Drug Etiology of Agranulocytosis and Aplastic Anemia (Hardcover)

Agranulocytosis and aplastic anaemia figure prominently among certain serious diseases which can be precipitated by drugs. Several hundred different agents with substantially different chemical and pharmacological properties have been implicated, although the evidence incriminating specific drugs has been largely anecdotal. This book describes the findings of a rigorous and comprehensive epidemiological investigation designed to provide reliable quantitative data on the drug aetiology of agranulocytosis and aplastic anaemia. This investigation was a large-scale, population based, case control study. Its objectives were to identify those drugs associated with agranulocytosis and aplastic anaemia, and to estimate incidence rates attributable to specific drugs. In both conceptual and practical terms, this study has broken new ground, by providing the most extensive documentation to date concerning the drug aetiology and incidence of the two dyscrasias.