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Neural Mechanisms of Selective Auditory Attention in Rats (Paperback) Loot Price: R1,467
Discovery Miles 14 670
Neural Mechanisms of Selective Auditory Attention in Rats (Paperback): Lung-Hao Tai
Neural Mechanisms of Selective Auditory Attention in Rats (Paperback): Lung-Hao Tai

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Neural Mechanisms of Selective Auditory Attention in Rats (Paperback)

Lung-Hao Tai

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Loot Price R1,467 Discovery Miles 14 670 | Repayment Terms: R136 pm x 12*

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How does attention modulate sensory representations? In order to probe the underlying neural mechanisms, we established a simple rodent model of modality-specific attention. Rats were trained to perform distinct auditory two-tone discrimination and olfactory odor discrimination in a two alternative choice (2AC) paradigm. To determine auditory cortex's role in this frequency discrimination task, we used GABA-A receptor agonist muscimol to transiently and reversibly inactivate auditory cortexes bilaterally in rats performing simple interleaved auditory and olfactory discrimination. With olfactory discrimination performance serving as internal control for motivation and decision making capability, we found only auditory two-tone discrimination was selectively impaired in these rats. This shows the auditory cortex is involved in this two-tone discrimination task. To investigate the neural correlate of modality-specific attention in the auditory cortex, we trained rats to perform interleaved auditory and olfactory blocks (of 50∼70 trials each) in a single session. In auditory blocks, pure tones were either presented with or without a neutral odor (caproic acid, n=2 and 3 respectively), and subjects were rewarded for discriminating auditory stimuli. In olfactory blocks, both task odors and pure tones were presented simultaneously, and subjects were rewarded for discriminating olfactory stimuli. We recorded neural responses in primary auditory cortex (area A1) in freely moving rats while subjects performed this behavior. Single unit responses to tones were heterogeneous, and included transient, sustained, and suppressed. We found 205 of 802 units recorded responsive to the stimuli we used. Of these 205 units, 18.5% showed modality-specific attentional modulation of the anticipatory activity before tone onset. In addition, we also observed in smaller proportion of units (11.2%) modality-specific attentional modulation of the tone-evoked responses; in most cases, the responses to a particular auditory stimulus was enhanced in the auditory block (or, equivalently, suppressed in the olfactory block). Attention increased choice probability of the population in the auditory block. We have also observed significant behavior choice probability in small proportions of units. Our results suggest that shifting attention between audition to olfaction tasks can modulate the activity of single neurons in primary auditory cortex.

General

Imprint: Proquest, Umi Dissertation Publishing
Country of origin: United States
Release date: September 2011
First published: September 2011
Authors: Lung-Hao Tai
Dimensions: 254 x 203 x 7mm (L x W x T)
Format: Paperback - Trade
Pages: 106
ISBN-13: 978-1-243-56589-1
Barcode: 9781243565891
Categories: Promotions
Books > Science & Mathematics > Biology, life sciences
Books > Science & Mathematics > Biology, life sciences > General
LSN: 1-243-56589-6

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