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Biochemistry is a major new textbook designed and created specifically for briefer courses in the subject. Written by Prof. Terry Brown of the University of Manchester (author of Genomes and Gene Cloning), the book provides the necessary detail and rigour expected for these courses, but without the extraneous material found in the larger textbooks. With an increasing number of students taking a short course in biochemistry there is a growing need for a book that covers the subject concisely and succinctly. Biochemistry has been designed from the outset for these shorter courses; it is not a cut-down version of one of the larger books that dominate the market. Although it is shorter, there is no compromise in content, style and coverage. The book is attractively designed in full colour throughout with all the pedagogical features expected in a major textbook. It covers what students should be expected to know and is written in the clear and accurate writing style for which Terry Brown is widely lauded. With its competitive price and resources for adopting lecturers (all of the illustrations and diagrams from the book, and answers to the end of chapter questions), Biochemistry will become the textbook of choice for any brief biochemistry course. Confirmed Adoptions Biochemistry is already the required text at the following institutions: Becker College, USA Bishop Burton College, UK Bournemouth University, UK Charles R. Drew University of Medicine and Science, USA Charleston Southern University, USA Colorado State University - Pueblo, USA Idaho State University, USA Liverpool John Moores University, UK Montclair State University, USA Newcastle University, UK Rivier University, USA Southeast Missouri State University, USA Staffordshire University, UK Stephen F Austin State University, USA Texas Christian University, USA The University of Texas at Austin, USA Umea University, Sweden University of Aberdeen, UK University of Bradford, UK University of Bedfordshire, UK University of Brighton, UK University of the Incarnate Word, USA University of Kansas, USA University of Miami Miller School of Medicine, USA University of Nottingham, UK University of Roehampton, UK University of Salford, UK University of the West of England, UK University of Tulsa, USA Valley City State University, USA Yale University School of Medicine, USA
Unlike other handbooks in this emerging field, this guide focuses
on the challenges and critical parameters in running a metabolomics
study, including such often-neglected issues as sample preparation,
choice of separation and detection method, recording and evaluating
data as well as method validation. By systematically covering the
entire workflow, from sample preparation to data processing, the
insight and advice offered here helps to clear the hurdles in
setting up and running a successful analysis, resulting in
high-quality data from every experiment.
With the increase in volume, velocity and variety of information, researchers can find it difficult to keep up to date with the literature in the field. As the synthesis of novel carbohydrates and carbohydrate mimetics continues to be a major challenge for organic chemists, not least because of the increasingly interdisciplinary nature of carbohydrate science, Carbohydrate Chemistry Volume 41 will prove invaluable. Covering both chemical and biological science, this series collates modern carbohydrate research from theory to application and will be of great benefit to any researcher who wishes to learn about the latest developments in the carbohydrate field.
PlantOmics: The Omics of Plant Science provides a comprehensive account of the latest trends and developments of omics technologies or approaches and their applications in plant science. Thirty chapters written by 90 experts from 15 countries are included in this state-of-the-art book. Each chapter describes one topic/omics such as: omics in model plants, spectroscopy for plants, next generation sequencing, functional genomics, cyto-metagenomics, epigenomics, miRNAomics, proteomics, metabolomics, glycomics, lipidomics, secretomics, phenomics, cytomics, physiomics, signalomics, thiolomics, organelle omics, micro morphomics, microbiomics, cryobionomics, nanotechnology, pharmacogenomics, and computational systems biology for plants. It provides up to date information, technologies, and their applications that can be adopted and applied easily for deeper understanding plant biology and therefore will be helpful in developing the strategy for generating cost-effective superior plants for various purposes. In the last chapter, the editors have proposed several new areas in plant omics that may be explored in order to develop an integrated meta-omics strategy to ensure the world and earth's health and related issues. This book will be a valuable resource to students and researchers in the field of cutting-edge plant omics.
This reference handbook is the first to provide a comprehensive
overview, systematically characterizing all known transporters
involved in drug elimination and resistance. Combining recent
knowledge on all known classes of drug carriers, from microbes to
man, it begins with a look at human and mammalian transporters.
This is followed by microbial, fungal and parasitic transporters
with special attention given to transport across those
physiological barriers relevant for drug uptake, distribution and
Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical.
"Toxicology and Epigenetics" reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of "in vivo" and "in vitro "models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research.
Topics covered include: environment, epigenetics and diseasesDNA methylation and toxicogenomics chromatin at the intersection of disease and therapyepigenomic actions of environmental arsenicalsenvironment, epigenetics and cardiovascular healthtoxicology, epigenetics and autoimmunityocular epigenomics: potential sites of environmental impact in development and diseasenuclear RNA silencing and related phenomena in animalsepigenomics - impact for drug safety sciencesmethods of global epigenomic profilingtranscriptomics: applications in epigenetic toxicology
"Toxicology and Epigenetics" is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.
This text examines in detail mathematical and physical modeling, computational methods and systems for obtaining and analyzing biological structures, using pioneering research cases as examples. As such, it emphasizes programming and problem-solving skills. It provides information on structure bioinformatics at various levels, with individual chapters covering introductory to advanced aspects, from fundamental methods and guidelines on acquiring and analyzing genomics and proteomics sequences, the structures of protein, DNA and RNA, to the basics of physical simulations and methods for conformation searches. This book will be of immense value to researchers and students in the fields of bioinformatics, computational biology and chemistry. Dr. Dongqing Wei is a Professor at the Department of Bioinformatics and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, China. His research interest is in the general area of structural bioinformatics.
For the 6th Edition of this highly regarded textbook devoted to lipids, the title has been modified from Lipid Biochemistry to Lipids to acknowledge the coming together of biological and medical sciences, the increasingly blurred boundaries between them and the growing importance of lipids in diverse aspects of science and technology. The principal aims of this new edition - to inform students and researchers about lipids, to assist teachers and encourage further research have not changed since previous editions. Significant advances in lipid science have demanded yet another extensive rewriting for this edition, with the addition of two new authors, to cover new knowledge of genes coding for proteins involved in lipid metabolism, the many lipids involved in cell signalling, the roles of lipids in health and disease and new developments in biotechnology in support of agriculture and industry. An introductory chapter summarizes the types of lipids covered and their identification and provides a guide to the contents. Chapters contain boxes illustrating special topics, key point summaries and suggested further reading. Lipids: Sixth Edition provides a huge wealth of information for upper-level students of biological and clinical sciences, food science and nutrition, and for professionals working in academic and industrial research. Libraries in all universities and research establishments where biological, medical and food and nutritional sciences are studied and taught should have copies of this excellent and comprehensive new edition on their shelves.
The continual change in climatic conditions induces a series of adaptations in plants to suit the unfavorable conditions for sustainable agriculture. For sustainable agriculture, it is important to unravel the precise mechanism(s) that disturb the homeostatic equilibrium at cellular and molecular level and also to enhance understanding to build strategies for the tolerance of plants. Osmolytes have long been identified as pivotal abiotic stress busters because of their role in plants in overcoming extremely harsh environmental conditions. This edited compilation attempts to put forth the scattered knowledge on osmolytes and their role in abiotic stress tolerance together and disseminate as a package to deal with the problems of lower productivity under stressful environment. It will enhance the understanding on osmolytes function and bioengineering of plants for abiotic stress tolerance. The book covers very interesting topics dealing with various osmolytes and the mechanistic approach for abiotic stress tolerance to pave the path of agricultural scientists, breeders for developing high yielding sustainable transgenic crops.
Enzyme biocatalysis is a fast-growing area in process biotechnology that has expanded from the traditional fields of foods, detergents, and leather applications to more sophisticated uses in the pharmaceutical and fine-chemicals sectors and environmental management. Conventional applications of industrial enzymes are expected to grow, with major opportunities in the detergent and animal feed sectors, and new uses in biofuel production and human and animal therapy. In order to design more efficient enzyme reactors and evaluate performance properly, sound mathematical expressions must be developed which consider enzyme kinetics, material balances, and eventual mass transfer limitations. With a focus on problem solving, each chapter provides abridged coverage of the subject, followed by a number of solved problems illustrating resolution procedures and the main concepts underlying them, plus supplementary questions and answers. Based on more than 50 years of teaching experience, Problem Solving in Enzyme Biocatalysis is a unique reference for students of chemical and biochemical engineering, as well as biochemists and chemists dealing with bioprocesses. Contains: Enzyme properties and applications; enzyme kinetics; enzyme reactor design and operation 146 worked problems and solutions in enzyme biocatalysis.
Chemical structure and bonding. The scope of the series spans the entire Periodic Table and addresses structure and bonding issues associated with all of the elements. It also focuses attention on new and developing areas of modern structural and theoretical chemistry such as nanostructures, molecular electronics, designed molecular solids, surfaces, metal clusters and supramolecular structures. Physical and spectroscopic techniques used to determine, examine and model structures fall within the purview of Structure and Bonding to the extent that the focus is on the scientific results obtained and not on specialist information concerning the techniques themselves. Issues associated with the development of bonding models and generalizations that illuminate the reactivity pathways and rates of chemical processes are also relevant. The individual volumes in the series are thematic. The goal of each volume is to give the reader, whether at a university or in industry, a comprehensive overview of an area where new insights are emerging that are of interest to a larger scientific audience. Thus each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years should be presented using selected examples to illustrate the principles discussed. A description of the physical basis of the experimental techniques that have been used to provide the primary data may also be appropriate, if it has not been covered in detail elsewhere. The coverage need not be exhaustive in data, but should rather be conceptual, concentrating on the new principles being developed that will allow the reader, who is not a specialist in the area covered, to understand the data presented. Discussion of possible future research directions in the area is welcomed. Review articles for the individual volumes are invited by the volume editors.
This book covers the current states of microbial and related technologies that have been developed for the efficient production of chemicals, fuels and materials by integrating strain and enzyme development, fermentation processes, and downstream processes. The book also covers how microbes and microbial products can be employed to facilitate petroleum recovery. Global consequences of bio-based production of chemicals, fuels and materials are also discussed with insights.
This second edition of The Physician's Guide provides paediatricians and other physicians with a unique aid to help them select the correct diagnosis from a bewildering array of complex clinical and laboratory data. Delay and mistakes in the diagnosis of inherited metabolic diseases may have devastating consequences. The guide, which includes a CD-ROM, describes 298 disorders which have been grouped into 35 chapters according to the type of condition. Within each group of disorders, chapters provide tables of pertinent clinical findings as well as reference and pathological values for crucial metabolites. Relevant metabolic pathways and diagnostic flow charts are included. There are three indices to make the book as user-friendly as possible.
An up-to-date overview of the dynamic field of whey protein utilization Whey Protein Production, Chemistry, Functionality and Applications explores the science and technology behind the rapidly increasing popularity of this most versatile of dairy by-products. With its richly nutritious qualities, whey protein has been widely used in the food industry for many years. The last decade has, however, seen manufacturers develop many innovative and exciting new applications for it, both in food and other areas. Taking account of these advances, this insightful work offers a full explanation of the technological and chemical breakthroughs that have made whey protein more in-demand than ever before. Topics covered include manufacturing technologies, thermal and chemical modifications, non-food uses, denaturation and interactions, and more. In its broad scope, the book encompasses: An up-to-date overview of recent developments and new applications Breakdowns of the chemical, nutritional, and functional properties of whey protein Commentary on the current and future outlooks of the whey protein market Examinations of the methods and manufacturing technologies that enable whey protein recovery A full guide to the numerous applications of whey protein in food production and other industries Whey Protein Production, Chemistry, Functionality and Applications is an unparalleled source of information on this highly adaptable and much sought-after commodity, and is essential reading for food and dairy scientists, researchers and graduate students, and professionals working in the food formulation and dairy processing industries.
Driven both by real industrial needs and curiosity for fundamental research, edible oil structuring has emerged as a subject of growing interest with applications in real food systems. With contributions from leading research groups around the world, this book provides a comprehensive and concise overview of the field with special emphasis on the updates from the last 5 years. New insights into the mechanism of gelation in mono- and multicomponent gels are discussed for several categories of previously known structuring agents along with the potential food applications of some of these systems. In addition, use of alternative methods to explore structuring properties of hydrophilic biopolymers are presented with illustrative examples. Some new concepts such as bio-based synthesis of supergelators, foamed oleogels and use of innovative dispersion techniques give a broader picture of the current research in edible oil structuring. This book will be of interest to students, academics and scientists involved in the research of edible oil structuring. It will be an important reference as it provides current information on the state-of-the-art of the field.
The Microbiology of Central Nervous System Infections, Volume 3, discusses modern approaches to the diagnosis, treatment and prophylaxis of central nervous system (CNS) infections. This new release is divided into five sections that cover treatment strategies, imaging, molecular diagnosis, management of CNS infections with metal nanoparticles, and prophylaxis of CNS infections, including bacterial, viral and fungal infections. The last section contains a chapter on transmissible spongiform encephalopathies and modern trends in its diagnosis and treatment. University teachers, medical practitioners, graduate and postgraduate students, researchers in microbiology, and those in the pharmaceutical and laboratory diagnostic industries will find the book very important.
This book explores environmental policymaking in Mexico as a vehicle to understanding the broader changes in the policy process within a system undergoing a democratic transformation. It constitutes the first major analysis of environmental policymaking in Mexico at the national level, and examines the implementation of forestry policy in Mexico's largest rain forest, the Selva Lacandona of the state of Chiapas.
This three-part treatment translates the technical language of research monographs on the theory of free energy transfer in biology, making the subject more accessible to those entering the field. Designed for upper-level classes in biochemistry or biophysics, it can also be used for independent study. 36 figures. 1989 edition.
Derived from the classic text originated by Lubert Stryer and continued by John Tymoczko and Jeremy Berg, Biochemistry: A Short Course focuses on the major topics taught in a one-semester biochemistry course. With its short chapters and relevant examples, it's uniquely effective in helping students see the connections between the biochemistry they're studying and their own lives. This new edition takes into account recent discoveries and advances that have changed how we think about the fundamental concepts in biochemistry and human health.
The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy. Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.
This glossary addresses the need for harmonised toxicology terminology. Fully comprehensive and rigorously reviewed by IUPAC Committees, it serves as the reference glossary for students and researchers in toxicology, and those involved in chemicals legislation, regulation and risk assessment. Toxicology uses terminology from chemistry, medicine, geology, botany, zoology, ecology, and veterinary medicine, as well as some legal terms. Toxicology has become crucial to global trade in chemicals as legislation is increasingly co-ordinated around the world and is based on the classification of toxicity. Consistent terminology is crucial for effective legislation and trade in the modern world.
By covering the full spectrum of topics relevant to peptidic drugs,
this timely handbook serves as an introductory reference for both
drug developers and biomedical researchers interested in
pharmaceutically active peptides, presenting both the advantages
and challenges associated with this molecular class.
This long-awaited first guide to sample preparation for proteomics studies overcomes a major bottleneck in this fast growing technique within the molecular life sciences. By addressing the topic from three different angles -- sample, method and aim of the study -- this practical reference has something for every proteomics researcher. Following an introduction to the field, the book looks at sample preparation for specific techniques and applications and finishes with a section on the preparation of sample types. For each method described, a summary of the pros and cons is given, as well as step-by-step protocols adaptable to any specific proteome analysis task.
Demonstrating the interdisciplinary nature of modern glycosciences, this volume covers research in the fields of polysaccharides and small carbohydrates from the synthetic and structural viewpoints, with applications ranging from biology to the bioeconomy. Key aspects of the synthesis and properties of imino disaccharides and regioselective glycosylation reactions are reviewed, glycosyltransferase inhibitors are shown to be potential future therapeutic agents, protein-carbohydrate interactions in plant cell-wall biodegradation are targeted by the use of glycan microarrays, biological properties of polysaccharidic microbial surface antigens are discussed with respect to their intimate structure, and contributions on carbohydrate-based hydrogelators, green/blue sugar-based surfactants and carbohydrate-based green solvents illustrate the modern design of tomorrow's chemicals. With the increase in volume, velocity and variety of information, researchers can find it difficult to keep up to date with the literature in their field and this book remains a valuable addition to any researcher's library.
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