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Adequate blood supply to the eye is an important prerequisite for normal visual function. Over the past 40 years our knowledge of ocular blood flow regulation has improved significantly. This reader-friendly textbook provides a comprehensive overview of the current knowledge of ocular blood flow. Lavishly illustrated, it evaluates the wide array of methods that have been used to measure ocular blood flow. Furthermore, it not only offers the reader an evidence-based summary of the physiological and pharmacological properties of ocular blood flow regulation, but also demonstrates the ocular blood flow abnormalities in different vascular diseases. This book will enhance the understanding of all who are interested in learning more about ocular blood flow in health and disease.
This text is written for the two semester anatomy & physiology course. The writing is comprehensive, providing the depth necessary for those courses not requiring prerequisites, and yet, is presented with such clarity that it nicely balances the thorough coverage. Clear descriptions and exceptional illustrations combine to help students develop a firm understanding of the concepts of anatomy and physiology and to teach them how to use that information. Great care has been taken to select important concepts and to perfectly describe the anatomy of cells, organs, and organ systems. The plan that has been followed for ten editions of this popular text is to combine clear and accurate descriptions of anatomy with precise explanations of how structures function and examples of how they work together to maintain life. To emphasize the concepts of anatomy and physiology, the authors provide explanations of how the systems respond to aging, changes in physical activity, and disease, with a special focus on homeostasis and the regulatory mechanisms that maintain it. This text has more clinical content than any other A & P book on the market.
Nutrition and Skeletal Muscle provides coverage of the evidence of dietary components that have proven beneficial for bettering adverse changes in skeletal muscle from disuse and aging. Skeletal muscle is the largest tissue in the body, providing elements of contraction and locomotion and acting as an important contributor to whole body protein and amino metabolism, glucose disposal and lipid metabolism. However, muscle loss, atrophy or weakness can occur when there are metabolic imbalances, disuse or aging. This book addresses the topic by providing insight and research from international leaders, making it the go-to reference for those in skeletal muscle physiology.
"Modelling Methodology for Physiology and Medicine, Second Edition, "offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration.
The focus of "Modelling Methodology for Physiology and Medicine,
Second Edition, "is the methodology that underpins good modeling
practice. It builds upon the idea of an integrated methodology for
the development and testing of mathematical models. It covers many
specific areas of methodology in which important advances have
taken place over recent years and illustrates the application of
good methodological practice in key areas of physiology and
medicine. It builds on work that the editors have carried out over
the past 30 years, working in cooperation with leading
practitioners in the field.
This volume of the series Space Life Sciences provides insights into the latest findings of gravity research and the effect of gravity on biological systems, specifically on a cellular and molecular level. It starts by explaining the underlying physics of gravity and presenting some novel ideas on the basic principles of gravity perception. It then goes on to discuss how, in response to gravity perception, secondary messengers such as calcium and hydrogen peroxide, might control responses further downstream, like gene and protein expression and modulation. Further, it describes the consequences for animal and plant cells as well as for metabolism. Written by experts in the field, this book is a valuable resource for students and researchers in biochemistry, medicine and biomedicine, wanting to gain a solid understanding of membrane biology, secondary messenger function and gene and protein expression, specifically in the context of gravity.
In this book, the physiotherapist, sleep specialist or general health-care provider finds a detailed review about what can be done to handle Restless Legs Syndrome and Periodic Leg Movements in terms of scientifically proven exercise and physical interventions in physiotherapy daily practice. For those new to the field, there's a basic overview of sleep and it's disorders, followed by chapters about the Restless Legs Syndrome and its companion disorder, the Periodic Leg Movements. Special patients force us to reinvent and think again the ways we deal with disorders. In this book, the health-care provider will gain a fresh perspective to deal with Restless Legs Syndrome and Periodic Leg Movements in all patients alike.
This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.
Punctuated with remarkable case studies, this book explores extraordinary encounters between hermaphrodites--people born with "ambiguous" sexual anatomy--and the medical and scientific professionals who grappled with them. Alice Dreger focuses on events in France and Britain in the late nineteenth century, a moment of great tension for questions of sex roles. While feminists, homosexuals, and anthropological explorers openly questioned the natures and purposes of the two sexes, anatomical hermaphrodites suggested a deeper question: just how many human sexes are there? Ultimately hermaphrodites led doctors and scientists to another surprisingly difficult question: what is sex, really? Hermaphrodites and the Medical Invention of Sex takes us inside the doctors' chambers to see how and why medical and scientific men constructed sex, gender, and sexuality as they did, and especially how the material conformation of hermaphroditic bodies--when combined with social exigencies--forced peculiar constructions. Throughout the book Dreger indicates how this history can help us to understand present-day conceptualizations of sex, gender, and sexuality. This leads to an epilogue, where the author discusses and questions the protocols employed today in the treatment of intersexuals (people born hermaphroditic). Given the history she has recounted, should these protocols be reconsidered and revised? A meticulously researched account of a fascinating problem in the history of medicine, this book will compel the attention of historians, physicians, medical ethicists, intersexuals themselves, and anyone interested in the meanings and foundations of sexual identity.
This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.
For one-semester Anatomy & Physiology courses. Focus on the essential what, how, & why of human anatomy & physiology With the 12th Edition of Essentials of Human Anatomy & Physiology, science educator Suzanne Keller joins bestselling author Elaine Marieb in helping learners focus on the essential What, How, & Why of A&P, without getting sidetracked in unnecessary details. Thoroughly updated with dozens of new figures, photos, and current information on medical recommendations and terminology, the 12th Edition continues to set the standard for brief, accessible one-semester A&P texts. The authors' hallmark clear and friendly writing style has been strengthened with familiar analogies and abundant mnemonic cues that help students learn and remember concepts. Continuing to offer just the right balance of anatomy, physiology, and clinical coverage, engaging new chapter previews help learners hone in on what structures and functions they are studying, how they function, and why they are important to learn. Mastering (TM) A&P not included. Students, if Mastering A&P is a recommended/mandatory component of the course, please ask your instructor for the correct ISBN and course ID. Mastering A&P should only be purchased when required by an instructor. Instructors, contact your Pearson rep for more information. Mastering A&P is an online homework, tutorial, and assessment program designed to engage students and improve results. Instructors ensure that students arrive ready to learn by assigning educationally effective content before class, and encourage critical thinking and retention with in-class resources such as Learning Catalytics (TM). Students can further master concepts after class through assignments that provide hints and answer-specific feedback. With a wide range of activities available, students can actively learn, understand, and retain even the most difficult concepts.
Develop both your clinical problem-solving and critical thinking skills with this comprehensive workbook. Inside you'll discover a clear-cut approach to integrating basic pathophysiology, risk factors, physical examination findings, and clinical laboratory data for 100 major health problems. This fundamental resource provides support for medical, pharmacy, nursing, and allied health studies. Using a case study approach, you'll learn appropriate disease management options to improve patient quality of life.
Features That Make Learning Easy
Now Available for Instructors Online answers to critical thinking and problem-solving questions in the Disease Summary and Patient Case sections, and an image bank that includes the figures and tables for each.
""Many Anatomy and Physiology (A&P) textbooks have been
written, most of them are limited by the absence of a significant
bank of self test material. This book fills that space by providing
the student engaged in active learning opportunities to assess
their learning in all the core areas of A&P. The explanatory
feedback material following answers to the test questions is
excellent. Now the student has a resource that actually guides them
towards success. It will complement any course that includes
introductory A&P. This book will be a very useful partner to
any student new to the subject that is motivated to learn and do
"This book will be of great benefit to student nurses revising
for exams as well as registered nurses wishing to refresh their
memory. The authors have a good awareness of the areas where
students struggle, and have focused special attention on
"This book is the perfect companion to help nurses explore their
own understanding of this key subject. Students and newly qualified
nurses alike will find the different kinds of tests a valuable
"This text is ideal for revision purposes or as a refresher for the basic workings of the human body. The book will help to build the foundations for learning the pathophysiology behind the body systems." Amy Hutchinson, Student Nurse, University of Ulster, UK
"An excellent book which I would recommend to all nursing
students studying Human Life Sciences or Anatomy and Physiology.
This is a really useful book to learn and revise from; each section
summarises the essential points and then tests your knowledge... I
wish I had had this book prior to my first exam "
Looking for a quick and effective way to revise and test your knowledge?
This handy book is the essential self-test resource for nurses studying basic anatomy & physiology and preparing for exams.
This book includes over 450 questions in total, each with fully explained answers. These include: 45 A&P illustrations 180 glossary terms Multiple choice questions True or false questions Labelling exercises Fill in the blank questions Each main body system has its own chapter, so you can get in depth practice for your exams. Body systems covered include: Integumentary system Musculoskeletal system Nervous system Endocrine system Cardiovascular system Respiratory system Digestive system Urinary system Immune and lymphatic system Reproductive system Written by lecturers at one of the UK's top nursing schools, this test book is designed to help you improve your results - and tackle your exams with confidence
Protein conversion from a water-soluble native conformation to the insoluble aggregates and fibrils, which can deposit in amyloid plaques, underlies more than 20 human diseases, representing a major public health problem and a scientific challenge. Such a conversion is called protein misfolding. Protein misfolding can also involve errors in the topology of the folded proteins and their assembly in lipid membranes. Lipids are found in nearly all amyloid deposits in vivo, and can critically influence protein misfolding in vitro and in vivo in many different ways. This book focuses on recent advances in our understanding of the role of lipids in modulating the misfolding of various proteins. The main emphasis is on the basic biophysical studies that address molecular basis of protein misfolding and amyloid formation, and the role of lipids in this complex process.
This volume synthesizes pathways in respiratory mechanics and the dynamics of air-blood and blood-cellular gas exchange for students and teachers in respiratory physiology. The authors strive to make physiology fun to learn. This aspect of knowledge acquisition is reflected in the way topics are approached, for example by using playing cards in what is coined `Respi-CARDology'. The first section of this book reviews the framework and foundations of basic respiratory physiology. Since this book was not written to be a comprehensive physiology text, the authors have focused on leading students to appreciate and understand integrative principles and homeostatic mechanisms in lung function. The second section of this book mainly deals with the clinical application of fundamental knowledge of respiratory physiology.
This book presents the current concepts of semaphorin biology. In the early 1990s, semaphorins were originally identified as axon guidance cues that function during neuronal development. However, cumulative findings have clarified that they have diverse functions in many physiological processes, including cardiogenesis, angiogenesis, vasculogenesis, osteoclastogenesis, retinal homeostasis, and immune regulation. Additionally, they have been implicated in the pathogenesis of various human diseases, including tumorigenesis/tumor metastasis, neuroregenerative diseases, retinal degeneration, irregular pulse/sudden death, and immune disorders. Based on this current research background, the book covers the essential state-of-the-art findings for basic scientists in biochemistry, molecular biology, neuroscience, developmental biology, and structural biology, as well as for physicians in neurology, cardiology, oncology, orthopedic surgery, otorhinolaryngology, ophthalmology, allergology, and rheumatology.
Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.
This book comprehensively reviews the characteristics of the body reflected in the skin due to differences in gender. It investigates the genetic and hormonal differences that can affect skin structure and function, and resulting in variations between women and men. The aging process and exogenous factors that differ according to differences in lifestyle between the sexes are also covered. Gender and Dermatology comprehensively outlines the various aspects of physiological differences between the skin of women and men using practical examples and review of the basic science. It is therefore an important clinically-relevant review for both the trainee and experienced practitioner in dermatology, primary care, geriatrics and immunology, while also being of interest to researchers in genetics and metabolic medicine.
The inner ear originates from an ectodermal thickening, the otic placode, which lies adjacent to the developing hindbrain. Complex interactions between regulatory signalling molecules guide development of the simple otic placode into the elaborate, multifunctional organs of hearing and balance. This book delves into recent research in the field, focusing on successive stages of inner ear development and how they are influenced by the co-ordinate activity of signalling molecules. This book begins with an overview of the evolutionary adaptation of the organ of Corti (organ of hearing) and the molecular signals that characterise ancestral development of the inner ear. Following this, the topics addressed include the complex signalling interactions underlying induction of the otic placode, key molecular mediators influencing inner ear development and patterning, genetic signalling of the vestibular (balance) system and clinical correlations to human balance disorders, commitment to auditory hair cell fate, and reliance of the inner ear on retinoic acid, a biologically-active derivative of vitamin A, for appropriate development. This timely and comprehensive book provides an excellent resource for researchers, clinician-scientists and students alike.
Learn to master the core terms, concepts, and processes of human anatomy and physiology! Corresponding to the chapters in Thibodeau and Patton's Structure & Function of the Body, 15th Edition, this engaging study guide contains variety of exercises, activities, and anatomy drawings to help you easily review, retain, and apply important A&P concepts! Brief synopsis of the core concepts from the textbook provides a comprehensive review of essential content. Diagrams, labeling exercises, and coloring exercises reinforce where the structures of the body are located. Crossword puzzles and word finds help readers master new vocabulary terms. Application questions ask readers to make judgments based on the information in the chapter. Matching and fill-in-the-blank exercises help readers better understand chapter content. Study tips in the preface provide insights on the most effective methods for learning and retaining information. Answers to exercises in the back of the book include references to the appropriate textbook page to give readers instant feedback. NEW! Updated art throughout enhances learning by presenting anatomy even more clearly.
This work provides a state-of-the art overview on the most relevant aspects of cell polarity. Volume 1 addresses cell polarity and cell migration (front-rear polarity), cell polarity and barrier formation (apico-basal polarity) and neuronal polarity. It particularly focuses on cell polarity at the molecular level and the underlying molecular mechanisms. It also elaborates the common principles and mechanisms that regulate cellular polarization in different cell types and contexts. Both volumes are intended for professors, group leaders and researchers in cell biology as well as medical professionals in the fields of anatomy, cell biology, physiology, pathology and tumor biology.
This work provides a state-of-the art overview on the most relevant aspects of cell polarity. Volume 2 discusses the physiological and pathophysiological relevance of cell polarity. It especially focuses on pathophysiological conditions in which one or several aspects of cell polarity are impaired, and in which a loss of cell polarity possibly contributes to disease (e.g. epithelial-to-mesenchymal transition in cancer, role of polarity proteins in cancer). Both volumes are intended for professors, group leaders and researchers in cell biology as well as for medical professionals working in anatomy, cell biology, physiology, pathology and tumor biology.
This is a self-contained monograph on human voice. It systematically expounds a theory of voice production initiated by Leonhard Euler, through an analysis of large amount of human voice data, especially simultaneously acquired voice signals and electroglottograph signals, as well as temporal variations of pressures directly below and above the vocal folds. Its contents include the physics and physiology of human voice production, parametrical representations of voice signals, and technology applications. Background knowledge on general acoustics and mathematical tools pertinent to quantitative descriptions of human voice are explained in detail.Readers of this monograph include researchers, practitioners and students in the fields of physiology and medicine, acoustics, computer science, telecommunication, acoustic phonetics, and vocal music.
Muscle hypertrophy--defined as an increase in muscular size--is one of the primary outcomes of resistance training. Science and Development of Muscle Hypertrophy is a comprehensive compilation of science-based principles to help professionals develop muscle hypertrophy in athletes and clients. With more than 825 references and applied guidelines throughout, no other resource offers a comparable quantity of content solely focused on muscle hypertrophy. Readers will find up-to-date content so they fully understand the science of muscle hypertrophy and its application to designing training programs. Written by Brad Schoenfeld, PhD, a leading authority on muscle hypertrophy, this text provides strength and conditioning professionals, personal trainers, sport scientists, researchers, and exercise science instructors with a definitive resource for information regarding muscle hypertrophy--the mechanism of its development, how the body structurally and hormonally changes when exposed to stress, ways to most effectively design training programs, and current nutrition guidelines for eliciting hypertrophic changes. The full-color book offers several features to make the content accessible to readers: - Research Findings sidebars highlight the aspects of muscle hypertrophy currently being examined to encourage readers to re-evaluate their knowledge and ensure their training practices are up to date. - Practical Applications sidebars outline how to apply the research conclusions for maximal hypertrophic development. - Comprehensive subject and author indexes optimize the book's utility as a reference tool. - An image bank containing most of the art, photos, and tables from the text allows instructors and presenters to easily teach the material outlined in the book. Although muscle hypertrophy can be attained through a range of training programs, this text allows readers to understand and apply the specific responses and mechanisms that promote optimal muscle hypertrophy in their athletes and clients. It explores how genetic background, age, sex, and other factors have been shown to mediate the hypertrophic response to exercise, affecting both the rate and the total gain in lean muscle mass. Sample programs in the text show how to design a three- or four-day-per-week undulating periodized program and a modified linear periodized program for maximizing muscular development. Science and Development of Muscle Hypertrophy is an invaluable resource for strength and conditioning professionals seeking to maximize hypertrophic gains and those searching for the most comprehensive, authoritative, and current research in the field.
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