The recent identification of susceptibility genes for
schizophrenia, depression and learning and memory dysfunction
suggest that psychiatric disorders may be influenced by a small
number of genes with multiple actions. This is the first book to
investigate the role of growth factors in these disorders, which
should provide clues to the underlying biochemical mechanisms. For
example, recent studies have substantiated the provocative finding
that "neuregulin 1 (NRG1)"is a candidate gene for schizophrenia.
Neuregulin and its receptors, the ErbB tyrosine kinases, are
essential for development of the cardiovascular and nervous
systems. Lack of NRG1 function may be involved in dysregulation of
synaptogenesis and synaptic plasticity in the adult mediated
through glutamate receptor function. Polymorphisms for BDNF
(brain-derived neurotrophic factor) have also been implicated in
the pathogenesis of schizophrenia. BDNF is a prevalent neurotrophic
factor that plays an important role in the pathophysiology of
depression, bipolar disease and other psychiatric disorders. Other
topics addressed in this book include neuroplasticity and
neurotrophic factors, signal transduction by neurotrophins,
intracellular trafficking of growth factors, trophic factors and
cognitive functions, neurotrophins and depression, and
pharmacological treatments of schizophrenia.
John Wiley & Sons
|Country of origin:
||Novartis Foundation Symposia, 701
||Electronic book text
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