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Sephadex is a trademark for cross-linked dextran gel used for gel
filtration. It was launched by Pharmacia in 1959, after development
work by Jerker Porath and Per Flodin. The name is derived from
separation Pharmacia dextran. It is normally manufactured in a bead
form and most commonly used for gel filtration columns. By varying
the degree of cross-linking, the fractionation properties of the
gel can be altered. These highly specialized gel filtration and
chromatographic media are composed of macroscopic beads
synthetically derived from the polysaccharide, dextran. The organic
chains are cross-linked to give a three dimensional network having
functional ionic groups attached by ether linkages to glucose units
of the polysaccharide chains.
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