluble vitamins;
Water-soluble vitamins; Vitamins as antioxidants; Vitamin
deficiencies / Hypervitaminosis - Enzymes/Proteins: Biotechnology
as applied biological science aimed at industrial exploitation -
Hormones: Biochemistry; Physiology - Pharmaceutical Chemistry /
Pharmaceutical Technology / Pharmaceutical Processes: Conception of
the active principles; Structural analysis; Antibiotics and their
way of action; Biochemistry; The Drug / The Medicament: Definition,
origin, way of action; Biochemistry - Medical Aspects in the
languages English, German, French and Portuguese.
For twenty years this book, now in its 5th edition, has provided
information on adverse drug interactions that is unrivalled in
coverage and scholarship.
Adverse drug reactions, many of them ascribable to interactions with other drugs or with chemical substances in food or the environment, are thought to cause or complicate one in twenty of hospital admissions.
The book is conveniently divided into two parts: Part 1 comments on drug interactions and their mechanisms, on a pharmacokinetic and pharmacodynamic level, while Part 2 consists of drug interaction tables, divided and subdivided into categories of disorders, and the drugs used in the treatment of these disorders.
If safety in drugs is to improve, education of prescribers is vitally important. This book, with its up-to-date and coordinated approach, serves that purpose well. The real threat, as the authors remind us, is the ignorance of practitioners, not the drug itself. The volume is therefore an essential addition to the shelves of those responsible for the prescription of drugs, in order to prevent a potential backlash when used in combination with other drugs or chemical substances.
This timely book provides an overview of natural
products/botanicals used for the management of insect-pest and
diseases. It will help readers to update and widen their knowledge
about natural products and their bio-activities against plant
pathogens. The volume explores activity, chemistry, toxicity and
geographic distribution of plants. Discussions concerning the
methodology used for the detection of active principles, their mode
of action and commercial prospects are of utmost importance and
worthy of note.
This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.
"Psychiatric Disorders" is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. "Psychiatric Disorders "has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on "Animal and Translational Models for CNS Drug Discovery" is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery.
This is the first volume in the three volume-set, "Animal and
Translational Models for CNS Drug Discovery" 978-0-12-373861-5,
andis also available for purchase individually.
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