Filled with industrial examples emphasizing the practical
applications of crystallization methodologies
Based on the authors' hands-on experiences as process engineers
at Merck, "Crystallization of Organic Compounds" guides readers
through the practical aspects of crystallization. It uses plenty of
case studies and examples of crystallization processes, ranging
from development through manufacturing scale-up. The book not only
emphasizes strategies that have been proven successful, it also
helps readers avoid common pitfalls that can render standard
The goal of this text is twofold:
- Build a deeper understanding of the fundamental properties of
crystallization as well as the impact of these properties on
crystallization process development.
- Improve readers' problem-solving abilities by using actual
industrial examples with real process constraints. "Crystallization
of Organic Compounds" begins with detailed discussions of
fundamental thermodynamic properties, nucleation and crystal growth
kinetics, process dynamics, and scale-up considerations. Next, it
investigates modes of operation, including cooling, evaporation,
anti-solvent, and reactive crystallization. The authors conclude
with special applications such as ultrasound in crystallization and
computational fluid dynamics in crystallization. Most chapters
feature multiple examples that guide readers step by step through
the crystallization of active pharmaceutical ingredients
With its focus on industrial applications, this book is
recommended for chemical engineers and chemists who are involved
with the development, scale-up, or operation of crystallization
processes in the pharmaceutical and fine chemical industries.
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