Target Discovery and Validation Reviews and Protocols, Volumes 1
and 2 review the most progressive and current methods for drug
target discovery and validation. These volumes explore how recent
improvement in understanding the molecular mechanisms of human
pathology is impacting drug target discovery in the laboratory and
in real therapeutics, specifically for cancers and autoimmune
Volume 1 focuses on novel and innovative techniques, and
presents the most up-to-date protocols available for maximizing the
likelihood of achieving target-selective inhibition in vivo while
minimizing side effects. The profound impact of genomics,
proteomics and bioinformatics on target discovery is explored, and
specific attention is given to the role of transgenic and knockout
animals in functional genomics and target validation. Cancer
researchers will find tremendous value in the molecular
classification of breast cancers and the review of protocols for
tumor antigens and cancer vaccines. The methods and protocols
collected here, all reviewed by leading scientists and clinicians,
present the practical details necessary for translating the
enormous discovery potential of the genome into real therapeutic
Volume 2 collects all the practical details required for
efficient translation of discovered targets into real
pharmaceutical drugs. Specific targets in cancers and autoimmunity
are described and the potential of using siRNAs, antisense
oligonucleotides and RNA aptamers in patients is reviewed. This
volume explores the tremendous impact of the application of
genotyping and gene expression profiling on the future of
healthcare, and presents cutting-edge protocols to aid inbringing
agents against specific targets closer to application in the
Collectively, these volumes provide a thorough review of the
most cutting-edge methods available for each step in drug target
identification, validation, and clinical application. For
researchers, an understanding of available methods aids in the
creation of innovative experiments in the laboratory, and the
successful translation of target discovery to real
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