Cbfa2t2 (Paperback)


Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Protein CBFA2T2 is a protein that in humans is encoded by the CBFA2T2 gene.In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

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Product Description

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Protein CBFA2T2 is a protein that in humans is encoded by the CBFA2T2 gene.In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

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Product Details

General

Imprint

Betascript Publishing

Country of origin

Germany

Release date

March 2011

Availability

Supplier out of stock. If you add this item to your wish list we will let you know when it becomes available.

First published

March 2011

Editors

, ,

Dimensions

152 x 229 x 5mm (L x W x T)

Format

Paperback - Trade

Pages

76

ISBN-13

978-6135253641

Barcode

9786135253641

Categories

LSN

6135253646



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