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Books > Science & Mathematics > Biology, life sciences > Biochemistry

Bioactive Lipid Mediators - Current Reviews and Protocols (Hardcover, 1st ed. 2015): Takehiko Yokomizo, Makoto Murakami Bioactive Lipid Mediators - Current Reviews and Protocols (Hardcover, 1st ed. 2015)
Takehiko Yokomizo, Makoto Murakami
R4,000 R3,194 Discovery Miles 31 940 Save R806 (20%) Shipped within 7 - 12 working days

This book summarizes the most recent progress in the studies of lipid mediators from the molecular to clinical level and introduces newly created tools for analysis including imaging mass spectrometry. Comprising 29 chapters divided into four major parts, the book describes the molecular natures of enzymes, transporters, and receptors for lipid mediators (Part I), the function of lipid mediators in Drosophila and Zebrafish (Part II), the relationships between lipid mediators and various diseases (Part III), and detailed procedures of extraction, preparation, and quantification of lipid mediators (Part IV). Research on lipid mediators initially started with analysis of the action of aspirin, and subsequent biochemical experiments identified many enzymes and receptors responsible for the biosynthesis and signal transduction of individual lipid mediators. Through the phenotypic analyses of transgenic and knockout mice, it has been shown that the dysregulation of some lipid mediators causes inflammatory, immune, or oncogenic disorders. Lipid mediators have attracted increased attention because their structures are conserved among different species, and their biosynthetic and signaling pathways have been deciphered at the molecular level. Many drugs that target lipid mediators are already being used in hospitals, and this book suggests further possibilities for development of a wide variety of such drugs. Very recently, highly sensitive mass spectrometry has begun to be used to identify novel lipid mediators that are present only in trace amounts in tissues but with robust biological activity. Written by international experts, this book provides readers a comprehensive view of lipid mediators and related topics and helps in the process of determining research targets for the near future.

VEGF Signaling - Methods and Protocols (Hardcover, 1st ed. 2015): Lorna Fiedler VEGF Signaling - Methods and Protocols (Hardcover, 1st ed. 2015)
Lorna Fiedler
R3,440 R2,692 Discovery Miles 26 920 Save R748 (22%) Shipped within 7 - 12 working days

This volume provides a collection of protocols for studying and manipulating VEGF signaling pathways in vitro and in vivo, and in particular, aims to present a range of both firmly established and newly emerging technologies, including those that are amenable to aiding in drug discovery or pre-clinical investigations. Each of the three sections begins with an introductory overview followed by supporting relevant methods. A major advantage of this book is that each chapter not only contains methodological detail rarely seen in other literature, but also contains a section on key notes and troubleshooting advice. Part I focuses on quantification of specific VEGF and VEGF receptor isoforms, beginning with a summary on VEGF splice variants, their function and their regulation. Part II relates to the study of VEGF dependent signaling in vitro, starting with a comprehensive overview of VEGF-mediated signal transduction in the cardiovascular system that highlights recent discoveries in the field. Part III first details genetic mouse models, then discusses techniques for studying physiological angiogenesis in the developing mouse embryo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, VEFG Signaling: Methods and Protocols is a useful tool for researching and understanding the basic biology of VEGF signaling and translating it into the clinic.

Protein Arginylation - Methods and Protocols (Hardcover, 1st ed. 2015): Anna S Kashina Protein Arginylation - Methods and Protocols (Hardcover, 1st ed. 2015)
Anna S Kashina
R3,130 R2,410 Discovery Miles 24 100 Save R720 (23%) Shipped within 7 - 12 working days

This volume presents a comprehensive overview of all the existing methods on analysing protein arginylation, from the early methods utilizing crude protein preparations and whole-cell assays to the latest advanced methods involving recombinant protein techniques, antibodies, high precision mass spectrometry, and chemical probes. This book also includes essays from the founders of the field, who originally discovered arginylation in the early 1960s and brought it to international recognition. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Protein Arginylation: Methods and Protocols would interest the emerging body of scientists involved in the studies of posttranslational arginylation and the rapidly growing community of researchers working on a broad range of posttranslational modifications, the analysis of which often meets similar challenges and utilizes similar principles as posttranslational arginylation.

Molybdenum and Tungsten Enzymes - Spectroscopic and Theoretical Investigations (Hardcover): Russ Hille, Carola Schulzke, Martin... Molybdenum and Tungsten Enzymes - Spectroscopic and Theoretical Investigations (Hardcover)
Russ Hille, Carola Schulzke, Martin L Kirk; Series edited by C. David Garner; Edited by (editors-in-chief) C. David Garner; Contributions by …
R4,259 Discovery Miles 42 590 Shipped within 7 - 12 working days

The book will cover the bio-, inorganic and bioinorganic chemistry of molybdenum containing enzymes, including mononuclear molybdenum-containing enzymes, the complex Fe/Mo enzyme nitrogenase, and also tungsten enzymes. The full range of physicochemical methods that are used to investigate their and function will be covered. There has been no comprehensive book in this area for the past 30 years, despite great progress in our understanding of molybdenum enzymes and relevant inorganic complexes of molybdenum, and as a result the proposed book will both fill an enormous gap in coverage of the field and at the same time document the latest research. The book will be useful for workers in the field of metal-containing enzymes, graduate students and young investigators interested in developing new research programs in the area. It will also serve as a useful reference for researchers outside the field. Cross promotion: Journals: Dalton Transactions and Metallomics. Books: "Iron-Containing Enzymes", Visser and Kumar, 2011; "Binding, Transport and Storage of Metal Ions in Biological Cells", Maret and Wedd, 2014.

Reviews of Environmental Contamination and Toxicology Volume 245 (Hardcover, 1st ed. 2018): Pim de Voogt Reviews of Environmental Contamination and Toxicology Volume 245 (Hardcover, 1st ed. 2018)
Pim de Voogt
R2,222 R1,996 Discovery Miles 19 960 Save R226 (10%) Shipped within 7 - 12 working days

Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.

Organic Mechanisms - Reactions, Stereochemistry and Synthesis (Hardcover, 3rd): Reinhard Bruckner Organic Mechanisms - Reactions, Stereochemistry and Synthesis (Hardcover, 3rd)
Reinhard Bruckner; Illustrated by Wolfgang Zettlmeier; Preface by Paul A. Wender; Edited by Michael Harmata
R2,526 R1,997 Discovery Miles 19 970 Save R529 (21%) Shipped within 7 - 12 working days

This English edition of a best-selling and award-winning German textbook Reaction Mechanisms: Organic Reactions . Stereochemistry . Modern Synthetic Methods is aimed at those who desire to learn organic chemistry through an approach that is facile to understand and easily committed to memory. Michael Harmata, Norman Rabjohn Distinguished Professor of Organic Chemistry (University of Missouri) surveyed the accuracy of the translation, made certain contributions, and above all adapted its rationalizations to those prevalent in the organic chemistry community in the English-speaking world.

Throughout the book fundamental and advanced reaction mechanisms are presented with meticulous precision. The systematic use of red "electron-pushing arrows" allows students to follow each transformation elementary step by elementary step. Mechanisms are not only presented in the traditional contexts of rate laws and substituent effects but, whenever possible, are illustrated using practical, useful and state-of-the-art reactions. The abundance of stereoselective reactions included in the treatise makes the reader familiar with key concepts of stereochemistry.

The fundamental topics of the book address the needs of upper-level undergraduate students, while its advanced sections are intended for graduate-level audiences. Accordingly, this book is an essential learning tool for students and a unique addition to the reference desk of practicing organic chemists, who as life-long learners desire to keep abreast of both fundamental and applied aspects of our science. In addition, it will well serve ambitious students in chemistry-related fields such as biochemistry, medicinal chemistry and pharmaceutical chemistry.

From the reviews:

"Professor Bruckner has further refined his already masterful synthetic organic chemistry classic; the additions are seamless and the text retains the magnificent clarity, rigour and precision which were the hallmark of previous editions. The strength of the book stems from Professor Bruckner s ability to provide lucid explanations based on a deep understanding of physical organic chemistry and to limit discussion to very carefully selected reaction classes illuminated by exquisitely pertinent examples, often from the recent literature. The panoply of organic synthesis is analysed and dissected according to fundamental structural, orbital, kinetic and thermodynamic principles with an effortless coherence that yields great insight and never over-simplifies. The perfect source text for advanced Undergraduate and Masters/PhD students who want to understand, in depth, the art of synthesis ."
Alan C. Spivey, Imperial College London

"Bruckner s Organic Mechanisms accurately reflects the way practicing organic chemists think and speak about organic reactions. The figures are beautifully drawn and show the way organic chemists graphically depict reactions. It uses a combination of basic valence bond pictures with more sophisticated molecular orbital treatments. It handles mechanisms both from the "electron pushing perspective" and from a kinetic and energetic view. The book will be very useful to new US graduate students and will help bring them to the level of sophistication needed to be serious researchers in organic chemistry."
Charles P. Casey, University of Wisconsin-Madison

"This is an excellent advanced organic chemistry textbook that provides a key resource for students and teachers alike."
Mark Rizzacasa, University of Melbourne, Australia."

Ecological Reviews - The Ecology of Plant Secondary Metabolites: From Genes to Global Processes (Hardcover, New): Glenn R.... Ecological Reviews - The Ecology of Plant Secondary Metabolites: From Genes to Global Processes (Hardcover, New)
Glenn R. Iason, Marcel Dicke, Susan E. Hartley
R2,170 R2,009 Discovery Miles 20 090 Save R161 (7%) Shipped within 7 - 12 working days

Plant secondary metabolites (PSMs) such as terpenes and phenolic compounds are known to have numerous ecological roles, notably in defence against herbivores, pathogens and abiotic stresses and in interactions with competitors and mutualists. This book reviews recent developments in the field to provide a synthesis of the function, ecology and evolution of PSMs, revealing our increased awareness of their integrative role in connecting natural systems. It emphasises the multiple roles of secondary metabolites in mediating the interactions between organisms and their environment at a range of scales of ecological organisation, demonstrating how genes encoding for PSM biosynthetic enzymes can have effects from the cellular scale within individual plants all the way to global environmental processes. A range of recent methodological advances, including molecular, transgenic and metabolomic techniques, are illustrated and promising directions for future studies are identified, making this a valuable reference for researchers and graduate students in the field.

Agricultural Proteomics Volume 1 - Crops, Horticulture, Farm Animals, Food, Insect and Microorganisms (Hardcover, 1st ed.... Agricultural Proteomics Volume 1 - Crops, Horticulture, Farm Animals, Food, Insect and Microorganisms (Hardcover, 1st ed. 2016)
Ghasem Hosseini Salekdeh
R3,839 R3,092 Discovery Miles 30 920 Save R747 (19%) Shipped within 7 - 12 working days

This book will cover several topics to elaborate how proteomics may enhance agricultural productivity. These include crop and food proteomics, farm animal proteomics, aquaculture, microorganisms and insect proteomics. It will also cover several technical advances, which may address the current need for comprehensive proteome analysis.An emerging field of the proteomics aim is to integrate knowledge from basic sciences and to translate it into agricultural applications to solve issues related to economic values of farm animals, crops, food security, health, and energy sustainability. Given the wealth of information generated and to some extent applied in agriculture, there is the need for more efficient and broader channels to freely disseminate the information to the scientific community.

Toxicogenomics in Predictive Carcinogenicity (Hardcover): Michael D Waters, Russell S. Thomas Toxicogenomics in Predictive Carcinogenicity (Hardcover)
Michael D Waters, Russell S. Thomas; Edited by (editors-in-chief) Diana Anderson; Contributions by Michael D Waters, Luoping Zhang, …
R4,274 Discovery Miles 42 740 Shipped within 7 - 12 working days

Toxicogenomics in Predictive Carcinogenicity describes toxicogenomics methods in predictive carcinogenicity testing, mode of action and safety evaluation, and cancer risk assessment. It illustrates these methods using case studies that have yielded significant new information on compounds and classes of compounds that have proven difficult to evaluate using conventional methods alone. This book additionally covers current and potential toxicogenomic research using stem cells as well as new bioinformatics methods for drug discovery and environmental toxicology.The information is needed because it has not previously been available. With the increasing complexity of research in mode of action investigations it is important to gain a better understand of approaches to data integration and health risk assessment. Furthermore, it is essential to consider how novel test systems and newer methods and approaches may be used in future to gain a better understanding of mechanisms. The proposed publication will provide details of chemical case studies not available in previous volumes and will demonstrate how various data is assembled and integrated to arrive at an informed assessment of chemical safety and human health risk. It will be the most current volume which comprehensively covers the subject. This publication is an indispensable tool for postgraduates, academics and industrialists working in biochemistry, genomics, carcinogenesis, pathology, pharmaceuticals, food technology, bioinformatics, risk assessment and environmental toxicology. Societies: American Association for Cancer Research AACR (http://www.aacr.org/) Environmental Mutagenesis and Genomics Society (http://www.emgs/org) International Association of Environmental Mutagen Societies (http://www.iaems/org) International Union of Toxicology (http://www.iutox.org/) Society of Toxicology (http://www.toxicology.org/) Journals for reviews: Cancer Research Mutation Research Toxicology Research Toxicology and Applied Pharmacology Regulatory Toxicology and Pharmacology Toxicology Toxicology Letters Critical Reviews in Toxicology Archives of Toxicology Pharmacology & Toxicology Fundamental and Applied Toxicology Toxicologic Pathology Clinical Toxicology Human and Experimental Toxicology International Journal of Toxicology Toxicology and Industrial Health Drug and Chemical Toxicology Drug safety Journal of Toxicology Toxicological Sciences Websites: American Association for Cancer Research AACR (http://www.aacr.org/) Environmental Mutagenesis and Genomics Society (http://www.emgs/org) International Association of Environmental Mutagen Societies (http://www.iaems/org) International Union of Toxicology (http://www.iutox.org/) Society of Toxicology (http://www.toxicology.org/) Cross-promote with the textbook Fundamental Toxicology

Who We Are and How We Got Here - Ancient DNA and the New Science of the Human Past (Hardcover): David Reich Who We Are and How We Got Here - Ancient DNA and the New Science of the Human Past (Hardcover)
David Reich 1
R624 R379 Discovery Miles 3 790 Save R245 (39%) Shipped within 7 - 12 working days
Protein Purification (Paperback, 2nd New edition): Philip Bonner Protein Purification (Paperback, 2nd New edition)
Philip Bonner
R885 Discovery Miles 8 850 Shipped within 7 - 12 working days

This second edition of Protein Purification provides a guide to the major chromatographic techniques, including non-affinity absorption techniques, affinity procedures, non-absorption techniques and methods for monitoring protein purity. The new edition of the book has been organized to encourage incremental learning about the topic, starting with the properties of water, progressing through the characteristics of amino acids and proteins which relate to the purification process. There is an overview of protein strategy and equipment, followed by discussions and examples of each technique and their applications. The basic theory and simple explanations given in Protein Purification make it an ideal handbook for final year undergraduates, and postgraduates, who are conducting research projects. It will also be a useful guide to more experienced researchers who need a good overview of the techniques and products used in protein purification. Key Features * Guide to the major techniques used in protein purification * Includes flowcharts to help the reader slect the best purification strategy * Contains step-by-step protocols that guide the reader through each technique and its use * Includes exercises and solutions

Omics in Plant Breeding (Paperback): Aluizio Borem, Roberto Fritsche-Neto Omics in Plant Breeding (Paperback)
Aluizio Borem, Roberto Fritsche-Neto
R1,808 R1,595 Discovery Miles 15 950 Save R213 (12%) Shipped within 7 - 12 working days

Computational and high-throughput methods, such as genomics, proteomics, and transcriptomics, known collectively as -omics, have been used to study plant biology for well over a decade now. As these technologies mature, plant and crop scientists have started using these methods to improve crop varieties. Omics in Plant Breeding provides a timely introduction to key omicsbased methods and their application in plant breeding. Omics in Plant Breeding is a practical and accessible overview of specific omics-based methods ranging from metabolomics to phenomics. Covering a single methodology within each chapter, this book provides thorough coverage that ensures a strong understanding of each methodology both in its application to, and improvement of, plant breeding. Accessible to advanced students, researchers, and professionals, Omics in Plant Breeding will be an essential entry point into this innovative and exciting field. A valuable overview of high-throughput, genomics-based technologies and their applications to plant breeding Each chapter explores a single methodology, allowing for detailed and thorough coverage Coverage ranges from well-established methodologies, such as genomics and proteomics, to emerging technologies, including phenomics and physionomics Aluizio Borem is a Professor of Plant Breeding at the University of Vicosa in Brazil. Roberto Fritsche-Neto is a Professor of Genetics and Plant Breeding at the University of Sao Paulo in Brazil.

Fundamentals of Intracellular Calcium (Paperback): Anthony K. Campbell Fundamentals of Intracellular Calcium (Paperback)
Anthony K. Campbell
R1,763 R1,560 Discovery Miles 15 600 Save R203 (12%) Shipped within 7 - 12 working days

The definitive text on the key component for cell functions--intracellular calcium This comprehensive book reveals the evidence for intracellular calcium as a universal switch in all animal, plant, fungal and microbial cells. It shows how the components required for calcium signaling are named and classified; covers the technology that has been developed to study intracellular calcium; describes how calcium is regulated inside cells and how it works to trigger an event; explains the role of intracellular calcium in disease, cell injury, and cell death; reveals how many drugs work through the calcium signaling system; and demonstrates how intracellular calcium is involved in the action of many natural toxins. The book also illustrates how the intracellular calcium signaling system has evolved over millions of years, showing why it was crucial to the origin of life. Additionally, the book promotes the importance of the molecular variation upon which the intracellular calcium signalling system depends. Featuring more than 100 figures (including detailed chemical structures as well as pictures of key pioneers in the field), a bibliography of some 1000 references, and a detailed subject index, this definitive work provides a unique source of scholarship for teachers and researchers in the biomedical sciences and beyond. Emphasizes two key scientific principles--the first to show how intracellular Ca2+ acts as a switch, to activate a wide range of cellular events, and the second demonstrating how an analogue mechanism can be superimposed on such a process Written by an internationally recognized expert in the field Filled with images and references to facilitate learning Fundamentals of Intracellular Calcium is an all-important text for post-graduate students and researchers working in biomedicine and biochemistry. It is also essential for undergraduate lecturers and their students in physiology, medicine, pharmacy, and the biosciences.

Proteomics in Human Reproduction - Biomarkers for Millennials (Paperback, 1st ed. 2016): Ashok Agarwal, Luna Samanta, Ricardo... Proteomics in Human Reproduction - Biomarkers for Millennials (Paperback, 1st ed. 2016)
Ashok Agarwal, Luna Samanta, Ricardo P. Bertolla, Damayanthi Durairajanayagam, Paula Intasqui
R1,225 R1,113 Discovery Miles 11 130 Save R112 (9%) Shipped within 7 - 12 working days

This Brief explores the use of proteomics as a tool for biomarker discovery in human reproduction and summarizes current findings and trends of proteomic studies in both male and female infertility. This simplifies this important but complex topic and equips the novice reader with sufficient background information on the use of proteomics in human reproduction. The up-to-date scenario on proteomic investigations will also appeal to researchers and post graduate students looking to keep abreast with the latest developments in reproductive research. This review summarizes current findings of contemporary proteomic studies on infertility in both males and females with various reproductive pathologies, and its use in predicting the outcome of assisted reproduction. In human reproduction, the search for biomarkers via proteomics is a fast-evolving approach that involves the analysis of proteins in the reproductive tissues and fluids, such as the male gametes, seminal plasma, ovarian and endometrial tissue, and follicular and uterine fluid. By comparing the protein profile of a healthy, fertile individual against that of an infertile individual, the differentially expressed proteins may give an indication to certain proteins that could serve as useful biomarkers that are related to infertility. As proteomic studies continue to unravel the dynamic proteome behind various infertility conditions, there is potential for the discovery of prognostic markers that could ultimately help in both natural and assisted human reproduction.

Hormones: A Very Short Introduction (Paperback): Martin Luck Hormones: A Very Short Introduction (Paperback)
Martin Luck
R204 R160 Discovery Miles 1 600 Save R44 (22%) Shipped within 7 - 12 working days

Hormones play an integral part in the balance and workings of the body. While many people are broadly aware of their existence, there are many misconceptions and few are aware of the nature and importance of the endocrine system. In this Very Short Introduction, Martin Luck explains what hormones are, what they do, where they come from, and how they work. He explains how the endocrine system operates, highlighting the importance of hormones in the regulation of water and salt in the body, how they affect reproduction and our appetites, and how they help us adjust to different environments, such as travel across time zones. In this fresh and modern treatment, Luck also touches on the ethical and moral issues surrounding research methods, testing on animals, and hormone misuse. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Chemistry for the Biosciences - The Essential Concepts (Paperback, 3rd Revised edition): Jonathan Crowe, Tony Bradshaw Chemistry for the Biosciences - The Essential Concepts (Paperback, 3rd Revised edition)
Jonathan Crowe, Tony Bradshaw
R881 Discovery Miles 8 810 Shipped within 7 - 12 working days

Chemistry enables our eyes to detect the world around us; it determines whether something tastes sweet or sour; it helps genetic information pass accurately from one generation to the next. Ultimately, chemistry powers life itself. We don't need to dig very deep to answer the question: why do biologists need chemistry? Building on the success of the first two editions, Chemistry for the Biosciences introduces students to all the chemistry they need to understand the biological world. Renowned for its clear and straightforward explanations, the book uses everyday examples and analogies throughout to help students get to grips with chemical concepts, and presents them in context of biological systems wherever possible so they can see how chemistry relates to their wider studies. With topics drawn from organic, physical and inorganic chemistry, students will encounter a broad range of essential concepts to master. Chemistry for the Biosciences includes many learning features - both in print and online - to help students grasp these concepts as quickly and thoroughly as possible. From the self-check questions throughout each chapter to help consolidate learning, to the Chemical Toolkits and Maths Tools that help students explore terminology, methods, and numerical skills that may be unfamiliar, the book is written to be a true course companion for students on biological and biomedical science degrees - one that will help them not only remember the essentials, but really understand them, setting students up for success in their later studies. Chemistry for the Biosciences 3/e is supported by an extensive Online Resource Centre, featuring: For registered adopters: Figures from the book in electronic format, ready to download; A test bank of questions, with feedback linked to the text. Multiple-choice questions to aid exam preparation and revision; Full solutions to self-check questions; Data analysis and numerical practice worksheets; Mini-tutorials that walk students through a range of key concepts introduced in the book.

The Clinical Application of Homocysteine (Hardcover, 1st ed. 2018): Seema Bhargava The Clinical Application of Homocysteine (Hardcover, 1st ed. 2018)
Seema Bhargava
R1,815 R1,632 Discovery Miles 16 320 Save R183 (10%) Shipped within 7 - 12 working days

This book helps clinicians to optimally and appropriately utilize homocysteine levels in the diagnosis, prediction and management of and research into vascular disease and many other conditions. It also familiarizes readers with the pathophysiology and clinical implications of hyperhomocysteinemia. Laboratory investigations are gaining importance in the diagnosis and prognosis of patients, and as such, scientists and laboratorians are constantly attempting to identify new markers that will help in earlier diagnosis and better prognostication of conditions with high morbidity and mortality, as well as high prevalence. According to the WHO, developing countries are home to 80% of patients with coronary artery disease (CAD) and stroke - conditions with a mortality second only to cancer. Intensive research in these areas has resulted in the identification of homocysteine (declared the `marker of the millennium') and several new markers for the diagnosis and prediction of CAD and stroke. The book is a valuable resource for clinicians and consultants in practice, as well as for postgraduate and undergraduate students of medicine, biotechnology and biochemistry.

Epigenetics for Drug Discovery (Hardcover): Nessa Carey Epigenetics for Drug Discovery (Hardcover)
Nessa Carey
R4,257 Discovery Miles 42 570 Shipped within 7 - 12 working days

1. Epigenetics for drug discovery and drug development 2.Epigenetics is one of the fastest moving fields in drug discovery 3. Medicinal chemists in industrey and academia, pharmaceutical industry 4. Issues in Toxicology Series, MedChemComm 5. Epigenetic drug discovery involves targetting enzymes responsible for histone modification, to modify gene expression.

Instant Access - Acid-Base, Fluids, & Electrolytes (Paperback, Ed): Robert Reilly, Mark Perazella Instant Access - Acid-Base, Fluids, & Electrolytes (Paperback, Ed)
Robert Reilly, Mark Perazella
R1,033 Discovery Miles 10 330 Shipped within 7 - 11 working days

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Essential Evidence-Based Data for Common Clinical Encounters "This is very useful for providers who desire a fast review of fluid, electrolyte, and acid-base disorders without asking for in-depth information. Background information about pathophysiology and references are not included, but are not needed. This makes the book unique and quite different from other available resources on the topic. 3 Stars."--Doody's Review Service Make sense of acid-base and electrolytes with this compact, on-the-go guide--filled with clinical facts, figures, and data. In this ultra-convenient resource, the authors have distilled down the most relevant insights from their acclaimed text Nephrology in 30 Days, giving you a complete, yet concise overview of acid-based and electrolytes--supported by evidence-based findings. You'll find at-a-glance tables and a bulleted format that puts key diagnostic and clinical information right at your fingertips. This one-stop guide gets you up to speed on the major issues in acid-base and electrolyte disturbances, from metabolic acidosis to serum calcium disorders. It's the perfect clinical companion to more in-depth acid-base texts--one that goes beyond educational principles to focus on the real world of clinical medicine and patient management. The perfect portable brain for the wards Vital facts and figures everyone forgets to remember Presented in easy-access tables

Antioxidants in Systems of Varying Complexity - Chemical, Biochemical, and Biological Aspects (Hardcover): Lyudmila N.... Antioxidants in Systems of Varying Complexity - Chemical, Biochemical, and Biological Aspects (Hardcover)
Lyudmila N. Shishkina, Alexander N Goloshchapov, Larissa I. Weisfeld
R2,902 R2,752 Discovery Miles 27 520 Save R150 (5%) Shipped within 7 - 12 working days
Synthetic Receptors for Biomolecules - Design Principles and Applications (Hardcover): Bradley Smith Synthetic Receptors for Biomolecules - Design Principles and Applications (Hardcover)
Bradley Smith; Series edited by Philip Gale, Jonathan Steed; Contributions by Eric Anslyn, George Gokel, …
R4,268 Discovery Miles 42 680 Shipped within 7 - 12 working days

Synthetic receptor molecules, molecules that mimic antibody recognition, are widely used for developing drug leads; drug delivery vehicles; imaging agents; sensing agents; capture agents and separation systems. Synthetic Receptors for Biomolecules covers the most effective synthetic receptors for each major class of biomolecules within the context of specific applications. The book starts with an introduction to the applications of synthetic receptors for biomolecules and their design and synthesis for biomolecule recognition. Dedicated chapters then cover synthetic receptors for the key biomolecules including inorganic cations; small organic and inorganic anions; carbohydrates; nucleosides/nucleotides; oligonucleotides; amino acids and peptides; protein surfaces as well as non-polar and polar lipids; Each chapter follows the same systematic format of (a) chemical structures and physical properties of the biomolecule, (b) biological recognition of the biomolecule, (c) synthetic receptors for the biomolecule, (d) future directions and challenges. Edited by a leader in the field, the book is written in an accessible style for readers new to supramolecular chemistry or for those looking for synthetic receptors.

Die Chemie des Lebens (German, Hardcover): Georg Schwedt Die Chemie des Lebens (German, Hardcover)
Georg Schwedt
R591 R523 Discovery Miles 5 230 Save R68 (12%) Shipped within 7 - 12 working days
Algorithmic and Artificial Intelligence Methods for Protein Bioinformatics (Hardcover): Yi Pan, Jianxin Wang, Min Li Algorithmic and Artificial Intelligence Methods for Protein Bioinformatics (Hardcover)
Yi Pan, Jianxin Wang, Min Li
R2,192 R1,929 Discovery Miles 19 290 Save R263 (12%) Shipped within 7 - 12 working days

An in-depth look at the latest research, methods, and applications in the field of protein bioinformatics This book presents the latest developments in protein bioinformatics, introducing for the first time cutting-edge research results alongside novel algorithmic and AI methods for the analysis of protein data. In one complete, self-contained volume, Algorithmic and Artificial Intelligence Methods for Protein Bioinformatics addresses key challenges facing both computer scientists and biologists, arming readers with tools and techniques for analyzing and interpreting protein data and solving a variety of biological problems. Featuring a collection of authoritative articles by leaders in the field, this work focuses on the analysis of protein sequences, structures, and interaction networks using both traditional algorithms and AI methods. It also examines, in great detail, data preparation, simulation, experiments, evaluation methods, and applications. Algorithmic and Artificial Intelligence Methods for Protein Bioinformatics: * Highlights protein analysis applications such as protein-related drug activity comparison * Incorporates salient case studies illustrating how to apply the methods outlined in the book * Tackles the complex relationship between proteins from a systems biology point of view * Relates the topic to other emerging technologies such as data mining and visualization * Includes many tables and illustrations demonstrating concepts and performance figures Algorithmic and Artificial Intelligence Methods for Protein Bioinformatics is an essential reference for bioinformatics specialists in research and industry, and for anyone wishing to better understand the rich field of protein bioinformatics.

Glycopolymer Code - Synthesis of Glycopolymers and their Applications (Hardcover): C. Remzi Becer, Laura Hartmann Glycopolymer Code - Synthesis of Glycopolymers and their Applications (Hardcover)
C. Remzi Becer, Laura Hartmann
R3,785 Discovery Miles 37 850 Shipped within 7 - 12 working days

Glycopolymers are important for cell signalling, recognition pathways, and their role in the immune system. They are gaining attention for new applications in tissue engineering and drug delivery. Glycopolymer Code discusses the preparation, characterization and applications of glycopolymers providing a complete overview of the topic with examples from the latest research. Specific chapters cover both basic and advanced synthesis techniques to prepare glycopolymers, the analytical techniques used to investigate lectin receptor glycopolymer interactions, the properties and types of lectins that are widely used to understand the multivalent interactions and various applications of synthetic glycopolymers. With contributions from leading researchers in the field, the book is a unique source for graduates and academics new to the subject and already working in the area of glycopolymers.

Recent Advances in Trace Elements (Hardcover): Katarzyna Chojnacka, Agnieszka Saeid Recent Advances in Trace Elements (Hardcover)
Katarzyna Chojnacka, Agnieszka Saeid
R3,484 R3,046 Discovery Miles 30 460 Save R438 (13%) Shipped within 7 - 12 working days

Comprehensive and multidisciplinary presentation of the current trends in trace elements for human, animals, plants, and the environment This reference provides the latest research into the presence, characterization, and applications of trace elements and their role in humans, animals, and plants as well as their use in developing novel, functional feeds, foods, and fertilizers. It takes an interdisciplinary approach to the subject, describing the biological and industrial applications of trace elements. It covers various topics, such as the occurrence, role, and monitoring of trace elements and their characterization, as well as applications from the preliminary research to laboratory trials. Recent Advances in Trace Elements focuses on the introduction and prospects of trace elements; tackles environmental aspects such as sources of emission, methods of monitoring, and treatment/remediation processes; goes over the biological role of trace elements in plants, animals, and human organisms; and discusses the relevance of biomedical applications and commercialization. A compendium of recent knowledge in interdisciplinary trace element research Uniquely covers production and characterization of trace elements, as well as the industrial and biomedical aspects of their use Paves the way for the development of innovative products in diverse fields, including pharmaceuticals, food, environment, and materials science Edited by well-known experts in the field of trace elements with contributions from international specialists from a wide range of areas Unique in presenting comprehensive and multidisciplinary information of the key aspects of trace elements research in a digestible form, this book is essential reading for the novice and expert in the fields of environmental science, analytical chemistry, biochemistry, materials science, pharmaceutical science, nutraceutical, and pharmaceutical sciences. It is also valuable for companies that implement new products incorporating trace elements to the market.

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