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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical)

The Material Gene - Gender, Race, and Heredity after the Human Genome Project (Paperback): Kelly E. Happe The Material Gene - Gender, Race, and Heredity after the Human Genome Project (Paperback)
Kelly E. Happe
R509 R429 Discovery Miles 4 290 Save R80 (16%) Shipped within 7 - 12 working days

Winner of the 2014 Diamond Anniversary Book Award Finalist for the 2014 National Communications Association Critical and Cultural Studies Division Book of the Year Award In 2000, the National Human Genome Research Institute announced the completion of a "draft" of the human genome, the sequence information of nearly all 3 billion base pairs of DNA. Since then, interest in the hereditary basis of disease has increased considerably. In The Material Gene, Kelly E. Happe considers the broad implications of this development by treating "heredity" as both a scientific and political concept. Beginning with the argument that eugenics was an ideological project that recast the problems of industrialization as pathologies of gender, race, and class, the book traces the legacy of this ideology in contemporary practices of genomics. Delving into the discrete and often obscure epistemologies and discursive practices of genomic scientists, Happe maps the ways in which the hereditarian body, one that is also normatively gendered and racialized, is the new site whereby economic injustice, environmental pollution, racism, and sexism are implicitly reinterpreted as pathologies of genes and by extension, the bodies they inhabit. Comparing genomic approaches to medicine and public health with discourses of epidemiology, social movements, and humanistic theories of the body and society, The Material Gene reworks our common assumption of what might count as effective, just, and socially transformative notions of health and disease.

Genetics And Ecotoxicology (Hardcover): Valery E. Forbes Genetics And Ecotoxicology (Hardcover)
Valery E. Forbes
R3,891 Discovery Miles 38 910 Shipped within 7 - 12 working days

This first volume in the series provides a detailed treatment in ecotoxicology and stresses why genetics is important in understanding if and how chemical contaminants affect populations. Written by an array of international contributors from various fields covering mammals, invertebrates, fish, plants, as well as molecular ecotoxicology, this book considers both ecological/evolutionary consequences and practical implications of the interplay between chemical toxicants and the genetic population.
In broadening the understanding of ecological response, this resource ranges from molecular to classical genetics, from plant to animal, from asexual to sexual, touching on some fundamental issues of evolutionary biology. In addition, gaps in our present understanding of genetic and ecotoxicological processes and future research directions have been identified.

Forensic DNA Profiling - A Practical Guide to Assigning Likelihood Ratios (Hardcover): Jo-Anne Bright, Michael Coble Forensic DNA Profiling - A Practical Guide to Assigning Likelihood Ratios (Hardcover)
Jo-Anne Bright, Michael Coble
R1,217 Discovery Miles 12 170 Shipped within 7 - 11 working days

DNA testing and its forensic analysis are recognized as the "gold standard" in forensic identification science methods. However, there is a great need for a hands-on step-by-step guide to teach the forensic DNA community how to interpret DNA mixtures, how to assign a likelihood ratio, and how to use the subsequent likelihood ratio when reporting interpretation conclusions. Forensic DNA Profiling: A Practical Guide to Assigning Likelihood Ratios will provide a roadmap for labs all over the world and the next generation of analysts who need this foundational understanding. The techniques used in forensic DNA analysis are based upon the accepted principles of molecular biology. The interpretation of a good quality DNA profile generated from a crime scene stain from a single source donor provides an unambiguous result when using the most modern forensic DNA methods. Unfortunately, many crime scene profiles however are not single source. They are described as mixed since they contain DNA from two or more individuals. Interpretation of DNA mixtures represents one of the greatest challenges to the forensic DNA analyst. As such, the book introduces terms used to describe DNA profiles and profile interpretation. Chapters explains DNA extraction methods, the Polymerase Chain Reaction (PCR), Capillary Electrophoresis (CE), likelihood ratios (LRs) and their interpretation, and population genetic models-including Mendelian inheritance and Hardy-Weinberg Equilibrium. It is important that analysts understand how LRs are generated in a probabilistic framework, ideally with an appreciation of both semi-continuous and fully-continuous probabilistic approaches. Key features: * The first book to focus entirely on DNA mixtures and the complexities involved with interpreting the results * Takes a hands-on approach offering theory with worked examples and exercises to be easily understood and implementable by laboratory personnel * New methods, heretofore unpublished previously, provide a means to innovate deconvoluting a mixed DNA profile, assign an LR, and appropriately report the weight of evidence * Includes a chapter on assigning LRs for close relatives (i.e., "It's not me, it was my brother"), and discusses strategies for the validation of probabilistic genotyping software. Forensic DNA Profiling fills the void for labs unfamiliar with LRs, and moving to probabilistic solutions, and for labs already familiar with LRs, but wishing to understand how they are calculated in more detail. The book will be a welcome read for lab professionals and technicians, students, and legal professionals seeking to understand and apply the techniques covered.

Metagenomics & its Applications in Agriculture, Biomedicine & Environmental Studies (Paperback): Robert W. Li Metagenomics & its Applications in Agriculture, Biomedicine & Environmental Studies (Paperback)
Robert W. Li
R1,908 R1,301 Discovery Miles 13 010 Save R607 (32%) Shipped within 7 - 12 working days

Metagenomics is the study of microbial communities sampled directly from their natural environment, without prior culturing. DNA sequencing (or alternatively, an assay of functional properties) is applied to the culture-independent analyses of complex and diverse ("meta") populations of microbes. The rapid growth of metagenomics entails an expanded focus on microbes in a wide range of basic and applied research fields, ranging from microbiology to agriculture, biomedicine to bioenergy, and from veterinary to clinical medicine. This book is an insightful and inclusive study on metagenomics and its applications.

Decoding the Genomic Control of Immune Reactions (Hardcover): Gregory R. Bock, Jamie A Goode Decoding the Genomic Control of Immune Reactions (Hardcover)
Gregory R. Bock, Jamie A Goode
R3,530 Discovery Miles 35 300 Shipped within 7 - 12 working days

This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections. The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend.

Specific problems addressed include the following: What kinds of information are we lacking to understand how the genome sequence specifies the differentiation and response of immune system cells, and system behaviour such as immunological memory and tolerance? Which genome sequences and cellular circuits cause or prevent pathological immune responses to foreign pathogens, allergens or self-tissues? Which host and pathogen genome sequences and cellular circuits explain the failure of sterilizing immune responses to sophisticated human pathogens such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses?

Containing contributions from a range of leading experts in the field, this book provides an important new perspective for clinical immunologists and basic researchers alike.

Molecular Biology - Principles of Genome Function (Paperback, 2nd Revised edition): Nancy Craig, Rachel Green, Carol Greider,... Molecular Biology - Principles of Genome Function (Paperback, 2nd Revised edition)
Nancy Craig, Rachel Green, Carol Greider, Gisela Storz, Cynthia Wolberger, …
R1,543 R1,380 Discovery Miles 13 800 Save R163 (11%) Shipped within 7 - 12 working days

The biological world operates on a multitude of scales - from molecules to cells to tissues to organisms to ecosystems. Throughout all these levels runs a common thread: the communication and onward passage of information - from cell to cell, from organism to organism and, ultimately, from generation to generation. But how does this information - no more than a static repository of data - come alive to govern the processes that constitute life? The answer lies in the concerted action of molecular components which cooperate through a series of carefully-regulated processes to bring the information in our genome to life. These components and processes lie at the heart of one of the most fascinating subjects to engage the minds of scientists today: molecular biology. Molecular Biology: Principles of Genome Function offers a fresh, distinctive approach to the teaching of molecular biology. It is an approach that reflects the challenge of teaching a subject that is in many ways unrecognizable from the molecular biology of the 20th century - a discipline in which our understanding has advanced immeasurably, but about which many questions remain to be answered. It is written with several guiding themes in mind: - A focus on key principles provides a robust conceptual framework on which students can build a solid understanding of the discipline; - An emphasis on the commonalities that exist between the three kingdoms of life, and the discussion of differences between the three kingdoms where such differences offer instructive insights into molecular processes and components, gives students an accurate depiction of our current understanding of the conserved nature of molecular biology, and the differences that underpin biological diversity; - An integrated approach demonstrates how certain molecular phenomena have diverse impacts on genome function by presenting them as themes that recur throughout the book, rather than as artificially separated topics At heart, molecular biology is an experimental science, and a central element to the understanding of molecular biology is an appreciation of the approaches taken to yield the information from which concepts and principles are deduced. Yet there is also the challenge of introducing the experimental evidence in a way that students can readily comprehend. Molecular Biology responds to this challenge with Experimental Approach panels, which branch off from the text in a clearly-signposted way. These panels describe pieces of research that have been undertaken, and which have been particularly valuable in elucidating difference aspects of molecular biology. Each panel is carefully cross-referenced to the discussion of key molecular biology tools and techniques, which are presented in a dedicated chapter at the end of the book. Beyond this, Molecular Biology further enriches the learning experience with full-colour, custom-drawn artwork; end-of-chapter questions and summaries; relevant suggested further readings grouped by topic; and an extensive glossary of key terms. Among the students being taught today are the molecular biologists of tomorrow; these individuals will be in a position to ask fascinating questions about fields whose complexity and sophistication become more apparent with each year that passes. Molecular Biology: Principles of Genome Function is the perfect introduction to this challenging, dynamic, but ultimately fascinating discipline. Online Resource Centre The Online Resource Centre to accompany Molecular Biology: Principles of Genome Function features For registered adopters of the text: Electronic artwork: Figures from the book are available to download, for use in lectures. Journal Club: Suggested research papers and discussion questions linked to topics featured in the book build on the Experimental Approach panels in the book itself, to guide the process of assimilating knowledge from the research literature Answers to end of chapter questions: Full answers to every end of chapter question are provided to assist with the grading of students' work For everyone: Links to video animations: Links to a range of animations that have been designed to illustrate some of the central processes in molecular biology, including those that are particularly challenging to visualize.

Epigenetic Regulation and Epigenomics (Hardcover): Robert A. Meyers Epigenetic Regulation and Epigenomics (Hardcover)
Robert A. Meyers
R8,306 R6,767 Discovery Miles 67 670 Save R1,539 (19%) Shipped within 7 - 12 working days

Epigenetics is a term in biology referring to heritable traits that do not involve changes in the underlying DNA sequence of the organism. Epigenetic traits exist on top of or in addition to the traditional molecular basis for inheritance. The "epigenome" is a parallel to the word "genome," and refers to the overall epigenetic state of a cell. Cancer and stem cell research have gradually focused attention on these genome modifications. The molecular basis of epigenetics involves modifications to DNA and the chromatin proteins that associate with it. Methylation, for example, can silence a nearby gene and seems to be involved in some cancers. Epigenetics is beginning to form and take shape as a new scientific discipline, which will have a major impact on Medicine and essentially all fields of biology. Increasingly, researchers are unearthing links between epigenetics and a number of diseases. Although in recent years cancer has been the main focus of epigenetics, recent data suggests that epigenetic plays a critical role in psychology and psychopathology. It is being realized that normal behaviors such as maternal care and pathologies such as Schizophrenia and Alzheimer's might have an epigenetic basis. It is also becoming clear that nutrition and life experiences have epigenetic consequences. Discover more online content in the Encyclopedia of Molecular Cell Biology and Molecular Medicine.

Recombinant Protein Production in Yeast - Methods and Protocols (Hardcover, 2012): Roslyn M. Bill Recombinant Protein Production in Yeast - Methods and Protocols (Hardcover, 2012)
Roslyn M. Bill
R3,319 R2,450 Discovery Miles 24 500 Save R869 (26%) Shipped within 7 - 12 working days

In the last few years, significant advances have been made in understanding how a yeast cell responds to the stress of producing a recombinant protein, and how this information can be used to engineer improved host strains. The molecular biology of the expression vector, through the choice of promoter, tag and codon optimization of the target gene, is also a key determinant of a high-yielding protein production experiment. Recombinant Protein Production in Yeast: Methods and Protocols examines the process of preparation of expression vectors, transformation to generate high-yielding clones, optimization of experimental conditions to maximize yields, scale-up to bioreactor formats and disruption of yeast cells to enable the isolation of the recombinant protein prior to purification. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Recombinant Protein Production in Yeast: Methods and Protocols, seeks to aid scientists in adopting yeast as a protein production host.

The Antisocial Personalities (Hardcover): David Thoreson Lykken The Antisocial Personalities (Hardcover)
David Thoreson Lykken
R1,402 Discovery Miles 14 020 Shipped within 7 - 12 working days

This volume presents a scholarly analysis of psychopathic and sociopathic personalities and the conditions that give rise to them. In so doing, it offers a coherent theoretical and developmental analysis of socialization and its vicissitudes, and of the role played in socialization by the crime-relevant genetic traits of the child and the skills and limitations of the primary socializing agents, the parents.
This volume also describes how American psychiatry's (DSM-IV) category of "Antisocial Personality Disorder" is heterogeneous and fails to document some of the more interesting and notorious psychopaths of our era. The author also shows why the antinomic formula "Nature "vs." Nurture" should be revised to "Nature "via" Nurture" and reviews the evidence for the heritability of crime-relevant traits. One of these traits -- fearlessness -- seems to be one basis for the primary psychopathy and the author argues that the primary psychopath and the hero may be twigs on the same genetic branch.
But crime -- the failure of socialization -- is rare among traditional peoples still living in the extended-family environment in which our common ancestors lived and to which our species is evolutionarily adapted. The author demonstrates that the sharp rise in crime and violence in the United States since the 1960s can be attributed to the coeval increase in divorce and illegitimacy which has left millions of fatherless children to be reared by over-burdened, often immature or sociopathic single mothers. The genus "sociopathic personality" includes those persons whose failure of socialization can be attributed largely to incompetent or indifferent rearing.
Two generalizations supported by modern behavior genetic research are that most psychological traits have strong genetic roots "and" show little lasting influence of the rearing environment. This book demonstrates that the important trait of socialization is an exception. Although traits that obstruct or facilitate socialization tend to obey these rules, socialization itself is only weakly heritable; this is because modern American society displays such enormous variance in the relevant environmental factors, mainly in parental competence. Moreover, parental incompetence that produces sociopathy in one child is likely to have the same result with any siblings. This book argues that sociopathy contributes far more to crime and violence than psychopathy because sociopaths are much more numerous and because sociopathy is a familial trait for both genetic and environmental reasons. With a provocative thesis and an engaging style, this book will be of principal interest to clinical, personality, forensic, and developmental psychologists and their students, as well as to psychiatrists and criminologists.

The Antisocial Personalities (Paperback): David Thoreson Lykken The Antisocial Personalities (Paperback)
David Thoreson Lykken
R926 Discovery Miles 9 260 Shipped within 7 - 12 working days

This volume presents a scholarly analysis of psychopathic and sociopathic personalities and the conditions that give rise to them. In so doing, it offers a coherent theoretical and developmental analysis of socialization and its vicissitudes, and of the role played in socialization by the crime-relevant genetic traits of the child and the skills and limitations of the primary socializing agents, the parents.
This volume also describes how American psychiatry's (DSM-IV) category of "Antisocial Personality Disorder" is heterogeneous and fails to document some of the more interesting and notorious psychopaths of our era. The author also shows why the antinomic formula "Nature "vs." Nurture" should be revised to "Nature "via" Nurture" and reviews the evidence for the heritability of crime-relevant traits. One of these traits -- fearlessness -- seems to be one basis for the primary psychopathy and the author argues that the primary psychopath and the hero may be twigs on the same genetic branch.
But crime -- the failure of socialization -- is rare among traditional peoples still living in the extended-family environment in which our common ancestors lived and to which our species is evolutionarily adapted. The author demonstrates that the sharp rise in crime and violence in the United States since the 1960s can be attributed to the coeval increase in divorce and illegitimacy which has left millions of fatherless children to be reared by over-burdened, often immature or sociopathic single mothers. The genus "sociopathic personality" includes those persons whose failure of socialization can be attributed largely to incompetent or indifferent rearing.
Two generalizations supported by modern behavior genetic research are that most psychological traits have strong genetic roots "and" show little lasting influence of the rearing environment. This book demonstrates that the important trait of socialization is an exception. Although traits that obstruct or facilitate socialization tend to obey these rules, socialization itself is only weakly heritable; this is because modern American society displays such enormous variance in the relevant environmental factors, mainly in parental competence. Moreover, parental incompetence that produces sociopathy in one child is likely to have the same result with any siblings. This book argues that sociopathy contributes far more to crime and violence than psychopathy because sociopaths are much more numerous and because sociopathy is a familial trait for both genetic and environmental reasons. With a provocative thesis and an engaging style, this book will be of principal interest to clinical, personality, forensic, and developmental psychologists and their students, as well as to psychiatrists and criminologists.

Genetic Ethics - An Introduction (Hardcover): Colin Farrelly Genetic Ethics - An Introduction (Hardcover)
Colin Farrelly
R1,228 R1,115 Discovery Miles 11 150 Save R113 (9%) Shipped within 7 - 12 working days

Colin Farrelly contemplates the various ethical and social quandaries raised by the genetic revolution. Recent biomedical advances such as genetic screening, gene therapy and genome editing might be used to promote equality of opportunity, reproductive freedom, healthy aging, and the prevention and treatment of disease. But these technologies also raise a host of ethical questions: Is the idea of "genetically engineering" humans a morally objectionable form of eugenics? Should parents undergoing IVF be permitted to screen embryos for the sex of their offspring? Would it be ethical to alter the rate at which humans age, greatly increasing longevity at a time when the human population is already at potentially unsustainable levels? Farrelly applies an original virtue ethics framework to assess these and other challenges posed by the genetic revolution. Chapters discuss virtue ethics in relation to eugenics, infectious and chronic disease, evolutionary biology, epigenetics, happiness, reproductive freedom and longevity. This fresh approach creates a roadmap for thinking ethically about technological progress that will be of practical use to ethicists and scientists for years to come. Accessible in tone and compellingly argued, this book is an ideal introduction for students of bioethics, applied ethics, biomedical sciences, and related courses in philosophy and life sciences.

Gene Editing, Law, and the Environment - Life Beyond the Human (Hardcover): Irus Braverman Gene Editing, Law, and the Environment - Life Beyond the Human (Hardcover)
Irus Braverman
R2,307 Discovery Miles 23 070 Shipped within 7 - 12 working days

Technologies like CRISPR and gene drives are ushering in a new era of genetic engineering, wherein the technical means to modify DNA are cheaper, faster, more accurate, more widely accessible, and with more far-reaching effects than ever before. These cutting-edge technologies raise legal, ethical, cultural, and ecological questions that are so broad and consequential for both human and other-than-human life that they can be difficult to grasp. What is clear, however, is that the power to directly alter not just a singular form of life but also the genetics of entire species and thus the composition of ecosystems is currently both inadequately regulated and undertheorized. In Gene Editing, Law, and the Environment, distinguished scholars from law, the life sciences, philosophy, environmental studies, science and technology studies, animal health, and religious studies examine what is at stake with these new biotechnologies for life and law, both human and beyond.

Shrews, Chromosomes and Speciation (Hardcover): Jeremy B. Searle, P. David Polly, Jan Zima Shrews, Chromosomes and Speciation (Hardcover)
Jeremy B. Searle, P. David Polly, Jan Zima
R1,597 R1,485 Discovery Miles 14 850 Save R112 (7%) Shipped within 7 - 12 working days

The chromosome complement (karyotype) often differs between related mammalian species (including humans vs chimpanzees), such that evolutionary biologists muse whether chromosomal difference is a cause or a consequence of speciation. The common shrew is an excellent model to investigate this problem because of its many geographical races (potential species) differing chromosomally, and its several sibling species (recently speciated forms) that are also chromosomally different. This system is an exceptional opportunity to investigate the role of chromosomes in speciation and this volume reflects detailed research following these approaches. Highlights include the demonstration that chromosomal re-arrangements can be associated with complete loss of gene flow and thus speciation and that selection within species hybrid zones may lead to de-speciation rather than speciation. This book represents an extraordinarily detailed consideration of the role of chromosomes in speciation in one astonishing species, providing insights to those interested in mammalian diversity, chromosomal evolution and speciation.

Bioinformation (Hardcover): Bronwyn Parry, Beth Greenhough Bioinformation (Hardcover)
Bronwyn Parry, Beth Greenhough
R1,115 R1,015 Discovery Miles 10 150 Save R100 (9%) Shipped within 7 - 12 working days

From DNA sequences stored on computer databases to archived forensic samples and biomedical records, bioinformation comes in many forms. Its unique provenance the fact that it is 'mined' from the very fabric of the human body makes it a mercurial resource; one that no one seemingly owns, but in which many have deeply vested interests. Who has the right to exploit and benefit from bioinformation? The individual or community from whom it was derived? The scientists and technicians who make its extraction both possible and meaningful or the commercial and political interests which fund this work? Who is excluded or even at risk from its commercialisation? And what threats and opportunities might the generation of 'Big Bioinformational Data' raise? In this groundbreaking book, authors Bronwyn Parry and Beth Greenhough explore the complex economic, social and political questions arising from the creation and use of bioinformation. Drawing on a range of highly topical cases, including the commercialization of human sequence data; the forensic use of retained bioinformation; biobanking and genealogical research, they show how demand for this resource has grown significantly driving a burgeoning but often highly controversial global economy in bioinformation. But, they argue, change is afoot as new models emerge that challenge the ethos of privatisation by creating instead a dynamic open source 'bioinformational commons' available for all future generations.

Stem Cells in Modeling Human Genetic Diseases (Hardcover, 1st ed. 2015): Mayana Zatz, Oswaldo Keith Okamoto Stem Cells in Modeling Human Genetic Diseases (Hardcover, 1st ed. 2015)
Mayana Zatz, Oswaldo Keith Okamoto
R3,297 R2,570 Discovery Miles 25 700 Save R727 (22%) Shipped within 7 - 12 working days

While most stem cell books focus on basic aspects and/or cell therapy, this book emphasizes the relevance of stem cells obtained from patients, the so-called "patients in a petri dish" as tools to investigate human genetic diseases for which there are no available effective treatment. Chapters embrace several examples of the use of iPS cell technology, a recent Nobel Prize-winning scientific breakthrough, to obtain patient-specific pluripotent cells from which many types of specialized cells involved in a particular disease can be generated, including psychiatric and neurodegenerative disorders, muscular dystrophies, laminopathies, among others. The text is a current and timely resource for postgraduate students, scientists and clinicians, interested in applications of this rapidly developing field of research in disease modeling, drug development, and emerging issues that it brings to regenerative medicine.

p53 - The Gene that Cracked the Cancer Code (Paperback): Sue Armstrong p53 - The Gene that Cracked the Cancer Code (Paperback)
Sue Armstrong 1
R233 R206 Discovery Miles 2 060 Save R27 (12%) Shipped within 7 - 12 working days

All of us have lurking in our DNA a most remarkable gene. Its job is straightforward - to protect us from cancer. This gene - known simply as p53 - constantly scans our cells to ensure that they grow and divide without mishap, as part of the routine maintenance of our bodies. If a cell makes a mistake in copying its DNA as part of its process of division, p53 stops it in its tracks, sending in the repair team before allowing the cell to carry on dividing. If the mistake is irreparable and the rogue cell threatens to grow out of control (as happens in cancer), p53 commands the cell to commit suicide. Cancer cannot develop unless p53 itself is damaged and malfunctioning. Not surprisingly, p53 is the most studied gene in history. This enormously important gene has teased the minds of some of the most colourful and ambitious scientists around the world. These characters populate Sue Armstrong's book p53: The Gene that Cracked the Cancer Code, the story of medical science's mission to unravel the mysteries of this gene and to get to the heart of what happens in our cells when they turn cancerous. p53: The Gene that Cracked the Cancer Code reveals the tale of the search for this gene, as well as the excitement of the hunt for new cures - the hype, the lost opportunities, the blind alleys and the thrilling breakthroughs.As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is still at the forefront of the game. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.

Annual Plant Reviews - Plant Nuclear Structure, Genome Architecture and Gene Regulation (Hardcover, Volume 46): David Evans,... Annual Plant Reviews - Plant Nuclear Structure, Genome Architecture and Gene Regulation (Hardcover, Volume 46)
David Evans, Katja Graumann, John A. Bryant
R3,054 R2,699 Discovery Miles 26 990 Save R355 (12%) Shipped within 7 - 12 working days

This timely volume brings together expert reviews of the recent significant advances in our knowledge and understanding of the organisation of the higher plant nucleus, and in particular in the relationship between nuclear organisation and the regulation of gene expression. Rapid progress has been made in a number of key areas over the last five years, including description and characterization of proteins of the nuclear envelope and nuclear pore complex, novel insights into nucleoskeletal structures, as well as developments related to chromatin organization, function and gene expression. These advances open the way for new research into areas such as stress tolerance, plant-pathogen interactions and ultimately crop improvement and food security. Continued research into plant nuclear structure, genome architecture and gene regulation also enriches our understanding of the origin and evolution of the nucleus and its envelope.

Edited by world-class researchers in plant cell biology, and comprising contributions from internationally-renowned academics, this latest volume in the prestigious Annual Plant Reviews series brings together a wealth of knowledge in the burgeoning field of plant nuclear structure and genetics.

"Annual Plant Reviews, Volume 46: Plant Nuclear Structure, Genome Architecture and Gene Regulation" is a vital resource for advanced students, researchers and professionals in plant science and related disciplines. Libraries in all research establishments where plant science, biochemistry, molecular biology, genetics and genomics and agricultural science are taught and studied will find this excellent volume an essential addition to their shelf.

Evolution and Selection of Quantitative Traits (Hardcover): Bruce Walsh, Michael Lynch Evolution and Selection of Quantitative Traits (Hardcover)
Bruce Walsh, Michael Lynch
R2,639 Discovery Miles 26 390 Shipped within 7 - 12 working days

Quantitative traits-be they morphological or physiological characters, aspects of behavior, or genome-level features such as the amount of RNA or protein expression for a specific gene-usually show considerable variation within and among populations. Quantitative genetics, also referred to as the genetics of complex traits, is the study of such characters and is based on mathematical models of evolution in which many genes influence the trait and in which non-genetic factors may also be important. Evolution and Selection of Quantitative Traits presents a holistic treatment of the subject, showing the interplay between theory and data with extensive discussions on statistical issues relating to the estimation of the biologically relevant parameters for these models. Quantitative genetics is viewed as the bridge between complex mathematical models of trait evolution and real-world data, and the authors have clearly framed their treatment as such. This is the second volume in a planned trilogy that summarizes the modern field of quantitative genetics, informed by empirical observations from wide-ranging fields (agriculture, evolution, ecology, and human biology) as well as population genetics, statistical theory, mathematical modeling, genetics, and genomics. Whilst volume 1 (1998) dealt with the genetics of such traits, the main focus of volume 2 is on their evolution, with a special emphasis on detecting selection (ranging from the use of genomic and historical data through to ecological field data) and examining its consequences.

Plastics in Food Packaging Conference (Paperback): Plastics Institute Of America Plastics in Food Packaging Conference (Paperback)
Plastics Institute Of America
R1,341 Discovery Miles 13 410 Shipped within 7 - 12 working days

This book contains papers, presented at the eighth annual FoodPlas conference held in Orlando, Florida in 1991, on the role of plastics in supermarkets, food processors and food companies, and on the regulations and design for plastics packaging.

Epigenetics, Nuclear Organization & Gene Function - With implications of epigenetic regulation and genetic architecture for... Epigenetics, Nuclear Organization & Gene Function - With implications of epigenetic regulation and genetic architecture for human development and health (Paperback)
John C. Lucchesi
R884 Discovery Miles 8 840 Shipped within 7 - 12 working days

Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.

Aristotle's Ladder, Darwin's Tree - The Evolution of Visual Metaphors for Biological Order (Hardcover): J. David... Aristotle's Ladder, Darwin's Tree - The Evolution of Visual Metaphors for Biological Order (Hardcover)
J. David Archibald
R1,319 R992 Discovery Miles 9 920 Save R327 (25%) Shipped within 7 - 12 working days

Leading paleontologist J. David Archibald explores the rich history of visual metaphors for biological order from ancient times to the present and their influence on humans' perception of their place in nature, offering uncommon insight into how we went from standing on the top rung of the biological ladder to embodying just one tiny twig on the tree of life. He begins with the ancient but still misguided use of ladders to show biological order, moving then to the use of trees to represent seasonal life cycles and genealogies by the Romans. The early Christian Church then appropriated trees to represent biblical genealogies. The late eighteenth century saw the tree reclaimed to visualize relationships in the natural world, sometimes with a creationist view, but in other instances suggesting evolution. Charles Darwin's On the Origin of Species (1859) exorcised the exclusively creationist view of the "tree of life," and his ideas sparked an explosion of trees, mostly by younger acolytes in Europe. Although Darwin's influence waned in the early twentieth century, by midcentury his ideas held sway once again in time for another and even greater explosion of tree building, generated by the development of new theories on how to assemble trees, the birth of powerful computing, and the emergence of molecular technology. Throughout Archibald's far-reaching study, and with the use of many figures, the evolution of "tree of life" iconography becomes entwined with our changing perception of the world and ourselves.

Learning About Your Genes: A Primer For Non-biologists (Hardcover): Errol C. Friedberg Learning About Your Genes: A Primer For Non-biologists (Hardcover)
Errol C. Friedberg
R852 Discovery Miles 8 520 Shipped within 7 - 12 working days

Genes were unknowingly discovered in the 19th century by Gregor Mendel, a Czechoslovakian monk. It was later established that genes are made of DNA, a biological compound found in tiny thread-like structures called chromosomes that are located in the nuclei of all cells in our bodies. DNA consists of chains of entities called bases of which there are four in nature. DNA consists of long chains of bases (sometimes referred to as DNA sequences) that are joined in any order, but the precise order and length of which constitute different genes.Many (but not all) genes carry a code called the genetic code, a code that instructs the synthesis (manufacture) of the many hundreds of proteins that we require to survive and execute the many functions of life. The genetic code was deciphered in relatively recent years and is considered one of the most significant discoveries in the history of biology.Genes that encode instructions for the synthesis of proteins and those that regulate the manufacture of proteins comprise a mere two percent of our DNA. Despite our extensive knowledge of biology and the sub-discipline of molecular biology (the study of biology at the molecular level), the function (if any) of the rest of the DNA in our cells is unknown.Research about genes and DNA has in recent years spawned an endeavor referred to as the Human Genome Project, an international collaboration that has successfully determined, stored, and rendered publicly available the sequences of almost all the genetic content of the chromosomes of the human organism, otherwise known as the human genome.DNA sequences that are unique to every person on earth have been discovered (DNA fingherprints) and are now used for identifying criminals. The book relates a specific example of identifying a criminal who murdered two women.This is the first and only book that we are aware of that educates non-biologists about genes. It is written in a style and uses a vocabulary that can be comprehended by the average reader who knows very little if anything about genes.

Genetics of Cattle, The (Hardcover, 2nd edition): Dorian J. Garrick, Anatoly Ruvinsky Genetics of Cattle, The (Hardcover, 2nd edition)
Dorian J. Garrick, Anatoly Ruvinsky
R3,187 Discovery Miles 31 870 Shipped within 7 - 12 working days

Since the time of domestication more than 10,000 years ago, cattle have played an increasingly crucial role in the development of human civilizations. Progress has been quite remarkable since the turn of the century; the sequencing of the bovine genome in 2009 launched new avenues for furthering our understanding of theoretical and practical aspects of cattle genetics. Covering a vast array of questions, this book reviews major topics from molecular and developmental genetics, disease resistance and immunogenetics to genetic improvement of dairy and beef breeds, addressing all current problems in the field. This second edition includes a new team of authors and completely new chapters on the genetics of fat production, nutrition, feed intake and efficiency, growth and body composition. Fully updated throughout, it provides a valuable resource on cattle genetics for researchers, breeders, veterinarians and postgraduate students.

The Carrot Genome (Hardcover, 1st ed. 2019): Philipp Simon, Massimo Iorizzo, Dariusz Grzebelus, Rafal Baranski The Carrot Genome (Hardcover, 1st ed. 2019)
Philipp Simon, Massimo Iorizzo, Dariusz Grzebelus, Rafal Baranski
R2,896 R2,584 Discovery Miles 25 840 Save R312 (11%) Shipped within 7 - 12 working days

This book provides an up-to-date review and analysis of the carrot's nuclear and organellar genome structure and evolution. In addition, it highlights applications of carrot genomic information to elucidate the carrot's natural and agricultural history, reproductive biology, and the genetic basis of traits important in agriculture and human health. The carrot genome was sequenced in 2016, and its relatively small diploid genome, combined with the fact that it is the most complete root crop genome released to date and the first-ever Euasterid II genome to be sequenced, mean the carrot has an important role in the study of plant development and evolution. In addition, the carrot is among the top ten vegetables grown worldwide, and the abundant orange provitamin A carotenoids that account for its familiar orange color make it the richest crop source of vitamin A in the US diet, and in much of the world. This book includes the latest genetic maps, genetic tools and resources, and covers advances in genetic engineering that are relevant for plant breeders and biologists alike.

Race Unmasked - Biology and Race in the Twentieth Century (Paperback): Michael Yudell Race Unmasked - Biology and Race in the Twentieth Century (Paperback)
Michael Yudell; Foreword by J. Craig Venter
R572 R449 Discovery Miles 4 490 Save R123 (22%) Shipped within 7 - 12 working days

Race, while drawn from the visual cues of human diversity, is an idea with a measurable past, an identifiable present, and an uncertain future. The concept of race has been at the center of both triumphs and tragedies in American history and has had a profound effect on the human experience. Race Unmasked revisits the origins of commonly held beliefs about the scientific nature of racial differences, examines the roots of the modern idea of race, and explains why race continues to generate controversy as a tool of classification even in our genomic age. Surveying the work of some of the twentieth century's most notable scientists, Race Unmasked reveals how genetics and related biological disciplines formed and preserved ideas of race and, at times, racism. A gripping history of science and scientists, Race Unmasked elucidates the limitations of a racial worldview and throws the contours of our current and evolving understanding of human diversity into sharp relief.

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