Oral submucous fibrosis (OSMF) is characterized by abnormal
collagen metabolism in the submucosal connective tissue.Its
influence on the overlying epithelium is not known but about 14% of
OSMF cases undergo malignant transformation to Squamous cell
carcinoma indicating an association with abnormality of the
epithelium. Here in our study we have defined the keratin
expression profile, by immunohistochemistry and quantitative image
analysis, using anti-keratin monoclonal antibody (CK 17) on 30 OSMF
samples and on 10 normal mucous membrane samples. The statistical
analysis was done using Chi- square test and the p - value was (p
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