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The evolution of dogs and the forces that drove its amazing transformation from a fierce wild carnivore, the wolf, to the astonishing range of comparatively docile domesticated dogs that we know today. Sykes paints a vivid picture of the dog as an ancient and essential ally. While undoubtedly it was the mastery of fire, language and agriculture that propelled Homo sapiens from a scarce, medium-sized primate to the position we enjoy today, Sykes crucially credits a fourth element for this success: the transformation of the wolf into the multi-purpose helpmate that is the dog. Drawing upon archaeology, history and genetics, Sykes shows how humans evolved to become the dominant species on Earth, but only with the help of our canine companions.
Vast numbers of different prokaryotic microorganisms shape the biosphere, with diverse metabolic capabilities. Determination of genome sequences for a wide range of bacteria and archaea now requires an in-depth knowledge of prokaryotic metabolic function to give biochemical, physiological and ecological meaning to the genomic information. This new edition describes up-to-date knowledge of the key metabolic processes that occur under different conditions, and the cellular processes that determine prokaryotic roles in the environment, biotechnology and human health. Essential for students of microbiology, applied microbiology, biotechnology, genomics and systems biology, this advanced textbook covers prokaryotic structure, composition, nutrient transport, biosynthesis and growth. Newly characterised metabolic pathways are included, as well as the latest understanding of metabolic regulation and stress responses. Additionally, the link between energetics, growth and survival is discussed as well as the maintenance of genetic integrity by the bacterial immune system.
Almost, but not quite human, the yeti and its counterparts from wild regions of the world, still exert a powerful atavistic influence on us. Is the yeti just a phantasm of our imagination, or is it a real creature? A survivor from our own savage ancestry? This is the mystery that Bryan Sykes set out to unlock. Three hair samples from the remote Himalayan kingdom of Bhutan are the cause of the investigation. The hair samples were from the miogi, the Bhutanese yeti, that legendary creature of the high snows that has haunted the imagination of travellers for centuries. Professor Sykes was asked to identify the hairs using DNA analysis. The miogi hairs did not surrender their secrets easily, but eventually two were identified as known species of bear. The third remained a mystery. Ten years later two scientific developments caused the migoi to enter Professor Sykes' thoughts again. The first, a purely technical improvement, meant that it was now possible to get a very good DNA signal from a single hair. The second development came from the surprising conclusion of an article published in 2010.This paper contained the details of the DNA sequence from another human species, Homo neanderthalensis, the Neanderthals, widely thought to be extinct. One of the many theories to account for the yeti legend is that there were small groups of Neanderthals that had managed to survive until recent times, or maybe even until the present day. If so, would it be possible to detect recent interbreeding between our own species and Neanderthals in the genomes of indigenous people living in remote regions. Locations where the yeti legends are strongest and the sightings most numerous? Professor Sykes set a goal to locate and analyse as many hair samples as possible, with links the yeti. In doing so Professor Sykes found himself entering a strange world of mystery and sensationalism, fraud and obsession and even the supernatural. Protected by the ruthless vigour of genetic analysis he was able to listen to the stories of the yeti without having to form an opinion. The only opinion that mattered was the DNA. Two years on the project is almost complete, and there have been some surprising and significant discoveries. The yeti remains an enigma. There is something out there. But what?
HUMAN HEREDITY: PRINCIPLES AND ISSUES, 10E, International Edition presents the concepts of human genetics in clear, concise language and provides relevant examples that you can apply to yourself, your family, and your work environment. Author Michael Cummings explains the origin, nature, and amount of genetic diversity present in the human population and how that diversity has been shaped by natural selection. The artwork and accompanying media visually support the material by teaching rather than merely illustrating the ideas under discussion. Examining the social, cultural, and ethical implications associated with the use of genetic technology, Cummings prepares you to become a well-informed consumer of genetic-based health care services or provider of health care services.
This book brings together all the fascinating strands of genetic science and explains in an accessible way how DNA is being mapped, classified, utilised and understood. With chapters on sequencing the human genome, genetic disorders, gene editing and therapy, human ancestry and cloning, this book shows how outstanding breakthroughs in genetic science is informing us about our past and defining our modern lives. * Explains the structure and purpose of DNA and how it was discovered * Tracks the history of human DNA, the development of our species, genetic disorders and mapping the human genome * Includes sections on the significance of DNA in crime detection and in the future of medicine
The analysis and interpretation of data is fundamental to the subject of genetics and forms a compulsory part of the undergraduate genetics curriculum. Indeed, the key skills that a genetics student requires are an ability to design and understand experimental strategies and to use problem-solving skills to interpret experimental results and data. Genetics? No Problem! provides students with a graded set of problems that aim to enthuse, challenge and entertain the reader. The book is divided into three sections introductory; intermediate and advanced each with 10 problems. For first level students there will be short genetics problems embedded in a wide range of scenarios, such as murder mysteries. As the book progresses, the stories will get longer and the science will get progressively more complex to challenge final year students and enable the reader to identify genetic disease in obscure organisms as well as designing and testing treatments and cures. Genetics? No Problem!: * Takes a unique, innovative approach that provides students with a set of graded problems designed to develop both their skills, and their ability to tackle problems with confidence * Includes problems embedded in a narrative, written in an interesting, informative and entertaining style by an Author with a proven track record in teaching, research and communication * Is well illustrated in full colour throughout. The book will prove invaluable to all students of genetics across a range of disciplines needing to get to grips with the analysis and interpretation of data that is fundamental to the subject.
From DNA sequences stored on computer databases to archived forensic samples and biomedical records, bioinformation comes in many forms. Its unique provenance the fact that it is 'mined' from the very fabric of the human body makes it a mercurial resource; one that no one seemingly owns, but in which many have deeply vested interests. Who has the right to exploit and benefit from bioinformation? The individual or community from whom it was derived? The scientists and technicians who make its extraction both possible and meaningful or the commercial and political interests which fund this work? Who is excluded or even at risk from its commercialisation? And what threats and opportunities might the generation of 'Big Bioinformational Data' raise? In this groundbreaking book, authors Bronwyn Parry and Beth Greenhough explore the complex economic, social and political questions arising from the creation and use of bioinformation. Drawing on a range of highly topical cases, including the commercialization of human sequence data; the forensic use of retained bioinformation; biobanking and genealogical research, they show how demand for this resource has grown significantly driving a burgeoning but often highly controversial global economy in bioinformation. But, they argue, change is afoot as new models emerge that challenge the ethos of privatisation by creating instead a dynamic open source 'bioinformational commons' available for all future generations.
The No.1 SUNDAY TIMES bestseller. A fascinating explanation of how evolution works, from bestselling author of THE GOD DELUSION, Richard Dawkins. The river of Dawkins's title is a river of DNA, flowing through time from the beginning of life on earth to the present - and onwards. Dawkins explains that DNA must be thought of as the most sophisticated information system imaginable: 'Life is just bytes and bytes of information,' he writes. Using this perspective, he describes the mechanisms by which evolution has taken place, gradually but inexorably, over a period of three thousand million years. It is the story of how evolution happens, rather than a narrative of what has actually happened in evolution. He discusses current views on the process of human evolution, including the idea that we all trace back to a comparatively recent African 'Eve', and speculates that the 'information explosion' that was unleashed on Earth when DNA came into being has almost certainly happened in other places in the universe.
DNA typing of non-human DNA is a fast developing area of research and professional practice. The application of DNA typing in wildlife forensic science is one of these prime uses of DNA typing and is gaining increasing profile. The use of DNA profiling in wildlife forensic science falls into two broad areas: species testing and genetic linkage. Species testing answers the question 'what species is this?' and genetic linkage answers the question 'did these two samples come from the same organism or population?' "Wildlife DNA Analysis: Applications in Forensic Science" provides an accessible introduction to both of these key areas. Clearly structured throughout, the introduction highlights the different types of crime where these techniques are regularly used. This chapter includes a discussion as to who performs forensic wildlife examinations, the standardisation and validation of methods, and the role of the expert witness in this type of alleged crime. This is followed by a detailed section on the science behind DNA typing including the problems in isolating DNA from trace material and subsequent genetic analysis are also covered. The book then undertakes a comprehensive review of species testing using DNA, including a step-by-step guide to sequence comparisons. A comparison of the different markers used in species testing highlights the criteria for a genetic marker. A full set of case histories illustrates the use of the different markers used. The book details the use of genetic markers to link two or more hairs/feather/leaves/needles to the same individual organism and the software used in population assignment. The problems and possibilities in isolating markers, along with the construction of allele databases are discussed in this chapter. The book concludes with evaluation and reporting of genetic evidence in wildlife forensic science illustrated by examples of witness statements. -An accessible introduction to this fast developing area of research within forensic science-Case studies throughout to link theory and practice and to highlight the use of DNA testing in species testing.-Covers both crimes against wildlife and offences where wildlife can provide vital evidence-Assumes only a basic background knowledge of DNA-Includes a comprehensive review of species testing using DNA, including a step-by-step guide to sequence comparisons
The study of emotions has rapidly expanded in recent decades, incorporating interdisciplinary research on the genetic underpinnings and neural mechanisms of emotion. This has involved a wide range of methods from as varied fields as behavioral genetics, molecular biology, and cognitive neuroscience, and has allowed researchers to start addressing complex multi-level questions such as: what is the role of genes in individual differences in emotions and emotional vulnerability to psychopathology, and what are the neural mechanisms through which genes and experience shape these emotion? Genes, Brain, and Emotions: Interdisciplinary and translational perspectives offers a comprehensive account of this interdisciplinary field of research, bridging psychology, genetics, and neuroscience, with rich sections dedicated to methods, cognitive and biological mechanisms, and psychopathology. Written by leading researchers who have each inspired new research directions and innovated methods and concepts, this book will be of interest to anyone working or studying in the field of affective science, whether they be behavioural geneticists, psychologists and psychiatrists, or cognitive neuroscientists.
A single species of fly, Drosophila melanogaster, has been the subject of scientific research for more than one hundred years. Why does this tiny insect merit such intense scrutiny? Drosophila's importance as a research organism began with its short life cycle, ability to reproduce in large numbers, and easy-to-see mutant phenotypes. Over time, laboratory investigation revealed surprising similarities between flies and other animals at the level of genes, gene networks, cell interactions, physiology, immunity, and behavior. Like humans, flies learn and remember, fight microbial infection, and slow down as they age. Scientists use Drosophila to investigate complex biological activities in a simple but intact living system. Fly research provides answers to some of the most challenging questions in biology and biomedicine, including how cells transmit signals and form ordered structures, how we can interpret the wealth of human genome data now available, and how we can develop effective treatments for cancer, diabetes, and neurodegenerative diseases. Written by a leader in the Drosophila research community, First in Fly celebrates key insights uncovered by investigators using this model organism. Stephanie Elizabeth Mohr draws on these "first in fly" findings to introduce fundamental biological concepts gained over the last century and explore how research in the common fruit fly has expanded our understanding of human health and disease.
Large-scale, interoperable biobanks are an increasingly important asset in today's life science research and, as a result, multiple types of biobanks are being established around the globe with very different financial, organizational and legal set-ups. With interdisciplinary chapters written by lawyers, sociologists, doctors and biobank practitioners, Global Genes, Local Concerns identifies and discusses the most pressing issues in contemporary biobanking. This timely book addresses pressing questions such as: how do national biobanks best contribute to translational research?; What are the opportunities and challenges that current regulations present for translational use of biobanks?; How does inter-biobank coordination and collaboration occur on various levels?; and how could academic and industrial exploitation, ownership and IPR issues be addressed and facilitated? Identifying that biobanks' foundational and operational set-ups should be legally and ethically sound, while at the same time reflecting the hopes and concerns of all the involved stakeholders, this book contributes to the continued development of international biobanking by highlighting and analysing the complexities in this important area of research. Academics in the fields of law and ethics, health law and biomedical law, as well as biobank managers and policymakers will find this insightful book a stimulating and engaging read.
The past few years have witnessed a revolution in our ability to obtain DNA from ancient humans. This important new data has added to our knowledge from archaeology and anthropology, helped resolve long-existing controversies, challenged long-held views, and thrown up remarkable surprises. The emerging picture is one of many waves of ancient human migrations, so that all populations living today are mixes of ancient ones, and often carry a genetic component from archaic humans. David Reich, whose team has been at the forefront of these discoveries, explains what genetics is telling us about ourselves and our complex and often surprising ancestry. Gone are old ideas of any kind of racial apurity.' Instead, we are finding a rich variety of mixtures. Reich describes the cutting-edge findings from the past few years, and also considers the sensitivities involved in tracing ancestry, with science sometimes jostling with politics and tradition. He brings an important wider message: that we should recognize that every one of us is the result of a long history of migration and intermixing of ancient peoples, which we carry as ghosts in our DNA. What will we discover next?
'A most moving and important biography, as well as an impressive account of a major event in the history of science'
Although Rosalind Franklin took the crucial photograph of DNA revealing its double helix structure, her work was overlooked when, four years after her death, three men – Maurice Wilkins of King's College London, Francis Crick of the Cavendish Laboratory and James Watson of Cambridge – were awarded the Nobel Prize for the discovery of DNA.
In this compelling biography of Franklin, Brenda Maddox tells the story of a remarkably single-minded, forthright and tempestuous young woman, who at the age of fifteen decided she wanted to be a scientist, but who was airbrushed out of the greatest scientific discovery of the twentieth century.
'Maddox is a dab hand at drawing a heroine out from behind the long shadows cast by men and her Franklin emerges as a determined, combative woman – a perfectionist who is plagued with self doubt'
'This magnificent biography gives a gripping yet nuanced account that resists the stock story-line of Franklin as the wronged heroine. What really happened is far more intriguing.'
'An exhilarating and vivid tale of scientific and personal politics at a time of rapid change in British science.'
Members of the fungal kingdom-the decomposers, the fermenters, the pathogens, the symbiotes-play critical roles in the ecology of our planet and have provided both benefits and hazards to humans for millennia. Pathogenic fungi are responsible for ca. 1.5 million deaths each year, yet other members of the Kingdom Fungi provide foods, medicines, industrial products, and more: a window for researchers into the workings of all eukaryotes. In The Fungal Kingdom, an international team of experts has assembled reviews by more than 170 mycologists, cell biologists, systems biologists, mathematicians, geneticists, and genomicists that cover the latest research and knowledge about all aspects of the Eumycota. The Fungal Kingdom is a rich collection of articles on all things fungi. These reviews present the latest fungal research and the impacts of fungi on agriculture, ecology, human health, and industrial applications as well as what lies ahead.
The evolution of psychotherapy in the 21st Century demands integration. Instead of choosing from the blizzard of modalities and schools of the past, therapists must move towards finding common denominators amongst them. Similarly, today's psychotherapy necessitates the integration of the mind and body, not the past practice of compartmentalisation of mental health and physical health. This book contributes to the sea change in how we conceptualise mental health problems and their solutions. Mind-Brain-Gene describes the feedback loops between the multiple systems contributing to the emergence of the mind and the experience of the self. It explains how our mental operating networks "self"-organise, drawing from and modifying our memory systems to establish and maintain mental health. Synthesising research in psychoneuroimmunology and epigenetics with interpersonal neurobiology and research on integrated psychotherapeutic approaches, John Arden explores how insecure attachment, deprivation, child abuse and trauma contribute to anxiety disorders and depression to produce epigenetic affects. To help people suffering from anxiety and depression, it is necessary to make sense of the multidirectional feedback loops between the stress systems and the dysregulation of the immune system that lead to those conditions. Successful psychotherapy modifies the feedback loops among the self-maintenance systems. Through the orchestration of the mental operating networks, psychotherapy promotes the re-regulation of immune system functions, stress systems, nutrition, microbiome (gut bacteria), sleep, physical inactivity, affect regulation and cognition. This book makes a strong case for healthcare and psychotherapy to be combined-together they can revolutionise the way we conceive of, and attain, optimal health in the 21st Century.
"From his work as part of the prosecution in the 1995 O. J. Simpson murder trial to his star billing on TV's America's Most Wanted, former San Diego prosecutor George "Woody" Clarke has been party to some of the justice system's most visible, controversial, and melodramatic moments. He puts that populist knack to work in this nonfiction page turner that should appeal just as much to true crime buffs as those concerned with the workings of the criminal justice system."-Publishers Weekly (starred review) "Clarke's account of the rise of DNA evidence is engaging and well paced, and the author comes across as likable and genuinely humble-a rarity in a book of war stories."-San Francisco Chronicle "As a former prosecutor who specialized in DNA evidence, Woody Clarke has the ability to make the difficult science that sometimes confuses a jury understandable to his reader."-Dominick Dunne Databases of both convicted offenders and no-suspect cases demonstrate the power of DNA testing to solve the unsolvable. George "Woody" Clarke chronicles his experiences in some of the most disturbing and notorious sexual assault and murder court cases in California. He charts the beginnings of DNA testing in police investigations and the fight for its acceptance by courts and juries and illustrates the power of science in cases he personally prosecuted or in which he assisted, including his work with the prosecution team in the trial of O. J. Simpson. As Clarke tells the story of how he came to understand and use this new form of evidence, readers will develop a new appreciation for the role of science in the legal system. George "Woody" Clarke, a judge of the Superior Court in San Diego County for the past several years, lectures internationally on DNA evidence and has cohosted America's Most Wanted.
Thoroughly updated and incorporating the most important advances in the fast-growing field of cancer biology, The Biology of Cancer, Second Edition, maintains all of its hallmark features admired by students, instructors, researchers, and clinicians around the world.
The Biology of Cancer is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The principles of cancer biology are presented in an organized, cogent, and in-depth manner. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology.
The new Second Edition has been comprehensively revised and updated to include major advances in cancer biology over the past six years. Updates include current information on:
Besides its value as a textbook, The Biology of Cancer is a useful reference for individuals working in biomedical laboratories and for clinical professionals.
Every copy of the book comes with an updated "Pathways in Human Cancer" poster and a DVD-ROM containing the book s art program, a greatly expanded selection of movies, audio file mini-lectures, Supplementary Sidebars, and a Media Guide."
Genetic diversity plays a very important role in survival and adaptability of a species because when a species's environment changes, slight gene variations are necessary to produce changes in the organisms' anatomy that enables it to adapt and survive. A species that has a large degree of genetic diversity among its population will have more variations from which to choose the most fit alleles. In this book, the authors discuss topics that include genetic diversity of human and animal papilloma viruses; conservation genetics of the lion; genetic diversity for quality traits in wild and ancient wheats; the genetic history of Morocco; different approaches to assess structure and genetic diversity in forest species; new genetic provisions for the reinstatement of ginseng natural populations; genetic and epigenetic variations in disease and drug response; genetic diversity and genetic rescue within wildlife populations; and genetic variability and advances in taxonomy.
Praise for the First Edition extremely well written a comprehensive and up-to-date overview of this important field. Journal of Environmental Quality Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition provides comprehensive coverage of recent advancements in microarray data analysis. A cutting-edge guide, the Second Edition demonstrates various methodologies for analyzing data in biomedical research and offers an overview of the modern techniques used in microarray technology to study patterns of gene activity. The new edition answers the need for an efficient outline of all phases of this revolutionary analytical technique, from preprocessing to the analysis stage. Utilizing research and experience from highly-qualified authors in fields of data analysis, Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition features: * A new chapter on the interpretation of findings that includes a discussion of signatures and material on gene set analysis, including network analysis * New topics of coverage including ABC clustering, biclustering, partial least squares, penalized methods, ensemble methods, and enriched ensemble methods * Updated exercises to deepen knowledge of the presented material and provide readers with resources for further study The book is an ideal reference for scientists in biomedical and genomics research fields who analyze DNA microarrays and protein array data, as well as statisticians and bioinformatics practitioners. Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition is also a useful text for graduate-level courses on statistics, computational biology, and bioinformatics.
The genetic history of the dog is a sensational example of the co-evolution of two species, man and wolf, to each other's mutual benefit. But how did this ancient partnership begin? To answer this question, Professor Bryan Sykes identifies tantalising clues in the recently mapped genetic makeup of both species. Sykes paints a vivid picture of the dog as an ancient and essential ally. While undoubtedly it was the mastery of fire, language and agriculture that propelled Homo sapiens from a scarce, medium-sized primate to the position we enjoy today, Sykes crucially credits a fourth element for this success: the transformation of the wolf into the multi-purpose helpmate that is the dog. Drawing upon archaeology, history and genetics, Sykes shows how humans evolved to become the dominant species on Earth, but only with the help of our canine companions.
The notion of matching diet with an individual's genetic makeup is transforming the way the public views nutrition as a means of managing health and preventing disease. To fulfill the promise of nutritional genomics, researchers are beginning to reconcile the diverse properties of dietary factors with our current knowledge of genome structure and gene function. What is emerging is a complex system of interactions that make the human genome exquisitely sensitive to our nutritional environment. Nutritional Genomics: The Impact of Dietary Regulation of Gene Function on Human Disease provides an integrated view of how genomic and epigenetic processes modulate the impact of dietary factors on health. Written as a resource for researchers, nutrition educators, and policy makers, this book contains the latest scientific findings on the mechanisms of action underlying diet-genome interactions. It presents a unique perspective on the fundamentals of nutritional genomics from genomics, transcriptomics, proteomics, and metabolomics. Contributing authors introduce the important areas of cell signaling and transduction, the intricate regulation of gene expression, and alteration of gene-linked chronic diseases, such as obesity-induced inflammation, insulin resistance, metabolic syndrome, cardiovascular disease, and cancer. The authors detail significant areas of interest within nutritional genomics-including plant-based foods as epigenetic modifiers of gene function and the effects of bioactive phytochemicals on inherited genotype and expressed phenotypes. They also discuss the role of vitamin D in various cancer risks and the gastrointestinal tract as a defense system. Given the key role played by agriculture and the food industry to produce foods to meet personalized health needs, the book also addresses agricultural breeding efforts to enhance nutritional value and the use of technology to increase bioactive ingredients in the food supply. The final chapters discuss manufacturing practices and novel processing techniques for retention of nutrients and bioactive components, as well as the need for regulatory oversight and proper labeling to establish assurance of safety and benefit. An excellent resource for this exciting field, the book identifies future directions for research and opportunities for improving global health and wellness by preventing, delaying, or mitigating chronic diseases with diet.
Life's Greatest Secret is the story of the discovery and cracking of the genetic code. This great scientific breakthrough has had far-reaching consequences for how we understand ourselves and our place in the natural world. The code forms the most striking proof of Darwin's hypothesis that all organisms are related, holds tremendous promise for improving human well-being, and has transformed the way we think about life. Matthew Cobb interweaves science, biography and anecdote in a book that mixes remarkable insights, theoretical dead-ends and ingenious experiments with the pace of a thriller. He describes cooperation and competition among some of the twentieth century's most outstanding and eccentric minds, moves between biology, physics and chemistry, and shows the part played by computing and cybernetics. The story spans the globe, from Cambridge MA to Cambridge UK, New York to Paris, London to Moscow. It is both thrilling science and a fascinating story about how science is done.
Whereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes. This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes. Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomyces cerevisiae and Drosophila melanogaster, as well as from human studies.
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