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Molecular Characterization of Tgf Mediated Cancer Cell Proliferation (Paperback) Loot Price: R1,391
Discovery Miles 13 910
Molecular Characterization of Tgf Mediated Cancer Cell Proliferation (Paperback): Garima Singh, Shiv Kishor Singh, Prof Dr...
Molecular Characterization of Tgf Mediated Cancer Cell Proliferation (Paperback): Garima Singh, Shiv Kishor Singh, Prof Dr...

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Molecular Characterization of Tgf Mediated Cancer Cell Proliferation (Paperback)

Garima Singh, Shiv Kishor Singh, Prof Dr Volker Ellenrieder

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Loot Price R1,391 Discovery Miles 13 910 | Repayment Terms: R129 pm x 12*

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TGF has a dual role in carcinogenesis, acting as a growth inhibitor in early tumor stages and a promoter of cell proliferation in advanced diseases. Although this cellular phenomenon is well established, the underlying molecular mechanisms remain elusive. Here, we report that sequential induction of NFAT and c-Myc transcription factors is sufficient and required for the TGF switch from a cell cycle inhibitor to a growth promoter pathway in cancer cells. TGF induces the expression and activation of NFAT factors, which then translocate into the nucleus to promote c-Myc expression. In response to TGF, activated NFAT factors bind to and displace Smad3 repressor complexes from the c-Myc promoter. c-Myc in turn stimulates cell cycle progression and growth through up-regulation of D-type cyclins. Most importantly, NFAT knockdown not only prevents c-Myc activation and cell proliferation, but also partially restores TGF-beta-induced cell cycle arrest and growth suppression. Taken together, this study provides the first evidence for a Smad-independent master regulatory pathway in TGF -promoted cell growth that is defined by sequential transcriptional activation of NFAT and c-Myc factors.

General

Imprint: VDM Verlag
Country of origin: Germany
Release date: November 2010
First published: November 2010
Authors: Garima Singh • Shiv Kishor Singh • Prof Dr Volker Ellenrieder
Dimensions: 229 x 152 x 6mm (L x W x T)
Format: Paperback - Trade
Pages: 100
ISBN-13: 978-3-639-29801-7
Barcode: 9783639298017
Categories: Books > Science & Mathematics > Biology, life sciences
Books > Science & Mathematics > Biology, life sciences > General
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LSN: 3-639-29801-2

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