The ability to regulate and manipulate the generation or remodeling
of blood vessels is key to the successful treatment of many chronic
diseases, both oncological and non-oncological. Several bioactive
compounds present in human diets are now known to exert an
inhibitive effect on the either the signaling or construction of
new blood vessels. The identification and characterization of these
anti-angiogenic molecules opens a new avenue for the research and
production of functional and medicinal foods with far reaching
implications for the food-based treatment of chronic degenerative
disease. Drawing from an extensive list of esteemed international
contributors, Anti-Angiogenic Functional and Medicinal Foods
explores the history and scope of the use of conventional foods,
nutraceuticals, and health products in North America, Europe, the
Middle East, Asia, India, Australia, and New Zealand. Recent
advancements in proteomics, genomics, and toxicogenomics give us a
far more detailed picture of the molecular basis of nutrition and
systems toxicology. Explaining the role of angiogenesis in various
chronic diseases, individual chapters consider endothelial cell
responses, the mechanism of the angiogenic cascade, and the
angiogenic function involved in tumors, cardiovascular disease,
inflammatory arthritis, and obesity. A collection of chapters
studies specific foods and their functional bioactive compounds
such as the effects of edible berry anthocyanins, various Chinese
medicinal foods, dietary flavonoids, probiotics, shark cartilage,
EPA and DHA, and marine polysaccharides. The book concludes with a
discussion of the challenges faced during the development and
delivery of anti-angiogenic functional food products. Presenting
the current research and state of the science, Anti-Angiogenic
Functional and Medicinal Foods provides researchers, scientists,
clinical nutritionists, and oncologists with a valuable reference
to this important and growing mode of therapy.
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