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Books > Science & Mathematics > Biology, life sciences > Biochemistry

Life, Death and Nitric Oxide (Paperback): Anthony R. Butler, Rosslyn Nicholson Life, Death and Nitric Oxide (Paperback)
Anthony R. Butler, Rosslyn Nicholson; Contributions by K.B. Nolan
R619 Discovery Miles 6 190 Shipped within 7 - 12 working days

Designated 'Molecule of the Year' in 1992 in recognition of its many biological roles, nitric oxide has wide significance in the world around us and the story of nitric oxide is still unfolding. This small and seemingly innocent molecule has for many years been known to play a significant role in both the creation of photochemical smogs and in the nitrogen cycle. It has an interesting chemistry as a metal ligand, and the bonding within the nitric oxide molecule has been extensively studied. More recently, the molecule has been in the spotlight for the role it plays in controlling blood flow, in the immune system and in brain activity. Life, Death and Nitric Oxide covers many of the topics relating to nitric oxide, from smog and catalytic converters to tumour growth, blood flow and Viagra, with the aim of finding out why such a simple molecule can do so much.

Biophysics and Biochemistry of Cartilage by NMR and MRI (Hardcover): Yang Xia, Konstantin Momot Biophysics and Biochemistry of Cartilage by NMR and MRI (Hardcover)
Yang Xia, Konstantin Momot
R4,762 Discovery Miles 47 620 Shipped within 7 - 12 working days

This unique book describes the latest information in the fundamental understanding of the biophysics and biochemistry of articular cartilage using the state-of-the-art practices in NMR and MRI. This is the first book of its kind, written by physicists and chemists on this important tissue, whose degradation contributes to osteoarthritis and related joint diseases. Connecting the fundamental science with the clinical imaging applications, the experts Editors provide an authoritative addition to the literature. Ideal for practising physical scientists and radiologists with an interest in the fundamental science as well as instrument manufacturers and clinical researchers working with articular cartilage.

Molybdenum and Tungsten Enzymes - Bioinorganic Chemistry (Hardcover): Russ Hille, Carola Schulzke, Martin L Kirk Molybdenum and Tungsten Enzymes - Bioinorganic Chemistry (Hardcover)
Russ Hille, Carola Schulzke, Martin L Kirk; Series edited by C. David Garner; Edited by (editors-in-chief) C. David Garner; Contributions by …
R3,783 Discovery Miles 37 830 Shipped within 7 - 12 working days

The book will cover the bio-, inorganic and bioinorganic chemistry of molybdenum containing enzymes, including mononuclear molybdenum-containing enzymes, the complex Fe/Mo enzyme nitrogenase, and also tungsten enzymes. The full range of physicochemical methods that are used to investigate their and function will be covered. There has been no comprehensive book in this area for the past 30 years, despite great progress in our understanding of molybdenum enzymes and relevant inorganic complexes of molybdenum, and as a result the proposed book will both fill an enormous gap in coverage of the field and at the same time document the latest research. The book will be useful for workers in the field of metal-containing enzymes, graduate students and young investigators interested in developing new research programs in the area. It will also serve as a useful reference for researchers outside the field. Cross promotion: Journals: Dalton Transactions and Metallomics. Books: "Iron-Containing Enzymes", Visser and Kumar, 2011; "Binding, Transport and Storage of Metal Ions in Biological Cells", Maret and Wedd, 2014.

Structural and Biochemical Characterization of the Yaxab Pore-Forming Toxin From Yersinia Enterocolitica (Hardcover, 1st Ed.... Structural and Biochemical Characterization of the Yaxab Pore-Forming Toxin From Yersinia Enterocolitica (Hardcover, 1st Ed. 2019)
Bastian Brauning
R2,425 R2,142 Discovery Miles 21 420 Save R283 (12%) Shipped within 7 - 12 working days
Principles Of Bioinorganic Chemistry (Paperback): Stephen J. Lippard, Jeremy M. Berg Principles Of Bioinorganic Chemistry (Paperback)
Stephen J. Lippard, Jeremy M. Berg
R1,365 Discovery Miles 13 650 Shipped within 7 - 12 working days

A concepts-orientated introduction to bioinorganic chemistry covering topics including: properties of biological molecules; physical methods in bioinorganic chemistry; control and utilization of metal ion concentrations in cells, and electron transfer proteins.

Zinc - Characteristics, Uses & Benefits (Hardcover, New): Masayoshi Yamaguchi Zinc - Characteristics, Uses & Benefits (Hardcover, New)
Masayoshi Yamaguchi
R2,013 R1,343 Discovery Miles 13 430 Save R670 (33%) Shipped within 7 - 12 working days

Zinc is one of the most abundant transition metals in the human body, and it has various benefits as an essential trace element in the regulation of the living body. Nutritional deficiency of zinc is known to induce many chronic diseases such as immune system disorders, rheumatoid arthritis, diabetes, obesity, atherosclerosis, cancers, bone growth retardation, osteoporosis and others. This book introduces the recent topics concerning the characteristics, uses and benefits of zinc. This book will be helpful in research development and also in the understanding of the various physiological-pathophysiological roles of zinc.

Hplc Of Biological Macro- Molecules, Revised And Expanded (Hardcover, 2nd New edition): Karen M. Gooding, Fred E. Regnier Hplc Of Biological Macro- Molecules, Revised And Expanded (Hardcover, 2nd New edition)
Karen M. Gooding, Fred E. Regnier
R5,533 R5,217 Discovery Miles 52 170 Save R316 (6%) Shipped within 7 - 12 working days

Completely revised and expanded to reflect the most recent innovations in HPLC from the past decade, this authoritative reference presents practical strategies for the evaluation and analysis of proteins, peptides, and polynucleotides and offers class-specific applications for the characterization and fractionation of biological macromolecules. Contains updated material on organic supports, size exclusion, ion exchange, hydrophobic interaction, and metal interaction chromatography With more than 2200 contemporary references-over 1000 more than the previous edition- HPLC of Biological Macromolecules, Second Edition is an essential source for biochemists and analytical biochemists, molecular and cell biologists, biophysicists, geneticists, chemical and biotechnological engineers, biochemical neuroendocrinologists, and upper-level undergraduate and graduate students in these disciplines.

Human Pathobiochemistry - From Clinical Studies to Molecular Mechanisms (Hardcover, 1st ed. 2019): Toshitaka Oohashi, Hirokazu... Human Pathobiochemistry - From Clinical Studies to Molecular Mechanisms (Hardcover, 1st ed. 2019)
Toshitaka Oohashi, Hirokazu Tsukahara, Francesco Ramirez, Chad L. Barber, Fumio Otsuka
R2,691 R2,092 Discovery Miles 20 920 Save R599 (22%) Shipped within 7 - 12 working days

This textbook uses a case-study approach to present the core principles of biochemistry and molecular biology in the context of human disease to students who will be involved in patient care. The 29 clinical cases have been carefully selected to cover key scientific concepts and some common, and other not so common, diseases. While the principal focus is on topics relating to metabolic disease, further subjects such as connective tissue disorders, neurological disorders, auto-inflammatory disorders, infective diseases, and cancer are also addressed. Each chapter provides a specific patient report that includes the natural history, pertinent clinical laboratory data, physical findings, subsequent diagnosis, and therapy. This is followed by a comprehensive discussion of the normal biochemical processes and reactions pertaining to the case, along with the pathophysiological mechanisms of the disease. Graphical diagrams are provided in each chapter for ease of comprehension.

Handbook of Antioxidants (Hardcover, 2nd New edition): Lester Packer Handbook of Antioxidants (Hardcover, 2nd New edition)
Lester Packer
R5,549 R5,233 Discovery Miles 52 330 Save R316 (6%) Shipped within 7 - 12 working days

Contains new and expanded material on antioxidants in beverages and herbal products, nitric oxide and selenium, and the effect of vitamin C on cardiovascular disease and of lipoic acid on aging, hyperglycemia, and insulin resistance!
Offering over 4200 contemporary references-2000 more than the previous edition-the Second Edition of the Handbook of Antioxidants is an up-to-the-minute source for nutritionists and dietitians, cell biologists and biochemists, cardiologists, oncologists, dermatologists, and medical students in these disciplines.

Forskolin - Sources, Mechanisms of Action & Health Effects (Paperback): Marty H Walker Forskolin - Sources, Mechanisms of Action & Health Effects (Paperback)
Marty H Walker
R1,736 R1,151 Discovery Miles 11 510 Save R585 (34%) Shipped within 7 - 12 working days

Forskolin is a labdane diterpene, isolated from plant Coleus forskohlii (Lamiaceae), which has been used in traditional Indian medicine, Ayurveda. Forskolin increases the production of cyclic adenosine monophosphatase (cAMP) by activating adenylate cyclase. Forskolin has many pharmacological effects and some of them are independent of cAMP. Coleus forskohlii root, which contains forskolin has been used in Ayurvedic medicine for cardiovascular disorders and gastrointestinal disorders. Recently, forskolin has been used as anti-obesity and anti-glaucoma agents. This book discusses the sources, mechanisms of action and health effects of forskolin.

D-Amino Acids - Physiology, Metabolism, and Application (Hardcover, 1st ed. 2016): Tohru Yoshimura, Toru Nishikawa, Hiroshi... D-Amino Acids - Physiology, Metabolism, and Application (Hardcover, 1st ed. 2016)
Tohru Yoshimura, Toru Nishikawa, Hiroshi Homma
R3,933 R3,212 Discovery Miles 32 120 Save R721 (18%) Shipped within 7 - 12 working days

This book presents a comprehensive overview of the roles of D-amino acids and latest research findings, to reveal their fascinating aspects and to facilitate better understanding of their important roles in physiology and diseases. It also provides useful hints for the development of drugs and functional foods. D-Amino acids were once called unnatural amino acids and were considered to be insignificant for eukaryotes especially in mammals. However, different D-amino acids have been revealed to be distributed in various mammalian tissues and to bear important physiological roles. For example, D-serine is implicated in memory formation and learning, and its abnormal concentration in tissues have been reported in neurological diseases such as schizophrenia and amyotrophic lateral sclerosis. D-Aspartate is found in a variety of mammalian tissues, particularly in the central nervous system and the genitals. D-Aspartate facilitates the endocrine secretion of prolactin, inhibits the secretion of melatonin, and plays a peculiar role in the control of reproductive functions in mammals, including the stimulation of testosterone synthesis. Written by the leading scientists in the field, this book is a valuable source of information for researchers in biochemistry, physiology, and neuroscience, as well as in the pharmaceutical and food industries.

Advanced Technologies for Protein Complex Production and Characterization (Hardcover, 1st ed. 2016): M. Cristina Vega Advanced Technologies for Protein Complex Production and Characterization (Hardcover, 1st ed. 2016)
M. Cristina Vega
R3,800 R3,403 Discovery Miles 34 030 Save R397 (10%) Shipped within 7 - 12 working days

This book presents advanced expression technologies for the production of protein complexes. Since complexes lie at the heart of modern biology, the expression, purification, and characterization of large amounts of high-quality protein complexes is crucial for the fields of biomedicine, biotechnology, and structural biology. From co-expression in E. coli, yeast, mammalian and insect cells to complex reconstitution from individual subunits, this book offers useful insights and guidance for successful protein expressionists. Across several sections readers will discover existing opportunities for the production of protein complexes in bacterial systems (including membrane proteins and cell-free co-expression), methylotrophic and non-methylotrophic yeasts, protozoa (Leishmania terantolae and Dictyostelium discoideum), baculovirus-infected insect cells, mammalian cells, plants and algae. Complex reconstitution from individually purified subunits or subcomplexes is discussed as a complementary strategy. A last section introduces briefly some of the biophysical and structural characterization techniques for macromolecular complexes using state-of-the-art solution scattering and nuclear magnetic resonance. This work is a guided tour over some of the most powerful and successful protein expression technologies, with a focus on co-expression and high-throughput applications. It is addressed to everyone interested in the production and characterization of macromolecular complexes, from university students who want an accessible description of the major co-expression systems to researchers in biomedicine and the life sciences seeking for an up-to-date survey of available technologies.

Heat Shock Proteins - Classification, Functions & Applications (Hardcover): Saad Usmani Heat Shock Proteins - Classification, Functions & Applications (Hardcover)
Saad Usmani
R3,156 R2,104 Discovery Miles 21 040 Save R1,052 (33%) Shipped within 7 - 12 working days

Over the last decade, major advances have been made in understanding the role of heat shock proteins (HSPs) in cellular functions. They are universally expressed by all living organisms and are one of the oldest protective mechanisms cells have against environmental stress. The present book is an effort to provide the reader with an overview on the broad and diverse role of HSPs in normal as well as abnormal animal and human physiology. It covers topics ranging from the role of HSPs in immune system and cancer biology to their effects in regulating the reproductive cycle. Each chapter has been written by well-respected investigators in the field, providing a well-balanced concise review of the subject.

CRC Handbook of Chemistry and Physics, 100th Edition (Hardcover, 100th New edition): John Rumble CRC Handbook of Chemistry and Physics, 100th Edition (Hardcover, 100th New edition)
John Rumble
R3,915 R3,613 Discovery Miles 36 130 Save R302 (8%) Shipped within 7 - 12 working days

In a world with access to unlimited amounts of data, how can users who need to make critical scientific and technical decisions find high quality, reliable data? Today, more than ever, the CRC Handbook of Chemistry and Physics remains a hallmark of quality. For over 100 years, the Handbook has provided property data on chemical compounds and all physical particles that have been reported in the literature, carefully reviewed by subject experts. Every year older collections are updated with the latest values and new areas will be added as science progresses.

Hemoglobin - Insights into Protein Structure, Function, and Evolution (Paperback): Jay F. Storz Hemoglobin - Insights into Protein Structure, Function, and Evolution (Paperback)
Jay F. Storz
R812 Discovery Miles 8 120 Shipped within 7 - 12 working days

The primary aim of this book is to provide a synthesis of our current understanding of hemoglobin function and evolution, and to illustrate how research on one particular family of proteins has provided general insights into mechanisms of protein evolution and biochemical adaptation. In doing so, it will also promote an appreciation of how mechanistic insights into protein function can enrich our understanding of how evolution works. Reciprocally, it highlights how approaches in evolutionary genetics (such as phylogenetic comparative methods and ancestral sequence reconstruction) can be brought to bear on questions about the functional evolution of proteins. This treatise on the functional evolution of hemoglobin illustrates how research on a single, well-chosen model system can enhance our investigative acuity and bring key conceptual questions into especially sharp focus.

Chemical Warfare Toxicology - Volume 1: Fundamental Aspects (Hardcover): Franz Worek, John Jenner, Horst Thiermann Chemical Warfare Toxicology - Volume 1: Fundamental Aspects (Hardcover)
Franz Worek, John Jenner, Horst Thiermann
R4,257 Discovery Miles 42 570 Shipped within 7 - 12 working days

Describes the toxicology of chemical warfare agents Recent worldwide events make this an important topic MedChemComm, Toxicology Research, Drug Discovery Series Toxicologists, biochemists and weapons specialists working in industry and academia. Covers current known and potential chemical warfare agents.

Chemical Warfare Toxicology - Volume 2: Management of Poisoning (Hardcover): Franz Worek, John Jenner, Horst Thiermann Chemical Warfare Toxicology - Volume 2: Management of Poisoning (Hardcover)
Franz Worek, John Jenner, Horst Thiermann
R4,259 Discovery Miles 42 590 Shipped within 7 - 12 working days

Describes the toxicology of chemical warfare agents Recent worldwide events make this an important topic MedChemComm, Toxicology Research, Drug Discovery Series Toxicologists, biochemists and weapons specialists working in industry and academia. Covers current known and potential chemical warfare agents.

Advanced Methods in Structural Biology (Hardcover, 1st ed. 2016): Toshiya Senda, Katsumi Maenaka Advanced Methods in Structural Biology (Hardcover, 1st ed. 2016)
Toshiya Senda, Katsumi Maenaka
R3,581 R2,833 Discovery Miles 28 330 Save R748 (21%) Shipped within 7 - 12 working days

This book provides practical information on a whole set of protein experiments for advanced structural biology, such as X-ray crystallography, NMR, electron microscopy, advanced mass spectroscopy, and surface plasmon resonance, as well as a wide variety of expression systems including eukaryotic and in vitro expression. In the past decade, structural genomics studies have pushed forward the development of automated methods in the field of structural biology, however there is an increasing need for the structural analysis of difficult targets, such as large protein complexes and membrane proteins, which are hard to achieve using conventional automated methods, and require knowledge that goes beyond standard protein chemistry protocols. To address these problems and to help researchers develop novel methods, this volume provides examples of the development of new protein investigation methods and their theoretical background. This book particularly appeals to graduate students, postdoctoral researchers, young investigators wishing to gain a better understanding of the theory behind experiments, and those seeking further advanced, practical structural biology methods.

Protocols for In Vitro Cultures and Secondary Metabolite Analysis of Aromatic and Medicinal Plants, Second Edition (Hardcover,... Protocols for In Vitro Cultures and Secondary Metabolite Analysis of Aromatic and Medicinal Plants, Second Edition (Hardcover, 2nd ed. 2016)
Shri Mohan Jain
R2,942 R2,598 Discovery Miles 25 980 Save R344 (12%) Shipped within 7 - 12 working days

This volume provides a detailed step-by-step description of protocols for the establishment of in vitro cultures of important medicinal plants, their mass multiplication in controlled environment, and step-wise secondary metabolite analysis. Many of these protocols also provide a basis for in vitro germplasm conservation or cryopreservation of medicinal plant species. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protocols for In Vitro Cultures and Secondary Metabolite Analysis of Aromatic and Medicinal Plants, Second Edition aims to ensure successful results in the further study of this vital field.

Nanomedicines - Design, Delivery and Detection (Hardcover): Martin Braddock Nanomedicines - Design, Delivery and Detection (Hardcover)
Martin Braddock
R4,260 Discovery Miles 42 600 Shipped within 7 - 12 working days

1. Covers the areas of nanomedicines and nanopharmacology. 2. This area is rapidly expanding. 3. MedChemComm, Chem Comm, Issues in Toxicology. 4. Medicinal chemists, pharmacologists and biochemists in industry and academia. 5. Provides details of the considerations that need to be made when developing Nanomedicines.

Human Blood Plasma Proteins - Structure and Function (Hardcover): Johann Schaller, Simon Gerber, Urs Kaempfer, Sofia Lejon,... Human Blood Plasma Proteins - Structure and Function (Hardcover)
Johann Schaller, Simon Gerber, Urs Kaempfer, Sofia Lejon, Christian Trachsel
R3,021 R2,649 Discovery Miles 26 490 Save R372 (12%) Shipped within 7 - 12 working days

Human plasma contains the most comprehensive version of the human proteome. The complexity of the 'plasma proteome' is quickly understood when one considers all the various forms of blood plasma proteins present in plasma: precursor and mature forms, splice variants, degradation products and of course all combinations of posttranslational modifications.

"Human Blood Plasma Proteins" gives an overview of the proteins found in human blood plasma, with special emphasis on their structure and function and relationship to pathological states and disease. Topics covered include: Introduction to blood components and blood plasma proteins Blood plasma protein domains, motifs and repeats Blood plasma protein families and posttranslational modifications Blood coagulation and fibrinolysis The complement system The immune system Enzymes Inhibitors Lipoproteins Hormones Cytokines and growth factors Transport and storage

The information of each protein discussed in this book in some detail is summarised at the end of each chapter in a Data Sheet, where one can find the most important data of each protein at one glance. Full cross-referencing to protein databases is given and many of the proteins discussed are accompanied by their 3D structure.

"Human Blood Plasma Proteins" is an essential atlas of this proteome for anyone working in biochemistry, protein chemistry and proteomics, structural biology, and medicine.

Structural Biology of Antiapoptotic Proteins of BCL-2 Family (Hardcover): Valery G Veresov Structural Biology of Antiapoptotic Proteins of BCL-2 Family (Hardcover)
Valery G Veresov
R3,490 R2,303 Discovery Miles 23 030 Save R1,187 (34%) Shipped within 7 - 12 working days

The BCL-2 family proteins are crucial regulators of the apoptotic process. This book covers recent structure-based insights into the mechanisms of action of antiapoptotic BCL-2 family proteins as well as into the interactions between antiapoptotic proteins and their ligands. While the main focus is on the apoptotic processes in mammals, the great part of the book is devoted to viral homologues of Bcl-2 family antiapoptotic proteins.

Semaphorin Signaling - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2017): Jonathan R. Terman Semaphorin Signaling - Methods and Protocols (Paperback, Softcover reprint of the original 1st ed. 2017)
Jonathan R. Terman
R3,301 R2,741 Discovery Miles 27 410 Save R560 (17%) Shipped within 7 - 12 working days

This volume arranged into three sections describes biochemical, in vitro, and in vivo protocols on Semaphorins. Chapters focus on approaches that would allow the novice to study Semaphorins and employ robust assays to characterize mechanisms of action. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Semaphorin Signaling: Methods and Protocols aims to ensure successful results in the further study of this vital field.

microRNAs in Toxicology and Medicine (Hardcover, New): Saura C. Sahu microRNAs in Toxicology and Medicine (Hardcover, New)
Saura C. Sahu
R3,311 R2,895 Discovery Miles 28 950 Save R416 (13%) Shipped within 7 - 12 working days

Providing insight into the current trends and future directions of research in this rapidly developing new field, microRNAs in Toxicology and Medicine is a comprehensive and authoritative compilation of developments in the role of microRNAs in disease and their use in toxicology, presented by internationally recognized investigators in a single, accessible volume. This valuable and excellent source of authoritative and up-to-date information for investigators, toxicologists, drug industry, risk assessors, and regulators in academia, industry, and government reflects the multidimensional and multidisciplinary character of this emerging area of research.

The Alkali Metal Ions: Their Role for Life (Hardcover, 1st ed. 2016): Astrid Sigel, Helmut Sigel, Roland K.O. Sigel The Alkali Metal Ions: Their Role for Life (Hardcover, 1st ed. 2016)
Astrid Sigel, Helmut Sigel, Roland K.O. Sigel
R4,457 R3,537 Discovery Miles 35 370 Save R920 (21%) Shipped within 7 - 12 working days

MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes proteins (enzymes) and nucleic acids (G-quadruplexes). Minerals containing sodium (Na+) and potassium (K+) are abundant in the Earth's crust, making Na+ and K+ easily available. In contrast, the alkali elements lithium (Li+), rubidium, and cesium are rare and the radioactive francium occurs only in traces. Since the intra- and extracellular, as well as the compartmental concentrations of Na+ and K+ differ significantly, homeostasis and active transport of these ions are important; this involves transporters/carriers and pore-forming ion channel proteins. Systems like Na+/K+-ATPases, H+/K+-ATPases or Na+/H+ antiporters are thoroughly discussed. The role of K+ in photosynthesis and the role of Na+ in charging the "battery of life" are pointed out. Also, the relationships between alkali metal ions and diseases (e.g., Parkinson or traumatic brain injury) are covered and the relevance of Li+ salts in medicine (pharmacology and mechanism) is reviewed. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 16, The Alkali Metal Ions: Their Role for Life, which are written by 44 internationally recognized experts from 12 nations. The impact of this vibrant research area is manifested in nearly 3000 references, over 30 tables and more than 150 illustrations (two thirds in color). MILS-16 also provides excellent information for teaching. Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems.

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