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Selumetinib (Paperback) Loot Price: R770
Discovery Miles 7 700
Selumetinib (Paperback): Erik Yama Tienne
Selumetinib (Paperback): Erik Yama Tienne

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Selumetinib (Paperback)

Erik Yama Tienne

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Loot Price R770 Discovery Miles 7 700 | Repayment Terms: R72 pm x 12*

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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Selumetinib (AZD6244, ARRY-142886), activating mutations in the BRAF gene, primarily at V600E, are associated with poorer outcomes in patients with papillary thyroid cancer. MAPK kinase (MEK), immediately downstream of BRAF, is a promising target for MAPK/ERK pathway inhibition. In addition to thyroid cancer, BRAF-activating mutations are prevalent in melanoma (-59%), colorectal cancer (5-22%), serous ovarian cancer (-30%), and several other tumor types. Four lines bearing V600E BRAF mutations were all sensitive to selumetinib, with GI50 clarification needed] values ranging from 14 to 50 nM. A positive control BRAF mutant melanoma line, SKMel28, exhibited a similar GI50 of 23 nM. A Phase II clinical trial about selumetinib in cancers with BRAF mutations is ongoing.

General

Imprint: Turbspublishing
Country of origin: United States
Release date: December 2011
First published: December 2011
Editors: Erik Yama Tienne
Dimensions: 229 x 152 x 5mm (L x W x T)
Format: Paperback - Trade
Pages: 76
ISBN-13: 978-6138661283
Barcode: 9786138661283
Categories: Promotions
Books > Science & Mathematics > Biology, life sciences
Books > Science & Mathematics > Biology, life sciences > General
LSN: 6138661281

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