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The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
This book is a methodological source on mice models of vascular diseases. Covering various areas, each chapter is written by a pioneering researcher who has developed an original vascular disease model. Notoriously difficult to reproduce, each model is described in detail and numerous photographs are provided with links to videos. Genetically modified mice are a very powerful tool for studying the pathogenesis of various diseases, including immunological and oncological disorders, but they had always been thought to be too small to be used in the field of cardiovascular disease. Recently, however, various mice models of vascular diseases have been reported, and these will make a substantial contribution to basic research on cardiovascular and metabolic disorders.
"Fish Disease: Diagnosis and Treatment, Second Edition" provides thorough, yet concise descriptions of viral, bacterial, fungal, parasitic and noninfectious diseases in an exhaustive number of fish species. Now in full color with over 500 images, the book is designed as a comprehensive guide to the identification and treatment of both common and rare problems encountered during the clinical work-up. Diseases are discussed following a systems-based approach to ensure a user-friendly and practical manual for identifying problems.
"Fish Disease: Diagnosis and Treatment, Second Edition" is the must-have reference for any aquaculturists, aquatic biologists, or fish health specialists dealing with diagnosing or treating fish diseases.
Just like humans, animals and plants suffer from infectious diseases, which can critically threaten biodiversity. This book describes key studies that have driven our understanding of the ecology and evolution of wildlife diseases. Each chapter introduces the host and disease, and explains how that system has aided our general understanding of the evolution and spread of wildlife diseases, through the development and testing of important epidemiological and evolutionary theories. Questions addressed include: How do hosts and parasites co-evolve? What determines how fast a disease spreads through a population? How do co-infecting parasites interact? Why do hosts vary in parasite burden? Which factors determine parasite virulence and host resistance? How do parasites influence the spread of invasive species? How do we control infectious diseases in wildlife? This book will provide a valuable introduction to students new to the topic, and novel insights to researchers, professionals and policymakers working in the field.
This book puts emphasis on the isolation, taxonomy, diagnosis (phenotypic, serology and molecular biology), epizootiology, pathogenicity mechanisms, and methods of disease control (by vaccination, immunostimulation, probiotics, prebiotics, plant products, and antimicrobial compounds. Co-infections, which are attributed to more than one microbial species have been discussed. Shortcomings in knowledge have been highlighted. This sixth edition is the successor to the original version, first published in 1987, and which fills the need for an up-to-date comprehensive text on the biological aspects of the bacterial taxa which cause disease in finfish. The book is primarily targeted at researcher workers, including postgraduate students, and diagnosticians. It is anticipated that the readership will include veterinary microbiologists, public health scientists and microbial ecologists.
Hematology data from "in vivo" toxicology studies remains one of the most predictive measures for human risk, as the same measurements made in pre-clinical toxicology studies can be made in early clinical trials.
Covering the three main blood cell types - erythrocytes, leukocytes and thrombocytes, this work is designed to clarify topics for new entrants to the fields of laboratory animal hematology and toxicology, especially those topics where the rules for human hematology do not always apply. An entire chapter is devoted to immunotoxicology, a scientific discipline that is closely aligned with hematology.
The text also addresses pre-analytical and analytical variables that affect animal studies, as these play a far more important part when interpreting data in contrast to humans where many of these variables can be well controlled or have less physiological effect. Information has been collated from published papers, textbooks and unpublished data: Readers are provided withkey references to encourage further study
Diseases are a major threat to both wild and farmed fish. Pathogen-induced alterations in viability and growth of wild fish stocks can have implications on diversity and ecological status of aquatic ecosystems, as fish are main components of aquatic communities, and they can directly affect the exploitation of wild and farmed fish as a protein source for human consumption. Fish diseases can be a major factor influencing abundance and distribution of wild fish. Disease-related reduction of reproduction and/or age-specific survival can strongly affect wild stocks as it has been demonstrated for several species in distinct geographical locations. The book will be useful for fish farmers, managers, researchers and graduate students interested in fish diseases.
Since the publication of the original edition in 1982,
pesticide-related poisonings, both single cases and epidemic-scale
situations, have continued to occur unabated. This new edition of
Pesticides and Neurological Diseases reviews current literature
describing the effects of insecticides (chlorinated hydrocarbons,
organophosphorus and carbamate esters, and the pyrethroid esters),
fungicides (organomercurials, dithiocarbamates), and herbicides
(chlorophenoxy acids and esters) on the mammalian nervous system.
Acute and chronic exposures have resulted in both subtle and
serious neurological deficits in the peripheral and central nervous
systems, marked by transient effects preceding those of delayed
onset and of persistent duration. The chapters have been largely
revised and rewritten to introduce newer theories of mechanism(s)
of action studied at the laboratory bench. New findings and
observations on human intoxications are included as well.
This two-volume work provides an overview on various state of the art experimental and statistical methods, modeling approaches and software tools that are available to generate, integrate and analyze multi-omics datasets in order to detect biomarkers, genetic markers and potential causal genes for improved animal production and health. The book will contain online resources where additional data and programs can be accessed. Some chapters also come with computer programming codes and example datasets to provide readers hands-on (computer) exercises. This first volume presents the basic principles and concepts of systems biology with theoretical foundations including genetic, co-expression and metabolic networks. It will introduce to multi omics components of systems biology from genomics, through transcriptomics, proteomics to metabolomics. In addition it will highlight statistical methods and (bioinformatic) tools available to model and analyse these data sets along with phenotypes in animal production and health. This book is suitable for both students and teachers in animal sciences and veterinary medicine as well as to researchers in this discipline.
This volume discusses a variety of animal models of diabetes, as well as describes techniques used to study end-points when using these models. The chapters in this book cover topics such as important considerations when working with mouse models of diabetes, highlighting factors that new investigators may not be aware of and some potential pitfalls in experimental outcomes; main characteristics of some commonly used animal models of diabetes research, ranging from mice to primates; animal models used to study specific aspects of beta-cell biology; and a focus on techniques used to assess blood glucose homeostasis, insulin action, and islet function in vivo and ex vivo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Animal Models of Diabetes: Methods and Protocols is a valuable resource that will help diabetes researchers design and carry out in vivo studies that will best suit their experimental questions and needs.
This book summarizes the results achieved so far by application of various biological systems (including genomics, transcriptomics, proteomics, and metabolomics) involved in the pathomechanisms and early diagnosis of periparturient diseases as specific biomarkers of disease in cattle. These emerging technologies help to extensively enhance our understanding of the etiology and pathogenesis of periparturient diseases of transition dairy cows. The book includes a chapter dedicated to 'omics' sciences and one that discusses the myths established in animal and veterinary sciences in recent decades and emerging, new paradigms. The diseases discussed include metritis, mastitis, laminitis, ketosis, rumen acidosis, periparturient immunosuppression, gastrointestinal microbiota and their involvement in disease, infertility, fatty liver, milk fever, and retained placenta. This book is intended for academics, veterinarians, animal nutritionists, researchers, and graduate students working in the field of 'omics sciences' with a special interest in dairy cattle health.
This book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.
This book provides a comprehensive overview of state-of-the-art applications of nanotechnology in biology and medicine, as well as model organisms that can help us understand the biological activity and associated toxicity of nanoparticles, and devise strategies to minimize toxicity and enhance therapies. Thanks to their high surface-to-volume ratio, nanoparticles are characterized by excellent biocompatibility and bioavailability, a high therapeutic index, and relatively low toxicity, which has led to their widespread application in the early diagnosis of diseases, comprehensive monitoring of disease progression, and improved therapeutics. The book also explores nanoparticle-based insecticides and their mechanisms of action, and provides a comparative analysis of the various model organisms that are used to understand the biological properties of nanoparticles. Further, it describes various in-vivo models that yield important insights into nanomaterial-mediated toxicity, promoting the optimal utilization of nanoparticles. In closing, the book discusses future perspectives and regulatory issues concerning the use of nanomaterials in translational research.
Infectious Diseases of Wild Mammals and Birds in Europe is a key resource on the diagnosis and treatment of infectious diseases in European wildlife that covers the distinctive nature of diseases as they occur in Europe, including strains, insect vectors, reservoir species, and climate, as well as geographical distribution of the diseases and European regulations for reporting, diagnosis and control. Divided into sections on viral infections, bacterial infections, fungal and yeast infections, and prion infections, this definitive reference provides valuable information on disease classification and properties, causative agents, epidemiology, pathogenesis, and implications for human, domestic and wild animal health.
Key features: - Brings together extensive research from many different disciplines into one integrated and highly useful definitive reference.- Zoonotic risks to human health, as well as risks to pets and livestock are highlighted.- Each disease is covered separately with practical information on the animal species in which the disease has been recorded, clinical signs of the disease, diagnostic methods, and recommended treatments and vaccination.- Wildlife vaccination and disease surveillance techniques are described.- Examines factors important in the spread of disease such as changing climate, the movement of animals through trade, and relaxations in the control of wide animal populations.
This multivolume handbook presents the most authoritative and
comprehensive reference work on major zoonoses of the world. The
Handbook of Zoonoses covers most diseases communicable to humans,
as well as those diseases common to both animals and humans. It
identifies animal diseases that are host specific and reviews the
effects of various human diseases on animals. Discussions address
diseases that remain important public and animal health problems
and the techniques that can control and prevent them.
This multivolume handbook presents the most authoritative and comprehensive reference work on major zoonoses of the world. The Handbook of Zoonoses covers most diseases communicable to humans, as well as those diseases common to both animals and humans. It identifies animal diseases that are host specific and reviews the effects of various human diseases on animals. Discussions address diseases that remain important public and animal health problems and the techniques that can control and prevent them.
Pathology of Wildlife and Zoo Animals is a comprehensive resource that covers the pathology of wildlife and zoo species, including a wide scope of animals, disease types and geographic regions. It is the definitive book for students, biologists, scientists, physicians, veterinary clinicians and pathologists working with non-domestic species in a variety of settings. General chapters include information on performing necropsies, proper techniques to meet the specialized needs of forensic cases, laboratory diagnostics, and an introduction into basic principles of comparative clinical pathology. The taxon-based chapters provide information about disease in related groups of animals and include descriptions of gross and histologic lesions, pathogenesis and diagnostics. For each group of animals, notable, unique gross and microscopic anatomical features are provided to further assist the reader in deciding whether differences from the domestic animal paradigm are "normal." Additional online content, which includes text, images, and whole scanned glass slides of selected conditions, expands the published material resulting in a comprehensive approach to the topic.
Pathobiology of Marine and Estuarine Organisms is a comprehensive, up-to-date review of aquatic animal pathobiology covering infectious and non-infectious diseases of vertebrates such as marine mammals and fishes, in addition to diseases of invertebrates such as crustacea, mollusks, and lower phyla. The book provides critical information on viral, fungal, bacterial, parasitic, and neoplastic diseases of fish and invertebrates.
Shortlisted for the 2018 TWS Wildlife Publication Awards in the edited book category Decomposition and recycling of vertebrate remains have been understudied, hampered largely due to these processes being aesthetically challenging (e.g., smell and sight). Technological innovations have provided the means to explore new and historically understood natural systems to give us a plethora of new information. Carrion Ecology, Evolution, and Their Applications covers a broad spectrum of topics including the molecular mechanistic foundations that provide the basis for intra- and interspecific interactions related to population biology, community ecology, and how this manifests into habitat- and ecosystem-level importance. The book connects the science of carrion decomposition from genes to ecosystems in multidisciplinary synthesis of the science. This book brings together a team of global experts involved with measuring and understanding the process and effects of carrion ecology in nature, with special application in such applied fields as forensic entomology, habitat management, animal production (e.g., livestock and aquaculture), and human and environmental health. It fills a large literature gap in ecology, providing a synthesis and future directions important for studies of carrion decomposition that improve the general understanding of decomposition in ecosystems. The book fuses multiple disciplines into a single message explaining the importance of vertebrate carrion ecology in nature. Illustrates Carrion Decomposition in a 16-Page Color Insert with 40 Photos The authors illustrate how the study of carrion transcends the globe and expands systems of inquiry, broadening awareness of this important ecosystem process. Whether you are a student, academic, or professional, you will find this book insightful for the fields of molecular ecology, microbiology, entomology, forensics, population biology, community and ecosystem ecology, and human and environmental health.
"Mouse Genetics: Methods and Protocols" provide selected mouse genetic techniques and their application in modeling varieties of human diseases. The chapters are mainly focused on the generation of different transgenic mice to accomplish" "the manipulation of genes of interest, tracing cell lineages and modeling human diseases. Composed in the highly successful "Methods in Molecular Biology "series format, each chapter contains a brief introduction, a list of necessary materials, systematic, readily reproducible methods and a notes section, which shares tips on troubleshooting in order to avoid known pitfalls.
Comprehensive and authoritative, "Mouse Genetics: Methods and Protocols" promises to deliver fundamental techniques and protocols to geneticists, molecular biologists, cell and developmental biologists, students and postdoctoral fellows working in the various disciplines of mouse biology and modeling human disease.
By the late 1890s, the question of bovine tuberculosis (TB) and infected meat had become one of national importance, reflecting a national sense of fear. Although the extent of the threat to health proved uncertain, bovine TB had come to stand at the centre of debates about diseased meat and public health. The anxiety it caused was part of a longer story, linked to concern over food safety, changes in how tuberculosis was understood, and to worries over diseased meat and the 'evils' of the urban meat trade. The Bovine Scourge explores the debates and fears that came to surround bovine TB, meat and public health between the 1860s and 1914. It traces how diseased meat and bovine TB emerged as a public health issue, examines the measures adopted to protect the public, and addresses how by the Edwardian era milk had become the major source of concern in discussion of bovine TB. It also raises important questions about the history of food safety, the concerns generated by diseased meat, and the role of the public health and veterinary profession in preventing the sale of contaminated food.KEIR WADDINGTON is a senior lecturer in the School of History and Archaeology at Cardiff University.
Stereotaxic neurosurgery in rodents is used by a variety of people working at research laboratories (research staff, technicians, students at animal facilities...). The present handbook presents all the steps necessary to complete a stereotaxic neurosurgery protocol in accordance with current animal welfare guidelines. This book will guide surgeons step by step, from anesthesia to the post-surgery recovery procedures, including asepsis of the surgical tools and surgical zone, analgesia, correctly identifying the reference points on the skull and brain targets, etc. In keeping with the current international trends, the authors above all focus on the following points: the consideration of pain and how to best treat it depending on the type of surgery; and ensuring asepsis. This book will serve as an important reference work and valuable guidebook for the scientific community.
Foundations of Wildlife Diseases is a comprehensive overview of the basic principles that govern the study of wildlife diseases. The authors integrate theoretical foundations with a thorough examination of the factors that can affect the health and fitness of animals. They include specific information on a wide array of infectious agents such as bacteria, viruses, arthropods, fungi, protista, and helminths, as well as immunity to these agents. Also provided is a foundation for the study of noninfectious diseases, cancers, and prion diseases that affect wildlife. Supporting students, faculty, and researchers in areas related to wildlife management, biology, and veterinary sciences, this volume fills an important gap in wildlife disease resources, focusing on mammalian and avian wildlife while also considering reptiles and amphibians. Foundations of Wildlife Diseases provides students with a structure for thinking about and understanding infective agents and their interactions with wildlife. Each chapter includes an outline, select definitions and concepts, an overview and summary, and literature cited.
This book provides comprehensive knowledge on diseases in livestock that are caused by viruses, parasites and bacteria. Emerging and re-emerging pathogens are presented in detail for various animal groups and in-depth insights into pathogenesis and epidemiology will be provided for each of them. In addition, state-of-the-art treatment possibilities, control measures as well as vaccination strategies are discussed. The recent years have witnessed a sharp increase in the number of emerging and re-emerging infectious diseases of livestock and many of these, including Influenza, Corona and Hanta are of public health importance. The reasons for this development are manifold:changes in the climate, life cycle of vectors and increased global travel. Also, due to extensive deforestation, livestock are increasingly coming in direct contact with wild animals that are reservoirs of many emerging pathogens. Recent progress in diagnosis and management of emerging infectious diseases are also topic of this book.
Studies in human patients and animal models of disease suggest a strong correlation between defects in dendrite development and common neurological disorders such as autism. Much of this book is thus dedicated toward highlighting recent advances in our understanding of the cellular and molecular mechanisms that regulate the development and maintenance of dendrites, a crucial component of neurons. The book begins by presenting the current state of knowledge on the building blocks or cell biology of dendrites. Mechanisms that sculpt the stereotypic architecture of dendritic arbors and shape their connectivity are also discussed, along with recent work describing how dendritic organization and connectivity are perturbed in disease. A unique aspect of the book is its exploration of diverse neuronal cell types across vertebrates and invertebrates, allowing a comparison of mechanisms across distinct circuits and species. The book comprises six parts, which cover the major advances in the field: Part 1, Introduction; Part 2, Basic Biology of Dendrites; Part 3, Patterning Dendritic Architecture of Neurons and Their Populations; Part 4, Cellular and Molecular Control of Dendrite Development and Maintenance; Part 5, Synapse Formation onto Dendrites; and Part 6, Dendrites in Disease. The book offers an excellent point of entry for students interested in neuroscience, as well as for clinicians.
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