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This comprehensive review of the factors that affect the harvesting and preparation of oocytes and the management of embryos will allow practitioners to make evidence-based decisions for successful IVF. The book reviews and re-considers the value of strategies and outcomes in the management of fertility and conception rates, centred on the production of oocytes, and successful development of the embryo. Authored by leading experts in the field, chapters engage with treatments and strategies that affect the production of oocytes and embryos, optimizing outcomes in the management of female fertility, conception rates, and live births. This vital guide covers controlled ovarian hyperstimulation, the role of AMH in determining ovarian reserve, and primary stimulation agents and the use of adjuncts. Integral for all clinicians and embryologists working in reproductive medicine units, readers are provided with evidence-based, comprehensive advice and review of all factors affecting the management of oocytes and the embryo that are vital for successful IVF cycles.
This clear, perceptive and incredibly helpful book enables women to empower themselves to deal with the difficult and emotionally fraught issues surrounding infertility. Written by experienced counsellor Claire Hall and fertility expert Dr Devora Lieberman, Empowered Fertility is a practical guide for women to help them through the experience of infertility and emerge with their mental wellbeing, friendships, relationships and finances intact. It contains clear, well-structured information and offers practical guidance. Each section of the book gives the reader information and support to address physical, psychological, emotional and social challenges that can arise when dealing with infertility, and also with IVF treatment. Subjects include managing expectations, dealing with fear, releasing control and handling changes in relationships. The reader can make use of the coaching tools and exercises to help with each step. For those who are starting or are in the midst of IVF treatment, the last section of the book forms an IVF Cycle Handbook, to guide women through their experience.
It's the first great mystery: where did you come from? How did your cells know what to build? What are bones made from? When did your eyes start working, and what did they see?
Join Katharina Vestre on an adventure to relive your very first moments. From your first cell to your first breath, this is your story as you have never heard it before.
Did you know that it took three attempts to make your kidneys? Or that tiny twirling hairs on your back showed your other organs where to go? Or that hiccups are probably a legacy from our ancient, underwater ancestors?
With the help of some cutting-edge science and a wry sense of humour, Vestre reveals all this and more. Like: how sperm know which way to swim. Why sex and gender are more complicated than one might think. What you have in common with every living being, and why you are unique. Set off on a true voyage of discovery through an inner universe whose secrets we are still unravelling. A miniature drama of cosmic significance, this is the amazing story of how you became you.
An age old mystery, the development of the microscopic embryo into
exceedingly complex plants and animals--into roses and cacti,
elephants and blue whales, apes and human beings--stands as one of
the most fundamental and important questions facing modern
biologists. How does one cell give rise
As our understanding of the human body broadens, so does the need for a comprehensive text that encompasses all aspects of human development. Essential Human Development is a great course companion that focuses on the human life cycle, ideal for the undergraduate student new to these fields, or for qualified practitioners looking for a reference guide. Featuring key information points and self-test assessments in each chapter, the book is organised in an accessible manner, beginning with fertilisation and embryology, then moving on to obstetric medicine, neonatal care and child health, with the final section exploring gynaecological medicine. Ensuring that information is placed in context to aid understanding, Essential Human Development is the perfect support for the modern medical school curriculum, as well as a vital reminder of the core information needed whilst on a women or child health clinical placement.
How does life begin? What drives a newly fertilized egg to keep dividing and growing until it becomes 40 trillion cells, a greater number than stars in the galaxy? How do these cells know how to make a human, from lips to heart to toes? How does your body build itself?
Magdalena Zernicka-Goetz was pregnant at 42 when a routine genetic test came back with that dreaded word: abnormal. A quarter of sampled cells contained abnormalities and she was warned her baby had an increased risk of being miscarried or born with birth defects. Six months later she gave birth to a healthy baby boy and her research on mice embryos went on to prove that – as she had suspected – the embryo has an amazing and previously unknown ability to correct abnormal cells at an early stage of its development.
The Dance of Life will take you inside the incredible world of life just as it begins and reveal the wonder of the earliest and most profound moments in how we become human. Through Magda’s trailblazing research as a professor at Cambridge – where she has doubled the survival time of human embryos in the laboratory, and made the first artificial embryo-like structures from stem cells – you’ll discover how early life is programmed to repair and organise itself, what this means for the future of pregnancy, and how we might one day solve IVF disorders, prevent miscarriages and learn more about the dance of life as it starts to take shape.
The Dance of Life is a moving celebration of the balletic beauty of life’s beginnings.
"Beautifully illustrated, detailed and clear, this is a wonderful introduction to human reproduction" - Professor Alice Roberts Follow the amazing transformation that occurs as a baby develops from a single cell into a fully formed human body. Hundreds of spectacular images show you the progress of human pregnancy in unprecedented detail. The computer generated imagery, illustrations, scans, and photographs show exactly how a baby changes and grows during pregnancy, and how the female body adapts to carry it. A chapter on labour and birth explains these processes with step-by-step illustrations and easy-to-grasp text. The Science of Pregnancy also looks at the nature of human pregnancy, including how it evolved, and explores the anatomy and physiology of both the male and female reproductive systems. The mysteries of DNA and genetics are unravelled and explained in clear, illustrated detail, including patterns of inheritance and the interplay of genes and environment. The book also provides straightforward, illustrated information on possible problems before, during, and after birth. Fascinating, clear, and authoritative, this new and updated edition of The Science of Pregnancy is the ideal visual guide for prospective parents and medical and midwifery students
The first edition of Color Atlas of Fetal and Neonatal Histology was an important step in updating the histology texts available to practicing pathologists and pathology trainees who perform fetal autopsy and/or participate in research involving fetal tissues. It was a well-received volume that filled a major gap in pathology references related to normal histology and provided a comprehensive, state-of-the art review of fetal and neonatal histology. While the basics of fetal histology have changed little in the intervening years since publication of the first edition, this successor edition provides new insights and a fresh perspective. This book contains six new chapters including: blood vessels and lymphatics, external genitalia, eye, ear, skin, and maceration changes. Many existing chapters have also been expanded to address a greater breadth of fetal and neonatal histology such as postnatal testis development and the cardiac conduction system. The "Special Considerations" sections were also expanded in many chapters to address particularly problematic issues within individual organ systems. The book reviews the histology of the major organ systems in the fetus and neonate and provides detailed images, up-to-date references, and practical guidelines for identifying tissues across all gestational ages of development. The second edition of Color Atlas of Fetal and Neonatal Histology serves as the ultimate go-to resource for pathologists and researchers dealing with, and interested in, fetal and neonatal histology. It provides a comprehensive summary of the current status of the field with excellent and extensive illustrative examples that help guide the clinical study of fetal and neonatal histology and stimulate investigative efforts with fetal tissue.
Embryology at a Glance is a highly illustrated and innovative introduction to key embryological concepts, with concise, memorable descriptions of major embryological developments. This new edition covers the basic principles of human development, from mitosis and meiosis, before exploring the primary formation of each body system, including the development of the musculoskeletal, circulatory, digestive, reproductive, and nervous systems during the foetal and neonatal periods. Key features include: New chapters on cell signalling genes, stem cells, and antenatal screening for common congenital and genetic defects Full colour photographs and illustrations Links to clinical practice highlighted throughout Timelines of each developmental stage MCQs and EMQs for revision and review A companion website at www.ataglanceseries.com/embryology featuring 15 brand new animations, and podcasts to help clearly explain the processes that occur during development. An additional instructor resource contains an image bank of all the figures from the book to aid teaching this fascinating area Embryology at a Glance provides the perfect alternative to the overwhelming detail seen in conventional embryology texts. It provides just the right level of detail on embryology and congenital abnormalities for all medical students and health professionals to develop a thorough understanding of human development and its implications for clinical practice.
Extensively revised to incorporate recent research and current clinical practice, The Developing Human: Clinically Oriented Embryology, 11th Edition, covers all aspects of normal and abnormal embryonic and fetal development. In a clear, concise manner and lavishly illustrated throughout, this textbook is designed to successfully meet the needs of medical and health sciences profession students, as well as those in graduate programs. It provides an easy-to-digest, comprehensive review of what can be a complex and challenging subject. BONUS online features such as multiple-choice questions and narrated animations further support student success. Guides readers month by month and stage by stage through embryo and fetal organ and systems development, using full-color photographs of clinical cases, relevant modern medical imaging, and numerous high-quality supportive figures. Includes many new 3D HD color rendered images of embryos and fetuses, as well as 3D reconstructions of whole embryos. Provides clinically-oriented problems for each chapter, with corresponding answers and explanations designed to facilitate discussion and learning. In addition, multiple-choice questions and answers are available online for supportive self-assessment. Features 18 exceptional color animations, now with narration, to help students as they explore and learn the complexity of embryological development. Provides the knowledge base needed for today's examinations, including USMLE Step 1, as well as for future clinical practice. Thoroughly updated information includes new annotations on fundamental molecular events during embryogenesis, now required for many professional examinations. Includes enhanced clinical material in all chapters, with updated tables, Clinical Case highlights and a critical chapter on common signalling pathways during development that covers gene editing (CRISPR/Cas9), induced pluripotent stem cells (iPS), a revision of the sonic hedgehog signalling pathway; and more. Details how molecular biology has affected clinical practice, including techniques such as recumbent DNA technology and stem cell manipulation. Includes an Enhanced eBook version with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
2015 BMA Medical Book Awards Highly Commended in Basic and Clinical Sciences Category! Larsen's Human Embryology works as a well-organized, straightforward guide to this highly complex subject, placing an emphasis on the clinical application of embryology and presenting it in an easily digestible manner. Ideal for visual students, this updated medical textbook includes a superior art program, brand-new online animations, and high-quality images throughout; clear descriptions and explanations of human embryonic development, based on all of the most up-to-date scientific discoveries and understanding, keep you abreast of the latest knowledge in the field. Take advantage of the most current advances in molecular biology and genetics. Review the material in a flexible manner that meets your specific needs thanks to a user-friendly design. Access high-yield content and quickly locate key information with help from newly condensed text and additional summary tables. Take advantage of key pedagogical features such as opening "Summary" boxes. Visualize complex concepts more clearly than before through a superior art program and outstanding clinical content and images throughout. Reinforce your understanding of the material and how it will relate to real-life scenarios with "Embryology in Practice" clinical closers added to each chapter. Access the complete contents online at Student Consult! View animations on Eye and Ear Development, test yourself with multiple self-assessment questions, and more!
The field of embryology has experienced a period of explosive growth since the previous edition of this book was published nearly a decade ago. The insights of genetic expression in determining the unfolding of the embryonic layers have revolutionised our understanding of some of the mechanisms of embryogenesis. As implied by the title of the new edition, Craniofacial Embryogenetics and Development, genetics is linked with embryology in this text. Virtually all embryological development has an underlying genetic component, and the basic science of genetics is the key in uncovering the many mysteries of embryogenesis. The tools of molecular genetics have provided insights into developmental mechanisms that allow us the ability to identify transient regions of genetic expression patterns. Unraveling the precise biochemical and mechanical interactions of discrete regions in the unfolding embryonic components remains a dauntingly-complex challenge to understanding the conversion of the genome into the phenome. The addition of genetic information gleaned from other mammalian species might aid in dissecting human embryology into comprehensible components to understand normal and abnormal development. This new edition is dedicated to this objective and will prove invaluable to plastic and orofacial surgeons, otolaryngologists, orthodontists, neonatal pediatricians, speech pathologists, teratologists, embryologists, and anatomists. Key Features: Provides clinicians with a basic background for assessing and treating craniofacial anomalies. Describes recent technical advances in optical projection tomography, photoacoustic and 3D imaging, small-angle X-ray scattered (SAXS) tomography and morphometrics and their impact on embryogenetics.
Too tiny to see with the naked eye, the human embryo was just a hypothesis until the microscope made observation of embryonic development possible. This changed forever our view of the minuscule cluster of cells that looms large in questions about the meaning of life. Embryos under the Microscope examines how our scientific understanding of the embryo has evolved from the earliest speculations of natural philosophers to today's biological engineering, with its many prospects for life-enhancing therapies. Jane Maienschein shows that research on embryos has always revealed possibilities that appear promising to some but deeply frightening to others, and she makes a persuasive case that public understanding must be informed by up-to-date scientific findings. Direct observation of embryos greatly expanded knowledge but also led to disagreements over what investigators were seeing. Biologists confirmed that embryos are living organisms undergoing rapid change and are not in any sense functioning persons. They do not feel pain or have any capacity to think until very late stages of fetal development. New information about DNA led to discoveries about embryonic regulation of genetic inheritance, as well as evolutionary relationships among species. Scientists have learned how to manipulate embryos in the lab, taking them apart, reconstructing them, and even synthesizing--practically from scratch--cells, body parts, and maybe someday entire embryos. Showing how we have learned what we now know about the biology of embryos, Maienschein changes our view of what it means to be alive.
The Fundamentals of Human Embryology covers embryonic development, with a unique focus on adult anatomy. Its goal is to impart to students a comprehensive overview of how the human embryo forms, not only as a basis for the student of human anatomy, but also as a link to abnormalities they may encounter in their clinical careers. Extensively illustrated with labeled line drawings, now enlarged for better visibility, this concise manual will meet the needs of both undergraduate and postgraduate students in the Human Sciences. Special features include: * Separate chapters on the neural crest, the skull and osteogenesis * In-depth coverage of head and neck embryology, including the development of the tooth, for students of dentistry, and speech and audiology In this Second Edition of the manual at the request of students and teachers, the authors have made the following changes: * Increased the size of the diagrams * Revised the text to comply with the Federative International Committee on Anatomical Terminology changes to the Terminologia Embryologica * Altered the sequencing of some topics to allow the development to flow more logically * Included an appendix of coloured photographs of congenital abnormalities to help students form a more realistic idea of developmental abnormalities.
2014 BMA Medical Book Awards 1st Prize Award Winner in Illustrated Book category and Highly Commended in Paediatrics category! Smith's Recognizable Patterns of Human Malformation has long been known as the source to consult on multiple malformation syndromes of environmental and genetic etiology as well as recognizable disorders of unknown cause. This esteemed medical reference book provides you with complete and authoritative, yet accessible guidance to help accurately diagnose these human disorders, establish prognoses, and provide appropriate management and genetic counseling. Recognize the visual signs of each environmental and genetic abnormality by consulting more than 1,500 full-color photographs and illustrations, many from the personal collections of Drs. Smith and Jones. Find all the answers you need about normal and abnormal morphogenesis, minor anomalies and their relevance, clinical approaches to specific diagnoses, and normal standards of measurement for the entire spectrum of human malformation syndromes. Efficiently identify genetic disorders in your patients with the inclusion of nearly 20 recently recognized entities/syndromes, as well as new chapters on Microdeletions and Microduplication Syndromes. Available digitally for the first time! You can now access Smith's as an eBook or online at Expert Consult.
Scientists and philosophers have long struggled to answer the questions of when human life begins and when human life has inherent value. The phenomenon of identical (monozygotic) twinning presents a significant challenge to the view that human life and human personhood begin at conception. The fact that a single embryo can split to generate two (or more) genetically identical embryos seems to defy the notion that prior to splitting an embryo can be a single human individual. In Untangling Twinning, Maureen Condic looks at the questions raised by human twinning based on a unique synthesis of molecular developmental biology and Aristotelian philosophy. She begins with a brief historical analysis of the current scientific perspective on the embryo and proceeds to address the major philosophic and scientific concerns regarding human twinning and embryo fusion: Is the embryo one human or two (or even more)? Does the original embryo die, and if not, which of the twins is the original? Who are the parents of the twins? What do twins, chimeras, cloning, and asexual reproduction in humans mean? And what does the science of human embryology say about human ensoulment, human individuality, and human value? Condic's original approach makes a unique contribution to the discussion of human value and human individuality, and offers a clear, evidence-based resolution to questions raised by human twinning. The book is written for students and scholars of bioethics, scientists, theologians, and attorneys who are involved in questions surrounding the human embryo.
Public attention on embryo research has never been greater. Modern reproductive medicine technology and the use of embryos to generate stem cells ensure that this will continue to be a topic of debate and research across many disciplines. This multidisciplinary book explores the concept of a 'healthy' embryo, its implications on the health of children and adults, and how perceptions of what constitutes child and adult health influence the concept of embryo 'health'. The concept of human embryo health is considered from preconception to pre-implantation genetic diagnosis to recent foetal surgical approaches. Burgeoning capacities in both genetic and reproductive science and their clinical implications have catalysed the necessity to explore the concept of a 'healthy' embryo. The authors are from five countries and 13 disciplines in the social sciences, humanities, biological sciences and medicine, ensuring that the book has a broad coverage and approach.
Completely revised from cover to cover, Human Embryology and Developmental Biology, 6th Edition, helps you master complex concepts on every aspect of normal and abnormal human development. Dr. Bruce M. Carlson provides authoritative, readable coverage of today's scientific knowledge in this fast-changing field, keeping you up to date with what you need to know for coursework, exams, and clinical practice. Features an extensive, full-color illustration program, with hundreds of superb clinical photos and embryological drawings - more than 50 new to this edition. Presents information in an integrated, easy-to-follow manner, incorporating molecular, experimental, and morphological material into each relevant area of the text. Includes numerous new, high-quality photos of congenital malformations. Provides major updates to many topics, including neuroembryology, early embryology, fetal imaging techniques, somite formation, and craniofacial development. Newly added series of animations for visualization of complex embryological processes. Offers helpful bonus material online, including the animations, there is also self-assessment questions, up-to-date references, and much more. Helps you understand the molecular basis of embryology, including the processes of branching and folding - essential knowledge for determining the root of many abnormalities. Features clinical vignettes and Clinical Correlations boxes to help you better understand the clinical manifestations of developmental abnormalities. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
This concise work on embryo transfer is yet another contribution to the persevering effort to disseminate latest information on the science and skill of performing an atraumatic and successful embryo transfer, the most critical culmination of the assisted reproductive technology (ART) stimulation cycle, and a rate-limiting step in dictating the success of treatment. The well-worded chapters draw the reader s attention to significant aspects, such as possible causes of failure at the embryo transfer stage, uterine evaluation, mock embryo transfer (ET), experience of the physician, and the use of ultrasound-guidance to monitor ET, that should be taken into account prior to initiating the actual embryo transfer. The protocol for difficult transfers, variables that affect the success of ET, and the influence of the catheter used for ET have been dealt with, while striking a balance between the myths and reality that surround ET. What makes this book unique is its pragmatic approach that can translate into solutions to the numerous frustrating ART failures that more often than not, and ignorantly so, may be attributed to an inefficient ET procedure. It helps the reader understand the integrity of embryo transfer, unravel its obvious simplicity and bridge the success between the several steps of ART. By highlighting the impeding problems associated with ET procedure and providing valid, scientific solutions, this stimulating edition will help the readers improve the ART success rates in their clinical practice.
This new book reviews the latest advances in the embryology, genetics, diagnosis, imaging, and therapy of congenital heart disease. The international cast of authors has combined its talents to produce a unique, expert perspective. This publication arrives at a very exciting time when new genetic, imaging, and therapeutic developments are changing the field. It is relevant to pediatricians, internal medicine specialists, medical geneticists, both pediatric and adult cardiologists, embryologists, imaging physicians, and cardiac surgeons. The reader is taken on a journey that begins with a historical overview of congenital cardiovascular anomalies and ends with developments in stem cell and tissue engineering. In between are chapters on cardiac embryogenesis; epidemiology; genetic syndromes associated with cardiovascular anomalies; single gene disorders; cardiac imaging; surgical and interventional therapies; and ethical considerations. 'Congenital Heart Disease' is an invaluable reference. In short, it provides essential information to create a comprehensive resource for all physicians involved with the diagnosis and treatment of cardiac malformations.
This textbook presents essential and accessible information about human embryology including practical information on human health issues and recent advances in human reproductive technology. Starting with biological basics of cell anatomy and fertilization, the author moves through the development of specific organs and systems, before addressing social issues associated with embryology. Each chapter includes specific objectives, general background, study questions, and questions to inspire critical thinking. Human Life Before Birth also contains two appendices and a full glossary of terms covered in the text. Clinicians and researchers in this field will find this volume indispensable. Key selling features: Explores all the developmental and embryological events that occur in human emryonic and fetal life Reviews basic cell biology, genetics, and reproduction focusing entirely on humans Summarizes the development of various anatomical systems Examines common birth defects and sexually transmitted diseases including emerging concerns such as Zika Documents assisted fertilization technologies and various cultural aspects of reproduction
This book is a synopsis of the key facts and concepts of human development. It is intended for students who are taking a human embryology course. The book includes the underlying mechanisms involved in clinically important congenital anomalies that will prove useful to medical and nursing.
The present anatomical atlas concentrates on the early weeks of prenatal development of the human embryo. It comprises more than 800 scanning electron-microscopic pictures of specimens of exclusively human embryos. The three-dimensional appearing illustrations show the development of the external form of the face, neck, trunk and limbs. Besides, the brain and the viscera of the head, neck, thorax, abdomen and pelvis - all dissected into layers - are represented in their position and spatial form. The juxtaposition of pictures of temporally close developmental stages reveals the changes in the form of the organs. Photographs of the same organic system are usually shown at the same magnification and clearly demonstrate the growth process. Simple outline drawings provided with the principal nomenclature facilitate the orientation within the specimens. A brief introduction to each chapter explains the most significant developmental steps depicted. This atlas is of great interest not only to anatomists, embryologists, histologists and developmental biologists, but also to biologists, biochemists and geneticists. Moreover, it serves as a valuable reference book for clinicians such as gynecologists, obstetricians, pediatric surgeons and pediatric cardiologists.
Vibrantly illustrated with full-color diagrams and clinical images, Langman's Medical Embryology , 14th Edition helps medical, nursing, and health professions students confidently develop a basic understanding of embryology and its clinical relevance. Concise chapter summaries, captivating clinical correlates boxes, clinical problems, and a clear, concise writing style make the subject matter accessible and engaging to students throughout their courses. Updated content reflects the latest clinical findings on the effects of the Zika virus, urogenital system disorders, and more. Clinical Correlates boxes tie clinically relevant content to case-based scenarios students may encounter in practice. More than 400 full-color illustrations, micrographs, and clinical images clarify key aspects of embryonic development. Problems to Solve with accompanying answers help assess student understanding. Chapter summaries and an expanded glossary reinforce understanding of key development stages, terms, and clinical conditions. Illustrated Development Chart provides visually guides students through the stages of embryonic development at a glance. Updated online review questions with answers help students test their understanding and identify areas of weakness. eBook available for purchase. Fast, smart, and convenient, today's eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and more
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