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Dental defects may be the physical expression of genetic
defects, and so they can often be seen in a variety of syndromes
associated with malformations of organs. However, dental defects
are often not recognized, identified, nor characterised despite
representing a possible diagnostic sign for an undiagnosed
condition. This book addresses this gap by providing an
understanding of dental genetics and its developmental biology
counterpart. With approximately seventy well-illustrated examples,
the authors present the clinical oro-facial manifestations
accompanying various syndromes, providing the necessary knowledge
for diagnostic purposes, as well as giving insight into recent
development for each specific condition. The clarity and format of
this book make it an ideal support guide both in the clinic and
while conducting research.
"Women and Health "is a comprehensive reference that addresses health issues affecting women of all ages - from adolescence through maturity. It goes far beyond other books on this topic, which concentrate only on reproductive health, and has a truly international perspective. It covers key issues ranging from osteoporosis to breast cancer and other cancers, domestic violence, sexually transmitted diseases, occupational hazards, eating disorders, heart disease and other chronic illnesses, substance abuse, and societal and behavioral influences on health.
In this second edition of "Women and Health," chapters
thoughtfully explore the current state of women s health and health
care, including the influences of sex and gender on the occurrence
of a wide variety of diseases and conditions. All chapters have
been extensively updated and emphasize the epidemiology of the
condition - the etiology, occurrence, primary and secondary
prevention (screening), risk factors, surveillance, changing trends
over time, and critical analysis of the diagnostic and treatment
options and controversies. Treatment sections in each chapter have
been expanded to create a stronger dialogue between epidemiologists
and women's health practitioners.
Basic Medical Endocrinology, Fourth Edition provides up-to-date
coverage of rapidly unfolding advances in the understanding of
hormones involved in regulating most aspects of bodily functions.
The discussion focuses on molecular and cellular aspects of hormone
production and action firmly rooted in the context of integrative
physiology. Topics are approached from the perspective of a
physiologist with over 40 years of teaching experience.
The pituitary gland is an important one since it controls several of the other hormone glands, such as the thyroid and adrenals. A pituitary adenoma is an abnormal growth or tumor in this gland, and they are the subject of very active clinical and pathological research.
This book examines the latest developments in this field and
discusses the most important molecules implicated in apoptosis,
angiogenesis and signal transduction. A good understanding of these
processes is needed to identify the best therapies.
PLATELETS is the definitive current source of state-of-the-art
knowledge about platelets and covers the entire field of platelet
biology, pathophysiology, and clinical medicine. Recently there has
been a rapid expansion of knowledge in both basic biology and the
clinical approach to platelet-related diseases including thrombosis
and hemorrhage. Novel platelet function tests, drugs, blood bank
storage methods, and gene therapies have been incorporated into
patient care or are in development. This book draws all this
information into a single, comprehensive and authoritative
Integrates the entire field of platelet biology, pathophysiology, and clinical medicine
Full color reference comprising 64 chapters, 1400 pages, and 16,000 references
Contributions from 126 world leaders in their fields New chapters on topics such as the regulation of platelet life span, platelet microRNAs, GPVI and CLEC-2, monitoring of antiplatelet therapy, novel antiplatelet therapy, and making platelets "ex vivo"
Nutritional oncology is an increasingly active interdisciplinary
field where cancer is investigated as both a systemic and local
disease originating with the changes in the genome and progressing
through a multi-step process which may be influenced at many points
in its natural history by nutritional factors that could impact the
prevention of cancer, the quality of life of cancer patients, and
the risk of cancer recurrence in the rapidly increasing population
of cancer survivors.
This original six chapter book will briefly review and integrate
the basic concepts behind water distribution and movement in the
body. This fills a knowledge gap that most medical and
undergraduate physiology students acquire when these topics are
studied separately. As of now, there is no textbook that fully
integrates renal, cardiovascular and water physiology in a clear
understandable manner. The book is intended primarily for medical
students and undergraduate physiology students. Chapters include:
1) Water and its Distribution; 2) Water Dynamics; 3) Fluid Handling
by the Heart and Blood Vessels; 4) Fluid Handling by the Kidneys;
5) Water and Oxygen Delivery; 6) Integration in the Response to
Hemorrhage, Volume Depletion, and Water Redistribution.
Presentsa complex and detailed topicin an original way that will allow students to understand more complex textbooks and explanations"
A classic nephrology reference for over 25years, "Seldin &
Giebisch s" The Kidney, is the acknowledged authority on renal
physiology and pathophysiology. In this 5th edition, such new and
powerful disciplines as genetics and cell biology have been
deployed to deepen and widen further the explanatory framework. Not
only have previous chapters been extensively updated, but new
chapters have been added to incorporate additional disciplines.
Individual chapters, for example, now provide detailed treatment of
the significance of cilia; the role of stem cells is now given
special consideration. Finally, there has been a significant
expansion of the section of pathophysiology, incorporating the
newer findings of cell biology and genetics. If you research the
development of normal renal function or the mechanisms underlying
renal disease, "Seldin & Giebisch s" The Kidney is your number
one source for information.
"Statistics in Medicine, Third Edition" makes medical statistics
easy to understand by students, practicing physicians, and
researchers. The book begins with databases from clinical medicine
and uses such data to give multiple worked-out illustrations of
every method. The text opens with how to plan studies from
conception to publication and what to do with your data, and
follows with step-by-step instructions for biostatistical methods
from the simplest levels (averages, bar charts) progressively to
the more sophisticated methods now being seen in medical articles
(multiple regression, noninferiority testing). Examples are given
from almost every medical specialty and from dentistry, nursing,
pharmacy, and health care management. A preliminary guide is given
to tailor sections of the text to various lengths of biostatistical
*User-friendly format includes medical examples, step-by-step methods, and check-yourself exercises appealing to readers with little or no statistical background, across medical and biomedical disciplines
*Facilitates stand-alone methods rather than a required sequence of reading and references to prior text.
* Covers trial randomization, treatment ethics in medical research, imputation of missing data, evidence-based medical decisions, how to interpret medical articles, noninferiority testing, meta-analysis, screening number needed to treat, and epidemiology.
* Fills the gap left in all other medical statistics books between the reader s knowledge of how to go about research and the book s coverage of how to analyze results of that research.
"New in this Edition: "
* New chapters on planning research, managing data and analysis, Bayesian statistics, measuring association and agreement, and questionnaires and surveys.
* New sections on what tests and descriptive statistics to choose, false discovery rate, interim analysis, bootstrapping, Bland-Altman plots, Markov chain Monte Carlo (MCMC), and Deming regression.
* Expanded coverage on probability, statistical methods and tests relatively new to medical research, ROC curves, experimental design, and survival analysis.
*35 Databases in Excel format used in the book and can be downloaded and transferred into whatever format is needed along with PowerPoint slides of figures, tables, and graphs from the book included on the companion site, http: //www.elsevierdirect.com/companion.jsp?ISBN=9780123848642
*Medical subject index offers additional search capabilities."
"In Situ Molecular Pathology and Co-Expression Analyses" explains, in easy-to-understand language, simplified waysof understanding and performing in situ hybridization and immunohistochemistry tests. The book also focuses on straightforward protocols used to simultaneously detect two or more proteins/nucleic acids within intact tissue by doing co-expression analyses.
The fields of in situ hybridization and immunohistochemistry have expanded rapidly due to the use of computer-based analysis. To get the most out of these automated platforms, researchers and diagnostic biomedical investigators must have a solid understanding of the basics of in situ-based tests, protocols, and regimens for troubleshooting.
Practicing molecular pathologists, clinical chemists, and
toxicologists, as well as clinicians and researchers in training,
will benefit from this book's clear presentation of protocols and
This Third Edition of Medical Cell Biology focuses on the
scientific aspects of cell biology important to medical students,
dental students, veterinary students, and prehealth undergraduates.
Maintaining a primary focus on eukaryotic cell biology, the text
explains general cell biology principles in the context of organ
systems and human and animal disease.
Bioactive Food as Dietary Interventions for the Aging
Populationpresents scientific evidence of the impact bioactive
foods can have in the prevention and mediation of age related
diseases. Written by experts from around the world, this volume
provides important information that will not only assist in
treatment therapies, but inspire research and new work related to
Important information for developing research on this rapidly growing population representing an increasingly significant financial burden
Documents foods that can affect metabolic syndrome and ways the associated information could be used to understand other diseases, which share common etiological pathways. "
Colin Mathers who leads the Global Burden of Disease group in WHO has confirmed that, in the 2004 GBD, 13.1% of global Daily Adjusted Life Years are attributable to mental or neurological disorders. While the proportions vary very widely from about 10% in low income countries to over 25% in high income countries, it is clear that there is a need for understanding how to address this issue.
This volume aims to provide a comprehensive overview of the
public health principles of mental and neurological disorders. This
vast range of health conditions affects people across the life
course, from developmental disabilities in childhood, to
schizophrenia and substance abuse in adults, and dementia in old
age. Despite this diversity, they all share many features: they are
mostly mediated through brain dysfunction or abnormalities, are
often chronic in course, typically benefit from multi-component
interventions, and are amongst the most neglected conditions in
global health. The volume will bring together chapters from the
Psychiatry, Neurology, Substance Abuse and Child Development
sections of the Encyclopedia of Public Health. The volume will be
the first comprehensive text on a public health approach to this
diverse group of health conditions and has no obvious
* Highlights the common features of many mental and neurological disorders
* Provides insights into potential "cross-over" methods of identification and treatment
* Includes chapters on the most frequently diagnosed mental and neurological challenges faced by public health systems
The field of gender-specific medicine examines how normal human
biology and physiology differs between men and women and how the
diagnosis and treatment of disease differs as a function of gender.
This revealing research covers various conditions that
predominantly occur in men as well conditions that predominantly
occur in women. Among the areas of greatest difference are
cardiovascular disease, mood disorders, the immune system, lung
cancer as a consequence of smoking, osteoporosis, diabetes,
obesity, and infectious diseases.
Longer bibliographies and suggested reviews/papers of particular relevance and importance will be added at the end of each section.
Each author will be asked to include recent meta-analysis of data
Each chapter will progress translationally from the basic science to the clinical applications of gender-specific therapies, drugs, or treatments
Section on drug metabolism will be eliminated but the subject will be incorporated into each relevant chapter
Section on aging will be eliminated but age will be considered as a variable in each of the separate chapters "
A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte.
Individuals active in muscle investigation--as well as those new
to the field--will find this work useful, as will students of
muscle biology. In the case of hte former, many wish to grasp
issues at the margins of their own expertise (e.g. clinical matters
at one end; molecular matters at the other), adn this book is
designed to assist them. Students, postdoctoral fellows, course
directors and other faculty will find this book of interest. Beyond
this, many clinicians in training (e.g. cardiology fellows) will
One major example of the synergy of bioactive foods and extracts is their role as an antioxidant and the related remediation of cardiovascular disease. There is compelling evidence tosuggest that oxidative stress is implicated in the physiology of several major cardiovascular diseases including heart failure and increased free radical formation and reduced antioxidant defences. Studies indicate bioactive foods reduce the incidence of these conditions, suggestive of a potential cardioprotective role of antioxidant nutrients.
BioactiveFood as Dietary Interventions for Cardiovascular
Diseaseinvestigates the role of foods, herbs and novel extracts in
moderating the pathology leading to cardiovascular disease. It
reviews existing literature, and presents new hypotheses and
conclusions on the effects of different bioactive components of the
While diet has long been recognized as having potential to
alleviate symptoms of inflammatory diseases including arthritis,
lupus and fibromyalgia, research indicates that specific foods
offer particular benefits in preventing or mitigating specific
symptoms. Bioactive Food as Dietary Interventions for Arthritis and
Inflammatory Diseases is the only available resource focused on
exploring the latest advances in bioactive food research written
for the scientist or professional audience.
Bioactive Food as Dietary Interventions for Liver and
Gastrointestinal Disease provides valuable insights for those
seeking nutritional treatment options for those suffering from
liver and/or related gastrointestinal disease including Crohn s,
allergies, and colitis among others. Information is presented on a
variety of foods including herbs, fruits, soy and olive oil. This
book serves as a valuable resource for researchers in nutrition,
nephrology, and gastroenterology.
* Addresses the most positive results from dietary interventions using bioactive foods to impact diseases of the liver and gastrointestinal system, including reduction of inflammation, improved function, and nutritional efficiency * Presents a wide range of liver and gastrointestinal diseases and provides important information for additional research * Associated information can be used to understand other diseases, which share common etiological pathways"
Understanding the complex factors contributing to the growing
childhood obesity epidemic is vital not only for the improved
health of the world's future generations, but for the healthcare
system. The impact of childhood obesity reaches beyond the
individual family and into the public arenas of social systems and
government policy and programs. "Global Perspectives on Childhood
Obesity" explores these with an approach that considers the current
state of childhood obesity around the world as well as future
projections, the most highly cited factors contributing to
childhood obesity, what it means for the future both for children
and society, and suggestions for steps to address and potentially
prevent childhood obesity.
Bringing the hard-to-quantify aspects of lived experience to
analysis, and emphasizing what might be lost in interventions if
cultural insights are absent, this book includes case studies from
across the Asia and Pacific regions -Bangladesh, Malaysia, New
Guinea, Indonesia, Thailand, South Korea, Australia, New Zealand,
Tuvalu and the Cook Islands. When Culture Impacts Health offers
conceptual, methodological and practical insights into
understanding and successfully mediating cultural influences to
address old and new public health issues including safe water
delivery, leprosy, Attention Deficit Hyperactivity Disorder and
body image. It contains useful methodological tools - how to map
cultural consensus, measure wealth capital, conduct a cultural
economy audit, for example. It provides approaches for discerning
between ethnic and racial constructs and for conducting research
among indigenous peoples. The book will be indispensible for
culture and health researchers in all regions.
This practical, easy-to-use guide, named to Doody s Core Titles 2013, addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. Clinicians and laboratory scientists can therefore rely on one reference which speaks to both their needs of accurate specimen analysis and optimal patient care.
Erroneous hospital and pathology laboratory results can be
confusing and problematic, especially in acute care situations.
While some factors creating interference, can be identified in the
laboratory, detecting many others is often dependent on clinical
details unavailable to the laboratory scientists or pathologists.
Therefore, clinicians must become proficient in identifying such
erroneous reports, and working with pathologists and laboratory
scientists so that they can understand the source of such
interferences, correct the results, and then decide what course of
action must be followed for proper patient management.
Thistranslational textoffers in-depth reviews of the metabolic
and nutritional disorders that are prevalent in patients with renal
disease. Chapter topics address the growing epidemic of obesity and
metabolic syndrome. Each chapterintegrates basic and clinical
approaches, from cell biology and genetics to diagnosis, patient
management and treatment. Chapters in sections 4-7include new
illustrative case reports, and all chaptersemphasize key concepts
with chapter-ending summaries. New featuresalso include the latest
National Kidney Foundation Clinical Practice Guidelines on
Nutrition in Chronic Renal Failure, the most recent scientific
discoveries and the latest techniques for assessing nutritional
status in renal disease, and literature reviews on patients who
receive continuous veno-venous hemofiltration with or without
Correct diagnosis (and therefore correct treatment) of renal, metabolic, and nutritional disorders depends on a strong understanding of the molecular basis for the disease both nephrologists and nutritionists will benefit
Nephrologists and nutritionists will gain insight into which treatments, medications, and diets to use based on the history, progression, and genetic make-up of a patient
Case Reports will offer an added resource for fellows, nutritionists, and dieticians who need a refresher course "
Cancer continues to be one of the major causes of death
throughout the developed world, which has led to increased research
on effective treatments. Because of this, in the past decade, rapid
progress in the field of cancer treatment has been seen. "Recent
Advances in Cancer Research and Therapy" reviews in specific
details some of the most effective and promising treatments
developed in research centers worldwide. While referencing advances
in traditional therapies and treatments such as chemotherapy, this
book also highlights advances in biotherapy including research
using Interferon and Super Interferon, HecI based and liposome
based therapy, gene therapy, and p53 based cancer therapy. There is
also a discussion of current cancer research in China including
traditional Chinese medicine. Written by leading scientists in the
field, this book provides an essential insight into the current
state of cancer therapy and treatment.
The use of model organisms together with the power of genetics
has profoundly affected our understanding of the physiology of one
organ, the skeleton, in two distinct but complementary ways. Thisis
the first translational reference to focus on these major
conceptual advances in bone biology and their development in the
clinic. Several advances have already been translated into
therapies and others are being tested for diseases as different as
osteoporosis, type-2 diabetes, and hypo-fertility. This book is a
timely reference for both basic and clinical researchers in bone
biology and endocrinology.
Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone research and therapeutics, as opposed to searching through thousands of journal articles "
The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry.
"Heart Development and Regeneration, " written by experts in the field, provides essential information on topics ranging from the evolution and lineage origins of the developing cardiovascular system to cardiac regenerative medicine. A reference for clinicians, medical researchers, students, and teachers, this publication offers broad coverage of the most recent advances.
Volume One discusses heart evolution, contributing cell lineages; model systems; cardiac growth; morphology and asymmetry; heart patterning; epicardial, vascular, and lymphatic development; and congenital heart diseases.
Volume Two includes chapters on transcription factors and
transcriptional control circuits in cardiac development and
disease; epigenetic modifiers including microRNAs, genome-wide
mutagenesis, imaging, and proteomics approaches; and the theory and
practice of stem cells and cardiac regeneration.
Authored by world experts in heart development and disease
New research on epigenetic modifiers in cardiac development
Comprehensive coverage of stem cells and prospects for cardiac regeneration
Up-to-date research on transcriptional and proteomic circuits in cardiac disease
Full-color, detailed illustrations
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