High Quality Content by WIKIPEDIA articles! Ubiquitin-conjugating
enzyme E2 E3 is a protein that in humans is encoded by the UBE2E3
gene. The modification of proteins with ubiquitin is an important
cellular mechanism for targeting abnormal or short-lived proteins
for degradation. Ubiquitination involves at least three classes of
enzymes: ubiquitin-activating enzymes, or E1s,
ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein
ligases, or E3s. This gene encodes a member of the E2
ubiquitin-conjugating enzyme family. The encoded protein shares
100% sequence identity with the mouse and rat counterparts, which
indicates that this enzyme is highly conserved in eukaryotes. Two
alternatively spliced transcript variants encoding the same protein
have been found for this gene.
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