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Guinn's Essentials of General, Organic and Biochemistry uses health and medicine as the framework for learning the fundamentals of chemistry in this student-centered one-semester text. The newly revised 3rd edition focuses on core concepts and necessary math skills, and features a revamped organization to align with traditional course organization and shorter, more condensed chapters. Easily digestible content and medical applications help reduce student anxiety and make chemistry meaningful for students preparing for future careers in nursing and other allied health professions. Paired with SaplingPlus and an embedded eBook, students will be able to focus their study with adaptive quizzing and understand the relevance of chemistry through videos, animations and case studies.
The activity of many biopharmaceutical polymers is dependent on conformation, and the next several years will see increased interest in the conformational analysis of these polymers resulting from the development of biosimilar or "follow-on" biological products. While a wide variety of approaches to analysis exists, finding the most viable ones would be much easier with a consolidated reference that details the benefits and cost of each approach, with an emphasis on real results and real products.
Explores the Growing Role of Conformational Analysis in Comparing Generic Biopharmaceuticals
Approaches to the Conformational Analysis of Biopharmaceuticals gathers the most useful techniques and methods into a single volume, putting the greatest emphasis on those approaches that have proven the most fruitful. Rather than cover specific uses of techniques in detail, this book provides commercial biotechnologists and researchers with the information and references they need to make good choices about the technology they choose to use. With a large number of references that direct readers to primary source material, it includes studies drawn from the gamut of current literature, covering physical methods, such as differential scanning calorimetry, light scanning, and analytical ultracentrifugation. It also addresses chemical methods, such as hydrogen deuterium exchange and trace labeling, along with infrared, ultraviolet, and Raman spectroscopy.
Written by Roger Lundblad, a true pioneer in protein science, this volume supplies the necessary information researchers need to access when deciding on the most cost-effective approach, including:
With a clear focus on relevant commercial biotechnology, this book belongs on the shelves of those serious researchers who are paving the way for the next generation of biopharmaceutical polymers.
Nutrition has long been considered more the domain of medicine and agriculture than of the biological sciences, yet it touches and shapes all aspects of the natural world. The need for nutrients determines whether wild animals thrive, how populations evolve and decline, and how ecological communities are structured. "The Nature of Nutrition" is the first book to address nutrition's enormously complex role in biology, both at the level of individual organisms and in their broader ecological interactions.
Stephen Simpson and David Raubenheimer provide a comprehensive theoretical approach to the analysis of nutrition--the Geometric Framework. They show how it can help us to understand the links between nutrition and the biology of individual animals, including the physiological mechanisms that determine the nutritional interactions of the animal with its environment, and the consequences of these interactions in terms of health, immune responses, and lifespan. Simpson and Raubenheimer explain how these effects translate into the collective behavior of groups and societies, and in turn influence food webs and the structure of ecosystems. Then they demonstrate how the Geometric Framework can be used to tackle issues in applied nutrition, such as the problem of optimizing diets for livestock and endangered species, and how it can also help to address the epidemic of human obesity and metabolic disease
Drawing on a wealth of examples from slime molds to humans, "The Nature of Nutrition" has important applications in ecology, evolution, and physiology, and offers promising solutions for human health, conservation, and agriculture.
Recipient of the CHOICE Outstanding Academic Title (OAT) Award. Molecular Biology: Structure and Dynamics of Genomes and Proteomes illustrates the essential principles behind the transmission and expression of genetic information at the level of DNA, RNA, and proteins. This textbook emphasizes the experimental basis of discovery and the most recent advances in the field while presenting a structural, mechanistic understanding of molecular biology that is rigorous, yet concise. The text is written for advanced undergraduate or graduate-level courses in molecular biology. Molecular Biology: Structure and Dynamics of Genomes and Proteomes is additionally supported by the Garland Science Learning System. This homework platform is designed to evaluate and improve student performance and allows instructors to select assignments on specific topics and review the performance of the entire class, as well as individual students, via the instructor dashboard. Students receive immediate feedback on their mastery of the topics, and will be better prepared for lectures and classroom discussions. The user-friendly system provides a convenient way to engage students while assessing progress. Performance data can be used to tailor classroom discussion, activities, and lectures to address students' needs precisely and efficiently. A free trial for the Garland Science Learning System will be available to use during the Spring and Fall 2017 semesters. For more information and to sign up for access, visit http://garlandscience.rocketmix.com/.
Human cells produce at least 30,000 different proteins. Each has a specific function characterized by a unique sequence and native conformation that allows it to perform that function. While research in this post-genomic era has created a deluge of invaluable information, the field has lacked for an authoritative introductory text needed to inform researchers and students in all of those fields now concerned with protein research. Introduction to Peptides and Proteins brings together some of the most respected researchers in protein science to present a remarkably coherent introduction to modern peptide and protein chemistry. The first sections of the book delve into - Basic peptide and protein science from assembly through degradation Traditional and emerging research methods including those used in bioinformatics and proteomics New computational approaches and algorithms used to find patterns in the vast data collected by sequencing projects After providing a foundation in tools and methods, the authors closely examine six protein families, including representative classes such as enzymes, cell-surface receptors, antibodies, fibrous proteins, and bioactive peptide classes. They concentrate on biochemical mechanisms and where possible indicate therapeutic or biotechnical possibilities. Then focusing on clinical aspects, the authors investigate misfolding as found in prion diseases, miscleavage as found in Alzheimer's, and mis-sequencing as found with some cancers. Drawing from some of their own research, the authors summarize recent achievements and emerging applications. They discuss the use of proteins and peptides as drugs and the solid-phase synthesis required for drug production. They also look at the use of peptides as functional biomolecules and research tools. No longer just the domain of biologists, many key advances in protein research started in physics labs and have involved contributions from a host of fields including statistics, drug development, genetics, and chemical spectroscopy. Introduction to Peptides and Proteins provides researchers across these fields with the thorough foundation needed to explore all the potential that protein research offers.
The flood of information on gene and protein sequences from the genome projects has revolutionized molecular and evolutionary biology and led to the rapid development of the science called genomics. Reliable prediction of the function of a novel gene/protein requires complex computational analysis of genomic and protein sequence information which exploit the principles governing the evolution of protein structure and function.
This book provides an up-to-date summary of the principles of protein evolution and discusses both the methods available to analyze the evolutionary history of proteins as well as those for predicting their structure-function relationships. This second edition, while retaining its accessible style and reader-friendly organization, is completely updated and boasts a new glossary and updated references. The chapter on genome evolution has been significantly expanded in order to cover genomes of model organisms sequenced since the completion of the first edition. "Protein Evolution" is ideal for senior undergraduates and graduate students taking courses in protein structure and evolution, as well as bioinformatics. It will also be a useful supplement for students taking wider courses in molecular evolution, as well as a valuable resource for professionals in the area of functional genomics.
This book summarizes the latest research results on the role of reactive oxygen species (ROS) in plants, particularly in many abiotic stresses, and their regulation. Redox homeostasis refers to maintaining a balance of oxidised and reduced state of biomolecules in a biological system for all-round sustenance. In a living system, redox reactions contribute to the generation of reactive oxygen species (ROS), which act as signalling molecules for developmental as well as stress-response processes in plants. It is presumed that, being sessile and an aerobe requiring oxygen for mitochondrial energy production, as well as producing oxygen during photosynthesis, the redox homeostasis process is more complex and regulated in plants than in animals. Any imbalance in the homeostasis is mainly compensated for by the production of various ROS molecules, which, though they can cause severe oxidative damage in excess, can also ideally act as signalling molecules.
This book is the first to be dedicated to the bioinformatics of carbohydrates and glycoproteins. It provides an introduction to this emerging field of science both for the experimentalist working in glycobiology and glycomics, and also for the computer scientist looking for background information for the development of highly sophisticated algorithmic approaches. The book provides an overview of the state-of-the-art in the field, with reviews on databases, and the tools in use for analysis, interpretation, and prediction of the structures of complex carbohydrates, and demonstrates the value of bioinformatics for glycobiology.
The availability of comprehensive databases and corresponding bioinformatics tools, to access and analyse the large amounts of experimental data relating to the structure of carbohydrates, will be a prerequisite for the success of the large-scale glycomics projects that aim to decipher new, so far unknown, biological functions of glycans. Efficient bioinformatics descriptions and tools can considerably enhance the efficiency of glycomics research, in terms of data quality, analysis and experimental costs.
For a complete understanding of the molecular processes in which carbohydrates are involved, such as protein-carbohydrate interactions and the impact of glycosylation on protein function, knowledge of the 3D structure of the carbohydrate, the protein-carbohydrate complex, or the glycoprotein is often indispensable. This book provides a thorough introduction into methods used for conformational analysis of carbohydrates.
Key features: Describes bioinformatic approaches to handle carbohydrate-active enzymes and glycosylation.Provides an overview on bioinformatics tools that facilitate analysis of carbohydrate structures.Gives introduction into molecular modelling of carbohydrate 3D structure and carbohydrates contained in the Protein Databank.Assumes only a basic knowledge of biology and bioinformatics.
This book provides an accessible introduction to the principles and tools for modeling, analyzing, and synthesizing biomolecular systems. It begins with modeling tools such as reaction-rate equations, reduced-order models, stochastic models, and specific models of important core processes. It then describes in detail the control and dynamical systems tools used to analyze these models. These include tools for analyzing stability of equilibria, limit cycles, robustness, and parameter uncertainty. Modeling and analysis techniques are then applied to design examples from both natural systems and synthetic biomolecular circuits. In addition, this comprehensive book addresses the problem of modular composition of synthetic circuits, the tools for analyzing the extent of modularity, and the design techniques for ensuring modular behavior. It also looks at design trade-offs, focusing on perturbations due to noise and competition for shared cellular resources. Featuring numerous exercises and illustrations throughout, Biomolecular Feedback Systems is the ideal textbook for advanced undergraduates and graduate students. For researchers, it can also serve as a self-contained reference on the feedback control techniques that can be applied to biomolecular systems. * Provides a user-friendly introduction to essential concepts, tools, and applications* Covers the most commonly used modeling methods* Addresses the modular design problem for biomolecular systems* Uses design examples from both natural systems and synthetic circuits* Solutions manual (available only to professors at press.princeton.edu)* An online illustration package is available to professors at press.princeton.edu
The availability of molecular imaging and measurement systems enables today's biologists to swiftly monitor thousands of genes involved in a host of diseases, a critical factor in specialized drug development. Systems Biology and Bioinformatics: A Computational Approach provides students with a comprehensive collection of the computational methods used in what is being coined the digital era of biology. Written by field experts with proven track records, this authoritative textbook first provides an introduction to systems biology and its impact on biology and medicine. The book then reviews the basic principles of molecular and cell biology using a system-oriented approach, with a brief description of the high-throughput biological experiments that produce databases. The text includes techniques to discover genes, perform nucleotide and amino acid sequence matching, and estimate static gene dynamic pathways. The book also explains how to use system-oriented models to predict the behavior of biological systems for important applications such as rational drug design. The numerous examples and problem sets allow students to confidently explore practical systems biology applications using real examples with real biological data, making Systems Biology and Bioinformatics: A Computational Approach an ideal text for senior undergraduate and first-year graduate students.
This authoritative book on MALDI MS, now finally available in its
second edition and edited by one of its inventors, gives an
in-depth description of the many different applications, along with
a detailed discussion of the technology itself.
The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.
Research into metal control in biological systems is undergoing rapid development. This new volume from the EIBC Book Series addresses how complex metal active sites are assembled and inserted into the metalloproteins that use them for catalysis. Metalloprotein Active Site Assembly provides a comprehensive description of the essential biosynthetic pathways for assembly of active sites covering all of the major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components (e.g., S trafficking) and organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin) that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since this is a relatively new, fast-developing area of research. Only within the past several years have the tools been available that allow these pathways to be revealed. The various pathways are at different levels of understanding; none have been completely defined, but we are just now at the stage of being able to make meaningful comparisons among the pathways. All these articles will be published as part of the Encyclopedia of Inorganic and Bioinorganic Chemistry: http://onlinelibrary.wiley.com/book/10.1002/9781119951438.
Parkinson's Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson's Disease and so links can be made between oxidative stress and Parkinson's Disease pathogenesis. This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson's Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson's Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics. Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant - based therapeutics for Parkinson's disease.
The constantly expanding terrain covered by biochemistry ranges from the study of the molecular make-up of cells to the great underlying issues of the origin, nature and unity of life.
Biochemists, claims Steven Rose, Professor of Biology at the Open University, are concerned with four main themes: the chemistry of living cells, how such chemicals are interconverted, and how cells maintain their structures and special functions. In starting from first principles and offering lucid accounts of all these topics, he also provides marvellously concise accounts of energy metabolism and the role of enzymes, and of information trafficking within and between cells by way of DNA and proteins.
First published in 1966 and now an established classic, The Chemistry of Life continues to hold its own as a clear and authoritative introductory text. While retaining its emphasis on biochemistry rather than molecular biology, this fourth edition has been fully updated and revised to include the latest developments in DNA and protein synthesis, cell regulation and immunology, and reflections on their social and medical implications.
Food proteins and bioactive peptides play a vital role in the growth and development of the body's structural integrity and regulation, as well as having a variety of other functional properties. Land animal-derived food proteins such as collagen and gelatine carry risks of contamination (such as BSE). Marine-derived proteins, which can provide equivalents to collagen and gelatin without the associated risks, are becoming more popular among consumers because of their numerous health beneficial effects. Most marine-derived bioactive peptides are currently underutilized. While fish and shellfish are perhaps the most obvious sources of such proteins and peptides, there is also the potential for further development of proteins and peptides from sources like algae, sea cucumber and molluscs. Marine-derived proteins and peptides also have potential uses in novel products, with the possibility of wide commercialization in the food, beverage, pharmaceutical and cosmetic industries, as well as in other fields such as photography, textiles, leather, electronics, medicine and biotechnology.
"Marine Proteins and Peptides: Biological Activities and Applications "presents an overview of the current status, future industrial perspectives and commercial trends of bioactive marine-derived proteins and peptides. Many of the industrial perspectives are drawn from the food industry, but the book also refers to the pharmaceutical and cosmetics industries. There have recently been significant advances in isolating functional ingredients from marine bio-resources and seafood by-products for use in these industries, but little has been published, creating a knowledge gap, particularly with regard to the isolation and purification processes. This book is the first to fill that gap.
"Marine Proteins and Peptides: Biological Activities and Applications" is a valuable resource for researchers in marine biochemistry field as well as food industry managers interested in exploring novel techniques and knowledge on alternative food protein sources. It will become a standard reference book for researchers involved in developing marine bio-resources and seafood by-products for novel nutraceutical, cosmetics, and pharmaceutical applications. It will also appeal to managers and product developers in the food, pharmaceutical and cosmetics industries, particularly those looking to use marine-derived proteins and peptides as substitutes or replacements for unfashionable or outdated food components.
For a quantitative description of variety cell responses to ionising radiation, a mathematical model is suggested. In contrast to the conventional point of view that the relative biological effectiveness (RBE) of densely ionising radiation is determined only by physical characteristics of radiation, this book presents extensive experimental data demonstrating the importance of cell recovery ability in the RBE manifestation. The most impressive data obtained was mostly for diploid mutant cells at the log-stage of growth, in which the RBE was close to unity. It was also shown that the recovery process itself was not damaged after exposure to high-LET radiation, as well as the enhanced RBE values due to the increased yield of irreversible radiation damage from which cells were incapable of recovering. A novel direction in the study of radioprotecting and radiosensitising action of chemical compounds is also discussed and confirmed in the book. A new conception for the mechanism of synergy is suggested, in accordance with the synergy due to the formation of additional effective damages resulting from the interaction of sublesions. These sublesions are supposed to be non-effective when each agent is applied separately. This concept led to the development of original mathematical models of synergy, which is reviewed by the authors. The model predicts a number of general rules of interaction, the condition under which the highest synergy can be achieved, its value, and the dependence of synergy on the intensity of agents applied. Validation of the model was also verified for various physical and chemical factors, biological objects and end points. The theory appears to be appropriate and the conclusions valid.
Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes.
In the last couple of decades, research in the area of tissue engineering has witnessed tremendous progress. The focus has been on replacing or facilitating the regeneration of damaged or diseased cell, tissue or organs by applying a biomaterial support system, and a combination of cells and bioactive molecules. In addition new smart materials have been developed which provide opportunities to fabricate, characterize and utilize materials systematically to control cell behaviours and tissue formation by biomimetic topography that closely replicate the natural extracellular matrix. Following on from Smart Materials for Tissue Engineering: Fundamental Principles, this book comprehensively covers the different uses of smart materials in tissues engineering, providing a valuable resource for biochemists, materials scientists and biomedical engineers working in industry and academia.
This volume focuses on solution and solid-state NMR of carbohydrates, glycoproteins, glyco-technologies, biomass and related topics. It is estimated that at least 80% of all proteins are glycoproteins. Because of the complexity, heterogeneity and flexibility of the sugar chains, the structural biology approaches for glycoconjugates have been generally avoided. NMR techniques although well established for structural analyses of proteins and nucleic acids, cannot be simply applied to this complex class of biomolecules. Nonetheless, recently developed NMR techniques for carbohydrates open the door to conformational studies of a variety of sugar chains of biological interest. NMR studies on glycans will have significant impact on the development of vaccines, adjuvants, therapeutics, biomarkers and on biomass regeneration. In this volume, the Editors have collected the most up-to-date NMR applications from experts in the field of carbohydrate NMR spectroscopy. Timely and useful, not only for NMR specialists, it will appeal to researchers in the general field of structural biology, biochemistry and biophysics, molecular and cellular biology and material science.
Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs. This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the metallome ] and include: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to "foreign" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know. The content from this book will publish online, as part of EIBC in December 2013, find out more about the Encyclopedia of Inorganic and Bioinorganic Chemistry, the essential online resource for researchers and students working in all areas of inorganic and bioinorganic chemistry.
The term `miktoarm polymers' refers to asymmetric branched macromolecules, a relatively new entry to the macromolecular field. Recent advances in their synthesis and intriguing supramolecular chemistry in a desired medium has seen a fast expansion of their applications. The composition of miktoarm polymers can be tailored and even pre-defined to allow a desired combination of functions, meaning polymer chemists can have complete control of the overall architecture of these macromolecules. By carefully selecting the composition, they can create supramolecular structures with intriguing properties, particularly for applications in biology. Miktoarm Star Polymers features chapters from experts actively working in this field, and provides the reader with a unique introduction to the fundamental principles of this exciting macromolecular system. Topics covered include the design, synthesis, characterization, self-assembly and applications of miktoarm polymers. The book is an excellent overview and up to date guide to those working in research in polymer chemistry, materials science, and polymers for medical applications.
Health consequences derived from alcohol drinking are a problem of increasing relevance worldwide. Ethanol toxicity is due essentially to its biotransformation products, acetaldehyde and different types of free radicals, which cause oxidative stress. Given that acetaldehyde and free radicals are highly reactive species is important to consider that, if generated in situ in a target tissue, they may cause toxicity. This book discusses the biochemistry, applications and safety concerns of acetaldehyde.
This book collates and reviews recent advances in the microbial metabolism of amino acids, emphasizing diversity - in terms of the range of organisms under investigation and their natural ecology - and the unique features of amino acid metabolism in bacteria, yeasts, fungi, protozoa and nematodes. As well as studying the individual amino acids, including arginine, sulfur amino acids, branched-chain amino acids and aromatic amino acids, a number of themes are explored throughout the work. These include: - Comparative issues between the metabolism of microbes and those of higher organisms, including plants and mammals - Potential for drug targets in pathways of both biosynthesis and degradation of amino acids - Relationship between amino acids or associated enzymes and virulence in parasitic pathogens - Practical implications for food microbiology and pathogen characterization - Future priorities relating to fundamental biochemistry of microrganisms, food quality and safety, human and animal health, plant pathology, drug design and ecology As the volume of research into the metabolism of amino acids grows, this comprehensive study of the subject is a vital tool for researchers in the fields of biological, medical and veterinary sciences, including microbiology, biochemistry, genetics and pathology. This book is also essential for corporate organizations with active research and development programmes, such as those in the pharmaceutical industry.
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