Design of experiments, or experimental design, (DoE) is the design
of all information-gathering exercises where variation is present,
whether under the full control of the experimenter or not. (The
latter situation is usually called an observational study.) Often
the experimenter is interested in the effect of some process or
intervention (the "treatment") on some objects (the "experimental
units"), which may be people, parts of people, groups of people,
plants, animals, etc. Design of experiments is thus a discipline
that has very broad application across all the natural and social
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