Mitochondrial DNA is constantly exposed to, and damaged by oxygen
radicals generated by Electron Transport Chain. This damage can
lead to a loss of genetic information about key proteins in the
ETC. What may follow is a dysfunction in cellular energy production
and cell death, unless it is repaired. An efficient DNA repair
mechanism in mitochondria keeps the amount of damage at an
acceptably low level. The research in this book explores the ways
to modulate the efficiency of mtDNA repair and evaluates its
contribution to the overall cell survival. Introduction of
Exonuclease III from E.coli into human mitochondria, either through
stable transfection, or by protein transduction leads to a
disruption of an efficient mtDNA repair and renders cells more
sensitive to the oxidative stress. Modulation of mtDNA repair in
this way can be a potentially useful treatment strategy for
pathological conditions were a destruction of abnormal cells is a
desired outcome, as in anticancer therapy. This work may be of
interest to students or professionals working in the field of mtDNA
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