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Meticulously reviewed and updated for today's medical students, Basic Immunology, 6th Edition, is a concise text expertly written by the same distinguished author team as the best-selling, comprehensive text, Cellular and Molecular Immunology. This focused, easy-to-understand volume uses full-color illustrations and clinical images, useful tables, and practical features such as Summary Point boxes, end-of-chapter review questions, glossary terms, and clinical cases-all designed to help students master this complex topic in the most efficient, effective manner possible. Emphasizes clinical aspects of immunology, including disease pathogenesis, the development of novel therapies based on basic science, and an appendix of clinical cases for real-world application. Provides top-notch instruction from experienced teachers, course directors, and lecturers led by well-known editor and author Dr. Abul Abbas. Features a highly readable writing style and practical organization, now with fully revised content and updated images to reflect recent important advances in today's understanding of the immune system. Provides additional online features such as answers to in-book chapter review questions, helpful animations, and self-assessment questions. Presents information in a format and style that maximizes usefulness to students and teachers studying medicine, allied health fields, and biology. Contains numerous features designed to help students understand key immunologic concepts: high-quality illustrations, practical tables, chapter outlines, bolded key points, and focus questions in every chapter for self-assessment and review. Includes an Enhanced eBook version with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
The Immune System, Fourth Edition emphasizes the human immune system and presents immunological concepts in a coherent, concise, and contemporary account of how the immune system works. Written for undergraduate, medical, veterinary, dental, and pharmacy students, it makes generous use of medical examples to illustrate points. This classroom-proven textbook offers clear writing, full-color illustrations, and section and chapter summaries that make the book accessible and easily understandable to students. The Fourth Edition is a major revision that brings the content up-to-date and improves clarity. Based on user feedback, there is now increased continuity and connectivity between chapters. The Immune System is additionally supported by the Garland Science Learning System. This homework platform is designed to evaluate and improve student performance and allows instructors to select assignments on specific topics and review the performance of the entire class, as well as individual students, via the instructor dashboard. Students receive immediate feedback on their mastery of the topics, and will be better prepared for lectures and classroom discussions. The user-friendly system provides a convenient way to engage students while assessing progress. Performance data can be used to tailor classroom discussion, activities, and lectures to address students' needs precisely and efficiently. For more information and sample material, visit http://garlandscience.rocketmix.com/. A free trial for the Garland Science Learning System will be available to use during the Fall 2016 and Spring 2017 semesters. Please contact us directly at firstname.lastname@example.org to sign up!
Case Studies in Immunology, Seventh Edition is intended for medical students and undergraduate and graduate students in immunology. It presents major topics of immunology through a selection of clinical cases that reinforce and extend the basic science. Each case history is preceded by essential scientific facts about the immunological mechanisms of that specific disorder. The cases themselves demonstrate how immunological problems are deconstructed in the clinic and each one is followed by a concise summary of the clinical finding and questions which can serve as discussion points. The book includes a total of 55 cases and can be used as either a standalone text, review aid, or as a companion to Janeway's Immunobiology, Ninth Edition and The Immune System, Fourth Edition.
Offering a basis for further research into the interactions of hosts and pathogens, this work gathers up-to-date findings, and details basic structures, functions and immunology. It provides descriptions of a variety of experimental endotoxin neutralizing agents, as well as a guide to clinical research initiatives and the latest treatments.
How the Immune System Works has helped thousands of students understand what's in their hefty immunology textbooks. In this book, Dr. Sompayrac cuts through the jargon and details to reveal, in simple language, the essence of this complex subject: how the immune system fits together, how it protects us from disease and, perhaps most importantly, why it works the way it does. Featuring Dr. Sompayrac's hallmark lively prose and engaging analogies, How the Immune System Works has been rigorously updated for this sixth edition, including the latest information on subjects such as vaccines, immunological memory, and cancer. A highlight of this edition is a new chapter on immunotherapies - currently one of the hottest topics in immunology. Whether you are completely new to immunology, or require a refresher, How the Immune System Works will provide you with a clear and engaging overview of this fascinating subject.
Describes the immunological aspects of blood transfusion medicine, examining the immuno-chemistry of blood group antigens, the immune destruction of cells, correlations between blood groups and disease, and the effect transfusion-induced retroviral infection has on immune response.
Short-listed for the Society of Biology Book Award 2014 Long-listed for the Royal Society Winton prize for science books 2014 In The Compatibility Gene, leading scientist Daniel M Davis tells the story of the crucial genes that define our relationships, our health and our individuality. We each possess a similar set of around 25,000 human genes. Yet a tiny, distinctive cluster of these genes plays a disproportionately large part in how our bodies work. These few genes, argues Davis, hold the key to who we are as individuals and our relationship to the world: how we combat disease, how our brains are wired, how attractive we are, even how likely we are to reproduce. The Compatibility Gene follows the remarkable history of these genes' discovery. From the British scientific pioneers who struggled to understand the mysteries of transplants to the Swiss zoologist who devised a new method of assessing potential couples' compatibility based on the smell of worn T-shirts, Davis traces a true scientific revolution in our understanding of the human body: a global adventure spanning some sixty years. 'Unusual results, astonishing implications and ethical dilemmas' The Times 'Packed with an insider's knowledge' New York Times 'He makes immunology as fascinating to popular science readers as cosmology, consciousness, and evolution' Steven Pinker 'An elegantly written, unexpectedly gripping account' Bill Bryson Guardian, Books of the Year Daniel M Davis is director of research at the University of Manchester's Collaborative Centre for Inflammation Research and a visiting professor at Imperial College, London. He has published over 100 academic articles, including papers in Nature and Science, and Scientific American. He has won the Oxford University Press Science Writing Prize and given numerous interviews for national and international media. He was elected a Fellow of the Academy of Medical Sciences in 2011.
New York Times bestselling author Charles Graeber tells the astonishing story of the group of scientists working on a code that can enable the human immune system to fight ― and perhaps even cure ― cancer.
For decades, scientists have puzzled over one of medicine’s greatest mysteries: why doesn’t our immune system fight cancer the way it does other diseases? The answer is a series of tricks that cancer has developed to turn off normal immune responses ― tricks that scientists have only recently discovered, and now are learning to defeat. We are in the midst of a revolution in our understanding of cancer and how to beat it.
Groundbreaking, riveting, and expertly told, The Breakthrough is the story of the game-changing and Nobel Prize-winning scientific discoveries that unleash our natural ability to recognise and defeat cancer, as told through the experiences of the patients, physicians, and immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, and the definitive account of a historic moment in medical science.
This volume focuses on various methods used by researchers to study mucosal-associated invariant T (MAIT) cells in the aspects described below. The chapters are organized into Four Parts: part One looks at the function and importance of MAIT cells in health and disease. It covers methods to isolate and characterize MAIT cells from human tissues including liver, colon tumors, placenta and decidua, and endometrium. Part Two discusses MR1 independent stimulation, and looks at the activation of MAIT cells by different stimulatory agents. Part Three describes various methods to develop tools to analyze, monitor, and generate MAIT cells in vitro, including the production of MR1-tetramers and how they can be loaded with bacterial antigens and used for the detection of MAIT cells. The last part covers the use of murine models to study MAIT cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, MAIT Cells: Methods and Protocols is a valuable resource for anyone interested in learning more about this developing field. Chapters 9 and 17 are open access under a CC BY 4.0 license.
The ways in which we can better understand cancer, HIV, and other autoimmune diseases through clinical immunology are of great interest to practitioners from the student level to the advanced PhD. Designed as an introduction for practitioners and residents, this book focuses on the clinical disease-state level of immunology. Essential Clinical Immunology" begins with the basic concepts and then details the immunological aspects of various disease states involving major organs of the body. The book explores how we can better understand disease and its treatment through clinical immunology. Looking forward, each chapter concludes with patterns for future research.
Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. This volume focuses on the immunopathology and immunotherapy of organ cancers in detail. It clearly explains their immunology and describes novel immunotherapy for specific cancers, including pediatric solid tumors, hematologic malignancies, gastrointestinal tumors, skin cancers, bone and connective tissue tumors, central nervous system tumors, lung cancers, genitourinary tract tumors and breast cancers. In so doing, it builds on the previous two volumes in Cancer Immunology, placing basic knowledge on tumor immunology and immunotherapy into a clinical perspective with the aim of educating clinicians on advances in cancer immunology and the most recent approaches in the immunotherapy of various tumors. This translational, clinically oriented book will be of special value to clinical immunologists, hematologists and oncologists.
This volume examines our current understanding of the biological effects of fibrous and particulate substances, including discussions on nanoparticles. It offers comprehensive information on the latest insights into the immunological effects of various irritants on the human body. Readers will benefit from the contributing authors' diverse perspectives and extensive discussions of key issues, which include molecular alterations of the immune system and autoimmune diseases in connection with asbestos and silica, among others. The chapters also discuss recommendations, practical methods, and nanosafety science in situations involving exposure to nanotoxic substances. Edited in collaboration with the Japanese Society for Hygiene, this book provides up-to-date information on the immunological effects of nanotoxic substances to researchers interested in environmental and occupational health. Presenting a number of recent concepts and findings in the field, it enables readers to gain a comprehensive knowledge of health problems caused by environmental fibrous and particulate substances.
As the number of surviving immune suppressed patients continues to rise, skin manifestations of patients have become increasingly important. AIDS patients, and renal, heart, liver, bone marrow, and lung transplant patients are now living longer and immunosuppressive drugs are being used more frequently. Diabetes is rising in the US and around the world, offering its own unique brand of immune suppressed skin diseases. The skin may be the earliest sign of these conditions and be the organ showing the most profound, earliest, and treatment limiting side effects. Skin Diseases in the Immunocompromised is the most comprehensive book on the topic available. It elucidates the signs of immune suppressed skin diseases to afford early diagnosis and management of this ever-increasing diverse group of illnesses. Organized for easy access, this book will be an essential resource for residents and fellows in dermatology and infectious diseases medical professionals.
This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing.
"Cancer Immunotherapy Meets Oncology" is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.
Immunology: A Short Course, 7th Edition introduces all the critical topics of modern immunology in a clear and succinct yet comprehensive fashion. The authors offer uniquely-balanced coverage of classical and contemporary approaches and basic and clinical aspects. The strength of Immunology: A Short Course is in providing a complete review of modern immunology without the burden of excessive data or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics, illustrated by uniformly drawn, full-color illustrations and photographs. This new edition of Immunology: A Short Course: Has been fully revised and updated, with a brand new art program to help reinforce learning Includes a new chapter on Innate Immunity to reflect the growth in knowledge in this area Highlights important therapeutic successes resulting from targeted antibody therapies Includes end of chapter summaries and review questions, a companion website at www.wileyimmunology.com/coico featuring interactive flashcards, USMLE-style interactive MCQs, figures as PowerPoint slides, and case-based material to help understand clinical applications
Janeway's Immunobiology is a textbook for students studying immunology at the undergraduate, graduate, and medical school levels. As an introductory text, students will appreciate the book's clear writing and informative illustrations, while advanced students and working immunologists will value its comprehensive scope and depth. Janeway's Immunobiology presents immunology from a consistent point of view throughout-that of the host's interaction with an environment full of microbes and pathogens. The Ninth Edition has been thoroughly revised bringing the content up-to-date with significant developments in the field, especially on the topic of innate immunity, and improving the presentation of topics across chapters for better continuity.
This book provides an informative update on scientific advances relating to transplant dermatology that may be applicable to clinical practice. Commentary is provided on the emerging role of viruses in transplant dermatology, the management of skin disease secondary to transplant medication, sunscreen use in transplant recipients, the role of revision of immunosuppression, and advances in photodynamic therapy. The latest staging and management criteria for high-risk squamous cell carcinoma and the implications for clinical practice are then analyzed. Finally, the management of other cutaneous malignancies is discussed, covering malignant melanoma, Merkel cell carcinoma, and rarer tumors that also behave aggressively and require special consideration in solid organ transplant patients. Each particular advance is addressed in an individual chapter by leaders in the field. The book both expands current knowledge and complements previous textbooks on the subject.
Essentials of Clinical Immunology provides the most up-to-date, core information required to understand diseases with an immunological basis. Clinically focussed, the sixth edition of this classic text presents theoretical and practical information in a simple yet thorough way. Essentials of Clinical Immunology covers the underlying pathophysiology, the signs and symptoms of disease, the investigations required and guidance on the management of patients. Perfect for clinical medical students, junior doctors and medical professionals seeking a refresher in the role of immunology in clinical medicine, this comprehensive text features fully updated clinical information, boxes with key points, real-life case histories to illustrate key concepts and an index of contents at the start of each chapter. A companion website at www.immunologyclinic.com provides additional learning tools, including more case studies, interactive multiple-choice questions and answers, all of the photographs and illustrations from the book, links to useful websites, and a selection of review articles from the journal Clinical and Experimental Immunology. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.
The primary focus of this book is to provide readers with a comprehensive overview of the recent advances in inflammation, especially in molecular biological and clinical aspects. Chapters contained in this book are written by invited authors from all over the world, who are well-known experts in their respective fields. In the book, chapters discussed include the molecular basis of inflammatory mechanisms, the functional roles of inflammation in diseases and new treatments of anti-inflammation. This book will be useful to all who wish to understand the scientific basis of inflammatory disease.
This book systematically reviews and discusses recent studies and articles on the immunology of female genital tract tissue. The scope is broad, encompassing innate immune responses, adaptive (humoral and cell-mediated) immunity, the immunology of menstruation, the immunology of viral and bacterial infections, the immunology of normal and abnormal pregnancy, and immunological infertility. Throughout, tables and illustrations are judiciously used to facilitate understanding. Immunology of the Female Genital Tract will serve as an invaluable source of up-to-date information for all with an interest in this subject.
Mount Sinai Expert Guides: Allergy and Clinical Immunology will provide trainees in allergy and immunology with an extremely clinical and accessible handbook covering the major disorders and symptoms, their diagnosis and clinical management. Perfect as a point-of-care resource on the hospital wards and also as a refresher for board exam preparation, the focus throughout is on providing rapid reference, essential information on each disorder to allow for quick, easy browsing and assimilation of the must-know information. All chapters follow a consistent template including the following features: * An opening bottom-line/key points section * Classification, pathogenesis and prevention of disorder * Evidence-based diagnosis, including relevant algorithms, laboratory and imaging tests, and potential pitfalls when diagnosing a patient * Disease management including commonly used medications with dosages, management algorithms and how to prevent complications * How to manage special populations, ie, in pregnancy, children and the elderly * The very latest evidence-based results, major society guidelines and key external sources to consult In addition, the book comes with a companion website housing extra features such as case studies with related questions for self-assessment, key patient advice and ICD codes. Each guide also has its own mobile app available for purchase, allowing you rapid access to the key features wherever you may be. If you're specialising in allergy and immunology and require concise, practical and clinical guidance from one of the world's leading institutions in this field, then this is the perfect book for you. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.
SITC's Guide to Managing Immunotherapy Toxicity is a practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Separated into two parts, Part One contains chapter-based overviews of immune checkpoint inhibitors in the clinic, starting with Anti-CTLA4 agents, Anti-PD1/PD-L1 agents, and approved immunotherapeutic combinations. These chapters cover relevant mechanisms of action, indications, and toxicities seen while combating early, advanced, and metastatic stages in cancer patients. Part Two is structured by common and uncommon toxicities that affect major organ sites throughout the body. It begins with a general summary of principles and management options followed by chapters focusing on specific toxicities such as rash and mucosal irritation, muscle and joint toxicity, diarrhea and colitis, pneumonitis, endocrine toxicities, neurological toxicities, cardiac toxicity, renal toxicity, hematologic toxicity, and ocular toxicities. Each chapter provides guidance on how to assess and treat the toxicity and how to support the patient through acute and chronic effects with detailed summary tables for quick reference. Part Two concludes with chapters covering management of special patient populations, including patients with autoimmune disease and geriatric patients, treatment and management of fatigue, and a final chapter dedicated to cost effectiveness and the toll of `financial toxicity 'on patients and caregivers. With chapters written by world recognized oncology leaders in the immuno-oncology field, this text provides thorough coverage of the toxicity and management of adverse effects for immune checkpoint inhibitors. It is an indispensable resource for clinical oncologists, emergency physicians, hospitalists and other medical practitioners in both the hospital and community clinic settings, especially as the use of immune checkpoint inhibitors becomes a fixture in oncology care. Key Features: Outlines strategies for treating high-risk patients facing an acute or chronic side effect to immunotherapy Provides numerous tables that condense and highlight pertinent information for quick reference Describes the various clinical presentations and toxic reactions caused by immunotherapy Includes access to the fully searchable downloadable eBook
BIOS Instant Notes in Immunology, Third Edition, is the perfect text for undergraduates looking for a concise introduction to the subject, or a study guide to use before examinations. Each topic begins with a summary of essential facts-an ideal revision checklist-followed by a description of the subject that focuses on core information, with clear, simple diagrams that are easy for students to understand and recall in essays and exams. BIOS Instant Notes in Immunology, Third Edition, is fully up-to-date and covers: * Overview of the Immune System * Cells and Molecules of the Innate Immune System * The Adaptive Immune System * Antibodies * The Antibody Response * The T Cell Response -- Cell-Mediated Immunity * Regulation of the Immune Response * Immunity to Infection * Vaccination * Immunodeficiency -- when the Immune System Fails * Hypersensitivity -- when the Immune System Misbehaves * Autoimmunity and Autoimmune Diseases * Transplantation * Tumor Immunology * Gender and the Immune System * Aging and the Immune System (Immunosenescence) * Immunotherapy
This book addresses important issues regarding the interaction between the nervous system, the immune system, and the digestive system. Gut flora has a profound influence on the shaping of the immune response, not only in the gastrointestinal system but also in the nervous system. Fascinatingly, manipulation of intestinal immune responses can be used to modulate neurological disease. Conversely, the nervous system and the psyche have significant effects on the functioning of the gut and liver. After introductory chapters on the neurology, the immunology and microbiology of the gut, the effects of the gut immune system and gut flora and its manipulation on neurological disease are discussed, followed by molecular mimicry and immune tolerance in neuroimmune diseases. Additionally, several chapters deal with gastrointestinal manifestations of neurological diseases. Neuro-Immuno-Gastroenterology is aimed at neurologists, gastroenterologists, and immunologists.
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