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This volume discusses membrane potential imaging in the nervous system and in the heart and modern optical recording technology. Additionally, it covers organic and genetically-encoded voltage-sensitive dyes; membrane potential imaging from individual neurons, brain slices, and brains in vivo; optical imaging of cardiac tissue and arrhythmias; bio-photonics modelling. This is an expanded and fully-updated second edition, reflecting all the recent advances in this field. Twenty chapters, all authored by leading names in the field, are cohesively structured into four sections. The opening section focuses on the history and principles of membrane potential imaging and lends context to the following sections, which examine applications in single neurons, networks, large neuronal populations and the heart. Topics discussed include population membrane potential signals in development of the vertebrate nervous system, use of membrane potential imaging from dendrites and axons, and depth-resolved optical imaging of cardiac activation and repolarization. The final section discusses the potential - and limitations - for new developments in the field, including new technology such as non-linear optics, advanced microscope designs and genetically encoded voltage sensors. Membrane Potential Imaging in the Nervous System and Heart is ideal for neurologists, electro physiologists, cardiologists and those who are interested in the applications and the future of membrane potential imaging.
Now in its second edition, this practical guide offers clear-headed guidance to the successful application of catheter ablation for atrial fibrillation. This book concentrates on clinically-relevant information that providers can put to immediate use caring for patients. * Takes a clear-headed practical approach to ablation of atrial fibrillation long on actionable, clinically-relevant guidance, succinct and to-the-point on the theory behind the procedure * Edited by three leading, internationally-known electrophysiologists with extensive experience in ablation for atrial fibrillation * Written by international team of experts reflecting global best practices from centers with considerable experience in the use of catheter ablation * Format designed to serve the needs of electrophysiologists regardless of experience, electrophysiology fellows, electrophysiology nurses and lab technical staff * Covers hot topics such as new noninvasive imaging techniques, the treatment of challenging left atrial flutters, options for persistent atrial fibrillation and when a redo ablation is needed; and novel application of ablation targeting the autonomic nervous system
The book represents a paradigm shift from the traditional static model of investigation of oxidative biology to the dynamic model of vascular oxidative stress. The investigation of vascular biology and cardiovascular medicine is made possible by the use of fluid dynamics, molecular signaling, genomic approach, tissue engineering, stem cell biology, and microfluidics. This is the first book to target a wide readership from academia to industry and government agencies in the field of cardiovascular diseases.
The rapid pace of device development and complexity in applications along with a lack of concise, problem-oriented references has made it difficult for non-electrophysiologists to confidently manage patients with implanted cardiac rhythm devices (ICRDs).
"Cardiac Rhythm Devices: A Case-Based Approach to Management " provides a practical, problem-oriented, and case-based guide to assist in troubleshooting and management of the common complications of ICRDs. Readers will gain fundamental understanding of the applications and clinical indications, procedural techniques, pre- and post-procedure management, and common complications and their management.
Nearly fifty in-depth case presentations provide real-world examples of issues associated with IRCDs and the many factors involved in clinical decision-making and effective management. The cases can be studied individually and in any order. Also included are handy indexes of "key points" that make it easy to quickly locate cases and discussions of any specific topic. This practical book is an indispensable resource and quick reference for the clinical cardiologist, cardiology fellow or any practitioner needing to improve understanding and skills in the application of IRCDs.
Akin to nitric oxide, carbon monoxide (CO) was initially viewed as a pure toxic gas, yet it has been recently demonstrated to be an important endogenous molecule of gas that has profound physiological and pathophysiological effects on the cardiovascular system. In spite of the growing understanding achieved in this field, until now a comprehensive book summarizing the extraordinary advances in the research of the cardiovascular effects of CO has not been available. Carbon Monoxide and Cardiovascular Functions responds to the vexing challenges and exciting opportunities that confront researchers and clinicians studying the biological roles of CO in the cardiovascular system. This book presents many never-before-published results including the first case of human CO deficiency. It also discusses disorders where the cardiovascular effects of CO might have been altered, including hypertension, diabetes, stroke, and ischemic heart damage. A product of the collected knowledge of internationally respected scientists, this book serves as a standard reference summarizing recent developments, scientific controversies, and future directions in the study of the biological actions of CO on the cardiovascular system. By covering both ancient and state-of-the-art methodologies in great detail, Carbon Monoxide and Cardiovascular Functions, affords a rapid mastery of the powerful new advances in CO study.
Of all the complications which arise from diabetes, cardiovascular complications are by far the most prevalent and the most deadly. Authored by some of the world's leading names in this area, this outstanding book provides all those managing diabetic patients with clinical, practical and succinct guidance to the diagnosis and management of cardiovascular complications in diabetes. With a joint endocrinology and cardiology focus, and with the very latest in clinical guidelines from the ADA, EASD, AHA, ASC and ESC, selected highlights include: - The role of new biomarkers of cardiovascular disease in diabetes - The latest on diagnosis of cardiovascular problems via vascular imaging - Hypertension and cardiovascular disease in the diabetic patient - Dyslipidaemia and its management in type 2 diabetes - Management of thrombosis, acute coronary syndrome and peripheral arterial disease in diabetes Key points, case studies and self-assessment questions allow for rapid-reference, quick understanding of all topics, thus ensuring that this is perfect reading for endocrinologists, diabetes specialists and cardiologists of all levels managing patients with diabetes and associated cardiovascular problems.
C omplications of Percutaneous Coronary Intervention: The Survival Handbook aims to serve as a reference manual for all cardiologists, particularly those in training, who face life-threatening complications of PCI on a day-to-day basis. Drawing on the background and experience of cardiologists from both sides of the Atlantic, the book aims to be a valuable, practical, and most of all readable resource for the interventional cardiologist. The principles and practices described in the book will be of interest to all practitioners of interventional catheter procedures, including interventional radiologists, vascular surgeons, and cardiologists.Few medical procedures have evolved as dramatically or as quickly as percutaneous coronary intervention (PCI). From its initial conception, PCI has evolved to become a very complex procedure. Each year in the United States well over 1,000,000 percutaneous coronary intervention procedures are performed. However as the volume and complexity of the procedures being performed has increased, so has the potential for procedural error leading to life-threatening complications. Knowledge of what complications can occur during PCI and how to deal with them is vital for the practicing cardiologist, and can mean the difference between life and death.
Not too long ago, it was thought that inflammation of blood vessels was the sole manifestation of systemic autoimmune diseases. Today, however, we know that disorders of coagulation, injuries to both neutrophils and endothelial cells, and certain lipids and amino acids are all intricately involved in the development of vascular disease. How are all these processes linked? What strategies can we employ or develop to halt the progression of vascular damage? What are the best ways to control acute vasculitis and vasospasm therapeutically? What are the risks and benefits of various strategies for the prevention of clotting? How soon should we initiate preventive strategies that protect blood vessels from arteriosclerosis in people with acute rheumatic diseases? What should be the nature of those strategies?
Percutaneous cardiac and endovascular procedures performed by a variety of interventional physicians continue to evolve and expand. One of the most important steps in performing these procedures is vascular access and their Achilles heel is vascular access site complications. This volume is here to help the clinician, providing a practical overview of the techniques and technologies used in top catheterization laboratories to access the arterial and venous beds. Dr. Mazen Abu-Fadel and his contributors, part of the renowned cardiovascular team at the University of Oklahoma College of Medicine, carefully walk the reader through the various techniques used to obtain vascular access into most arterial and venous sites. They thoroughly describe current data, techniques, advantages, risks, and benefits of each vascular access site. Covering everything from anatomic landmarks to closures devices, Arterial and Venous Access in the Cardiac Catheterization Lab offers a complete overview of each procedure. In addition, it provides an up-to-date guide to the best medical technologies and equipment used when performing these procedures. Arterial and Venous Access in the Cardiac Catheterization Lab is an invaluable resource for a wide range of clinical personnel, from attending physicians and trainees to nursing staff and vascular technicians. Written by experienced leaders in the field, it demonstrates how to perform complex, risky procedures while providing patients with expert care.
The world is witnessing a burgeoning global epidemic of chronic cerebro- and cardiovascular disease and depression disorders. The reader will find this comprehensive book to be a long-needed, up-to-date knowledge base on these increasingly recognized comorbid conditions that have long-term consequences for individual function and well-being and society in general. This comprehensive book outlines the complex and bidirectional relationship between various types of depression and cerebro- and cardiovascular diseases. It is written by a range of experts in the field, including psychiatrists, cardiologists, neuroscientists, psychologists, and epidemiologists, with the aim of presenting and discussing the most recent evidence on the pathophysiology, neurobiology, and clinical presentation of these common and disabling comorbid conditions and the available pharmacological, psychological, and behavioral interventions. By elucidating the underlying clinical and neurobiological mechanisms in the brain and the rich interplay between the body and the brain biology, the book brings together the latest knowledge of this overlapping area in Psychiatry and Cardiology. The clear descriptions of evidence-based approaches to clinical treatment ensure that it will serve as both an up-to-date overview and a future guide for practicing clinicians and graduate students.
Thebook comprises the contribution of several authors who are among the mostrenowned scientists working in the field of mathematical modeling and numerical simulation of the human cardiocirculatory system. The contributions cover a wide range of topics, from the pre processing of clinical data, to the set up of mathematical equations, their numerical solution, both in-vivo and in-vitro validation. They address the flow in the systemic arterial tree and the complex electro-fluid-mechanical coupling in the human heart. Many examples of patient-specific simulations are addressed. This book is addressed to all scientists (from PhD level up to professional scientists) interested in the mathematical modeling and numerical simulation of the human cardiocirculatory system."
Today's echocardiography continues to be a low-cost, minimal-risk procedure with the potential to yield a vast amount of detailed, precise anatomic and physiologic information. Dr. Catherine Otto's Textbook of Clinical Echocardiography, 6th Edition, clearly outlines how to master the core principles of echocardiographic imaging in order to make an initial diagnosis and integrate this data in clinical decision making for patients with a wide range of cardiovascular diseases. Ideal for cardiology fellows, medicine residents, and cardiac sonography students, this bestselling text teaches all the essential elements of ultrasound physics, tomographic and 3D anatomy, image acquisition, advanced imaging modalities, and application in specific disease categories- all with a practical, problem-based approach. Concentrates on the foundational concepts you need to know to perform and interpret echocardiographic studies and to pass your board exams. Covers all advanced echo techniques, including contrast echo, 3D echo, and myocardial mechanics, as well as intraoperative and intra-procedural transesophageal echocardiography (TEE). Discusses what alternative diagnostic approaches to initiate when echocardiography does not provide a definitive answer. Includes new Echo Math boxes in each chapter for quick review and greater comprehension. Provides new ASE recommendations for chamber quantitation, including updated tables of normal measurements. Matches full-color anatomic drawings of heart structures with the 2D and 3D echocardiographic views. Pairs state-of-the-art echo images with more than 360 videos that illustrate the full range of cardiac disease diagnosed with this powerful imaging approach. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you click on each figure to see the corresponding video, as well as search all of the text, figures, and references from the book on a variety of devices.
This comprehensive text examines both global and local coronary blood flow based on morphometry and mechanical properties of the coronary vasculature. Using a biomechanical approach, this book addresses coronary circulation in a quantitative manner based on models rooted in experimental data that account for the various physical determinants of coronary blood flow including myocardial-vessel interactions and various mechanisms of autoregulation. This is the first text dedicated to a distributive analysis (as opposed to lumped) and provides digital files for detailed anatomical data (e.g., diameters, lengths, node-to-node connections) of the coronary vessels. This book also provides appendices with specific mathematical formulations for the biomechanical analyses and models in the text. Written by Dr. Ghassan S. Kassab, a leader in the field of coronary biomechanics, Coronary Circulation: Anatomy, Mechanical Properties, and Biomechanics is a synthesis of seminal topics in the field and is intended for clinicians, bioengineers, and researchers as a compendium on the topic. The detailed anatomical and mechanical data provided are intended to be used as a platform to address new questions in this exciting and clinically very important research area.
Compiled by a team of students and practising doctors and consultants from the University of Edinburgh Medical School, Cardiology in a Heartbeat provides practical advice to enable the reader to get to grips with the subject quickly and easily. This unique author team brings the reader the best of both worlds: the student authors focus on what students need to know whilst the contributions from senior medics ensure the book is accurate and covers the subject completely. The attractive full-colour layout and short, consistent chapters mean the book is easy to navigate through; this is especially useful when the reader wants to quickly brush up on a particular topic or find an answer to a specific question. The book boasts an array of design features specifically for students (such as pro-tips, exam essentials, mnemonics, `in a nutshell' sections) to really help the reader understand the subject and, just as importantly, to pass their exams. A proportion of the proceeds from sales of this book will be donated to the British Heart Foundation
Postgraduate Vascular Surgery is your concise pocket guide to the FRCS and MRCS exams. Covering the full range of surgical interventions, including diagnosis, management, clinical investigation and treatment, all chapters have been written by specialists in their field. The chapters are structured with key bullet points for easy reference, as well as tables, figures and charts to aid understanding. Relevant references are included for further exploration of a particular topic. Tips and tricks on passing the exam are included. This book is aimed at candidates for the FRCS and intercollegiate MRCS exams, surgical trainees and those following a sub-speciality of vascular surgery.
This book provides a concise overview over the pathology of retinal angiogenic diseases and explains why anti-angiogenic therapy is effective in so many patients. The reader is guided through the various clinical indications for anti-angiogenic therapy and made aware of its merits as well as current challenges and limitations. It is explained how, since its introduction for the treatment of exudative age-related macular degeneration in 2006, anti-angiogenic therapy has revolutionized the way in which we treat a range of ocular diseases. All of the authors are established experts in their respective fields who share their extensive knowledge and clinical experience with the reader. This book is both a valuable introduction to anti-angiogenic therapy in ophthalmology and a day-to-day companion for all ophthalmologists seeing patients with some of the most prevalent retinal diseases.
The latest edition of this must-have text book promises an evidence-based and practical approach covering the very latest in cardiorespiratory care. The textbook covers a wide range of cardiorespiratory conditions and discusses treatment of patients in different clinical settings such as critical care, the ward area and out-patient departments. It begins with physiology and pathology and progresses into a detailed patient assessment section and a discussion of specific respiratory and cardiac conditions. The final section covers different groups of people who may require physiotherapy such as infants, children, and adults with specific conditions including a considered section on palliative care. Critical thinking is facilitated by clinical reasoning boxes in the text, and problem-solving is aided by case studies at the end of each chapter. There are also relevant practice tips to enable transfer of learning into the clinical environment. The text is supported by over 280 line drawings and diagrams along with over 70 x-rays and photographs to further illustrate the points under discussion. Q & A case studies, with scans and x-rays Outcome measures for problems and diseases Boxes with learning and practice tips to encourage reflection Tables with definitions, normal values and comparisons Practical techniques described with precision Expanded cardiovascular section Updated practical details on physiotherapy techniques Extra chapters on surgical complications and interventions Comprehensive coverage of Critical Care procedures and rehabilitation Practicalities of the management of children and infants Update on the evaluation of outcomes
Coronary artery disease (CAD) is the leading cause of death and illness in the United States, and though much progress has been made in reducing cardiac risk factors, obesity and diabetes mellitus are on the rise. Preventing Illness Among People With Coronary Heart Disease explores recent advances in drug treatments for CAD risk factors and how these interventions can play an important role in improving the length and quality of patients'lives by addressing health behaviors and the need for behavioral change. This advanced text shows readers how mental health problems such as anxiety, depression, and alcoholism interplay with patients'physical health and how certain interventions can improve patients'outlook and health status.Preventing Illness Among People With Coronary Heart Disease brings together researchers from a variety of disciplines to address subjects critical to secondary and tertiary preventive care for patients with coronary heart disease (CHD). This outstanding volume concentrates on studies from three major areas to help primary care practitioners and family practice physicians intervene successfully with risky behaviors among their patients prone to or afflicted with coronary artery disease. These include the effects of heart disease on patients'mental health and quality of life and the role of formal behavioral interventions in promoting health among patients with heart disease.Readers of Preventing Illness Among People With Coronary Heart Disease acquire a solid understanding of the factors influencing CAD patients'behavioral patterns and mental states and how the prevalence of CAD can be reduced. Among the vital topics readers learn about are: the effects of alcohol upon CHD and blood pressure CHD risk factors in the elderly exercise interventions coping strategies and cardiac illness strategies for assessment and prevention smoking and cardiovascular diseasePreventing Illness Among People With Coronary Heart Disease seeks to provoke greater discussion and scientific activity among professionals in the field to improve understanding of the interplay of mental health, physical health, and behavioral medicine for patients with heart disease. Primary care practitioners, family practice physicians, medical students, and others interested in preventive cardiology, preventive care, or chronic disease management will learn about recent advances in research and treatment approaches that can be applied immediately to daily practice.
This is a book for any care provider - from advanced students and nurses to residents and even specialists - who needs to master the interpretation of ECGs, especially while "on the spot" at the point of care. This easy-to-use, visual guide takes a novel approach, foregrounding the visual clues or "keys" that readers can learn to recognize in ECGs and thus make rapid decisions about next steps at the point of care. The comparatively minimal text focuses on "must-know" information about the underlying cause of ECG abnormalities. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from Google Play or the MedHand Store.
Deliver safe, accurate care during electrocardiographic monitoring, with the newly updated ECG Interpretation Made Incredibly Easy! Sixth edition. This easy-to-follow, fully illustrated text explains the basics of cardiac physiology, then leads you through recognizing and treating arrhythmias, with step-by-step guidance on current medications, devices, and monitoring equipment. Take advantage of this real-world, expert nursing advice to reinforce your class materials, prepare for the NCLEX or certification exam, and strengthen your ECG interpretation skills. Features: * Coverage of topics including: o ECG fundamentals - cardiac anatomy and physiology; obtaining and interpreting a rhythm strip o Identifying and interpreting arrhythmias - atrial, junctional, ventricular, atrioventricular, and more * Hundreds of photos, illustrations, and diagrams explain key concepts and provide clear direction on vital procedures, including: o The 8-Step Method for interpreting a rhythm strip o Nonpharmacologic and pharmacologic treatments for arrhythmias, including pacemakers, ICDs, and antiarrhythmics o Obtaining and interpreting a 12-lead ECG o Troubleshooting equipment problems * Helpful practice questions and quick guides include: o End-of-book multiple choice Q&A o Sample rhythm strips to help you practice your interpretation skills o A Quick Guide to arrhythmias * Special features: o Ages and stages - Identifies differences in ECGs and pacemaker needs, according to the patient's age o Now I get it - Clear-cut directions for performing complex procedures, such as using an automated external defibrillator o Don't skip this strip - Identifies the arrhythmias that have the most serious consequences o Mixed signals - Insights on solving common problems in ECG monitoring and interpretation o I can't waste time - Key points you need to know for conditions that require quick identification and treatment o Quick quiz - Questions with answers/explanations at end of every chapter, to help you remember vital points
Disease conditions that affect the human heart and the methods used to diagnose and treat them are all covered in one concise volume. * Illustrations include diagrams of the heart, examples of test results, and images of devices used to treat heart disease * A glossary defines medical terms used in the book
Comparative Cardiovascular Dynamics of Mammals offers never-before-published data on the structure and function of the circulatory systems of the different mammalian species. This text explores classic allometry, dimensional analysis, and modern hemodynamics to establish similarity principles that provide a necessary and important step in understanding the natural common design and functional features of the cardiovascular systems of different mammals. Fluid and blood vessel mechanics, pulse transmission characteristics, cardiac energetics and mechanics, as well as heart-arterial system interaction are included in this essential reference. The sensitivity of parameters and similarity of principles in the diagnosis of cardiovascular diseases are also addressed. This book also describes the natural processes involved in the functional development of the mammalian cardiovascular system. By using modern methods to present recent findings on the similarities and differences of the mammalian cardiovascular system, the author provides an easily understood approach to this dynamic field of study.
Cardiovascular disease (CVD) is the number one killer of men and
women in industrialized countries. In older age groups, CVD is also
the most important cause for hospitalization, and, in many
countries, it is the basis of early retirement from work. Thus, CVD
is associated with enormous costs for care and loss of
productivity, as well as for disabilities, pensions, etc. All this
has motivated clinicians and scientists to develop and implement
new methodologies and technologies to better care for patients who
are hospitalized for heart disease.
This third volume in the "Progress in Hypertension" series is dedicated to the memory of Professor Kozo Okamoto the creator of spontaneously hypertensive rats (SHR), stroke-prone spontaneously hypertensive rats (SHRSP) and malignant stroke-prone spontaneously hypertensive rats (M-SHRSP). The papers in this volume deal with pathophysiology and pharmacology of SHR. The contributions describe new trends in SHR research from haemodynamic characteristics to immunological views. The emphasis is placed on the development of transgenic rats and the use of tissue culture studies to elaborate SHR characteristics. The possible use of SHRSP as a model of cerebrovascular dementia can also serve as a novel concept to facilitate the study of vascular dementia. The role of excitatory amino SHR are also covered in this book.
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