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Break the rules, not the fast with world-renowned biohacker and New York Times bestselling author Dave Asprey.
For more than a decade, the Bulletproof founder Dave Asprey has shared his unique point of view and expertise to help fans become the best versions of themselves. From living longer to getting smarter, maximising performance to practising mindfulness, Dave's followers look to him for his take on the most effective techniques to become healthier and more powerful than most doctors think is possible. Asprey has been fasting for years, long before it gained widespread popularity, and if you're a fan of The Bulletproof Diet, you have been enjoying some of the benefits of Intermittent Fasting too.
In Fast This Way, Dave asks readers to forget everything they think they know about the ancient practice and takes them on a journey through cutting-edge science to examine the ways novice fasters and Intermittent Fasting loyalists can up-end their relationship with food and upgrade their fasting game beyond calorie restriction.
Fast This Way is a compelling read through the latest thinking on fasting and gives readers the manual and toolkit to make the most of their fasts and their personal biology.
Ideal for those studying biochemistry for the first time, this proven book balances scientific detail with readability and shows you how principles of biochemistry affect your everyday life. Designed throughout to help you succeed (and excel!), the book includes in-text questions that help you master key concepts, end-of-chapter problem sets grouped by problem type that help you prepare for exams, and state-of-the art visuals that help you understand key processes and concepts. In addition, visually dynamic "Hot Topics" cover the latest advances in the field, while "Biochemical Connections" demonstrate how biochemistry affects other fields, such as health and sports medicine. The accompanying OWL homework offers end-of-chapter problems in digital form, giving you on-demand access to hints, solutions, and other information directly related to the problem.
Very Short Introductions: Brilliant, Sharp, Inspiring From the simplest bacteria to humans, all living things are composed of cells of one type or another, all of which have fundamentally the same chemistry. This chemistry must provide mechanisms that allow cells to interact with the external world, a means to power the cell, machinery to carry out varied processes within the cell, a structure within which everything runs, and also governance through a web of interlocking chemical reactions. Biochemistry is the study of those reactions, the molecules that are created, manipulated, and destroyed as a result of them, and the massive macromolecules (such as DNA, cytoskeletons, proteins and carbohydrates) that form the chemical machinery and structures on which these biochemical reactions take place. It didn't take long for an understanding of the chemistry of life to turn into a desire to manipulate it. Drugs and therapies all aim to modify biochemical processes for good or ill: Penicillin, derived from mould, stops bacteria making their cell walls. Aspirin, with its origins in willow bark, inhibits enzymes involved in inflammatory responses. A few nanograms of botulinum toxin (botox), can kill by preventing the release of neurotransmitters from the ends of nerves and so leads to paralysis and death, or give a wrinkle free forehead (if administered in very tiny quantities).This Very Short Introduction discusses the key concepts of biochemistry, as well as the historical figures in the field and the molecules they studied, before considering the current science and innovations in the field, and the interaction between biochemistry, biotechnology, and synthetic biology. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
Bringing this best-selling textbook right up to date, the new edition uniquely integrates the theories and methods that drive the fields of biology, biotechnology and medicine, comprehensively covering both the techniques students will encounter in lab classes and those that underpin current key advances and discoveries. The contents have been updated to include both traditional and cutting-edge techniques most commonly used in current life science research. Emphasis is placed on understanding the theory behind the techniques, as well as analysis of the resulting data. New chapters cover proteomics, genomics, metabolomics, and bioinformatics, as well as data analysis and visualisation. Using accessible language to describe concepts and methods, and with a wealth of new in-text worked examples to challenge students' understanding, this textbook provides an essential guide to the key techniques used in current bioscience research.
Bank filtration (BF) is a natural water treatment process which induces surface water to flow in response to a hydraulic gradient through soil/sediment and into a vertical or horizontal well. It is a relatively cost-effective, robust and sustainable technology. From a historical perspective, BF is first mentioned in the bible, and the process has been recognized as a proven method for drinking water treatment in Europe for more than 100 years. However, the mechanisms of removal of different contaminants during BF are not fully understood. This study showed that BF is an effective multiple objective barrier for removal of different contaminants present in surface water sources including bulk organic matter and organic micropollutants (OMPs) like pharmaceutically active compounds and endocrine disrupting compounds. It was found that biodegradation and adsorption play primary and secondary roles, respectively, in the removal of OMPs during soil passage. Furthermore, using field data from BF sites and chemical properties of OMPs, models were developed to estimate the removal of OMPs during soil passage. It can be concluded that the removal efficiencies of BF for these contaminants can be maximised by proper design and operation of recovery wells taking into consideration source water quality characteristics and local hydrogeological conditions.
Why do elephants have sturdier thigh bones than humans? Why can't ostriches fly? How do bacteria swim through fluids? With each chapter structured around relevant biological case studies and examples, this engaging, full-colour book introduces fundamental physical concepts essential in the study of biological phenomena. Optics is introduced within the context of butterfly wing colouration, electricity is explained through the propagation of nerve signals, and accelerated motion is conveniently illustrated using the example of the jumping armadillo. Other key physical concepts covered include waves, mechanical forces, thermodynamics and magnetism, and important biological techniques are also discussed within this context, such as gel electrophoresis and fluorescence microscopy. A detailed appendix provides further discussion of the mathematical concepts utilised within the book, and numerous exercises and quizzes allow readers to test their understanding of key concepts. This book is invaluable to students aiming to improve their quantitative and analytical skills and understand the deeper nature of biological phenomena.
Numerous pharmaceutical substances and their metabolites have been identified in the aquatic environment. Due to their unique environmental fate and lack of appropriate biomonitoring techniques, the potential risk of these compounds to public and environmental health has largely been undetermined. Recent interest in quantifying pharmaceuticals in waste effluents and aquatic environments has identified the need to develop bioanalytical assays that will accurately reflect presence of these compounds. The goal of this research was to investigate the use of DNA microarrays as a bioanalytical tool for analysis of pharmaceutical contamination in re-use waters. Results from this study suggest that prototypic pharmaceutical contaminants target molecular events associated with pharmaceutical-induced gene induction and repression in exposed organisms. Gene expression profiles are subsequently evaluated as a means to discern pharmaceutical exposure. When fully developed, this bioanalytical approach will provide an efficient and robust method for screening pharmaceutical contaminants in reuse and other water matrices.
Advanced Biological Treatment Processes for Industrial Wastewaters provides unique information relative to both the principles and applications of biological wastewater treatment systems for industrial effluents. Case studies document the application of biological wastewater treatment systems in different industrial sectors such as chemical, petrochemical, food-processing, mining, textile and fermentation. With more than 70 tables, 100 figures, 200 equations and several illustrations, the book provides a broad and deep understanding of the main aspects to consider during the design and operation of industrial wastewater treatment plants. Students, researchers and practitioners dealing with the design and application of biological systems for industrial wastewater treatment will find this book invaluable.
Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques are likely to generate the most desirable reactions. Incorporating elements from the author's role of Career Investigator of the Medical Research Council of Canada and his extensive teaching career, the book emphasizes learning rather than memorization. The text uses clear language and schematics to present concepts progressively, carefully excluding unnecessary details and providing a historical context in which to appreciate the development of the field.
The author first outlines the fundamentals of peptide synthesis, focusing on the intermediates in aminolysis reactions. Gradually the text builds into discussions of the applicability of coupling reactions, stereomutation, methods of deprotection, solid-phase synthesis, side-chain protection and side reactions, and amplification on coupling methods. The book clarifies the differences between oxazolones from amino-acid derivativesand segments and the implications of their formation on the chiral integrity of products. The author offers a critical analysis of the mechanisms of coupling reactions and the desirability of preactivation. The text explains hindrance and the nucleophilicity of tertiary amines and rationalizes their use. The book also explores mechanisms of acidolysis and the dual role of nucleophiles as reactants and scavengers.
Chemistry of Peptide Synthesis supplies a broad, yet straightforward approach that appeals to those with limited knowledge of organic chemistry or chemists from other fields as well as in-depth coverage that can be appreciated by experienced peptidologists.
In wastewater reclamation systems, microbiological monitoring is conducted to ensure that the users of reclaimed water are exposed to minimal risks from exposure to pathogens. Typically, utilities rely on the use of process controls to remove or inactivate pathogens. Routine monitoring of indicator organisms is conducted to evaluate overall process performance and for regulatory compliance. However, the effectiveness of individual treatment processes for removal of pathogens is dependent on process variables. This project was conducted to compare the effectiveness of biological treatment, filtration, and disinfection for removal of bacterial and viral indicators, enteric viruses, and protozoan pathogens. Six full-scale treatment facilities were each sampled a minimum of four times over a one year period. The relative impacts of loading conditions, process design, and operating parameters on the removal/inactivation of a suite of nine microbial species (bacteria, coliphages, enteric viruses, and protozoan pathogens) was evaluated. Bacterial removal was consistent for all types of biological systems, however, increased virus removal was associated with biological nutrient removal and nitrification processes. Parasite removal was highly variable. The effectiveness of filtration was impacted most by the use of upstream chemicals (either chlorine or coagulant chemicals). Chlorine disinfection was more effective in cases where ammonia levels were low (biological nutrient removal or nitrification facilities). Infectivity assays for protozoan pathogens suggest that the proportion of infective cysts or oocysts increases with increasing level of treatment.
Although ingestion of high levels of arsenic is believed to cause certain cancers, estimates of cancer risk resulting from exposure to low levels of arsenic are the subject of considerable debate. An improved understanding of arsenic toxicity and the dose-response relationship for relatively low levels of arsenic could improve the risk assessment process. The overall objective of this study was to contribute to a better understanding of arsenic health effects. A specific aim was to investigate the cellular response of exposure to arsenic. This includes the analysis of cells treated with arsenic alone or in combination with other DNA-damaging agents in order to identify mechanisms of DNA damage, the influence of arsenic on DNA repair, and potential critical genes responsible for repair of DNA damage. The researchers conducted the following steps as part of the project approach: 1. Measured cell killing by arsenic compounds, using human and hamster cells harboring mutations in specific DNA repair genes, to determine if arsenic kills cells by causing DNA damage and, if so, which DNA repair pathway(s) would be involved in repairing the damage. 2. Measured cell killing to assess the relationship between ionizing radiation and arsenic, i.e., to define if the combination of the two treatments is additive or synergistic. 3. Conducted assays for DNA damage using capillary electrophoresis laser-induced fluorescence. 4. Monitored the effects of arsenite and benzo[a]pyrene diol epoxide (BPDE) in the induction and repair of BPDE-DNA adducts in A549 cells. 5. Performed arsenic speciation analysis and test species stability. 6. Measured the interaction of arsenicals with metallothionein Project highlights include: Cells from the cancer-prone disorder, Ataxia telangiectasia, were hypersensitive to killing by arsenite, but this may not be due to DNA damage. The toxicity of the combination of arsenite and gamma-radiation was additive, not synergistic, implying that radiation and arsenic kill cells by distinct mechanisms. Arsenite enhanced the formation of benzo[a]pyrene-DNA adducts but the kinetics of repair remained unaltered. Arsenite, therefore, either renders DNA more accessible to DNA damaging agents or inhibits other processes that inactivate benzo[a]pyrene metabolites, such as reaction with glutathione. Trivalent methylation metabolites of arsenic readily reacted with metallothionein, a small cysteine-rich protein. Through this project, analytical techniques were developed for the determination of arsenic species. These techniques are useful for monitoring the occurrence of arsenic. They are also useful for determining exposure and metabolism of arsenic compounds ingested from drinking water. It is also important to recognize that genetic variation may make some individuals more sensitive to the harmful effects of arsenic. Originally published by AwwaRF for its subscribers in 2004. This publication can also be purchased and downloaded via Pay Per View on Water Intelligence Online - click on the Pay Per View icon below
Explains models from natural flash systems Discusses theoretical considerations of flash systems Presents approaches and procedures for designing synthetic flash systems Explores methods for preparing flash systems for specific applications The design of environment-sensitive devices for biomedical and pharmaceutical applications has improved significantly due to recent advances in smart polymer and hydrogel technology. Despite their capacity to carry out functions that previously were unobtainable, smart polymers and hydrogels tend to have painfully slow response times. On the other hand biological systems go through phase changes at an extremely fast rate. This book examines the natural systems that respond almost instantaneously to environmental stimuli, and thus gives the reader an understanding of the mechanisms that govern these responses. The book includes chapters on how to go about designing a synthetic "flash" system based on the naturally occurring systems. It also deals with potential applications of flash systems in biomedical and pharmaceutical areas.
Photosensitization of Porphyrins and Phthalocyanines covers the scentific background to porphyrins and phthalocyanines, and applications of the compounds, especially for the application for photosensitization. It also has a review of advances in research and applications in this field.
This text addresses critical topics in the expanding market and production for lipids. It combines novel and traditional methods from technological and biological perspectives to achieve the most effective pathways for production of modified lipids. The book is organized into three sections exploring development, new production methods and successful products and uses.
The discovery of molecular and cellular mechanisms of pathology, together with the present data on drug treatment result in enhanced drug design and testing. The known mechanisms of biological activity as displayed by ascorbic acid and other natural reductones are the reason that they are considered to be physiologically compatible antioxidants, many of which are trace elements in food. The pharmacological potential of natural antioxidants may be enhanced by chemical modification. Biotic antioxidants possess an important potential to be a reliable basis of the development of new multipurpose drugs, within the framework of existing technological structures. This book shows approaches for possible use of these natural antioxidants. In particular, such an approach is described for the case of the design of superoxide dismutase models with anti-tumour activity.
This work describes the essential steps in the development of biocatalytic processes from concept to completion. This integrated text combines the fundamentals of biocatalysis with technological experience and in-depth commercial case studies. The book starts with an introductory look at this history and present scope of biocatalysis, followed by overviews of: applications of specific enzymes; bioprocess case studies; biocatalyst selection and production; enzyme performance - activity and stability; non-conventional media - aqueous/organic biphasic, organic, gaseous media; immobilization; protein engineering and metabolic engineering; process concepts; bioreactor selection and design; patents; and commercial and financial aspects. Written by industrial and academic experts, this world is intended for the bookshelf of anyone teaching biocatalysis or working in the chemical, food, manufacturing of pharmaceutical industries who is seeking to exploit the potential of biocatalysts.
Phosphorus is one of the major nutrients limiting the productivity of terrestrial, wetland and aquatic ecosystems. Over the last decade several research projects were conducted on Florida's ecosystems from state and federal agencies and private industry to address water quality issues, and to develop management practices to control nutrient loads.
Handbook of Biodegradable Polymers, the seventh volume in the Drug Delivery and Targeting book series, provides a source manual for synthetic procedures, properties and applications of bioerodible polymers. The authors describe widely available materials such as polyactides, collagen and gelatin, as well as polymers of emerging importance, such as the genetically-engineered and elastin-based polymers which are either proprietary or in early stages of development. Section I addresses synthetic absorbable polymers, and Section 2 profiles natural, semi-synthetic and biosynthetic polymers. Section 3 discusses the surface characterization of degradable polymers, the modeling of biodegradation and non-medical polymers. This book is ideal for researchers from academia and industry as well as chemists, pharmacists and physicians who deal with biopolymers, drug delivery and targeting, bioengineering and implantable devices.
This is a compilation of questions with answers for students of toxicology. The questions are a mixture of short answer, problem-solving, data interpretation and multiple choice and cover all the major areas of toxicology, including mechanisms of toxicity, toxic responses, factors affecting the toxicity of compounds and the metabolism and disposition of toxic compounds. The book should also be useful for qualified toxicologists and scientists working in related areas who are preparing for internal examinations.
The egg is a chemical storehouse-within an incubating egg a complicated set of chemical reactions take place that convert the chemicals into a living animal. Using hen eggs as a model, this new text explores the use of eggs for food, industrial, and pharmaceutical applications. It covers the chemistry, biology, and function of lipids; carbohydrates; proteins; yolk antibody (IgY); and other materials of eggs. The novel merits of egg materials over others used in the same products are also discussed. These areas of egg technology have never been compiled before in one source.
Provides a detailed survey of new therapies for autoimmune diseases, exploring the rationale for their use and clinical data regarding their potential benefit. The book emphasizes biological interventions based on the pathogenesis of autoimmunity, ranging from altering tolerance to modifying cytokines and changing lymphocyte function.
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