Myopia is a refractive abnormality of the eye in which the parallel
light rays from an object at optical infinity are focused by the
eye in front of the retina rather than on it. This is the first
experimental study on Myopia in Pakistan because this disease is
spreading here day by day with prevalence rate of 36.5%.
Microsatellite markers have been proved as an efficient and
powerful tool for discovering any diseased locus. So a panel of
these markers was used in this study. Blood samples of various
myopic families were collected from various areas of Punjab and
their DNA was extracted with the standard protocol. The
amplification of DNA was done with primers of microsatellite
markers belonging to the loci MYP6, MYP7 and MYP8. Genotyping was
done for linkage analysis through PAGE. Haplotypes were made and
the results showed potential linkage against MYP7 locus in one of
the five familes with autosomal dominant mode of inheritance. Later
the LOD Score for this family was calculated and maximum LOD score
came out to be 0.0803 at the marker D11S904 that showed very low
percentage of linkage. This can be confirmed by extending the
family by further sampling.
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