Downstream processing is an essential practice in the production
and purification of biosynthethic materials, which is especially
important in the production of pharmaceutical products. This book
covers the fundamentals and the design concepts of various
downstream recovery and purification steps (unit operations)
involved in biochemical and chemical processes. The book describes
cell breakage and recovery of intracellular material, isolation of
solids, product recovery, product enrichment, and product polishing
and finishing. It also covers basic chemical engineering
purification techniques such as distillation, absorption,
adsorption, etc. Described in the book are several case studies
that discuss the various unit operation in each of the processes.
An important point to consider is the economics of the downstream
operation, and this book provides practical information on capital
costs and operating expenses in addition to other operating cost
factors with respect to downstream processing. Green chemistry and
safety issues are also addressed. Practicing chemical engineers in
biotechnology and pharmaceutical chemistry and other areas will
find this book valuable as a reference on downstream techniques
used in biological processes. Students in chemical engineering
would benefit from this book as well.
Apple Academic Press Inc.
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