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Hyaluronic acid is an essential part of connective, epithelial and neural tissues, and contributes to cell proliferation and migration. It is used as a stimulating agent for collagen synthesis and is a common ingredient in skin-care products, a multi-billion dollar industry, as it is believed to be a key factor in fighting the aging process. Hyaluronic Acid: Production, Properties, Application in Biology and Medicine consists of six chapters discussing the various issues of hyaluronic acid research. In Chapter 1, a historical analysis recounts the discovery and milestones of the research leading to the practical applications of hyaluronan. Chapter 2 is dedicated to biological role of the hyaluronic acid in nature, in particular in the human body. The chapter starts from the phylogenesis of hyaluronic acid, then describes hyaluronan functions in human ontogenesis and especially the role which hyaluronan plays in extracellular matrix of the different tissues. Chapter 3 describes the methods to manufacture and purify hyaluronic acid, including the analytical means for assessing quality of the finished product. Chapter 4 discusses the structure and rheological properties of hyaluronic acid considering effects on conformation and biological properties related to molecular weight. In Chapter 5, the physical and chemical methods for modifying the structure of hyaluronan are discussed including cross-linking using bi-functional reagents, solid-phase modification and effects of the combined action of high pressures and shift deformation. The final chapter focuses on the products derived from hyaluronic acid, including therapeutics composed of modified hyaluronan conjugated to vitamins, amino acids and oligo-peptides. The biological roles and medical applications of this polysaccharide have been extensively studied and this book provides a wealth of scientific data demonstrating the critical role of hyaluronic acid and its promise as a multifaceted bio-macromolecule. Approaching hyaluronic acid from multiple angles, this book links relationships between its biological functions, structure and physical chemical properties. It will be an invaluable resource to researchers, both industrial and academic, involved in all aspects of hyaluronan-based technologies.
This book focuses on actual morphofunctional findings of cells and tissues in living animal organs. Medical and biological scientists need to know the real in vivo morphology and immunolocalization of the molecular components in living animal organs. Recently, the live imaging of cells and tissues of animals with fluorescence-labeled proteins by gene manipulation has become more and more popular in biological fields. Current research, meanwhile, has revealed that immunohistochemical or morphological studies exclusively depend on living animal organs. The cryotechnique is one of the most useful tools for immunohistochemistry and bioimaging of animal organs. This book describes the epoch-making cryotechnique originally developed by the editors. The book also makes the management of living animal morphology more accessible not only for biomedical researchers but also for clinical doctors, providing a valuable resource work on the current perspectives of in vivo morphology.
If you're working on or studying the effects of drug metabolisms, then this reference is for you "Order today and benefit from the special introductory price - full details below."
"Handbook of Metabolic Pathways of Xenobiotics" is an essential new reference which presents the metabolic fate of xenobiotics in animals and plants, and shows the metabolic pathways in the environment.
Presenting a comprehensive guide to understanding the metabolisms of xenobiotics, the "Handbook of Metabolic Pathways of Xenobiotics" spans five volumes: Volumes 1-2 are Review Articles and Volumes 3-5 are Compound Articles. Review Articles present detailed reviews on the techniques and methods used to establish in vitro and in vivo metabolic pathways. Compound Articles are carefully selected lists of key chemicals representing agrochemicals, pharmaceuticals, animal health products and industrial chemicals.
An essential addition to every library, this introduction, guide and catalogue presents:
Current topics in the metabolism of xenobioticsTopics of both scientific and regulatory importance are covered, including in vitro high throughput metabolism screens, computer-aided metabolism predictions, and advances in bioanalytical techniques.
Techniques and methods used in metabolic pathways29 chapters provide an introduction to the understanding of drug metabolism and detail how to establish in vitro and in vivo metabolic pathways.
Biotransformation pathwaysPresented as a catalogue of short articles covering major pharmaceuticals, agrochemicals, animal health products and industrial chemicals. Each article summarizes the chemical properties and uses, and presents a detailed review of the chemical and metabolic pathways in soil, plants and animals.
Over 450 examples of xenobiotics and their fate in animals and plantsEach compound includes systematic information about the metabolic pathway of drugs for human and veterinary medicine, agrochemicals and major industrial chemicals.
Chemical and biological fate dataThe Handbook summarises data from scientific literature, patent literature, industrial resources and regulatory agencies, such as the EPA, FDA, EU, WHO and FAO, in a single reference for the first time.
An essential reference for everyone working and studying pharmacokinetics and drug metabolismCoverage of the chemical and biological reactivity of molecules and primary sub-structures makes this an ideal reference for students and research scientists. The broad and diverse coverage of chemical and biological fate under different exposure and biological compartments make this a useful resource for regulatory and developmental scientists.
Experience the scope of content offered in the "Handbook of Metabolic Pathways of Xenobiotics "for yourself, download these articles today: Review Article: Fundamentals of organic chemistry as applicable to the biotransformation of foreign compoundsReview Article: Metabolic stability screen in drug discovery Review Article: Unusual metabolic reactions and pathwaysCompound Article: Ganoderic acid DCompound Article: MilnacipranCompound Article: TenofovirOrder your copy today and take advantage of this special introductory price: 795.00 / 1030.00 / $1275.00"HURRY This price is only valid until the 30th April 2014." Prices will revert back to 950.00 / 1220.00 / $1495.00 thereafter.
Online Edition Coming Soon Featuring the same great content as the five volume print set, the "Handbook of Metabolic Pathways for Xenobiotics" will be available on Wiley Online Library in summer 2014. The online reference will benefit from the enhanced functionality powered by "The Smart Article" - learn more about "The Smart Article "at wileyonlinelibrary.com/thesmartarticle. Free trials will be available when the Online Edition goes live, bookmark this page or sign-up for regular product alerts at www.wiley.com/email to stay informed.
Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create tailor-made' peptides and proteins with improved pharmacological properties. Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include: * Computer modeling of peptides and proteins * Peptidomimetics * Design and synthesis of cyclic peptides * Carbohydrates in peptide and protein design * De novo design of peptides and proteins * Medical development applications * An extended case study - the design of insulin variants Design of Peptides and Proteins presents the state-of-the-art of this exciting approach for therapeutics, with contributions from international experts. It is an essential resource for academic and industrial scientists in the fields of peptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry and medicinal/pharmaceutical chemistry.
Grasp biochemistry basics, apply the science, and ace your exams Are you baffled by biochemistry? If so here's the good news ? you don't have to stay that way! Biochemistry For Dummies shows you how to get a handle on biochemistry, apply the science, raise your grades, and prepare yourself to ace any standardized test. This friendly, unintimidating guide presents an overview of the material covered in a typical college-level biochemistry course and makes the subject easy to understand and accessible to everyone. From cell ultrastructure and carbohydrates to amino acids, proteins, and supramolecular structure, you'll identify biochemical structures and reactions, and send your grades soaring. * Newest biology, biochemistry, chemistry, and scientific discoveries * Updated examples and explanations * Incorporates the most current teaching techniques From water biochemistry to protein synthesis, Biochemistry For Dummies gives you the vital information, clear explanations, and important insights you need to increase your understanding and improve your performance on any biochemistry test.
Gain a solid foundation in organic chemistry and the chemistry of the human body, as well as a better understanding of biochemical interactions with INTRODUCTION TO ORGANIC AND BIOCHEMISTRY, 8E, International Edition. Designed to make challenging information accessible to everyone and ideal for those entering health careers, this proven book shows chemistry applied to normal human biochemical pathways and discusses biochemical conditions present in disease.
Bringing this best-selling textbook right up to date, the new edition uniquely integrates the theories and methods that drive the fields of biology, biotechnology and medicine, comprehensively covering both the techniques students will encounter in lab classes and those that underpin current key advances and discoveries. The contents have been updated to include both traditional and cutting-edge techniques most commonly used in current life science research. Emphasis is placed on understanding the theory behind the techniques, as well as analysis of the resulting data. New chapters cover proteomics, genomics, metabolomics, and bioinformatics, as well as data analysis and visualisation. Using accessible language to describe concepts and methods, and with a wealth of new in-text worked examples to challenge students' understanding, this textbook provides an essential guide to the key techniques used in current bioscience research.
Written by a well-respected and experienced author, this textbook fills the gap for a concise introduction to the key concepts of organic stereochemistry and the most important classical and modern methods in stereoselective synthesis. The concepts are extensively illustrated in color, with practical examples and question-answer sets to help consolidate the reader's knowledge. In addition, animations are available from the Wiley website. A must-have for students in chemistry, biochemistry, and life sciences, as well as researchers in pharmaceutical and agrochemical companies in need of a quick introduction to the field.
This volume argues for the importance of essential nutrients in our diet. Over the last two decades there has been an explosion of research on the relationship of Omega-3 fatty acids and the importance of antioxidants to human health. Expert authors discuss the importance of a diet rich in Omega-3 Fatty acids for successful human growth and development and for the prevention of disease. Chapters highlight their contribution to the prevention and amelioration of a wide range of conditions such as heart disease, diabetes, arthritis, cancer, obesity, mental health and bone health. An indispensable text designed for nutritionists, dietitians, clinicians and health related professionals, Omega-3 Fatty Acids: Keys to Nutritional Health presents a comprehensive assessment of the current knowledge about the nutritional effects of Omega-3 fatty acids and their delivery in foods.
This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although several of their essential physiological roles have been revealed, many unknown and so far not fully understood functions have remained. In humans, there are eight active isozymes having distinct tissue and subcellular distribution patterns with different substrates and physiological roles. Accordingly, aberrant regulation of the enzyme reactions or expression may lead to or has been implicated in various pathologies including neurodegeneration, fibrosis, cancer, inflammation, celiac disease, and hemostasis disorders.To provide those who are new to the field with basic knowledge and recent information on transglutaminase structures and reactions, the mechanism by which transglutaminases modify substrate proteins and their contributions to multiple biological phenomena as well as disease phenotypes, the publication of the present transglutaminase book was planned, to consist of review articles by 17 expert investigators working in this exciting area of research. The book contains detailed information related to several transglutaminases from aspects in chemical and cellular biology, medical sciences, and biotechnology that will also supply starting points for drug discovery. Although many prominent findings have been published in recent years, this type of comprehensive review book has been missing in the scientific literature. This volume will be useful for investigators who either currently work on or will start addressing transglutaminase-related research, and beyond that, for a broad audience in the scientific community.
Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Destined to set the standard, this book meets the need for a didactic textbook focusing on the role of model systems in bioinorganic chemistry. The first part features concepts in bioinorganic chemistry such as electron transfer, medicinal inorganic chemistry, bioorganometallics and metal DNA complexes, while the second part presents inorganic model chemistry on metallo-enzymes, organized by metal ion.
Experts in the pertinent fields provide a didactically well-organized background on relevant biological systems, as well as on their structural, functional and spectroscopic properties. All chapters are similarly structured, each one beginning with a timeline featuring the most important historical facts on the subject, followed by a table of the most significant enzymes. The authors also summarize key developments and open questions within the respective model systems.
This book is aimed at senior undergraduate and graduate students in chemistry, biochemistry, life science and related fields.
Plants and plant-derived compounds and drugs are becoming more and more popular with increasing numbers of scientists researching plant analysis. The quality control of herbal drugs is also becoming essential to avoid severe health problems, and in the future many more new drugs will be developed from plant sources. This three-volume Handbook, featuring 47 detailed review articles, is unique as it deals with chemical and biological methodologies for plant analysis. It presents the most important and most accurate methods which are available for plant analysis. This comprehensive work is divided into six sections as follows: Sample preparation and identification discussing plant selection and collection, followed by extraction and sample preparation methodologies. Extraction and sample preparation methodologies Instrumentation for chemical analysis - several instrumentations for chemical plant analysis are presented with an emphasis on hyphenated techniques, e.g. the coupling between HPLC and mass spectroscometry, and HPLC with NMR. Strategies for selective classes of compounds coverage of the most interesting classes of compounds such as polysaccharides, saponins, cardiotonic glycosides, alkaloids, terpenoids, lipids, volatile compounds and polyphenols ( flavonoids, xanthones, coumarins, naphthoquinones, anthraquinones, proanthocyanidins, etc.). Biological Analysis - includes phenotyping, DNA barcoding techniques, transcriptome analysis , microarray, metabolomics and proteomics. Drugs from Plants covers the screening of plant extracts and strategies for the quick discovery of novel bioactive natural products. Safety assessment of herbal drugs is highly dependent on outstanding chromatographic and spectroscopic methods which are also featured here. This Handbook introduces to scientists involved in plant studies the current knowledge of methodologies in various fields of chemically- and biochemically-related topics in plant research. The content from this Handbook will publish online within the Encyclopedia of Analytical Chemistry via Wiley Online Library: http://www.wileyonlinelibrary.com/ref/eac Benefit from the introductory offer, valid until 30 November 2014! Introductory price: GBP425.00 / $695.0 0 / 550.00 List price thereafter: GBP495.00 / $795.00 / 640.00
Understanding, identifying and influencing the biological systems are the primary objectives of chemical biology. From this perspective, metal complexes have always been of great assistance to chemical biologists, for example, in structural identification and purification of essential biomolecules, for visualizing cellular organelles or to inhibit specific enzymes. This inorganic side of chemical biology which continues to receive considerable attention is referred to as inorganic chemical biology. Inorganic Chemical Biology: Principles, Techniques and Applications provides a comprehensive overview of the current and emerging role of metal complexes in chemical biology. There is a strong emphasis on fundamental theoretical chemistry and experiments which have been carried out in living cells or organisms throughout all chapters. Outlooks for the future applications of metal complexes in chemical biology are also discussed. Topics covered include: * Metal complexes as tools for structural biology * AAS, XRF and MS as detection techniques for metals in chemical biology * Probing DNA using metal complexes * Detection of metal ions, anions and small molecules using metal complexes * Photo-release of metal ions in living cells * Metal complexes as enzyme inhibitors and catalysts in living cells Written by a team of international experts, Inorganic Chemical Biology: Principles, Techniques and Applications is a must-have for bioinorganic, bioorganometallic and medicinal chemists as well as chemical biologists working in both academia and industry.
"Ideas in Chemistry and Molecular Sciences" gives an account of the most recent results of research in life sciences in Europe based on a selection of leading young scientists participating in the 2008 European Young Chemists Award competition. In addition to this, the authors provide the state of the art of their field of research and the perspective or preview of future directions.
This first book on the market covers the many new and important RNA species discovered over the past five years, explaining current methods for the enrichment, separation and purification of these novel RNAs. Building up from general principles of RNA biochemistry and biophysics, this book addresses the practical aspects relevant to the laboratory researcher throughout, while discussing the performance and potential problems of the methods discussed. An appendix contains a glossary with the important terms and techniques used in RNA analysis. By explaining the basic and working principles of the methods, the book allows biochemists and molecular biologists to gain much more expertise than by simply repeating a pre-formulated protocol, enabling them to select the procedure and materials best suited to the RNA analysis task at hand. As a result, they will be able to develop new protocols where needed and optimize and fine-tune the general purpose standard protocols that come with the purification equipment and instrumentation.
In contrast to existing books which either focus exclusively on the
pharmacological properties of plant natural products or cover the
secondary metabolism of plants as one section in general plant
science book, this is the first to cover all aspects in one volume.
This updated and up-to-date version of the first edition continues with the really interesting stuff to spice up a standard biophysics and biophysical chemistry course. All relevant methods used in current cutting edge research including such recent developments as super-resolution microscopy and next-generation DNA sequencing techniques, as well as industrial applications, are explained. The text has been developed from a graduate course taught by the author for several years, and by presenting a mix of basic theory and real-life examples, he closes the gap between theory and experiment. The first part, on basic biophysical chemistry, surveys fundamental and spectroscopic techniques as well as biomolecular properties that represent the modern standard and are also the basis for the more sophisticated technologies discussed later in the book. The second part covers the latest bioanalytical techniques such as the mentioned super-resolution and next generation sequencing methods, confocal fluorescence microscopy, light sheet microscopy, two-photon microscopy and ultrafast spectroscopy, single molecule optical, electrical and force measurements, fluorescence correlation spectroscopy, optical tweezers, quantum dots and DNA origami techniques. Both the text and illustrations have been prepared in a clear and accessible style, with extended and updated exercises (and their solutions) accompanying each chapter. Readers with a basic understanding of biochemistry and/or biophysics will quickly gain an overview of cutting edge technology for the biophysical analysis of proteins, nucleic acids and other biomolecules and their interactions. Equally, any student contemplating a career in the chemical, pharmaceutical or bio-industry will greatly benefit from the technological knowledge presented. Questions of differing complexity testing the reader's understanding can be found at the end of each chapter with clearly described solutions available on the Wiley-VCH textbook homepage under: www.wiley-vch.de/textbooks
Encompassing 150 articles written by leading scientists in the field, the third edition of "General and Applied Toxicology" provides a comprehensive and in-depth review of the basic science of toxicology, its specializations, and the application of toxicological knowledge.
This new edition reflects developments within the field that have taken place since the second edition was published in 1999. These include: New information developed in the areas of both the fundamental and applied aspects of toxicology Considerable increase in the development of fundamental information and its applications, refinement of technical methods, advances in mechanistic toxicology, and greater interest in areas of toxicology previously regarded as of limited scope Changing approaches to methodological, interpretative, regulatory, and ethical aspects of basic and applied toxicology
"General and Applied Toxicology, 3rd Edition" is the first port of call for academic researchers, industrial researchers, regulatory professionals, and advanced students looking for timely and authoritative information in the field. Due to the increase in public and media interest in exposure to toxic substances, this provides an indispensable general reference source for general physicians, lawyers, law enforcement agencies, information resource facilities, and members of the general public.
New online resource available now
In 2011, the content from the third edition of "General and Applied Toxicology" merged with the two-volume "Handbook of Systems Toxicology." The result? "General, Applied and Systems Toxicology" - a new online resource combining traditional toxicology with the latest developments to present the ultimate reference in toxicology For full details visit wileyonlinelibrary.com/ref/gast
Presents the physical background of ligand binding and instructs on how experiments should be designed and analyzed Reversible Ligand Binding: Theory and Experiment discusses the physical background of protein-ligand interactions providing a comprehensive view of the various biochemical considerations that govern reversible, as well as irreversible, ligand binding. Special consideration is devoted to enzymology, a field usually treated separately from ligand binding, but actually governed by identical thermodynamic relationships. Attention is given to the design of the experiment, which aids in showing clear evidence of biochemical features that may otherwise escape notice. Classical experiments are reviewed in order to further highlight the importance of the design of the experiment. Overall, the book supplies students with the understanding that is necessary for interpreting ligand binding experiments, formulating plausible reaction schemes, and analyzing the data according to the chosen model(s). Topics covered include: theory of ligand binding to monomeric proteins; practical considerations and commonly encountered problems; oligomeric proteins with multiple binding sites; ligand binding kinetics; hemoglobin and its ligands; single-substrate enzymes and their inhibitors; two-substrate enzymes and their inhibitors; and rapid kinetic methods for studying enzyme reactions. * Bridges theory of ligand binding and allostery with experiments * Applies historical and physical insight to provide a clear understanding of ligand binding * Written by a renowned author with long-standing research and teaching expertise in the area of ligand binding and allostery * Based on FEBS Advanced Course lectures on the topic Reversible Ligand Binding: Theory and Experiment is an ideal text reference for students and scientists involved in biophysical chemistry, physical biochemistry, biophysics, molecular biology, protein engineering, drug design, pharmacology, physiology, biotechnology, and bioengineering.
What the Periodic Table did for the visualization of chemical
concepts, this chart will achieve for structural biology. This
truly innovative product addresses a growing need in the scientific
community -- making the entire spectrum of protein structures
instantly accessible on one handy chart. By way of a clever
arrangement into rows and columns, this is much more than a simple
field guide to individual protein structures: It is also an
invaluable aid to understanding the principles behind protein
This Springer Protocols manual is a practical guide to the application of key molecular biology techniques in microbiological research. The focus is on experimental protocols, which are presented in an easy-to-follow way, as step-by-step procedures for direct use in the laboratory. Notes on how to successfully apply the procedures are included, as well as recommendations regarding materials and suppliers. In addition to the practical protocols, important background information and representative results of experiments using the described methods are presented. Researchers in all areas applying microbial systems, such as in molecular biology, genetics, pathology, and agricultural research will find this work of great value.
This book expands the debate on the future of science and technology at the Curious2018 - Future Insight Conference, held on the occasion of Merck's 350-year anniversary. In the respective chapters, some of the world's top scientists, managers and entrepreneurs explore breakthrough technologies and how they can be applied to make a better world for humanity. Divided into three parts, the book begins with an introduction to the vision of the conference and to the importance of curiosity for innovation, while also exploring the latest scientific developments that are shaping the future of healthcare, medicine, the life and material sciences, digitalization and new ways of working together. In the second part, particular attention is paid to new therapies and diagnostics; here, readers will learn how synthetic biology and chemistry are being used to solve problems that are essential to the future of humanity. The role of in-silico research is also discussed. In the final part of the book, readers will find some thoughts on ethical principles guiding our application of science and technology to create a bright future for humanity. Given its interdisciplinary appeal, the book will inspire curiosity in a wide readership, from scholars and researchers to professionals with an interest in exploring the future of science and technology, solving the problems of today, and paving the way for a better tomorrow.Chapters 1, 2, 3 and 17 are available open access under a Creative Commons Attribution-NonCommercial 4.0 International License via link.springer.com.
Biochemistry is a major new textbook designed and created specifically for briefer courses in the subject. Written by Prof. Terry Brown of the University of Manchester (author of Genomes and Gene Cloning), the book provides the necessary detail and rigour expected for these courses, but without the extraneous material found in the larger textbooks. With an increasing number of students taking a short course in biochemistry there is a growing need for a book that covers the subject concisely and succinctly. Biochemistry has been designed from the outset for these shorter courses; it is not a cut-down version of one of the larger books that dominate the market. Although it is shorter, there is no compromise in content, style and coverage. The book is attractively designed in full colour throughout with all the pedagogical features expected in a major textbook. It covers what students should be expected to know and is written in the clear and accurate writing style for which Terry Brown is widely lauded. With its competitive price and resources for adopting lecturers (all of the illustrations and diagrams from the book, and answers to the end of chapter questions), Biochemistry will become the textbook of choice for any brief biochemistry course. Confirmed Adoptions Biochemistry is already the required text at the following institutions: Becker College, USA Bishop Burton College, UK Bournemouth University, UK Charles R. Drew University of Medicine and Science, USA Charleston Southern University, USA Colorado State University - Pueblo, USA Idaho State University, USA Liverpool John Moores University, UK Montclair State University, USA Newcastle University, UK Rivier University, USA Southeast Missouri State University, USA Staffordshire University, UK Stephen F Austin State University, USA Texas Christian University, USA The University of Texas at Austin, USA Umea University, Sweden University of Aberdeen, UK University of Bradford, UK University of Bedfordshire, UK University of Brighton, UK University of the Incarnate Word, USA University of Kansas, USA University of Miami Miller School of Medicine, USA University of Nottingham, UK University of Roehampton, UK University of Salford, UK University of the West of England, UK University of Tulsa, USA Valley City State University, USA Yale University School of Medicine, USA
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