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Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
This fully updated and extended second edition provides a comprehensive overview on the basic concepts of the rapidly developing field of osteoimmunology and also offers in-depth insights into the molecular mechanisms of bone diseases. Clinical data is presented and put into context with the latest research findings. This second edition in addition discusses the latest topics in transplantation immunology. The book addresses scientists and physicians working in immunology, pathophysiology and osteology.
Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs and ADAMS and cysteine protease cathepsins. The text specifically addresses the role of extracellular proteases in cancer cell invasion, stroke and infectious diseases, describing the basic biochemistry behind these disease states, as well as therapeutic strategies based on protease inhibition. With its trans-disciplinary scope, this reference bridges the gap between fundamental research and biomedical and pharmaceutical application, making this required reading for basic and applied scientists in the molecular life sciences.
The best cardiovascular review available for the USMLE (R), exam review, and course work Cardiovascular Physiology, Ninth Edition is a concise and enjoyable way for you to gain a fundamental knowledge of the basic operating principles of the intact cardiovascular system and how those principles apply to clinical medicine. Succinct but thorough, it focuses on the facts and concepts you must know to get a solid "big picture" overview of how the cardiovascular system operates in normal and abnormal situations. No other text will prove more valuable in enhancing your ability to evaluate the myriad new information you will be exposed to throughout your career, than Cardiovascular Physiology. There is no faster or more effective way to learn how the key principles of cardiovascular function apply to common and pathological challenges than this engagingly written, time-proven guide. Medical students will find it to be an outstanding review for the USMLE (R) Step 1 and experienced clinicians will find it be a valuable clinical refresher. Features*NEW! Increased focus on cardiovascular energetics*"Perspectives" section in each chapter that identify important, currently unresolved issues *Clarifies the details of physiologic mechanisms and their role in pathologic states*Links cardiovascular physiology to diagnosis and treatment*Summarizes key concepts at the end of each chapter*Highlights must-know information with chapter objectives*Reinforces learning with study questions at the end of each chapter
Filled with compelling case studies that connect key content to real-world health care scenarios, Memmler's Structure and Function of the Human Body , 11th Edition, provides easy-to-understand, beautifully illustrated coverage of the essentials of normal anatomy and physiology. The first text designed specifically to meet the needs of allied health students, this acclaimed resource has evolved over the years to address changing course requirements and student needs. This edition continues the tradition with a new, more accessible design, a wide range of new study tools, and a robust multimedia electronic ancillary package for both instructors and students. Throughout the book, anatomic art illustrates concepts with accuracy and simplicity; case studies highlighting anatomy and physiology demonstrate the relevance of the content to a career in the health professions; and hallmark pedagogy blends remediation, reinforcement, and real-world focus to ensure student success. * Personalized chapter-by-chapter quizzes powered by PrepU help students learn more and improve their pass rates on exams, while giving instructors a window into their students' progress by pinpointing misconceptions, strengths, and weaknesses. * A&P in Action boxes open each chapter with a scenario that integrates chapter content into a medical setting, bringing the information to life for students. * A&P in Action Revisitedboxes , which appear later in the chapter, expand on the opening scenario and encourage students to apply the chapter's concepts to the outcome of each case. * A full-body The Body Visible transparency insert assists students in performing a virtual dissection of the human body from skin down to bone and allows them to test themselves on their understanding of skin, muscles, bones, veins/arteries, etc. New associated chapter questions deepen student understanding. * New Process Diagrams ensure student mastery by calling out and illustrating the steps of a complex process, such as negative feedback control for maintaining homeostasis. * New Cadaver Photograph-related Questions help students apply anatomic knowledge to novel situations. * New Casepoints (in-chapter review questions) link content to the opening case study. * New Critical Thinking Questions that challenge students to apply concepts to the A&P in Action case study help them to understand how basic concepts of anatomy and physiology relate to clinical situations. * New Misconception Alerts , marked by an icon, point out common student misconceptions (identified by the PrepU adaptive quizzing program) to improve understanding of important ideas. * New One Step at a Time features expand on basic science concepts introduced in the case study or the text by walking students step-by-step through higher level critical thinking activities, such as developing scientific learning and problem-solving skills. * Checkpoint questions throughout each chapter help students review key points. * Hot Topicsboxes focus on cutting-edge topics and research, reinforcing the link between anatomy and physiology and everyday life. * Clinical Perspectives boxes focus on diseases and disorders related to the chapter, helping students understand what happens when the normal structure-function relationship breaks down. * Health Maintenanceboxes offer useful information on how to keep the body healthy. * A Closer Lookboxes provide in-depth scientific detail on selected topics. * Zooming In questions in the figure captions allow students to test their understanding of important visual aspects of the illustration. * A Look Backfeature provides a short paragraph highlighting content from prior chapters that will help students understand the current chapter. * Learning Objectives identify the important content to learn in each chapter. * A strong conceptual focus is reflected in more illustrations of basic biologic concepts and more learning diagrams that take students step-by-step through complex processes, such as sensory pathways, cardiac function, and nerve impulse transmission. * Ancillary callouts identify additional resources available online, such as animations, supplementary figures, a quiz bank, and health career information to enhance learning. * End-of-chapter study aids include a summary overview (visual outline), key terms (end-of-chapter list), a word anatomy (medical terminology) activity, and questions for study and review that test recall, comprehension, and critical thinking with a variety of question styles, including fill-in-the-blank, multiple-choice, short-answer, and short essay, as well as questions that require students to apply body process and system knowledge to the chapter-opening case study.
Now in its fourth edition Testosterone: Action, Deficiency, Substitution provides the most up-to-date and comprehensive source of information on testosterone and its role in human physiology and pathology. It covers biosynthesis and mechanisms of action and reviews their effects on brain and behavior, spermatogenesis, hair growth, bones, muscles, erythropoiesis, the cardiovascular system and the prostate. The therapeutic uses of testosterone preparations are carefully evaluated as well as its abuse and detection in competitive sport. This new edition also devotes sections to exploring the effects of testosterone on female physiology and sexual function, and the experimental use of testosterone in male hormonal contraception. Testosterone: Action, Deficiency, Substitution has been written and edited by world experts in the fields of clinical andrology and endocrinology and provides a unique and invaluable guide for andrologists, endocrinologists, urologists, internists and those working in reproductive medicine.
Offering a concise, illustrated summary of biochemistry and its relevance to clinical medicine, Medical Biochemistry at a Glance is intended for students of medicine and the biomedical sciences such as nutrition, biochemistry, sports science, medical laboratory sciences, physiotherapy, pharmacy, physiology, pharmacology, genetics and veterinary science. It also provides a succinct review and reference for medical practitioners and biomedical scientists who need to quickly refresh their knowledge of medical biochemistry. The book is designed as a revision guide for students preparing for examinations and contains topics that have been identified as 'high-yield' facts for the United States Medical Licensing Examination (USMLE), Step 1. This third edition: * Has been thoroughly revised and updated and is now in full colour throughout * Is written by the author of the hugely successful Metabolism at a Glance (ISBN 9781405107167) * Features updated and improved clinical correlates * Expands its coverage with a new section on Molecular Biology * Includes a brand new companion website of self-assessment questions and answers at www.ataglanceseries.com/medicalbiochemistry
The gene's eye view of life, proposed in Richard Dawkins acclaimed
bestseller The Selfish Gene, sees living bodies as mere vehicles
for the replication of genetic codes. But in The Music of Life,
world renowned physiologist Denis Noble argues that, to truly
understand life, we must look beyond the "selfish gene" to consider
life on a much wider variety of levels.
The latest edition of this well organised and authoritative book provides a comprehensive account of the mechanics of the neuro-musculo-skeletal system. Covering the key areas including the properties of biomaterials, common measuring techniques and modelling, "Biomechanics of the Musculo-skeletal System, Third Edition" also integrates historical aspects thus building a bridge between old and familiar knowledge and the latest developments in biomechanics. As with the previous edition there are numerous applications and extensive questions and answers at the end of sections. Specific changes for this edition include: Major revision of the section on biological materials including bone, cartilage, ligament, tendon, muscle and joints and new discussion of failure and healingExtensive updating of material covering force, pressure distribution, optical methods and simulationIncrease in the number and type of applications across a broad range of disciplines
"Biomechanics of the Musculo-skeletal System, Third Edition" is an invaluable resource for all students, professionals and researchers concerned with biomechanical aspects of the human or animal body.
This Study Guide is the ideal companion to the Eleventh Edition of Memmler's Structure and Function of the Human Body, the acclaimed classic text for anatomy and physiology. Following the text's organization chapter by chapter, the Study Guide offers a full complement of self-study aids to engage students in learning and enable them to assess and build their knowledge as they advance through the text. Most importantly, it allows them to get the most out of their study time, with a variety of exercises that meet the needs of all types of learners. Self-study aids include all-new illustrations, chapter overviews, writing exercises, coloring and labeling exercises, concept maps, practical application scenarios, matching exercises, short-essay questions, multiple-choice, fill-in-the-blank, and true-false questions, and more. --Chapter overviews --Writing exercises --Coloring and labeling exercises --Concept maps --Practical application scenarios --Matching exercises --Short-essay questions --Multiple-choice, fill-in-the-blank, and true-false questions --Information on real-life anatomy and physiology in action and updates on current research trials and applications. --Answers to the Study Guide are in the Instructor's Manual that accompanies the text as well as on thePoint site for the main text.
This book was written by many outstanding investigators who have spent decades to study different aspects of blood-tissue barrier function. They have summarized some of the latest and fascinating development in their fields of research including the blood-brain barrier, the blood-retinal barrier, the gut barrier, the blood-biliary barrier, the blood-follicle barrier, the blood-epididymis barrier, the blood-testis barrier, the tight junction barrier in general as well as barriers in the female reproductive tract. Included are also chapters that focus on topics that are physiologically applicable to all blood-tissue barriers. Many of these chapters also include information on specific human diseases, such as pathological changes of the gut barrier that cause bowel disorders resulting from inflammation of the epithelial lining in the intestine, and infertility in men as a result of disruption of the blood-epididymal and/or blood-testis barriers; and on new therapeutic approaches (e.g., drug delivery across the blood-brain and the blood-retinal barriers).
This book presents a large amount of information related to the heat shock response and heat shock factor (HSF), describes core observations about molecular mechanisms and pathophysiological roles, and provides fundamental concepts on the basis of information from diverse aspects. This adaptive response to high temperature or protein misfolding is a fundamental mechanism to maintain the capacity of protein homeostasis, or proteostasis, and is evolutionally conserved among all living organisms, including bacteria and humans, on the earth. Furthermore, physiological and pathological roles of HSF have been extensively studied in fruit fly, worm, and mouse models. It has been revealed that HSF plays roles in development of the brain, reproductive and sensory organs, and in ageing, inflammation, and circadian rhythm. Analysis of the mechanisms have uncovered that HSF exerts a wide range of effects on gene expression and epigenetic status on the whole genome. Moreover, loss or gain of HSF function is also closely related to protein-misfolding diseases including neurodegenerative diseases, psychiatric diseases, heart diseases, and cancers. Therefore, HSF is now thought to be a promising therapeutic target for treatment of these refractory diseases. For undergraduate students, this is a highly understandable source of information on heart shock response and HSF, covering the basis of HSF biology, the physiological role of HSF, and disease associated with HSF function. This book not only serves as a guide to the heat shock response and HSF for students and young researchers in other fields, but also is a cornerstone for future work in the field related to the heat shock response and HSF.
Get some extra help mastering core terms, concepts and processes related to the anatomy and physiology of the human body with this comprehensive study aid! Study Guide for Anatomy & Physiology, 9th Edition provides a variety of chapter activities and questions - including crossword puzzles, word scrambles, and questions in the multiple choice, true or false, labeling, matching, and application formats - to help you apply concepts and test your A&P knowledge. More than 1,200 review questions cover multiple choice, matching, true-false, fill-in-the-blank, and completion formats. Mind tester activities include crossword puzzles, word scrambles, and more to make the process of learning basic anatomy and physiology more engaging. Apply What You Know sections encourage critical thinking and application of core content. Did You Know sections cover factual tidbits that will interest users. Topics for review tell the reader what to review in the textbook prior to beginning the exercises in the study guide. Answer key containing all the answers to study guide questions is located in the back of the guide. NEW! Modified chapter structure reflects the new organization of chapters in the Patton 9th Edition main text.
This volume provides methods for characterization of muscarinic receptor in crystallography studies that advanced our understanding of structural properties and activation mechanism of muscarinic receptors and are cornerstone in molecular modeling and computer-based approaches to study muscarinic receptors. Muscarinic Receptor: From Structure to Animal Models guides readers through binding techniques, protocols to investigate molecular properties of muscarinic receptors, protocols to study muscarinic receptors in the central nervous system using autoradiography and PET studies and protocols on animals with knock-out and knock-in muscarinic genes to study role of muscarinic receptors in physiology and behavior. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.Concise and easy-to-use, Muscarinic Receptor: From Structure to Animal Models aims to ensure successful results in the further study of this vital field.
Now in its fourth edition, Basic Biomechanics of the Musculoskeletal System uses a direct and comprehensive approach to present students with a working knowledge of biomechanical principles of use in the evaluation and treatment of musculoskeletal dysfunction. The text opens with a chapter that introduces the basic terminology and concepts of biomechanics; the remainder of the book then focuses on the biomechanics of tissues and structures, the biomechanics of joints, and applied biomechanics.
Provides the most comprehensive, authoritative reference on the
study of bone biology and related diseases. It is the essential
resource for anyone involved in the study of bone biology. It is
the most comprehensive, complete, up-to-date source of information
on all aspects of bones and bone biology in one convenient source.
It takes the reader from the basic elements of fundamental research
to the most sophisticated concepts in therapeutics. Bone research
in recent years has generated enormous attention, mainly because of
the broad public health implications of osteoporosis and related
The Sixth Edition of this international bestseller frames research findings in physiology in a reader-friendly format, making this textbook a favourite of lecturers and students alike. It offers a simple way for students to develop an understanding of the body's abilities to perform various types and intensities of exercise and sport, to adapt to stressful situations and to improve its physiological capacities. Students and instructors can take advantage of the web-based ancillaries that accompany the text and include new animations, videos and audio clips. Physiology of Sport and Exercise has been a cornerstone textbook of the engaging field of exercise physiology. Through dynamic and interactive learning activities, easy-to-follow layouts, and research-oriented content, students and instructors will find this an invaluable resource for their continued education.
Eureka - an innovative series for students that fully integrates core science, clinical medicine and surgery. With its engaging and authoritative text, featuring insightful clinical cases, graphic narratives, SBAs and a wealth of other learning tools, Eureka has everything students need to succeed in medicine and pass their exams. Eureka - content that reflects today's medical degree courses with their emphasis on: relevance and application of core science to clinical practice skills required to examine and communicate with patients integrated care across primary and acute care settings Eureka - 15 clinical titles, 5 science titles: Clinical titles - disease-based, clinical cases, system-specific core science Science titles - bedrock biomedical principles, clinical cases Series features across titles: Engaging clinical cases show how skilled clinician would work through a presentation, and put diseases and biomedical principles into patient context Innovative graphic narratives bring clinical cases to life, show how to approach difficult scenarios and convey the experience of being a patient Starter questions - stimulating answers to intriguing questions make learning fun Boxes highlight tips, tricks and key learning points Physiology First principles chapter clearly explains key concepts and mechanisms relevant to the study of medicine e.g. cell signalling mechanisms and homeostasis Systems-based chapters describe the processes that underpin normal functions such as circulation, respiration and digestion, each chapter introduced by an engaging clinical case that features a unique graphic narrative Self-Assessment - 80 multiple choice questions in clinical SBA format, in line with current exam format
Eureka - an innovative series for students that fully integrates core science, clinical medicine and surgery. With its engaging and authoritative text, featuring insightful clinical cases, graphic narratives, SBAs and a wealth of other learning tools, Eureka has everything students need to succeed in medicine and pass their exams. Eureka - content that reflects today's medical degree courses with their emphasis on: relevance and application of core science to clinical practice skills required to examine and communicate with patients integrated care across primary and acute care settings Eureka - 15 clinical titles, 5 science titles: Clinical titles - disease-based, clinical cases, system-specific core science Science titles - bedrock biomedical principles, clinical cases Series features across titles: Engaging clinical cases show how skilled clinician would work through a presentation, and put diseases and biomedical principles into patient context Innovative graphic narratives bring clinical cases to life, show how to approach difficult scenarios and convey the experience of being a patient Starter questions - stimulating answers to intriguing questions make learning fun Boxes highlight tips, tricks and key learning points Biochemistry & Metabolism First principles chapter clearly explains the key concepts and mechanisms relevant to the study of medicine e.g. types of biochemical reaction, enzymes and cofactors Systems-based chapters describe the structures such as proteins and fats and processes such as haemoglobin metabolism that underpin normal functions, each chapter introduced by an engaging clinical case that features a unique graphic narrative Self-Assessment - 80 multiple choice questions in clinical SBA format, in line with current exam format
This book will provide the reader with an overview of the essential meanings of key words in the physiology of various organ systems. This book is linked to a Question and Answer book on these organ systems that was published previously by Springer and will focus on cardiovascular, pulmonary and renal physiology. Each physiology system will be organized in to five different sections, covering the main areas of interest and each section will contain at least ten clear definitions of the main topics in this area. This book will present an easy reference guide for those just starting out in the area of physiology and for those who are interested in clear and succinct definitions of key terms.
The Comparative Anatomy and Histology of the Cerebellum was first published in 1972. Minnesota Archive Editions uses digital technology to make long-unavailable books once again accessible, and are published unaltered from the original University of Minnesota Press editions.This is the third and final volume of the late Dr. Larsell's definitive work on the cerebellum, brought to completion for publication by Dr. Jansen. Two additional contributing authors for this volume are Enrico Mugnaini, M.D., and Helge K. Korneliussen, M.D.The first section of this volume deals with the morphology of the human cerebellum. The morphogenetic development, the fissure formation, and the differentiation of the cerebellar lobules are described in detail, and followed by a comprehensive account of the adult cerebellum, its lobes and lobules. It is shown that the ten major lobules which Dr. Larsell distinguished in other mammals are recognizable also in man.Chapters on the cerebellum connections include detailed accounts of all afferent and efferent cerebellar tracts. A subsequent chapter, by Drs. Jansen and Korneliussen, is devoted to the fundamental plan of cerebellar organization. The final chapters, by Dr. Mugnaini, deal with the histology and cytology of the cerebellar cortex. A comprehensive account is given of electron micrographs, a virtual atlas of the ultrastructure of the cerebellar cortex, illustrate the description.
The Comparative Anatomy and Histology of the Cerebellum was first published in 1970. Minnesota Archive Editions uses digital technology to make long-unavailable books once again accessible, and are published unaltered from the original University of Minnesota Press editions. This is the second volume of the late Dr. Larsell's comprehensive monograph on the cerebellum, the first volume of which is described below. A third volume, on the human cerebellum, will be published by the University of Minnesota Press next spring to complete the work. This second volume deals with the morphogenetic development and morphology of the cerebellum of all orders of mammals from monotremes through apes. The descriptions cover the cerebellum in about forty species with special emphasis on the cerebellum of the albino rate, rabbit, cat, and rhesus monkey. Dr. Larsell's comparative anatomical studies over a period of many years led to the conclusion that fundamentally the mammalian cerebellum is composed of ten subdivisions. With few exceptions (the smallest and most primitive cerebella) the subdivisions are identified in all mammals. The descriptions of the cerebella are based on the author's personal investigations but the relevant literature is thoroughly reviewed also.
Written with health professions students in mind, the Third Edition of Anatomy and Physiology for Health Professionals offers an engaging, approachable, and comprehensive overview of human anatomy and physiology. The Third Edition features a total of six multifaceted `Units' which build upon an understanding of basic knowledge, take readers through intermediate subjects, and finally delve into complex topics that stimulate critical thinking. Heavily revised with updated content throughout, chapters include useful features, such as Common Abbreviations, Medical Terminology, the Metric System and more! Students will want to take advantage of the many resources available to reinforce learning -including Test Your Understanding questions that regularly assess comprehension, flash cards for self-study, an interactive eBook with more than 20 animations, and interactive and printable Lab Exercises and Case Studies. FEATURES Provides a comprehensive overview of human anatomy and physiology Presents content in an accessible manner targeted to health professions students Offers access to helpful animations and interactive learning tools Includes clinical images such as X-rays, CT scans and MRIs Covers the effects of aging on various body systems Offers robust end of chapter assessments for learners
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