Aldosterone is a hormone that increases the reabsorption of sodium
and water and the release (secretion) of potassium in the kidneys.
This increases blood volume and, therefore, increases blood
pressure. Conversely, drugs that interfere with the secretion or
action of aldosterone are in use as antihypertensives. One example
is spironolactone which lowers blood pressure by blocking the
aldosterone receptor. Aldosterone is part of the renin-angiotensin
system. A measurement of aldosterone in blood may be termed a
plasma aldosterone concentration (PAe, which may be compared to
plasma renin activity (PRA) as a PAC/PRA ratio.
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