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Nucleic Acid Hybridization in the Study of Cell Differentiation (Hardcover) Loot Price: R1,484
Discovery Miles 14 840
You Save: R140 (9%)
Nucleic Acid Hybridization in the Study of Cell Differentiation (Hardcover): H Ursprung
Nucleic Acid Hybridization in the Study of Cell Differentiation (Hardcover): H Ursprung

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Nucleic Acid Hybridization in the Study of Cell Differentiation (Hardcover)

H Ursprung

Series: Results and Problems in Cell Differentiation, 3

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List price R1,624 Loot Price R1,484 Discovery Miles 14 840 | Repayment Terms: R138 pm x 12* You Save R140 (9%)

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The informational content of cells is encoded in the nucleotide sequences of their DNA. The restrictions on base pairing- A pairing with T (U), and G pairing with C - in nature assures the fidelity of replication of DNA in cell division, and of transcription. In the test tube, these restrictions can be exploited for ascertaining similarities and dissimilarities of nucleic acids of varying origin by measuring the kinetics of reassociation of polynucleotides to double-stranded molecules in DNA- DNA renaturation or RNA-DNA hybridization experiments, and by determining the thermal stability and other physical-chemical properties of the resulting hybrid molecules. This method has enormous potential for developmental biology. It offers a more direct approach to the ever-present question of the genetic identity of different cell types in an individual organism, and a more direct test of the hypothesis of diffe- rential gene function. It offers the possibility of localizing genes on chromosomes without the use of Mendelian genetics. It is an indispensable tool in the isolation, purification, and characterization of genes. This volume brings together six articles by investigators actively working on various aspects of developmental biology who use nucleic acid hybridization as a tool in their research. Sound in theory, the method is in a honing phase as regards the technical detail. This is expressed in the hesitation with which some of the conclusions are rightly drawn.

General

Imprint: Springer-Verlag
Country of origin: Germany
Series: Results and Problems in Cell Differentiation, 3
Release date: June 1972
First published: 1972
Editors: H Ursprung
Format: Hardcover - Cloth over boards
Pages: 87
ISBN-13: 978-3-540-05742-0
Barcode: 9783540057420
Categories: Books > Science & Mathematics > Biology, life sciences > Cellular biology
Books > Science & Mathematics > Biology, life sciences > Cellular biology > General
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LSN: 3-540-05742-0

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