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Epidermal growth factor receptor substrate 15 is a protein that in
humans is encoded by the EPS15 gene.This gene encodes a protein
that is part of the EGFR pathway. The protein is present at
clathrin-coated pits and is involved in receptor-mediated
endocytosis of EGF. Notably, this gene is rearranged with the
HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternate
transcriptional splice variants of this gene have been observed but
have not been thoroughly characterized.
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