Proteoglycans (PGs) - a family of macromolecules composed of
glycosaminoglycans (GAGs) covalently linked to a protein core - are
widely distributed in human and animal tissue and appear to be
synthesized by virtually all types of cells. Age-related changes of
PGs and GAGs are visible in most tissues investigated so far. This
volume provides both an introduction to PG and GAG biochemistry and
detailed information about age-related changes of these substances
in different organs and tissues. Short outlines are given on PG/GAG
changes in the most important diseases of old age as well as on the
influences on PG/GAG metabolism and the therapeutic use of these
substances. The possible causal role of PGs and GAGs in the aging
process is also discussed.
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