As central actors in most biological functions, proteins are the
subject of intense study. This has driven the development of
increasingly sophisticated approaches for the study of proteins,
which has extended to proteomic level methodologies. Yet currently
no book has addressed all aspects of functional microarrays in a
coherent and integrated fashion. Until now. Meeting the need for
comprehensive and authoritative information, Functional Protein
Microarrays in Drug Discovery provides an up-to-date overview of
the field and the background required to actually design and
develop arrays or perform and analyze array experiments. The book
is divided into five main sections that address critical aspects of
the field. The first focuses on the generation of functional
protein content, the first and perhaps most challenging aspect of
protein microarrays. The second section describes `standard' and
state-of-the-art fabrication methods, focusing on issues of
particular significance to functional protein microarrays.
Similarly, the third section reviews current and next generation
approaches to assay detection. The fourth and largest section,
dedicated to applications, spans the breadth of published
applications, from biomolecular interaction discovery and
characterization to humoral response biomarker profiling, enzyme
substrate identification and drug discovery. The final section
addresses fundamental computational issues including image and data
analysis as well as data visualization. While the field's early
successes have set the stage for rapid growth, it is not without
challenges. Indeed, challenges are to be expected in a fast-moving,
interdisciplinary endeavor such as this, where molecular biology,
protein chemistry, bioinformatics, engineering, and physical
sciences intersect. As the first integrated reference for
functional protein microarrays, this book helps you not only meet
the challenges but also excel in your research. X. Y. Zhu, one of
the contributors to this text, was recently featured in an article
in Austin's The Statesman. Daniel E. Levy, editor of the Drug
Discovery Series, is the founder of DEL BioPharma, a consulting
service for drug discovery programs. He also maintains a blog that
explores organic chemistry.
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