"Essentials of Pharmaceutical Preformulation" is a study guide
which describes the basic principles of pharmaceutical
physicochemical characterisation. Successful preformulation
requires knowledge of fundamental molecular concepts (solubility,
ionisation, partitioning, hygroscopicity and stability) and
macroscopic properties (physical form, such as the crystalline and
amorphous states, hydrates, solvates and co-crystals and powder
properties), familiarity with the techniques used to measure them
and appreciation of their effect on product performance,
recognising that often there is a position of compromise to be
reached between product stability and bioavailability.
This text introduces the basic concepts and discusses their
wider implication for pharmaceutical development, with reference to
many case examples of current drugs and drug products. Special
attention is given to the principles and best-practice of the
analytical techniques that underpin preformulation (UV
spectrophotometry, TLC, DSC, XRPD and HPLC). The material is
presented in the typical order that would be followed when
developing a medicine and maps onto the indicative pharmacy
syllabus of the Royal Pharmaceutical Society of Great Britain
Undergraduate-level pharmacy students and R&D / analytical
scientists working in the pharmaceutical sector (with or without a
pharmaceutical background) will find this text easy to follow with
relevant pharmaceutical examples.Essential study guide for pharmacy
and pharmaceutical science studentsCovers the pharmaceutical
preformulation components of the Royal Pharmaceutical Society of
Great Britain's indicative syllabusEasy to follow text highlighted
with relevant pharmaceutical examplesSelf-assessment assignments in
a variety of formatsWritten by authors with both academic and
industrial experienceCompanion website with further information to
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