Chapters: Clopidogrel. Source: Wikipedia. Pages: 24. Not
illustrated. Free updates online. Purchase includes a free trial
membership in the publisher's book club where you can select from
more than a million books without charge. Excerpt: Clopidogrel is
an oral, thienopyridine class antiplatelet agent used to inhibit
blood clots in coronary artery disease, peripheral vascular
disease, and cerebrovascular disease. It is marketed by
Bristol-Myers Squibb and Sanofi-Aventis under the trade name
Plavix. The drug works by irreversibly inhibiting a receptor called
P2Y12, an adenosine diphosphate ADP chemoreceptor. Adverse effects
include hemorrhage, Severe neutropenia, and Thrombotic
thrombocytopenic purpura (TTP). Clopidogrel is a pro-drug whose
action may be related to an adenosine diphosphate (ADP) receptor on
platelet cell membranes. The drug specifically and irreversibly
inhibits the P2Y12 subtype of ADP receptor, which is important in
aggregation of platelets and cross-linking by the protein fibrin.
The blockade of this receptor inhibits platelet aggregation by
blocking activation of the glycoprotein IIb/IIIa pathway. The
IIb/IIIa complex functions as a receptor mainly for fibrinogen and
vitronectin but also for fibronectin and von Willebrand factor.
Activation of this receptor complex is the "final common pathway"
for platelet aggregation, and is important in the cross-linking of
platelets by fibrin. Platelet inhibition can be demonstrated two
hours after a single dose of oral clopidogrel, but the onset of
action is slow, so that a loading-dose of 300600mg is usually
administered. Clopidogrel is indicated for: It is also used, along
with aspirin, for the prevention of thrombosis after placement of
intracoronary stent or as an alternative antiplatelet drug for
patients who are intolerant to aspirin. International guidelines
granted the highest grade of recommendation for NSTE-ACS, PCI and
stent, for clopidogrel in addition to...More: http:
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