In Breast Cancer Chemosensitivity, a group of world leading experts
review critical aspects of resistance to systemic therapy in breast
cancer patients. Beginning with a clinical overview of the problem
Breast Cancer Chemosensitivity moves on to focus on the latest
findings of molecular mechanisms of drug resistance. These include
in-depth discussions on multidrug resistance by P-glycoprotein and
the multidrug resistance protein family, resistance to therapeutic
agent-induced apoptosis, cell cycle deregulation, deregulation of
DNA repair, loss of tumor suppressor genes, integrin-mediated
adhesion, insulin-like growth factors, epidermal growth factor, and
ErbB2 in modulating breast cancer response to systemic therapy,
especially, certain chemotherapeutic agents. Breast Cancer
Chemosensitivity provides an example of using novel approaches for
chemosensitization of breast cancer cells that gives readers an
idea about the future direction in breast cancer treatment.
Springer New York
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