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TRAF and TNF receptor-associated protein is a protein that in
humans is encoded by the TTRAP gene.This gene encodes a member of a
superfamily of divalent cation-dependent phosphodiesterases. The
encoded protein associates with CD40, tumor necrosis factor (TNF)
receptor-75 and TNF receptor associated factors (TRAFs), and
inhibits nuclear factor-kappa-B activation. This protein has
sequence and structural similarities with APE1 endonuclease, which
is involved in both DNA repair and the activation of transcription
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