The past few years have seen considerable advances in our
understanding of the molecular basis underlying cutaneous cell
adhesion mechanisms. Co-authored by a number of leading experts in
the field DEGREESCell Adhesion and Migration in Skin Disease
provides a comprehensive overview of the critical role played by
cell adhesion in determining the structure and function of both
healthy and diseased human skin. The book is divided into three
main sections, with each one addressing a principal function of
adhesion molecules. The first part focuses on the epidermis, which
as the skin's outermost layer, acts as the human body's primary
barrier of defence. Roles played by cytoskeletal intermediate
filaments and junctional complexes in cutaneous cell adhesion are
emphasised with descriptions of blistering skin diseases that can
arise if these molecules malfunction. The second part describes the
macromolecular interactions responsible for the anchorage of cells
to the underlying extracellular basement membrane.The experimental
approaches detailed in the text not only reveal how the molecular
components of the dermal-epidermal junction have been elucidated,
but also highlight how mutations in the genes which encode these
molecules are responsible for many heritable skin diseases.
Leukocytes continually infiltrate the skin and patrol it for
potentially harmful pathogens. Control of leukocyte adhesion to
resident cells within the skin and to the extracellular matrix
plays a key role in controlling these processes. These mechanisms
constitute the primary focus of the final section. The pivotal role
of leukocytes is examined in conjunction with the chronic
inflammatory diseases which arise when components of the skin's
finely tuned defence strategy go awry and the potential for these
anomalies to be pinpointed as important immunotherapeutic targets
for skin dis
|Country of origin:
• John McGrath
||Electronic book text
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