High Quality Content by WIKIPEDIA articles! Ubiquitin-conjugating
enzyme E2 G2 is a protein that in humans is encoded by the UBE2G2
gene. The modification of proteins with ubiquitin is an important
cellular mechanism for targeting abnormal or short-lived proteins
for degradation. Ubiquitination involves at least three classes of
enzymes: ubiquitin-activating enzymes, or E1s,
ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein
ligases, or E3s. This gene encodes a member of the E2
ubiquitin-conjugating enzyme family. The encoded protein shares
100% sequence identity with the mouse counterpart. This gene is
ubiquitously expressed, with high expression seen in adult muscle.
Two alternatively spliced transcript variants encoding distinct
isoforms have been found for this gene. Ube2g2 is known to
interact with a variety of other proteins, including but not
limited to ubiquitin, the E3 gp78, and the Hrd1 RING.
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