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Books > Science & Mathematics > Biology, life sciences > Cellular biology

The Cell - A Visual Tour of the Building Block of Life (Hardcover): Jack Challoner The Cell - A Visual Tour of the Building Block of Life (Hardcover)
Jack Challoner
R895 R739 Discovery Miles 7 390 Save R156 (17%) Ships in 7 - 11 work days

The cell is the basic building block of life. In its 3.5 billion years on the planet, it has proven to be a powerhouse, spreading life first throughout the seas, then across land, developing the rich and complex diversity of life that populates the planet today. With The Cell: A Visual Tour of the Building Block of Life, Jack Challoner treats readers to a visually stunning tour of these remarkable molecular machines. Most of the living things we're familiar with--the plants in our gardens, the animals we eat--are composed of billions or trillions of cells. Most multicellular organisms consist of many different types of cells, each highly specialized to play a particular role--from building bones or producing the pigment in flower petals to fighting disease or sensing environmental cues. But the great majority of living things on our planet exist as single cell. These cellular singletons are every bit as successful and diverse as multicellular organisms, and our very existence relies on them. The book is an authoritative yet accessible account of what goes on inside every living cell--from building proteins and producing energy to making identical copies of themselves--and the importance of these chemical reactions both on the familiar everyday scale and on the global scale. Along the way, Challoner sheds light on many of the most intriguing questions guiding current scientific research: What special properties make stem cells so promising in the treatment of injury and disease? How and when did single-celled organisms first come together to form multicellular ones? And how might scientists soon be prepared to build on the basic principles of cell biology to build similar living cells from scratch.

Aniridia - Recent Developments in Scientific and Clinical Research (Hardcover, 1st ed. 2015): Mohit Parekh, Barbara Poli,... Aniridia - Recent Developments in Scientific and Clinical Research (Hardcover, 1st ed. 2015)
Mohit Parekh, Barbara Poli, Stefano Ferrari, Corrado Teofili, Diego Ponzin
R4,345 Discovery Miles 43 450 Ships in 7 - 11 work days

The aim of this book is to highlight the latest findings in Aniridia research. Aniridia, meaning "without iris", is a rare genetic disorder affecting vision, characterized by the incomplete formation of the iris (the coloured part of the eye that surrounds the black pupil). It may also cause other segments of the eye to be under-developed such as the optic nerve and the macula (the central part of the retina). Aniridia and associated conditions affect individuals differently. So while some affected people are partially sighted or blind, others may have near normal sight. Aniridia is congenital (present at birth) and is caused by a dysfunction of the PAX6 gene, situated on the 11th chromosome that causes the premature cessation of eye development. Aniridia affects between 1:40,000 to 1:100,000 people, and affects males and females equally. People with Aniridia may also experience secondary conditions such as Photophobia, Nystagmus, Glaucoma, Cataracts and Keratopathy.

Schaum's Outline of Molecular and Cell Biology (Paperback, Ed): William Stansfield, Raul Cano, Jaime Colome Schaum's Outline of Molecular and Cell Biology (Paperback, Ed)
William Stansfield, Raul Cano, Jaime Colome
R656 R563 Discovery Miles 5 630 Save R93 (14%) Ships in 7 - 11 work days

Finally, a book that covers everything you need to know to master any molecular biology course--without overwhelming you with unnecessary information Most textbooks on molecular and cell biology are massive tomes that bombard you with a lot of confusing, extraneous information. This effective study aid succeeds where those books fail, covering only what you need to know and providing essential information and techniques that will improve your comprehension and help you perform better in the classroom. Use it in conjunction with your textbook--or to study on your own--and watch your grades climb! Each chapter contains logically organized, easy-to-digest blocks of information that teach you important principles and prepare you for advanced studies. The question-and-answer format helps you learn the material quickly. Review questions at the end of each chapter let you test your retention. Chapters build upon one another, moving from basic to more advanced subjects and concluding with an in-depth examination of the origin and evolution of life. Other chapters cover: Cells: their Structure, Metabolism, and Reproduction; Biomacromolecules; Chromosomes: their Structure, Replication, and Recombination; Mutations; Genetics of Bacteria and their Viruses; Genetic Engineering/Recombinant DNA Technology; Eykaryotic Cells and their Viruses; Cellular Communication; Development in Multicellular Organisms; and more.

Stem Cells and Tissue Repair - Methods and Protocols (Paperback, 2nd ed. 2020): Chrissa Kioussi Stem Cells and Tissue Repair - Methods and Protocols (Paperback, 2nd ed. 2020)
Chrissa Kioussi
R3,228 Discovery Miles 32 280 Ships in 7 - 11 work days

This volume looks at a collection of stem cell and regenerative techniques used by both novice and expert scientists. Chapters cover topics such as tissue repaired by expansion and reprogramming; induced pluripotent stem cells driven in neuronal or vascular differentiation; using mesenchymal stem cells to derive skeletal muscle, osteoblasts, and spermatogonial cells; and the technique of monitoring the development of sub-organ microenvironments in the developing pancreas. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Stem Cells and Tissue Repair: Methods and Protocols, Second Edition is a valuable resource that provides readers with the latest descriptions and references for exploring this vast field in regenerative medicine.

Protein Kinases in Drug Discovery, Volume 124 (Hardcover): Rossen Donev Protein Kinases in Drug Discovery, Volume 124 (Hardcover)
Rossen Donev
R3,329 Discovery Miles 33 290 Ships in 12 - 17 work days

Protein Kinases in Drug Discovery, Volume 124 discusses the latest information on protein kinases and how they modify other proteins by chemically adding phosphate groups to them. New chapters in this release include Transport Proteins and AMPs: Implications in Human Disease, Protein kinase CK2 inhibition as a pharmacological strategy, Emerging role of Protein kinase in diabetes mellitus: From Mechanism to therapy, Dual Roles of ATP-binding site in Protein Kinases: Orthosteric inhibition and Allosteric Regulation, Pseudokinases in drug discovery and development: progress, challenges and future prospects, Comparison of knowledge-based vs. combinatorial peptide library approaches for the identification of protein kinase substrates, and more.

Pathogenesis of Systemic Lupus Erythematosus - Insights from translational research (Hardcover, 1st ed. 2021): Alberta Hoi Pathogenesis of Systemic Lupus Erythematosus - Insights from translational research (Hardcover, 1st ed. 2021)
Alberta Hoi
R2,895 Discovery Miles 28 950 Ships in 12 - 17 work days

The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature.This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.

Male Infertility: Understanding, Causes and Treatment (Hardcover, 1st ed. 2017): Rajender Singh, Kiran Singh Male Infertility: Understanding, Causes and Treatment (Hardcover, 1st ed. 2017)
Rajender Singh, Kiran Singh
R5,591 R4,014 Discovery Miles 40 140 Save R1,577 (28%) Ships in 12 - 17 work days

This book covers the latest research on male infertility. The topics discussed range from understanding the genetic basis of infertility, to its causes and treatment. Since infertility is also of great interest to the general public, the book also includes a detailed description of what infertility is and how one can understand the different types. Given the complex etiology of infertility, the book includes a number of chapters defining the known and probable causes of male infertility. Providing detailed information suitable for patients and clinicians alike, it also features a separate section on treatment, the ultimate goal.

Cellular Pathology, third edition - An Introduction to Techniques and Applications (Paperback, 3rd Revised edition): D.J. Cook,... Cellular Pathology, third edition - An Introduction to Techniques and Applications (Paperback, 3rd Revised edition)
D.J. Cook, P.J. Warren
R773 Discovery Miles 7 730 Ships in 12 - 17 work days

This third edition of the popular Cellular Pathology textbook provides a thorough coverage of all the key areas of histological and cytological techniques. It is written for students studying courses in biomedical sciences, healthcare science or other subjects allied to medicine. The book provides essential information on those techniques that have particular relevance to both the diagnosis of disease and also for research in pathology. This 3rd edition has been thoroughly updated and extended to: include changes in established practice accommodate newly emerging techniques such as in molecular diagnostics provide an introduction to the latest immunological methods, microscopy techniques, image analysis systems and approaches in liquid-based cytology show all images in full colour. Additionally, the general principles of pathology are given a more rigorous treatment and the approach to good laboratory practice has been expanded. This edition continues to feature learning objectives, revision notes, recommended further reading and self-evaluation questions, all of which really help the student to understand the subject. The book further benefits from an increased number of photographs that illustrate typical results and techniques - all in full colour. Cellular Pathology 3e reflects the current requirements of cellular pathology teaching and practice and provides essential reading for any course that relates to cellular pathology, histology and histopathology.

Essential Cell Biology (Hardcover, Fifth Edition): Bruce Alberts, Karen Hopkin, Alexander Johnson, David Morgan, Martin Raff,... Essential Cell Biology (Hardcover, Fifth Edition)
Bruce Alberts, Karen Hopkin, Alexander Johnson, David Morgan, Martin Raff, …
R3,931 Discovery Miles 39 310 Ships in 12 - 17 work days

This text features lively, clear writing and exceptional illustrations, making it the ideal textbook for a first course in both cell and molecular biology. Thoroughly revised and updated, the Fifth Edition maintains its focus on the latest cell biology research. For the first time ever, Essential Cell Biology will come with access to Smartwork5, Norton's innovative online homework platform, creating a more complete learning experience.

Cell Cycle Checkpoints - Methods and Protocols (Hardcover, 1st ed. 2021): James J. Manfredi Cell Cycle Checkpoints - Methods and Protocols (Hardcover, 1st ed. 2021)
James J. Manfredi
R4,308 Discovery Miles 43 080 Ships in 7 - 11 work days

This volume explores the latest advancements in the field of cell cycle checkpoints and their implications for human diseases. Chapters in this book cover topics such as post-translationally modified p53 by western blotting; CHK1 cellular localization by immunofluorescence microscopy; DNA affinity purification; knockdown of target genes by siRNA in vitro; and calreticulin exposure in mitotic catastrophe. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Cell Cycle Checkpoints: Methods and Protocols is a valuable resource for researcher interested in learning more about this developing field.

G Protein-Coupled Receptor Screening Assays - Methods and Protocols (Hardcover, 2nd ed. 2021): Sofia Aires M. Martins, Duarte... G Protein-Coupled Receptor Screening Assays - Methods and Protocols (Hardcover, 2nd ed. 2021)
Sofia Aires M. Martins, Duarte Miguel F. Prazeres
R4,752 Discovery Miles 47 520 Ships in 7 - 11 work days

This fully updated edition targets not only those assays directly involved in the discovery of GPCR-active compounds but also those involved in cell-based experiments designed to study physiological responses. Whether coming from academia or industry, or being an experienced researcher or a newcomer to the field, the reader will find accessible methods and protocols that cover the latest developments on receptor purification, molecular biology, recombinant engineering, and analytical techniques that enable the real time monitoring of the complex GPCR signaling cascade and identification of potential drug targets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, G Protein-Coupled Receptor Screening Assays: Methods and Protocols, Second Edition aims to provide the tools necessary to contribute to the advancement of GPCR research and discovery and ultimately lead to the availability of innovative and more efficient drugs.

Biomolecular Interactions Part A, Volume 166 (Hardcover): Arun K. Shukla Biomolecular Interactions Part A, Volume 166 (Hardcover)
Arun K. Shukla
R3,800 Discovery Miles 38 000 Ships in 12 - 17 work days

Biomolecular Interactions: Part A, Volume 166, the latest release in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics in cell biology. Each chapter is written by an international board of authors.

Plant Aquaporins - From Transport to Signaling (Hardcover, 1st ed. 2017): Francois Chaumont, Stephen D. Tyerman Plant Aquaporins - From Transport to Signaling (Hardcover, 1st ed. 2017)
Francois Chaumont, Stephen D. Tyerman
R5,985 R3,568 Discovery Miles 35 680 Save R2,417 (40%) Ships in 12 - 17 work days

Aquaporins are channel proteins that facilitate the diffusion of water and small uncharged solutes across cellular membranes. Plant aquaporins form a large family of highly divergent proteins that are involved in many different physiological processes. This book will summarize the recent advances regarding plant aquaporins, their phylogeny, structure, substrate specificity, mechanisms of regulation and roles in various important physiological processes related to the control of water flow and small solute distribution at the cell, tissue and plant level in an ever-changing environment.

Plant Phosphoproteomics - Methods and Protocols (Hardcover, 1st ed. 2021): Xu Na Wu Plant Phosphoproteomics - Methods and Protocols (Hardcover, 1st ed. 2021)
Xu Na Wu
R4,724 Discovery Miles 47 240 Ships in 7 - 11 work days

This detailed protocol book provides phosphoproteomics techniques currently developed for use in plants, as well as offering a variety of methodologies to analyze different types of plant phosphoproteomic data. Suitable protocols for every stage of the experiment, from protein isolation and phosphopeptides enrichment to large-scale data analysis, have been considered and explored. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Plant Phosphoproteomics: Methods and Protocols serves as an ideal guide for researchers examining phosphoproteomics in the field of plant sciences.

Cancer Stem Cells - Methods and Protocols (Paperback, 2009 ed.): John S Yu Cancer Stem Cells - Methods and Protocols (Paperback, 2009 ed.)
John S Yu
R3,676 Discovery Miles 36 760 Ships in 7 - 11 work days

Cancer is a devastating disease that affects millions of people in the world. Our the- pies for tumors have mostly been based on classical chemotherapy and antiproliferative treatments. More recently, directed therapies against a causative oncogene have led to prominent reduction in tumor rates for some cancers. For instance, chronic myelogenous leukemia that is due to a BCR-ABL translocation can be targeted with Gleevec. Despite these advances in individual tumors, a number of patients are treated for their primary tumors and ultimately relapse. Relapsing tumors can be due to resistance to chemotherapy or to antioncogene drugs. Another hypothesis is that heterogeneity in the tumor leads to an inability of classical chemotherapy to completely eradicate all cells of the tumor. This concept of heterogeneity has led some investigators to propose a cancer stem cell model. As patients are treated with chemotherapy, most of the dividing cells are killed, but this leaves a small subset of cells that have the ability to remake the entire tumor. These are cancer stem cells. They possess the signals of self-renewal and yet can also differentiate. If one could understand more about the cells that remain after classical chemotherapy or the cells that can remake the tumor among the heterogeneous population, this information would have a huge impact on our treatment of cancer.

Polymeric Biomaterials for Tissue Regeneration - From Surface/Interface Design to 3D Constructs (Hardcover, 1st ed. 2016):... Polymeric Biomaterials for Tissue Regeneration - From Surface/Interface Design to 3D Constructs (Hardcover, 1st ed. 2016)
Changyou Gao
R4,769 R2,916 Discovery Miles 29 160 Save R1,853 (39%) Ships in 12 - 17 work days

This book reviews state-of-the-art of polymeric biomaterials for regenerative medicine, and highlights advances in both basic science and clinical practice. It summarizes the latest techniques in polymeric scaffold fabrication, delivery carriers, physicochemical property modulation, as well as their influence on adhesion and the performance of biomolecules, cells and tissues. It also describes methods for creating biofunctional surfaces/interfaces and subsequently modulating the host response to implantable materials. Lastly, it discusses the applications of biomaterials and constructs in soft-tissue regenerative medicine. It is a valuable resource for materials scientists and engineers wishing to identify research priorities to fulfill clinical needs and provides physicians with insights into emerging novel biomaterials. This integrated approach also offers engineering students a sense of the relevance of materials science in the development of novel therapeutic strategies.

In Vivo Cryotechnique in Biomedical Research and Application for Bioimaging of Living Animal Organs (Hardcover, 1st ed. 2016):... In Vivo Cryotechnique in Biomedical Research and Application for Bioimaging of Living Animal Organs (Hardcover, 1st ed. 2016)
Shinichi Ohno, Nobuhiko Ohno, Nobuo Terada
R4,336 R1,712 Discovery Miles 17 120 Save R2,624 (61%) Ships in 12 - 17 work days

This book focuses on actual morphofunctional findings of cells and tissues in living animal organs. Medical and biological scientists need to know the real in vivo morphology and immunolocalization of the molecular components in living animal organs. Recently, the live imaging of cells and tissues of animals with fluorescence-labeled proteins by gene manipulation has become more and more popular in biological fields. Current research, meanwhile, has revealed that immunohistochemical or morphological studies exclusively depend on living animal organs. The cryotechnique is one of the most useful tools for immunohistochemistry and bioimaging of animal organs. This book describes the epoch-making cryotechnique originally developed by the editors. The book also makes the management of living animal morphology more accessible not only for biomedical researchers but also for clinical doctors, providing a valuable resource work on the current perspectives of in vivo morphology.

Biomaterials in Tissue Engineering and Regenerative Medicine - From Basic Concepts to State of the Art Approaches (Hardcover,... Biomaterials in Tissue Engineering and Regenerative Medicine - From Basic Concepts to State of the Art Approaches (Hardcover, 1st ed. 2021)
Birru Bhaskar, Parcha Sreenivasa Rao, Naresh Kasoju, Vasagiri Nagarjuna, Rama Raju Baadhe
R3,972 Discovery Miles 39 720 Ships in 7 - 11 work days

This book comprehensively explores the basic concepts and applications of biomaterials in tissue engineering and regenerative medicine. The book is divided into four sections; the first section deals with the basic concepts and different types of biomaterials used in tissue engineering. The second section discusses the functional requirements and types of materials that are used in developing state-of-the-art of scaffolds for tissue engineering applications. The third section presents the applications of biomaterials for hard and soft tissue engineering, as well as for specialized tissue engineering. The last section addresses the future prospects of nanobiomaterials, intelligent biomaterials, and 3D bioprinting biomaterials in tissue engineering and regenerative medicine. It also discusses various in vitro disease models for tissue bioengineering and regenerative medicine. As such, it offers a valuable resource for students, researchers, scientists, entrepreneurs, and medical/healthcare professionals.

Oxidative Stress - Human Diseases and Medicine (Hardcover, 1st ed. 2021): Canhua Huang, Yuanyuan Zhang Oxidative Stress - Human Diseases and Medicine (Hardcover, 1st ed. 2021)
Canhua Huang, Yuanyuan Zhang
R3,687 Discovery Miles 36 870 Ships in 7 - 11 work days

This book offers a systematic review of the cutting-edge knowledge in stress medicine. Cellular redox imbalance, resulting from overproduction of reactive oxide species (ROS), leads to oxidative stress and subsequent occurrence and development of many diseases, such as cancer, diabetes, pain, etc. In addition, ROS can induce post-translational modification of proteins and play roles through redox signaling pathways. In this book, the authors attempt to re-define the key concepts in oxidative stress, such as oxidative eustress and oxidative distress, revisit the pivotal signaling of oxidative stress in human diseases, and discuss the debate in current anti-oxidant strategies, such as natural products and drug repurposing. This book serves as a reference to graduate students and researchers in this growing field.

Decellularized Materials - Preparations and Biomedical Applications (Hardcover, 1st ed. 2021): Xiao-Ming Li, Huiqi Xie Decellularized Materials - Preparations and Biomedical Applications (Hardcover, 1st ed. 2021)
Xiao-Ming Li, Huiqi Xie
R3,952 Discovery Miles 39 520 Ships in 7 - 11 work days

This book will consist of 8 chapters, in which important issues regarding decellularized materials (DMs) will be discussed. This book will provide special knowledge of materials for the persons with biomedical background, and special biomedical knowledge for the persons with the background of materials, which will hopefully become a valuable informative read for the researchers and students of biomedical engineering major.

Suppression and Regulation of Immune Responses - Methods and Protocols, Volume II (Hardcover, 1st ed. 2016): Maria Cristina... Suppression and Regulation of Immune Responses - Methods and Protocols, Volume II (Hardcover, 1st ed. 2016)
Maria Cristina Cuturi, Ignacio Anegon
R3,985 R2,468 Discovery Miles 24 680 Save R1,517 (38%) Ships in 12 - 17 work days

This second volume expands upon the previous edition with new research and objectives in immunoregulation and immune tolerance. Chapters cover topics ranging from new molecular and cellular mechanisms of tolerance; generation and characterization of mice regulatory macrophages; recent advances in the treatment of immune-mediated inflammatory disorders; and novel mechanisms and therapeutic perspectives on food allergies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Suppression and Regulation of Immune Responses: Methods and Protocols, Volume II is a great resource for current research and inspiration for new studies in immune tolerance.

The Evolutionary Origins of Life and Death (Hardcover): Pierre M Durand The Evolutionary Origins of Life and Death (Hardcover)
Pierre M Durand
R2,537 Discovery Miles 25 370 Ships in 7 - 11 work days

The question of why an individual would actively kill itself has long been an evolutionary mystery. Pierre M. Durand's ambitious book answers this question through close inspection of life and death in the earliest cellular life. As Durand shows us, cell death is a fascinating lens through which to examine the interconnectedness, in evolutionary terms, of life and death. It is a truism to note that one does not exist without the other, but just how does this play out in evolutionary history? These two processes have been studied from philosophical, theoretical, experimental, and genomic angles, but no one has yet integrated the information from these various disciplines. In this work, Durand synthesizes cellular studies of life and death looking at the origin of life and the evolutionary significance of programmed cellular death. The exciting and unexpected outcome of Durand's analysis is the realization that life and death exhibit features of coevolution. The evolution of more complex cellular life depended on the coadaptation between traits that promote life and those that promote death. In an ironic twist, it becomes clear that, in many circumstances, programmed cell death is essential for sustaining life.

Cellular Biophysics and Modeling - A Primer on the Computational Biology of Excitable Cells (Hardcover): Greg Conradi Smith Cellular Biophysics and Modeling - A Primer on the Computational Biology of Excitable Cells (Hardcover)
Greg Conradi Smith
R2,411 Discovery Miles 24 110 Ships in 12 - 17 work days

What every neuroscientist should know about the mathematical modeling of excitable cells. Combining empirical physiology and nonlinear dynamics, this text provides an introduction to the simulation and modeling of dynamic phenomena in cell biology and neuroscience. It introduces mathematical modeling techniques alongside cellular electrophysiology. Topics include membrane transport and diffusion, the biophysics of excitable membranes, the gating of voltage and ligand-gated ion channels, intracellular calcium signalling, and electrical bursting in neurons and other excitable cell types. It introduces mathematical modeling techniques such as ordinary differential equations, phase plane, and bifurcation analysis of single-compartment neuron models. With analytical and computational problem sets, this book is suitable for life sciences majors, in biology to neuroscience, with one year of calculus, as well as graduate students looking for a primer on membrane excitability and calcium signalling.

Structure and Function of Membrane Proteins (Hardcover, 1st ed. 2021): Ingeborg Schmidt-Krey, James C. Gumbart Structure and Function of Membrane Proteins (Hardcover, 1st ed. 2021)
Ingeborg Schmidt-Krey, James C. Gumbart
R4,759 Discovery Miles 47 590 Ships in 7 - 11 work days

This book examines detailed experimental and computational approaches for the analysis of many aspects vital to the understanding of membrane protein structure and function. Readers will receive guidance on the selection and use of methods for over-expression and purification, tools to characterize membrane proteins within different phospholipid bilayers, direction on functional studies, and approaches to determine the structures of membrane proteins. Detailed experimental steps for specific membrane proteins with critical notes allow the protocols to be modified to different systems. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of practical information and implementation advice that leads to excellent, reproducible results. Authoritative and up-to-date, Structure and Function Studies of Membrane Proteins serves as an ideal guide for biologists, biochemists, and biophysicists striving to further understand these essential proteins and their many biological roles.

Optogenetics - Light-Sensing Proteins and Their Applications in Neuroscience and Beyond (Hardcover, 2nd ed. 2021): Hiromu Yawo,... Optogenetics - Light-Sensing Proteins and Their Applications in Neuroscience and Beyond (Hardcover, 2nd ed. 2021)
Hiromu Yawo, Hideki Kandori, Amane Koizumi, Ryoichiro Kageyama
R4,388 Discovery Miles 43 880 Ships in 12 - 17 work days

This book, now in a thoroughly revised second edition, offers a comprehensive review of the rapidly growing field of optogenetics, in which light-sensing proteins are genetically engineered into cells in order to acquire information on cellular physiology in optical form or to enable control of specific network in the brain upon activation by light. Light-sensing proteins of various living organisms are now available to be exogenously expressed in neurons and other target cells both in vivo and in vitro. Cellular functions can thus be manipulated or probed by light. The new edition documents fully the extensive progress since publication of the first edition to provide an up-to-date overview of the physical, chemical, and biological properties of light-sensing proteins and their application in biological systems, particularly in neuroscience but also in medicine and the optical sciences. Underlying principles are explained and detailed information provided on a wide range of optogenetic tools for the observation and control of cellular signaling and physiology, gene targeting technologies, and optical methods for biological applications. In presenting the current status of optogenetics and emerging directions, this milestone publication will be a "must read" for all involved in research in any way related to optogenetics.

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