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Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > Cellular physiology

Molecular Diagnostics (Paperback): Anthony Warford, Nadege Presneau Molecular Diagnostics (Paperback)
Anthony Warford, Nadege Presneau
R1,011 Discovery Miles 10 110 Ships in 10 - 15 working days

One of the most notable trends in biomedical science in recent years has been the increasing use of molecular techniques as part of the diagnosis of disease. As such, there is a growing need for students to understand the technological basis of molecular analysis and to have a comprehensive appreciation of their use in diagnosis. Combining coverage of molecular techniques with their application to diagnostic pathology, this book provides students with a thorough and up to date appreciation of the scope of molecular analysis, the principles of the technology used, and thematic diagnostic application. As part of the Fundamentals of Biomedical Science series, the book provides a unique blend of theory and practice, featuring a range of learning features to help students assimilate the information presented quickly and effectively. It will be relevant to undergraduate students on a wide variety of biomedical pathways, cutting across traditional discipline boundaries to provide a unified overview of molecular diagnostics.

Methods in Molecular Biophysics - Structure, Dynamics, Function for Biology and Medicine (Hardcover, 2nd Revised edition):... Methods in Molecular Biophysics - Structure, Dynamics, Function for Biology and Medicine (Hardcover, 2nd Revised edition)
Nathan R. Zaccai, Igor N. Serdyuk, Joseph Zaccai
R1,582 Discovery Miles 15 820 Ships in 10 - 15 working days

Current techniques for studying biological macromolecules and their interactions are based on the application of physical methods, ranging from classical thermodynamics to more recently developed techniques for the detection and manipulation of single molecules. Reflecting the advances made in biophysics research over the past decade, and now including a new section on medical imaging, this new edition describes the physical methods used in modern biology. All key techniques are covered, including mass spectrometry, hydrodynamics, microscopy and imaging, diffraction and spectroscopy, electron microscopy, molecular dynamics simulations and nuclear magnetic resonance. Each method is explained in detail using examples of real-world applications. Short asides are provided throughout to ensure that explanations are accessible to life scientists, physicists and those with medical backgrounds. The book remains an unparalleled and comprehensive resource for graduate students of biophysics and medical physics in science and medical schools, as well as for research scientists looking for an introduction to techniques from across this interdisciplinary field.

Cellular Biophysics and Modeling - A Primer on the Computational Biology of Excitable Cells (Paperback): Greg Conradi Smith Cellular Biophysics and Modeling - A Primer on the Computational Biology of Excitable Cells (Paperback)
Greg Conradi Smith
R1,048 Discovery Miles 10 480 Ships in 10 - 15 working days

What every neuroscientist should know about the mathematical modeling of excitable cells. Combining empirical physiology and nonlinear dynamics, this text provides an introduction to the simulation and modeling of dynamic phenomena in cell biology and neuroscience. It introduces mathematical modeling techniques alongside cellular electrophysiology. Topics include membrane transport and diffusion, the biophysics of excitable membranes, the gating of voltage and ligand-gated ion channels, intracellular calcium signalling, and electrical bursting in neurons and other excitable cell types. It introduces mathematical modeling techniques such as ordinary differential equations, phase plane, and bifurcation analysis of single-compartment neuron models. With analytical and computational problem sets, this book is suitable for life sciences majors, in biology to neuroscience, with one year of calculus, as well as graduate students looking for a primer on membrane excitability and calcium signalling.

Prokaryotic Metabolism and Physiology (Hardcover, 2nd Revised edition): Byung Hong Kim, Geoffrey Michael Gadd Prokaryotic Metabolism and Physiology (Hardcover, 2nd Revised edition)
Byung Hong Kim, Geoffrey Michael Gadd
R3,528 R3,294 Discovery Miles 32 940 Save R234 (7%) Ships in 10 - 15 working days

Vast numbers of different prokaryotic microorganisms shape the biosphere, with diverse metabolic capabilities. Determination of genome sequences for a wide range of bacteria and archaea now requires an in-depth knowledge of prokaryotic metabolic function to give biochemical, physiological and ecological meaning to the genomic information. This new edition describes up-to-date knowledge of the key metabolic processes that occur under different conditions, and the cellular processes that determine prokaryotic roles in the environment, biotechnology and human health. Essential for students of microbiology, applied microbiology, biotechnology, genomics and systems biology, this advanced textbook covers prokaryotic structure, composition, nutrient transport, biosynthesis and growth. Newly characterised metabolic pathways are included, as well as the latest understanding of metabolic regulation and stress responses. Additionally, the link between energetics, growth and survival is discussed as well as the maintenance of genetic integrity by the bacterial immune system.

Prokaryotic Metabolism and Physiology (Paperback, 2nd Revised edition): Byung Hong Kim, Geoffrey Michael Gadd Prokaryotic Metabolism and Physiology (Paperback, 2nd Revised edition)
Byung Hong Kim, Geoffrey Michael Gadd
R1,338 Discovery Miles 13 380 Ships in 10 - 15 working days

Vast numbers of different prokaryotic microorganisms shape the biosphere, with diverse metabolic capabilities. Determination of genome sequences for a wide range of bacteria and archaea now requires an in-depth knowledge of prokaryotic metabolic function to give biochemical, physiological and ecological meaning to the genomic information. This new edition describes up-to-date knowledge of the key metabolic processes that occur under different conditions, and the cellular processes that determine prokaryotic roles in the environment, biotechnology and human health. Essential for students of microbiology, applied microbiology, biotechnology, genomics and systems biology, this advanced textbook covers prokaryotic structure, composition, nutrient transport, biosynthesis and growth. Newly characterised metabolic pathways are included, as well as the latest understanding of metabolic regulation and stress responses. Additionally, the link between energetics, growth and survival is discussed as well as the maintenance of genetic integrity by the bacterial immune system.

Cancer Stem Cells - Philosophy and Therapies (Hardcover): Lucie Laplane Cancer Stem Cells - Philosophy and Therapies (Hardcover)
Lucie Laplane
R910 R848 Discovery Miles 8 480 Save R62 (7%) Ships in 10 - 15 working days

An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Rather than eliminating all cancerous cells-with harmful side-effects for patients-CSC theory suggests that it is sufficient to target CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells-self-renewal and differentiation. According to this theory, only CSCs and no other cancer cells can induce tumor formation. To date, researchers have not agreed on the defining feature of CSCs-their stemness. Drawing from a philosophical perspective, Laplane shows that four ideas are in play: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell's relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers.

Anatomy, Histology, & Cell Biology: PreTest Self-Assessment & Review, Fourth Edition (Paperback, 4th edition): Robert Klein,... Anatomy, Histology, & Cell Biology: PreTest Self-Assessment & Review, Fourth Edition (Paperback, 4th edition)
Robert Klein, George C. Enders
R1,026 Discovery Miles 10 260 Ships in 7 - 11 working days

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. PreTest is the closest you can get to seeing the USMLE Step 1 before you take it 500 USMLE-type questions and answers! "This edition of PreTest is full of extremely high-yield information in a presentation that is logical and effective. The questions and explanations are invaluable, and the HY tables and figures make it easy to review important material efficiently." -- Gustaf Van Acker III, Fourth Year MD/PhD Candidate, University of Kansas School of Medicine "This book was an excellent refresher for anyone looking to review information for either their final course exam or for the USMLE Step 1." -- Ben Chidester, Second Year Medical Student, Eastern Virginia Medical School Great for course review and the USMLE Step 1, Anatomy, Histology, & Cell Biology: PreTest asks the right questions so you'll know the right answers. You'll find 500 clinical-vignette style questions and answers along with complete explanations of correct and incorrect answers. The content has been reviewed by students who recently passed their exams, so you know you are studying the most relevant and up-to-date material possible. No other study guide targets what you really need to know in order to pass like PreTest! Content that covers all the must-know topics: High-Yield Facts,Embryology: Early and General,Cell Biology: Membranes,Cell Biology: Cytoplasm,Cell Biology: Intracellular Trafficking,Cell Biology: Nucleus,Epithelium,Connective Tissues,Specialized Connective Tissues: Bones and Cartilage,Muscle and Cell Motility,Nervous System,Cardiovascular System, Blood and Bone Marrow,Lymphoid System and Cellular Immunology,Respiratory System,Integumentary System,Gastrointestinal Tract and Glands,Endocrine Glands,Reproductive System,Urinary System,Eye and Ear,Head and Neck Thorax,Abdomen,Pelvis,Extremities and Spine

Astrocytes - Wiring the Brain (Hardcover): Eliana Scemes, David C. Spray Astrocytes - Wiring the Brain (Hardcover)
Eliana Scemes, David C. Spray
R3,855 Discovery Miles 38 550 Ships in 10 - 15 working days

Astrocytes play diverse roles in central nervous system (CNS) function and dysfunction, and the connections that the astrocyte makes with other cells of the brain are essential for a variety of important neural tasks. Bringing together contributions from international experts at the top of their field, Astrocytes: Wiring the Brain emphasizes cellular connections and surveys the most current findings on astrocyte activity. The first section of the book identifies major astrocyte biomarkers and describes how they define the different connectivity domains. Next, the book examines the role of these connections. It explains how their function can be manipulated under physiological conditions and how dysfunction of the connectivity leads to aberrant brain performance. The final section explores the alterations of glia that have been observed in specific diseases of the brain. These include epilepsy, autoimmune encephalitis, Alzheimer's disease, autism, and major depression. The book identifies key mechanisms responsible for these alterations. An important and emerging field, astrocytes and their functions are critical to neuroscientists and neurologists, both in academia and in industry, particularly in the search for and development of new drugs to combat a variety of diseases affecting the CNS. As research continues to grow in this area, this volume will spur heightened advances and understanding into the effects of these neural cells on a range of pathologies.

High-Density Lipoproteins - From Basic Biology to Clinical Aspects (Hardcover): Christopher J. Fielding High-Density Lipoproteins - From Basic Biology to Clinical Aspects (Hardcover)
Christopher J. Fielding
R5,242 R4,776 Discovery Miles 47 760 Save R466 (9%) Ships in 10 - 15 working days

This book meets the long-awaited need for a comprehensive overview of the biological role of HDLs. Edited by one of the pioneers in HDL and cholesterol research, this monograph summarizes current knowledge on HDL turnover, regulation and physiology. Clearly structured, the various sections cover HDL structure, formation, secretion and removal, as well as plasma metabolic factors. The biological activities and clinical aspects are equally discussed, as is the impact of HDL on common diseases and their prevention.

Chromogranins: from Cell Biology to Physiology and Biomedicine (Hardcover, 1st ed. 2017): Bruno Tota Chromogranins: from Cell Biology to Physiology and Biomedicine (Hardcover, 1st ed. 2017)
Bruno Tota
R4,356 R3,453 Discovery Miles 34 530 Save R903 (21%) Ships in 10 - 15 working days

The volume is designed to provide an integrated overview of the results from the last fifteen years of research on Chromogranins in relation to cell biology, physiology and biomedicine. The different chapters highlight novel activities of these proteins, including their role in granule biogenesis, hormone co-storage, stimulus-processing-secretion coupling, autonomic sympathetic/parasympathetic balance, immune and cardiocirculatory function, and the response to stress. Biomedical aspects are also illustrated with focus on the prognostic and diagnostic significance of Chromogranin in the presence of tumors, cardiovascular diseases and inflammatory conditions. The volume is of interest for laboratory and clinical scientists, PhD and Post-doc students that will be inspired to go deep inside the molecular, biochemical, physiological, pharmacological and clinical aspects of these fascinating multifaceted proteins.

Cell Physiology (Paperback, Ed): David Landowne Cell Physiology (Paperback, Ed)
David Landowne
R1,401 Discovery Miles 14 010 Ships in 7 - 11 working days

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. A meticulous presentation of core essentials for a targeted, high-yield reviewThis is a concise, readable distillation of material you are required to know about cell physiology. Emphasizes understanding key concepts rather than merely memorizing facts Packed with self-study questions, explicit diagrams, and clinical examples Includes current and up-to-date basic and clinical science concepts

Histopathology (Paperback, 2nd Revised edition): Guy Orchard, Brian Nation Histopathology (Paperback, 2nd Revised edition)
Guy Orchard, Brian Nation
R1,126 Discovery Miles 11 260 Ships in 10 - 15 working days

Biomedical scientists are the foundation of modern healthcare, from cancer screening to diagnosing HIV, from blood transfusion for surgery to food poisoning and infection control. Without biomedical scientists the diagnosis of disease, the evaluation of the effectiveness of treatment, and research into the causes and cures of disease would not be possible. The Fundamentals of Biomedical Science series has been written to reflect the challenges of practicing biomedical science today. It draws together essential basic science with insights into laboratory practice to show how an understanding of the biology of disease is coupled to the analytical approaches that lead to diagnosis. Assuming only a minimum of prior knowledge, the series reviews the full range of disciplines to which a Biomedical Scientist may be exposed-from microbiology to cytopathology to transfusion science. Histopathology describes the processes and practices that are central to the role of the histopathology biomedical scientist, from presampling to diagnosis to laboratory management. It demonstrates throughout how an understanding of cell and tissue physiology is vital to the successful identification of clinical conditions.

Annual Plant Reviews - The Golgi Apparatus and the Plant Secretory Pathway (Hardcover, Volume 9): David G. Robinson Annual Plant Reviews - The Golgi Apparatus and the Plant Secretory Pathway (Hardcover, Volume 9)
David G. Robinson
R5,168 R4,590 Discovery Miles 45 900 Save R578 (11%) Ships in 10 - 15 working days

Annual Plant Reviews, Volume 9 The Golgi apparatus is at the fulcrum of secretory traffic, beginning at the endoplasmic reticulum and culminating at the cell surface or lytic/vacuolar compartments. Its major functions are protein glycosylation and polysaccharide synthesis, on one hand, and protein sorting on the other. With advances in our understanding of how the Golgi apparatus operates in plants, the possibility of manipulating the timing, type and site of delivery of secretory macromolecules is therefore becoming more and more feasible. This will be important not only for improving crop production, but also for increasing the use of plants as bioreactors for vaccines and other therapeutic agents. This volume concentrates on the major developments of the last few years, drawing attention to the distinct differences between the plant and non-plant Golgi apparatus and highlighting unsolved problems. A chapter is included on the yeast Golgi apparatus. This is a volume for researchers and professionals in plant cell biology, biochemistry, physiology and molecular biology.

Mitochondrial Biology - New Perspectives (Hardcover): Derek J. Chadwick, Jamie A Goode Mitochondrial Biology - New Perspectives (Hardcover)
Derek J. Chadwick, Jamie A Goode
R4,280 Discovery Miles 42 800 Ships in 10 - 15 working days

With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of mitochondrial fission and fusion. Further chapters address mitochondria and oxidative stress and their roles in cell signalling and cell death. The book includes extensive, fascinating discussion of the biochemistry of mitochondrial cell signalling (especially involving calcium) and of oxidative stress. The nature of the proteins engaged in these processes, many only recently discovered, is covered in detail.

Mitochondria have been strongly implicated in neurodegenerative diseases such as Parkinson's, Huntington's and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations. The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function.

Cellular Biophysics and Modeling - A Primer on the Computational Biology of Excitable Cells (Hardcover): Greg Conradi Smith Cellular Biophysics and Modeling - A Primer on the Computational Biology of Excitable Cells (Hardcover)
Greg Conradi Smith
R2,579 R2,385 Discovery Miles 23 850 Save R194 (8%) Ships in 10 - 15 working days

What every neuroscientist should know about the mathematical modeling of excitable cells. Combining empirical physiology and nonlinear dynamics, this text provides an introduction to the simulation and modeling of dynamic phenomena in cell biology and neuroscience. It introduces mathematical modeling techniques alongside cellular electrophysiology. Topics include membrane transport and diffusion, the biophysics of excitable membranes, the gating of voltage and ligand-gated ion channels, intracellular calcium signalling, and electrical bursting in neurons and other excitable cell types. It introduces mathematical modeling techniques such as ordinary differential equations, phase plane, and bifurcation analysis of single-compartment neuron models. With analytical and computational problem sets, this book is suitable for life sciences majors, in biology to neuroscience, with one year of calculus, as well as graduate students looking for a primer on membrane excitability and calcium signalling.

The Male Role in Pregnancy Loss and Embryo Implantation Failure (Hardcover, 1st ed. 2015): Richard Bronson The Male Role in Pregnancy Loss and Embryo Implantation Failure (Hardcover, 1st ed. 2015)
Richard Bronson
R4,345 R3,443 Discovery Miles 34 430 Save R902 (21%) Ships in 10 - 15 working days

Novel topics compiled in this one-of-a-kind volume provide tantalizing hints for clinical application through future translational research. Only recently have we come to ask what role the male might play in pregnancy loss and embryo implantation failure, beyond contributing an abnormal set of paternal chromosomes at fertilization. This volume explores the recent evidence that these conditions might also be related to the transmission of previously unrecognized chromosomal micro-deletions and duplications, or via the epigenetic dysregulation of early embryonic gene function by spermatozoal microRNAs or alterations in sperm DNA methylation patterning, or by DNA damage secondary to either reactive oxygen species or environmental toxicants. In addition, the composition of seminal plasma has been found to be highly complex, containing many factors that play important roles in altering the uterine environment and the female immune system permissive of embryo implantation and trophectoderm outgrowth leading to successful pregnancy. Coverage includes an examination of both spermatozoa and seminal fluid component factors.

Endothelial Progenitor Cells - A New Real Hope? (Hardcover, 1st ed. 2017): Carmela Rita Balistreri Endothelial Progenitor Cells - A New Real Hope? (Hardcover, 1st ed. 2017)
Carmela Rita Balistreri
R3,464 R2,625 Discovery Miles 26 250 Save R839 (24%) Ships in 10 - 15 working days

This book explores the role of endothelial progenitor cells (EPCs) in the context of regenerative medicine (RegMed). In particular, it reveals the value of RegMed as a new TM branch intended to improve the health and quality of life, by restoring, maintaining or enhancing tissue and functions of organs. The book is divided into three chapters, the first of which describes the relevance of translational medicine (TM) as a new research approach to counteract the imposing challengeof age-related diseases. Of the diverse RegMed approaches, particular attention is paid to stem/progenitor cell-based therapies, their benefits and shortcomings, as well as to the description of types of stem and progenitor cells considered for regenerative cell therapies, such as EPCs as emerging candidates for RegMed applications. In turn, the second chapter outlines the clinical relevance of EPCs as both potential predictors, diagnostic and prognostic biomarkers of age-related diseases and therapeutic agents,discussing their advantages, disadvantages, and conflicting data. Chapter three proposes a potential roadmap for revising the findings and creating a clearer picture of valid data, which can provide support for various important aspects, i.e.isolating and characterizing EPCs by establishing standardized criteria for EPC research, identifying appropriate sub-populations for cell therapy, timing, dosing, priming of cells,and defining delivery modes for different applications. The book concludes with an overview of innovative strategies that could improve the efficacy of cell therapy at all levels, including cell priming, bio-nanotechnology, and tissue engineering.

Lipids and Cellular Membranes in Amyloid Diseases (Hardcover): Raz Jelinek Lipids and Cellular Membranes in Amyloid Diseases (Hardcover)
Raz Jelinek
R4,129 R3,209 Discovery Miles 32 090 Save R920 (22%) Ships in 10 - 15 working days

Addressing one of the biggest riddles in current molecular cell biology, this ground-breaking monograph builds the case for the crucial involvement of lipids and membranes in the formation of amyloid deposits. Tying together recent knowledge from in vitro and in vivo studes, and built on a sound biophysical and biochemical foundation, this overview brings the reader up to date with current models of the interplay between membranes and amyloid formation.
Required reading for any researcher interested in amyloid formation and amyloid toxicity, and possible avenues for the prevention or treatment of neurodegenerative disorders.
From the contents:
* Interactions of Alpha-Synuclein with Lipids
* Interaction of hIAPP and its Precursors with Membranes
* Amyloid Polymorphisms: Structural Basis and Significance in Biology and Molecular Medicine
* The Role of Lipid Rafts in Alzheimer's Disease
* Alzheimer's Disease as a Membrane-Associated Enzymopathy of Beta-Amyloid Precursor Protein (APP) Secretases
* Impaired Regulation of Glutamate Receptor Channels and Signaling Molecules by Beta-Amyloid in Alzheimer's Disease
* Membrane Changes in BSE and Scrapie
* Experimental Approaches and Technical Challenges for Studying Amyloid-Membrane Interactions
and more

Stem Cells and Bone Tissue (Hardcover): Rajkumar Rajendram, Victor R. Preedy, Vinood B. Patel Stem Cells and Bone Tissue (Hardcover)
Rajkumar Rajendram, Victor R. Preedy, Vinood B. Patel
R3,228 Discovery Miles 32 280 Ships in 10 - 15 working days

Stem cells potentially offer a novel therapeutic platform to treat bone disease. They also help the scientist understand the molecular and cellular aetiology of bone disorders. Gaining knowledge on the nature and application of stem cell sciences is a prerequisite for understanding their potential in treating or preventing bone disorders. Stem Cells and Bone Tissue is designed to address these areas in three sections: Introductory Text and Sources of Stem Cells for Skeletal Tissue Cellular and Molecular Aspects Conditions, Applications, Treatments and Repairs Coverage includes general aspects of stems cells, sources of stems cells, isolation and purification, applications in regeneration, nanoscale topography, myostatin (GDF-8) signalling, c-Jun, Lnk, cell-derived Factor 1/CXCR4, chromatin remodelling, osteoporosis, osteoarthritis, hypophosphatasia, osteopetrosis, osteogenesis, and many other areas of merit too numerous to mention.

Biomaterials for Stem Cell Therapy - State of Art and Vision for the Future (Hardcover): Loredana De Bartolo, Augustinus Bader Biomaterials for Stem Cell Therapy - State of Art and Vision for the Future (Hardcover)
Loredana De Bartolo, Augustinus Bader
R5,378 Discovery Miles 53 780 Ships in 10 - 15 working days

Focused on stem cell applications, this book bridges the fields of biomaterials, offering new insights into constructing and regenerating tissues and organs. Its unique feature is linking diseases of the human body to current thinking on how to deal with them in the context of current concepts and technologies by means of an in-depth focus on biomaterials. The book assembles recent advances and covers a range of topics related to stem cell biology, biomaterials and technological approaches such as bioreactors written by top researchers in the field. Stem cells of both embryonic and adult origin are discussed with applications ranging, but not limited to, nerve regeneration, liver, pancreas, skin, trachea, cartilage and bone repair and cardiovascular therapy. Developments in the field reflecting the design and construction of the human body and its principal anatomy are discussed from a materials point of view. The book will be a valuable tool for biomaterial scientists, tissue engineers, clinicians as well as stem cell biologists involved in basic research and applications of adult and embryonic stem cells. It will also be a source of reference for students in biotechnology, biomedical engineering, biology, biochemistry, materials sciences, pharmaceuticals, and veterinary and human medicine.

Adhesion-GPCRs - Structure to Function (Hardcover, 2010 ed.): Simon Yona, Martin Stacey Adhesion-GPCRs - Structure to Function (Hardcover, 2010 ed.)
Simon Yona, Martin Stacey
R4,277 R3,342 Discovery Miles 33 420 Save R935 (22%) Ships in 10 - 15 working days

Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand-receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation.

Cellular and Molecular Basis of Mitochondrial Inheritance - Mitochondrial Disease and Fitness (Paperback, 1st ed. 2019): Peter... Cellular and Molecular Basis of Mitochondrial Inheritance - Mitochondrial Disease and Fitness (Paperback, 1st ed. 2019)
Peter Sutovsky
R2,397 R1,912 Discovery Miles 19 120 Save R485 (20%) Ships in 10 - 15 working days

This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers.

The Biology and Therapeutic Application of Mesenchymal Cells - 2 Volume Set (Hardcover): Kerry Atkinson The Biology and Therapeutic Application of Mesenchymal Cells - 2 Volume Set (Hardcover)
Kerry Atkinson
R10,647 R9,425 Discovery Miles 94 250 Save R1,222 (11%) Ships in 10 - 15 working days

The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues. Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues Written and edited by leaders in the field The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine. About the Author Kerry Atkinson, MBBS MD DTM&H FRCP FRACP, is an Adjunct Professor at the University of Queensland Centre for Clinical Research in Brisbane, Australia, an Adjunct Professor in the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia and a Specialist in Internal Medicine at the Salisbury Medical Centre, Brisbane, Queensland, Australia.

Melanins and Melanosomes - Biosynthesis, Structure, Physiological and Pathological Functions (Hardcover): Jan Borovansky,... Melanins and Melanosomes - Biosynthesis, Structure, Physiological and Pathological Functions (Hardcover)
Jan Borovansky, Patrick A. Riley
R3,505 R2,746 Discovery Miles 27 460 Save R759 (22%) Ships in 10 - 15 working days

The surface pigmentation of vertebrates is controlled by specialized cells able to synthesize a variety of pigments collectively known as melanins. Recent research has shown that melanins are produced not only in the skin but also in many other sites such as the eye, inner ear, muscles, etc., - where they are engaged in some unanticipated roles. The details of the synthetic pathway, the complexities of its regulation and biological significance that have been unravelled in recent research comprise a fascinating story and are of key importance in understanding the nature of diseases, including malignant melanoma one of the most rapidly spreading cancers.

Cellular Signal Transduction in Toxicology and Pharmacology - Data Collection, Analysis, and Interpretation (Hardcover):... Cellular Signal Transduction in Toxicology and Pharmacology - Data Collection, Analysis, and Interpretation (Hardcover)
Jonathan W. Boyd, Richard R Neubig
R3,067 R2,745 Discovery Miles 27 450 Save R322 (10%) Ships in 10 - 15 working days

Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets. Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research Includes detailed presentations of study methodology and data collection, analysis, and interpretation Discusses tools like experimental design, sample handling, analytical measurement techniques

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