One approach to organic synthesis is retrosynthetic analysis. With
this approach a chemist will start with the structure of their
target molecule and progressively cut bonds to create simpler
molecules. Reversing this process gives a synthetic route to the
target molecule from simpler starting materials. This
"disconnection" approach to synthesis is now a fundamental part of
every organic synthesis course.
"Organic Synthesis: The Disconnection Approach, 2nd Edition"
introduces this important technique, to help students to design
their own organic syntheses. There are forty chapters: those on the
synthesis of given types of molecules alternate with strategy
chapters in which the methods just learnt are placed in a wider
context. The synthesis chapters cover many ways of making each type
of molecule starting with simple aromatic and aliphatic compounds
with one functional group and progressing to molecules with many
functional groups. The strategy chapters cover questions of
selectivity, protection, stereochemistry, and develop more advanced
thinking via reagents specifically designed for difficult
Examples are drawn from pharmaceuticals, agrochemicals, natural
products, pheromones, perfumery and flavouring compounds,
dyestuffs, monomers, and intermediates used in more advanced
synthetic work. Reasons for wishing to synthesise each compound are
This second edition has been fully revised and updated with a
modern look. Recent examples and techniques are included and
illustrated additional material has been added to take the student
to the level required by the sequel, "Organic Synthesis: Strategy
Several chapters contain extensive new material based on courses
that the authors give to chemists in the pharmaceutical
"Organic Synthesis: The Disconnection Approach, 2nd edition"
provides a full course in retrosynthetic analysis for chemistry and
biochemistry students and a refresher for organic chemists working
in industry and academia.
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