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Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > Cellular physiology

Molecular Diagnostics (Paperback): Anthony Warford, Nadege Presneau Molecular Diagnostics (Paperback)
Anthony Warford, Nadege Presneau
R826 Discovery Miles 8 260 Shipped within 7 - 12 working days

One of the most notable trends in biomedical science in recent years has been the increasing use of molecular techniques as part of the diagnosis of disease. As such, there is a growing need for students to understand the technological basis of molecular analysis and to have a comprehensive appreciation of their use in diagnosis. Combining coverage of molecular techniques with their application to diagnostic pathology, this book provides students with a thorough and up to date appreciation of the scope of molecular analysis, the principles of the technology used, and thematic diagnostic application. As part of the Fundamentals of Biomedical Science series, the book provides a unique blend of theory and practice, featuring a range of learning features to help students assimilate the information presented quickly and effectively. It will be relevant to undergraduate students on a wide variety of biomedical pathways, cutting across traditional discipline boundaries to provide a unified overview of molecular diagnostics.

Cellular Biophysics and Modeling - A Primer on the Computational Biology of Excitable Cells (Paperback): Greg Conradi Smith Cellular Biophysics and Modeling - A Primer on the Computational Biology of Excitable Cells (Paperback)
Greg Conradi Smith
R856 Discovery Miles 8 560 Shipped within 7 - 12 working days

What every neuroscientist should know about the mathematical modeling of excitable cells. Combining empirical physiology and nonlinear dynamics, this text provides an introduction to the simulation and modeling of dynamic phenomena in cell biology and neuroscience. It introduces mathematical modeling techniques alongside cellular electrophysiology. Topics include membrane transport and diffusion, the biophysics of excitable membranes, the gating of voltage and ligand-gated ion channels, intracellular calcium signalling, and electrical bursting in neurons and other excitable cell types. It introduces mathematical modeling techniques such as ordinary differential equations, phase plane, and bifurcation analysis of single-compartment neuron models. With analytical and computational problem sets, this book is suitable for life sciences majors, in biology to neuroscience, with one year of calculus, as well as graduate students looking for a primer on membrane excitability and calcium signalling.

Prokaryotic Metabolism and Physiology (Paperback, 2nd Revised edition): Byung Hong Kim, Geoffrey Michael Gadd Prokaryotic Metabolism and Physiology (Paperback, 2nd Revised edition)
Byung Hong Kim, Geoffrey Michael Gadd
R1,158 R1,097 Discovery Miles 10 970 Save R61 (5%) Shipped within 7 - 12 working days

Vast numbers of different prokaryotic microorganisms shape the biosphere, with diverse metabolic capabilities. Determination of genome sequences for a wide range of bacteria and archaea now requires an in-depth knowledge of prokaryotic metabolic function to give biochemical, physiological and ecological meaning to the genomic information. This new edition describes up-to-date knowledge of the key metabolic processes that occur under different conditions, and the cellular processes that determine prokaryotic roles in the environment, biotechnology and human health. Essential for students of microbiology, applied microbiology, biotechnology, genomics and systems biology, this advanced textbook covers prokaryotic structure, composition, nutrient transport, biosynthesis and growth. Newly characterised metabolic pathways are included, as well as the latest understanding of metabolic regulation and stress responses. Additionally, the link between energetics, growth and survival is discussed as well as the maintenance of genetic integrity by the bacterial immune system.

Prokaryotic Metabolism and Physiology (Hardcover, 2nd Revised edition): Byung Hong Kim, Geoffrey Michael Gadd Prokaryotic Metabolism and Physiology (Hardcover, 2nd Revised edition)
Byung Hong Kim, Geoffrey Michael Gadd
R2,915 R2,717 Discovery Miles 27 170 Save R198 (7%) Shipped within 7 - 12 working days

Vast numbers of different prokaryotic microorganisms shape the biosphere, with diverse metabolic capabilities. Determination of genome sequences for a wide range of bacteria and archaea now requires an in-depth knowledge of prokaryotic metabolic function to give biochemical, physiological and ecological meaning to the genomic information. This new edition describes up-to-date knowledge of the key metabolic processes that occur under different conditions, and the cellular processes that determine prokaryotic roles in the environment, biotechnology and human health. Essential for students of microbiology, applied microbiology, biotechnology, genomics and systems biology, this advanced textbook covers prokaryotic structure, composition, nutrient transport, biosynthesis and growth. Newly characterised metabolic pathways are included, as well as the latest understanding of metabolic regulation and stress responses. Additionally, the link between energetics, growth and survival is discussed as well as the maintenance of genetic integrity by the bacterial immune system.

Lipids and Cellular Membranes in Amyloid Diseases (Hardcover): Raz Jelinek Lipids and Cellular Membranes in Amyloid Diseases (Hardcover)
Raz Jelinek
R3,836 R2,682 Discovery Miles 26 820 Save R1,154 (30%) Shipped within 7 - 13 working days

Addressing one of the biggest riddles in current molecular cell biology, this ground-breaking monograph builds the case for the crucial involvement of lipids and membranes in the formation of amyloid deposits. Tying together recent knowledge from in vitro and in vivo studes, and built on a sound biophysical and biochemical foundation, this overview brings the reader up to date with current models of the interplay between membranes and amyloid formation.
Required reading for any researcher interested in amyloid formation and amyloid toxicity, and possible avenues for the prevention or treatment of neurodegenerative disorders.
From the contents:
* Interactions of Alpha-Synuclein with Lipids
* Interaction of hIAPP and its Precursors with Membranes
* Amyloid Polymorphisms: Structural Basis and Significance in Biology and Molecular Medicine
* The Role of Lipid Rafts in Alzheimer's Disease
* Alzheimer's Disease as a Membrane-Associated Enzymopathy of Beta-Amyloid Precursor Protein (APP) Secretases
* Impaired Regulation of Glutamate Receptor Channels and Signaling Molecules by Beta-Amyloid in Alzheimer's Disease
* Membrane Changes in BSE and Scrapie
* Experimental Approaches and Technical Challenges for Studying Amyloid-Membrane Interactions
and more

Methods in Molecular Biophysics - Structure, Dynamics, Function for Biology and Medicine (Hardcover, 2nd Revised edition):... Methods in Molecular Biophysics - Structure, Dynamics, Function for Biology and Medicine (Hardcover, 2nd Revised edition)
Nathan R. Zaccai, Igor N. Serdyuk, Joseph Zaccai
R1,278 Discovery Miles 12 780 Shipped within 7 - 12 working days

Current techniques for studying biological macromolecules and their interactions are based on the application of physical methods, ranging from classical thermodynamics to more recently developed techniques for the detection and manipulation of single molecules. Reflecting the advances made in biophysics research over the past decade, and now including a new section on medical imaging, this new edition describes the physical methods used in modern biology. All key techniques are covered, including mass spectrometry, hydrodynamics, microscopy and imaging, diffraction and spectroscopy, electron microscopy, molecular dynamics simulations and nuclear magnetic resonance. Each method is explained in detail using examples of real-world applications. Short asides are provided throughout to ensure that explanations are accessible to life scientists, physicists and those with medical backgrounds. The book remains an unparalleled and comprehensive resource for graduate students of biophysics and medical physics in science and medical schools, as well as for research scientists looking for an introduction to techniques from across this interdisciplinary field.

Cancer Stem Cells - Philosophy and Therapies (Hardcover): Lucie Laplane Cancer Stem Cells - Philosophy and Therapies (Hardcover)
Lucie Laplane
R687 Discovery Miles 6 870 Shipped within 7 - 13 working days

An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Rather than eliminating all cancerous cells-with harmful side-effects for patients-CSC theory suggests that it is sufficient to target CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells-self-renewal and differentiation. According to this theory, only CSCs and no other cancer cells can induce tumor formation. To date, researchers have not agreed on the defining feature of CSCs-their stemness. Drawing from a philosophical perspective, Laplane shows that four ideas are in play: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell's relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers.

Atlas of the Morphology of the Human Cerebral Cortex on the Average MNI Brain (Hardcover): Michael Petrides Atlas of the Morphology of the Human Cerebral Cortex on the Average MNI Brain (Hardcover)
Michael Petrides
R3,966 R2,971 Discovery Miles 29 710 Save R995 (25%) Shipped within 7 - 12 working days

This cytoarchitectonic atlas of the human cerebral cortex depicts the cellular structure of the human cortex, detailing the arrangement of neuronal cell bodies as well as the relationships between cytoarchitectonic boundaries and anatomical landmarks. Presentation in MNI Stereotaxic Space will enables the atlas to serves as a useful working tool for structural/functional neuroimagers attempting to identify the cytoarchitectonic area within which a functional activation or a structural change has occurred. An introductory section discusses the history and current state of cytoarchitectonic studies, and a separate chapter on methods is also provided. Mapping of the frontal lobe, parietal lobe, insula, temporal lobe, occipital lobe and white matter fascicule follows.
Architectonic areas presented on average MNI brain (rather than a single brain), so individual peculiarities of the surface morphology of any given brain are regularized, thus helping the reader to see the essence of the location of an area.

Features full-page high quality photomicrographs for each cytoarchitectonic area of the cortex, with supplementary zoom images of particular details.

Offers commentary on the relation of sulci and gyri to architectonic areas, which will be useful to those looking to identify the cortical area within which functional or structural changes happened

Contains section discussing white matter fasciculi that permit connectivity between the cytoarchitectonic areas

Commentary pages on relationship to nonhuman primate cortex (macaque monkey) enables links to be made to the primate species in which most of the experimental anatomical and physiological information has been and continues to be gathered.

Anatomy, Histology, & Cell Biology: PreTest Self-Assessment & Review (Paperback, 4th edition): Robert Klein, George C. Enders Anatomy, Histology, & Cell Biology: PreTest Self-Assessment & Review (Paperback, 4th edition)
Robert Klein, George C. Enders
R792 Discovery Miles 7 920 Shipped within 7 - 11 working days

PreTest is the closest you can get to seeing the USMLE Step 1 before you take it

500 USMLE-type questions and answers

""This edition of "PreTest" is full of extremely high-yield information in a presentation that is logical and effective. The questions and explanations are invaluable, and the HY tables and figures make it easy to review important material efficiently."" -- Gustaf Van Acker III, Fourth Year MD/PhD Candidate, University of Kansas School of Medicine

""This book was an excellent refresher for anyone looking to review information for either their final course exam or for the USMLE Step 1."" -- Ben Chidester, Second Year Medical Student, Eastern Virginia Medical School

Great for course review and the USMLE Step 1, "Anatomy, Histology, & Cell Biology: PreTest" asks the right questions so you'll know the right answers. You'll find 500 clinical-vignette style questions and answers along with complete explanations of correct and incorrect answers. The content has been reviewed by students who recently passed their exams, so you know you are studying the most relevant and up-to-date material possible. No other study guide targets what you really need to know in order to pass like "PreTest"

Content that covers all the must-know topics:
High-Yield Facts, Embryology: Early and General, Cell Biology: Membranes, Cell Biology: Cytoplasm, Cell Biology: Intracellular Trafficking, Cell Biology: Nucleus, Epithelium, Connective Tissues, Specialized Connective Tissues: Bones and Cartilage, Muscle and Cell Motility, Nervous System, Cardiovascular System, Blood and Bone Marrow, Lymphoid System and Cellular Immunology, Respiratory System, Integumentary System, Gastrointestinal Tract and Glands, Endocrine Glands, Reproductive System, Urinary System, Eye and Ear, Head and Neck Thorax, Abdomen, Pelvis, Extremities and Spine

Chromogranins: from Cell Biology to Physiology and Biomedicine (Hardcover, 1st ed. 2017): Bruno Tota Chromogranins: from Cell Biology to Physiology and Biomedicine (Hardcover, 1st ed. 2017)
Bruno Tota
R3,598 R2,848 Discovery Miles 28 480 Save R750 (21%) Shipped within 7 - 12 working days

The volume is designed to provide an integrated overview of the results from the last fifteen years of research on Chromogranins in relation to cell biology, physiology and biomedicine. The different chapters highlight novel activities of these proteins, including their role in granule biogenesis, hormone co-storage, stimulus-processing-secretion coupling, autonomic sympathetic/parasympathetic balance, immune and cardiocirculatory function, and the response to stress. Biomedical aspects are also illustrated with focus on the prognostic and diagnostic significance of Chromogranin in the presence of tumors, cardiovascular diseases and inflammatory conditions. The volume is of interest for laboratory and clinical scientists, PhD and Post-doc students that will be inspired to go deep inside the molecular, biochemical, physiological, pharmacological and clinical aspects of these fascinating multifaceted proteins.

Melanins and Melanosomes - Biosynthesis, Structure, Physiological and Pathological Functions (Hardcover): Jan Borovansky,... Melanins and Melanosomes - Biosynthesis, Structure, Physiological and Pathological Functions (Hardcover)
Jan Borovansky, Patrick A. Riley
R3,256 R2,286 Discovery Miles 22 860 Save R970 (30%) Shipped within 7 - 13 working days

The surface pigmentation of vertebrates is controlled by specialized cells able to synthesize a variety of pigments collectively known as melanins. Recent research has shown that melanins are produced not only in the skin but also in many other sites such as the eye, inner ear, muscles, etc., - where they are engaged in some unanticipated roles. The details of the synthetic pathway, the complexities of its regulation and biological significance that have been unravelled in recent research comprise a fascinating story and are of key importance in understanding the nature of diseases, including malignant melanoma one of the most rapidly spreading cancers.

Histopathology (Paperback, 2nd Revised edition): Guy Orchard, Brian Nation Histopathology (Paperback, 2nd Revised edition)
Guy Orchard, Brian Nation
R921 Discovery Miles 9 210 Shipped within 7 - 12 working days

Biomedical scientists are the foundation of modern healthcare, from cancer screening to diagnosing HIV, from blood transfusion for surgery to food poisoning and infection control. Without biomedical scientists the diagnosis of disease, the evaluation of the effectiveness of treatment, and research into the causes and cures of disease would not be possible. The Fundamentals of Biomedical Science series has been written to reflect the challenges of practicing biomedical science today. It draws together essential basic science with insights into laboratory practice to show how an understanding of the biology of disease is coupled to the analytical approaches that lead to diagnosis. Assuming only a minimum of prior knowledge, the series reviews the full range of disciplines to which a Biomedical Scientist may be exposed-from microbiology to cytopathology to transfusion science. Histopathology describes the processes and practices that are central to the role of the histopathology biomedical scientist, from presampling to diagnosis to laboratory management. It demonstrates throughout how an understanding of cell and tissue physiology is vital to the successful identification of clinical conditions.

High-Density Lipoproteins - From Basic Biology to Clinical Aspects (Hardcover): Christopher J. Fielding High-Density Lipoproteins - From Basic Biology to Clinical Aspects (Hardcover)
Christopher J. Fielding
R5,295 R3,695 Discovery Miles 36 950 Save R1,600 (30%) Shipped within 7 - 13 working days

This book meets the long-awaited need for a comprehensive overview of the biological role of HDLs. Edited by one of the pioneers in HDL and cholesterol research, this monograph summarizes current knowledge on HDL turnover, regulation and physiology. Clearly structured, the various sections cover HDL structure, formation, secretion and removal, as well as plasma metabolic factors. The biological activities and clinical aspects are equally discussed, as is the impact of HDL on common diseases and their prevention.

Cellular and Molecular Basis of Mitochondrial Inheritance - Mitochondrial Disease and Fitness (Paperback, 1st ed. 2019): Peter... Cellular and Molecular Basis of Mitochondrial Inheritance - Mitochondrial Disease and Fitness (Paperback, 1st ed. 2019)
Peter Sutovsky
R1,980 R1,578 Discovery Miles 15 780 Save R402 (20%) Shipped within 7 - 12 working days

This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers.

Matrix Metalloproteinases In Health And Disease: Sculpting The Human Body (Hardcover): Constance E. Brinckerhoff Matrix Metalloproteinases In Health And Disease: Sculpting The Human Body (Hardcover)
Constance E. Brinckerhoff
R2,540 R2,351 Discovery Miles 23 510 Save R189 (7%) Shipped within 7 - 12 working days

The biochemistry and cell biology of Matrix Metalloproteinases (MMPs) are not necessarily straightforward, but basic information on the history of these enzymes, their various functions that extend far beyond the cleaving of the extracellular matrix, and the complex mechanisms that control their expression are valuable to both scientists and clinicians. This volume summarizes the salient features and functions of MMPs and applies this information in a practical manner in order to understand how they contribute to normal physiology and pathology of selected diseases. Chapters by noted clinicians Jean-Michel Dayer, MD in rheumatology, Jian Cao, MD in oncology, and Peter Libby, MD in cardiology, represent important practical and clinically-oriented contributions.

Cell Physiology (Paperback, Ed): David Landowne Cell Physiology (Paperback, Ed)
David Landowne
R1,082 Discovery Miles 10 820 Shipped within 7 - 11 working days

"A meticulous presentation of core essentials for a targeted, high-yield review"

This is a concise, readable distillation of material you are required to know about cell physiology. Emphasizes understanding key concepts rather than merely memorizing facts Packed with self-study questions, explicit diagrams, and clinical examples Includes current and up-to-date basic and clinical science concepts

Cellular Biophysics and Modeling - A Primer on the Computational Biology of Excitable Cells (Hardcover): Greg Conradi Smith Cellular Biophysics and Modeling - A Primer on the Computational Biology of Excitable Cells (Hardcover)
Greg Conradi Smith
R2,130 R1,964 Discovery Miles 19 640 Save R166 (8%) Shipped within 7 - 12 working days

What every neuroscientist should know about the mathematical modeling of excitable cells. Combining empirical physiology and nonlinear dynamics, this text provides an introduction to the simulation and modeling of dynamic phenomena in cell biology and neuroscience. It introduces mathematical modeling techniques alongside cellular electrophysiology. Topics include membrane transport and diffusion, the biophysics of excitable membranes, the gating of voltage and ligand-gated ion channels, intracellular calcium signalling, and electrical bursting in neurons and other excitable cell types. It introduces mathematical modeling techniques such as ordinary differential equations, phase plane, and bifurcation analysis of single-compartment neuron models. With analytical and computational problem sets, this book is suitable for life sciences majors, in biology to neuroscience, with one year of calculus, as well as graduate students looking for a primer on membrane excitability and calcium signalling.

Mitochondrial Biology - New Perspectives (Hardcover): Derek J. Chadwick, Jamie A Goode Mitochondrial Biology - New Perspectives (Hardcover)
Derek J. Chadwick, Jamie A Goode
R3,237 R3,005 Discovery Miles 30 050 Save R232 (7%) Shipped within 7 - 13 working days

With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of mitochondrial fission and fusion. Further chapters address mitochondria and oxidative stress and their roles in cell signalling and cell death. The book includes extensive, fascinating discussion of the biochemistry of mitochondrial cell signalling (especially involving calcium) and of oxidative stress. The nature of the proteins engaged in these processes, many only recently discovered, is covered in detail.

Mitochondria have been strongly implicated in neurodegenerative diseases such as Parkinson's, Huntington's and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations. The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function.

Annual Plant Reviews - The Golgi Apparatus and the Plant Secretory Pathway (Hardcover, Volume 9): David G. Robinson Annual Plant Reviews - The Golgi Apparatus and the Plant Secretory Pathway (Hardcover, Volume 9)
David G. Robinson
R4,258 R2,973 Discovery Miles 29 730 Save R1,285 (30%) Shipped within 7 - 13 working days

Annual Plant Reviews, Volume 9 The Golgi apparatus is at the fulcrum of secretory traffic, beginning at the endoplasmic reticulum and culminating at the cell surface or lytic/vacuolar compartments. Its major functions are protein glycosylation and polysaccharide synthesis, on one hand, and protein sorting on the other. With advances in our understanding of how the Golgi apparatus operates in plants, the possibility of manipulating the timing, type and site of delivery of secretory macromolecules is therefore becoming more and more feasible. This will be important not only for improving crop production, but also for increasing the use of plants as bioreactors for vaccines and other therapeutic agents. This volume concentrates on the major developments of the last few years, drawing attention to the distinct differences between the plant and non-plant Golgi apparatus and highlighting unsolved problems. A chapter is included on the yeast Golgi apparatus. This is a volume for researchers and professionals in plant cell biology, biochemistry, physiology and molecular biology.

The Male Role in Pregnancy Loss and Embryo Implantation Failure (Hardcover, 1st ed. 2015): Richard Bronson The Male Role in Pregnancy Loss and Embryo Implantation Failure (Hardcover, 1st ed. 2015)
Richard Bronson
R3,590 R2,840 Discovery Miles 28 400 Save R750 (21%) Shipped within 7 - 12 working days

Novel topics compiled in this one-of-a-kind volume provide tantalizing hints for clinical application through future translational research. Only recently have we come to ask what role the male might play in pregnancy loss and embryo implantation failure, beyond contributing an abnormal set of paternal chromosomes at fertilization. This volume explores the recent evidence that these conditions might also be related to the transmission of previously unrecognized chromosomal micro-deletions and duplications, or via the epigenetic dysregulation of early embryonic gene function by spermatozoal microRNAs or alterations in sperm DNA methylation patterning, or by DNA damage secondary to either reactive oxygen species or environmental toxicants. In addition, the composition of seminal plasma has been found to be highly complex, containing many factors that play important roles in altering the uterine environment and the female immune system permissive of embryo implantation and trophectoderm outgrowth leading to successful pregnancy. Coverage includes an examination of both spermatozoa and seminal fluid component factors.

Effects of Exercise on Hypertension - From Cells to Physiological Systems (Hardcover, 1st ed. 2015): Linda S. Pescatello Effects of Exercise on Hypertension - From Cells to Physiological Systems (Hardcover, 1st ed. 2015)
Linda S. Pescatello
R2,833 R2,379 Discovery Miles 23 790 Save R454 (16%) Shipped within 7 - 12 working days

As the first primer on the effects of exercise on human hypertension, Effects of Exercise on Hypertension: From Cells to Physiological Systems provides the state-of-the-art effects of exercise on the many possible mechanisms underlying essential hypertension in humans. The book contains chapters by distinguished experts on the effects of exercise on physiological systems known to be involved in hypertension development and maintenance as well as less well known aspects of hypertension such as 24-hour ambulatory blood pressure profile and oxidative stress. An emerging area, the effects of resistance exercise training on blood pressure is also covered. A unique aspect of the book is that it covers the effects of exercise mimetics on vascular cell adaptations in order to begin to elucidate some of the cellular mechanisms that may underlie blood pressure reductions with exercise training. Lastly, the book will end with a chapter on the interactive effects of genes and exercise on blood pressure. Chapters are grouped by physiological system or mechanism. The text begins with two overview chapters; one on the general effects of aerobic exercise training and the second on the general effects of resistance exercise training on blood pressure. Each chapter begins with a bulleted list of key points. Effects of Exercise on Hypertension: From Cells to Physiological Systems will be of great value to professional individuals in cardiovascular medicine, the cardiovascular sciences, allied health care professionals, and medical and graduate students in the cardiovascular sciences and medicine.

Stem Cells: A Very Short Introduction (Paperback): Jonathan Slack Stem Cells: A Very Short Introduction (Paperback)
Jonathan Slack
R117 R104 Discovery Miles 1 040 Save R13 (11%) Shipped within 4 - 9 working days

The topic of stem cells has been very high profile in the media in recent years. There is much public interest in stem cells but also much confusion and misinformation, with some companies already offering 'stem cell products' and bogus 'stem cell therapies'. In this Very Short Introduction, Jonathan Slack introduces stem cells; what they are, what scientists do with them, what stem cell therapies are available today, and how they might be used in future. Despite important advances, clinical applications of stem cells are still in their infancy. Most real stem cell therapy today is some form of bone marrow transplantation. Slack introduces stem cells by explaining the difference between embryonic stem cells, which exist only in laboratory cultures, and tissue-specific stem cells, which exist in our bodies. Embryonic stem cells can become any cell type in the body, so diseases that may in future be treated by functional cells derived from these sorts of stem cell include diabetes, Parkinson's disease, heart disease, and spinal trauma. He then goes on to discuss the properties of tissue-specific stem cells and the important technique of bone marrow transplantation. Slack concludes by analysing how medical innovation has occurred in this area in the past, and draws out some of the lessons for the development of new therapies in the future. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Adhesion-GPCRs - Structure to Function (Hardcover, 2010 ed.): Simon Yona, Martin Stacey Adhesion-GPCRs - Structure to Function (Hardcover, 2010 ed.)
Simon Yona, Martin Stacey
R3,533 R2,757 Discovery Miles 27 570 Save R776 (22%) Shipped within 7 - 12 working days

Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand-receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation.

Extracellular and Intracellular Signaling (Hardcover): James D. Adams Jr., Keith Parker Extracellular and Intracellular Signaling (Hardcover)
James D. Adams Jr., Keith Parker; Series edited by David E Thurston, Ana Martinez, Salvatore Guccione, …
R3,212 Discovery Miles 32 120 Shipped within 7 - 12 working days

Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. They are causative agents for diseases including hypertension, diabetes, heart disease, and arthritis so offer new, and often more approachable, targets for drug design. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets. Written by colleagues at the same institution, but with contributions from leading international authorities, it is the result of close cooperation between the authors of different chapters. Readers are introduced to a new approach to disease causation by adipokines and toxic lipids. Heart disease, migraines, stroke, Alzheimer's disease, diabetes, cancer, and arthritis are approached from the perspective of prevention and treatment by alteration of extracellular signalling. Evidence is presented that the avoidance of toxic lifestyles can reduce the incidence of such illnesses and new therapeutic targets involving adipokines, ceramide and endocannabinoids are discussed.

RNA Exosome (Hardcover, 2010 ed.): Torben Heick Jensen RNA Exosome (Hardcover, 2010 ed.)
Torben Heick Jensen
R3,527 R2,750 Discovery Miles 27 500 Save R777 (22%) Shipped within 7 - 12 working days

The diversity of RNAs inside living cells is amazing. We have known of the more "classic" RNA species: mRNA, tRNA, rRNA, snRNA and snoRNA for some time now, but in a steady stream new types of molecules are being described as it is becoming clear that most of the genomic information of cells ends up in RNA. To deal with the enormous load of resulting RNA processing and degradation reactions, cells need adequate and efficient molecular machines. The RNA exosome is arising as a major facilitator to this effect. Structural and functional data gathered over the last decade have illustrated the biochemical importance of this multimeric complex and its many co-factors, revealing its enormous regulatory power. By gathering some of the most prominent researchers in the exosome field, it is the aim of this volume to introduce this fascinating protein complex as well as to give a timely and rich account of its many functions. The exosome was discovered more than a decade ago by Phil Mitchell and David Tollervey by its ability to trim the 3'end of yeast, S. cerevisiae, 5. 8S rRNA. In a historic account they laid out the events surrounding this identification and the subsequent birth of the research field. In the chapter by Kurt Januszyk and Christopher Lima the structural organization of eukaryotic exosomes and their evolutionary counterparts in bacteria and archaea are discussed in large part through presentation of structures.

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