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This issue of Hematology/Oncology Clinics, edited by Dr. Frits van Rhee and Dr. Nikhil C. Munshi, focuses on Castleman's Disease. Topics include, but are not limited to, Epidemiology; Pathogenesis; Role of Interleukin 6 in Castleman Disease; Pathology, Diagnosis; Unicentric Castleman Disease; Treatment of HHV8 related Multicentric Castleman Disease; Treatment of HHV8 negative Castleman Disease; TAFRO Syndrome; POEMS; and more.
This is a concise, practical, case-based book documenting examples and scenarios that will help you manage challenging clinical issues for patients with myeloproliferative neoplasms. The editors and authors have strived to distil the very latest information in this rapidly advancing field in a way that will help you to update your practice and manage your patients. The key focuses are: diagnosis, both standard and challenging; both day-to-day management as well as special situations such as surgery, thrombotic events and pregnancy; and finally, managing evolving situations with MPN such as progression to acute myeloid leukemia. This book is an outstanding resource that includes a discussion of both classical myeloproliferative neoplasms, such as essential thrombocythemia, polycythemia vera and myelofibrosis, and also less common disorders such as systemic mast cell disease, hypereosinophilia, MPN/MBS overlap syndromes and atypical CML, amongst others. This book is a practical reference for practitioners, hematologists, medical oncologists and trainees.
MRI provides the best means of imaging the bone marrow directly and of non-invasively assessing its composition. Normal age-related bone marrow changes, alterations related to red marrow reconversion, and pathological bone marrow processes generally conform to certain patterns that reflect the underlying marrow changes and can be clearly recognized on MR images. In addition to conventional pulse sequences, advanced MRI techniques such as Dynamic Contrast-Enhanced MRI and Diffusion-Weighted Imaging depict marrow changes at the microvascular and cellular level respectively. This book provides radiologists with in-depth information on the MRI appearances of normal, abnormal and treated marrow following a structured, pattern-based approach. MRI findings for various diseases that affect the bone marrow, particularly those of a malignant nature, are presented in detail. MRI pattern recognition not only offers a systematic approach to image interpretation and diagnosis but also has prognostic implications with regard to some disease entities. Each chapter includes a wealth of high-quality images, together with Key Points summarizing the most important information. In addition to radiologists, practitioners with an interest in hematology and oncology will find this textbook-atlas to be a valuable resource for the latest, clinically relevant advances in bone marrow imaging.
This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health. Among the management topics addressed are the choices, advantages, and pitfalls of first-, second-, and third-line treatments; the European LeukemiaNet recommendations; management of adverse effects of tyrosine kinase inhibitors (TKI); management of CML blast crisis; management of pregnancy in the context of CML; the role of hematopoietic cell transplantation; the current experience with TKI discontinuation; and the value of interferon in improving the outcome of TKI treatment. Various aspects of relevance to treatment outcome are discussed, including prognostic scores, molecular monitoring (principles and interlaboratory standardization), and response-related predictors of survival. Furthermore, updates are provided on the increasing prevalence of CML and its implications and on the changing cost of care for CML, taking into account the impact of availability of generic imatinib.
This volume provides a comprehensive, state-of-the art review of myeloid neoplasms. The book presents updated information on epidemiology, clinical presentation, morphologic findings, molecular genomic abnormalities, pathogenesis, and target therapies. The text helps to guide accurate diagnosis, the administration of appropriate ancillary molecular tests, patient management, and investigative efforts. The book also includes over 200 illustrations, photographs, and tables. Written by experts in the field, Precision Molecular Pathology of Myeloid Neoplasms serves as a valuable resource for pathologists, hematologists/oncologists, fellows, and researchers in understanding the molecular pathology of myeloid neoplasms.
This issue of Hematology/Oncology Clinics of North America is devoted to Neuroendocrine tumors. Articles in this issue include: Pathology Classification of Neuroendocrine Tumors; Clinical Presentation and Diagnosis of Neuroendocrine Tumors; Surgical Management of Gastrointestinal Carcinoid Tumors; Systemic Therapies for Advanced Gastrointestinal Carcinoid Tumors; Thymic and Bronchial Carcinoid Tumors; Surgical Management of Pancreatic Neuroendocrine Tumors; Systemic Therapies for Advanced Pancreatic Neuroendocrine Tumors; Pheochromocytoma and Paraganglioma; Poorly Differentiated Neuroendocrine Tumors; Role of Somatostatin Analogs in the Treatment of Neuroendocrine Tumors; Peptide Receptor Radiotherapy in the Treatment of Neuiroendocrine Tumors; Hepatic-Directed Therapies in Patients with Neuroendocrine Tumors; and Neuroendocrine Tumor Clinical Trial Interpretation and Design.
This issue of Hematology/Oncology Clinics of North America, guest edited by Dr. Robert Brodsky, is devoted to Complement-mediated Hemolytic Anemias. Articles in this outstanding issue include: Complement: An overview for the clinician; Warm autoimmune hemolytic anemia; Cold Agglutinin Disease; ABO incompatible blood transfusions; Paroxysmal cold hemoglobinuria; Paroxysmal nocturnal hemoglobinuria; Congenital CD59 deficiency; Atypical Hemolytic Uremic Syndrome (HUS); Typical Hemolytic Uremic Syndrome (HUS); Thrombotic thrombocytopenic purpura; and Pharmacologic complement inhibitors.
Clinics Collections: Lipid Disorders draws from Elsevier's robust Clinics Review Articles database to provide multidisciplinary teams, including general practitioners, cardiologists, endocrinologists, pathologists, cardiologists, rheumatologists, and hepatologists, with practical clinical advice and insights on this highly prevalent condition and its comorbidities. Clinics Collections: Lipid Disorders guides readers on how to apply current primary research findings on lipid disorders to everyday practice to help overcome challenges and complications, keep up with new and improved treatment methods, and improve patient outcomes. . Areas of focus include lipids and biomarkers, lipids and pharmacotherapy, lipids and heart disease, lipids and chronic disease, lipids and pediatrics, lipids and women's health and special considerations. . Each article begins with keywords and key points for immediate access to the most critical information. . Articles are presented in an easy-to-digest and concisely worded format. Elsevier's Clinics Collections provide concise reviews of today's most prevalent conditions and significant medical developments. Other Clinics Collections titles available include Type II Diabetes Mellitus, Asthma, Obesity, and Pain Management
This issue of Hematology/Oncology Clinics of North America, devoted to Multiple Myeloma, is edited by Dr. Kenneth C. Anderson. Articles in this issue include: Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma; Diagnosis and Risk Stratification in Myeloma; Treatment of Newly Diagnosed Transplant Eligible Patients; Treatment of Newly Diagnosed Transplant Ineligible Patients; Treatment of Relapsed/Refractory Myeloma; Maintenance Therapy; Novel Targeted Therapies; Novel Immune-based Therapies; Allotransplantation in Myeloma; and Waldenstrom's Macroglobulinemia.
Topics in this clinically focused publication devoted to Anticoagulants are: Antithrombin clinical applications and anti-inflammatory effects; Pharmacology and laboratory testing of oral direct thrombin inhibitor Dabigatran; Pharmacology and laboratory testing of the oral Xa inhibitors; Clincial use of the new oral anticoagulants; Pharmacology and safety of new oral anticoagulants-the challenge of bleeding; Emergency reversal of Warfarin anticoagulation - prothrombin complex concentrate compared with plasma; Prothrombin complex concentrate as reversal agent for new oral anticoagulants - lessons from prelinical models; Bleeding with new oral anticoagulants - clinical presentation and management; Treatment of ICH with new oral anticoagulants - a neurologist's view; Management of anticoagulation agents in trauma patients; and Anticoagulation and pediatric patients.
Written by the leading names in pediatric oncology and hematology, Nathan and Oski's Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color, two-volume set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children. Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones. Develop a thorough, understanding of the underlying science of diseases through summaries of relevant pathophysiology balanced with clear, practical clinical guidance. Nathan and Oski's is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children. Quickly and effortlessly access the key information you need with the help of a consistent organization from chapter to chapter and from volume to volume. Stay at the forefront of your field thanks to new and revised chapters covering topics such as paroxysmal nocturnal hemoglobinuria, lysosomal storage diseases, childhood genetic predisposition to cancer, and oncology informatics. Learn about the latest breakthroughs in diagnosis and management, making this the most complete guide in pediatric hematology and oncology. Discover the latest in focused molecularly targeted therapies derived from the exponential growth of knowledge about basic biology and genetics underlying the field. Rely on it anytime, anywhere! Access the full text, images, and more at Expert Consult.
Natural killer (NK) cells are important effector cells of innate immune system implicated in many physiological processes including elimination of cancer cells and virus infected cells. NK cells comprise a majority of large granular lymphocytes circulating in peripheral blood with a minority derived from T cell lineage. Even though NK cells were first described more than 40 years ago, it was not until the 1980s and 1990s when immunophenotyping was incorporated into clinical diagnostic methods and resulted in discovery of distinct disorders of large granular lymphocytes and NK cells. Since then, significant progress was made in our better understanding of immunophenotypic and genotypic characteristics, biology, functions as well as disorders of these cells. Most recently, clinical studies using NK-cell based immunotherapy have shown promising results in treatment of some of malignant diseases. Disorders of large granular lymphocytes and NK cells are rare comprising only about 1% of all lymphoid malignancies in western countries. The rarity of these conditions was a main reason that the progress in our understanding of pathogenesis and development of novel therapeutic approaches has been delayed compared to development in more common B cell lymphoid malignancies. The low incidence of these diseases and scarcity of prospective clinical trials also limit the availability of evidence based research literature as well as comprehensive reviews about NK cell disorders. Thus, the editors decided to take on the challenging task and summarize our current knowledge about malignant and benign diseases of large granular lymphocytes in this book based on the best available evidence. The editors selected topics most relevant to clinical practice in order to provide a useful guide for practicing physicians. Chapters describing four disorders (T-cell large granular lymphocytic leukemia, chronic lymphoproliferative disorder of NK cells, extranodal NK cell lymphoma and aggressive NK cell leukemia) incorporated into most recent 2016 revision of classification of lymphoid malignancies are separated into experimental, diagnositc and clinical parts for easier understanding and reading. We are aware of challenges and inherited limitations of any larger project like this one due to a rapid progress especially in the field of genomics, which may not be incorporated in this book before it is published. The editors and contributing authors would like to thank the publisher NOVA for their support.
Myeloproliferative disorders are a group of clonal haematological neoplasms characterised by proliferation of one or more cells of myeloid lineage. They are the result of acquired mutations in the progenitor cell leading to hyper proliferation or neoplastic expansion of more mature forms of myeloid cells. Cells retain their functional ability with some degree of defects and also lead to suppression of normal stem cells. The most common type of Myeloproliferative Neoplasms (MPN) can broadly be classified into BCR ABL positive (Chronic Myelogenous Leukemia) and BCR ABL negative Disorders (Polycythemia Vera PV, Essential Thrombocytosis ET and Primary Myelofibrosis PMF). There are other rare types which have relatively low incidence like chronic neutrophilic leukemia, chronic eosinophilic leukemia, systemic mastocytosis and myeloproliferative neoplasms unclassifiable. These are the indolent type of haematological malignancies associated with marrow hypercellularity and organomegaly, with gradual progression to myelofibrosis or transformation to acute leukemias. During the dormant course of the BCR ABL negative MPN, they are more prone to thrombo-hemorrhagic complications and the treatment strategy is directed mostly to prevent complications. The past decade; therapies for BCR ABL positive disease (CML) have been a milestone achievement in keeping the disease in remission for many years, preventing major complications and halting the progression of the disease. This book discusses the classification, diagnosis and treatment of myeloproliferative diseases and provides insight on the symptoms and risk factors involved in the diseases.
This issue of Hematology/Oncology Clinics, guest edited by Drs. Matthew Heeney and Alan Cohen, is devoted to Iron Disorders. Articles in this issue include: Hereditary Hemochromatosis (HFE and Non-HFE); Iron Refractory Iron Deficiency Anemia (IRIDA); Sideroblastic Anemia; Anemia of Chronic Disease/Inflammation; Pathophysiology of Transfusional Iron Overload; Transfusional Iron Overload and Iron Chelation Therapy; Iron Overload and its Management in Non-Transfusion-Dependent Thalassemia; Treatment of Iron Deficiency Anemia; and Iron Overload Assessment.
This issue of Emergency Medicine Clinics edited by Drs. John Perkins and and Jonathan Davis focuses on emergencies related to Hematology/Oncology and covers topics such as: Oncologic Mechanical Emergencies, Neutropenic Fever, Oncologic Metabolic Emergencies, Acute Leukemias, Pediatric Oncologic Emergencies, Chemotherapeutic Medications and their Emergent Complications, Anemia, Thrombotic Microangiopathies (TTP, HUS, HELLP), Congenital Bleeding Disorders, Acquired Bleeding Disorders and Antithrombotic agents, Sickle Cell Disease, and more!
Biomedical scientists are the foundation of modern healthcare, from cancer screening to diagnosing HIV, from blood transfusion for surgery to food poisoning and infection control. Without biomedical scientists, the diagnosis of disease, the evaluation of the effectiveness of treatment, and research into the causes and cures of disease would not be possible. The Fundamentals of Biomedical Science series has been written to reflect the challenges of practicing biomedical science today. It draws together essential basic science with insights into laboratory practice to show how an understanding of the biology of disease is coupled to the analytical approaches that lead to diagnosis. Assuming only a minimum of prior knowledge, the series reviews the full range of disciplines to which a Biomedical Scientist may be exposed - from microbiology to cytopathology to transfusion science. Haematology provides a broad-ranging overview of the study of blood, the dynamic fluid that interfaces with all organs and tissues to mediate essential transport and regulatory functions. Written with the needs of the biomedical scientist centre-stage, it provides a firm grounding in the physiology of blood, and the key pathophysiological states that can arise. It demonstrates throughout how an understanding of the physiology underpins the key investigations carried out by a biomedical scientist to forge a clear link between science and practice. The second edition includes a new chapter on acquired disorders of haemostasis. Online Resource Centre The Online Resource Centre to accompany Haematology features: For registered adopters of the book: * Figures from the book, available to download For students: * Answers to case study and self-check questions. * An interactive Digital Microscope, encouraging the exploration of tissue samples * Video podcasts including interviews with practicing biomedical scientists, and 'in the lab' footage showing biomedical science in practice
"The HDL Handbook: Biological Functions to Clinical
Implications" brings laboratory research in HDL from bench to
bedside in this needed resource for researchers and clinicians
studying cholesterol, lipids, epidemiology, biochemistry, molecular
medicine, and pathophysiology of cardiovascular diseases. In
addition, researchers and clinicians working with an aging
population, corporate researchers, post-doctorates; medical
students and graduate students will find this publication
usefulbecause the scope of coverage includes basic science,
genetics, epidemiology, and treatment of HDL cholesterol as well as
potential targets to modify HDL cholesterol.
This issue focuses on three disease sections: Diabetes, Hematology and Coagulation, and covers diagnostic and management issues during pregnancy of selected topics in each section. The chapters cover new concepts, evolving management and important impacts on the mother and unborn child.
The opening chapter of this compilation is dedicated to the quantification of selenium and platinum in blood serum by electrothermal atomic absorption spectrometry. While selenium is an essential trace element in many selenoproteins, platinum is found in the human body as a consequence of chemotherapy treatment after the administration of Pt-based drugs. For these reasons, their reliable quantification is extremely important. The authors go on to discuss how the early diagnosis of neurodegenerative diseases is important for more efficient treatment and prophylaxis. Currently, the dominant hypothesis of the pathogenesis of Alzheimer's disease is amyloid cascade resulting in accumulation of amyloid-I(2) in brain structures. In conclusion, the authors discuss the major barrier to a widespread use of blood serum eye drops represented by the lack of standardized processes for the preparation, conservation, and dispensation of the products. Future perspectives of homologous serum eye drops include the introduction of tailored eye drops screened for the desired content of growth factors for each patient and ocular surface disease.
Decreased platelet counts can be due to a number of disease processes causing decreased platelet production, increased platelet destruction, or can be medication-induced. Health care providers have to differentiate inherited thrombocytopenias, primary immune thrombocytopenias (ITP), secondary immune thrombocytopenias, myelodysplastic syndromes with thrombocytopenia, bone marrow failure syndromes and non-immune thrombocytopenias. ITP is the most common cause of isolated thrombocytopenia. This book focuses on discussing ITP in adults; new treatment for ITP; thrombocytopenia during pregnancy; the different diagnosis of thrombocytopenia; heparin-induced thrombocytopenia; and thrombocytopenia in dengue.
Hemostasis (coagulation and fibrinolysis) is of importance in a broad range of medical disciplines. A high-quality hemostasis diagnosis enables a good therapy, which can be rather complicated without laboratory help. This new yearbook gathers important contributions in this field and presents them in a coherent and logical format.
Hemostasis (coagulation and fibrinolysis) is of importance in a broad range of medical disciplines. A high-quality hemostasis diagnosis enables a good therapy, which can be rather complicated without laboratory help. This yearbook gathers important contributions in this field and presents them in a coherent and logical format.
Dr. Connors has provided comprehensive coverage of the pregnant patient with hematologic disorders--from management in early pregnancy to delivery. Hematologic disorders covered include anemia, myeloproliferative disorders, von Willebrand disease, leukemia and lymphoma, thrombochytopenia, and thrombophilia. Other important topics in this issue include anesthesia in the pregnant patient with a hematologic disorder as well as transfusion medicine.
In this book, world-renowned experts in the field of hematopoietic cell transplantation examine a range of issues and controversies relating to apheresis, with the aim of identifying current trends and best practices. Readers will find up-to-date guidance on donor evaluation, CD34+ cell mobilization strategies, options and selection of apheresis device, anticoagulation techniques in apheresis, the role of prediction algorithms in determining procedure eligibility and length, and the prevention and management of complications. Applications of apheresis devices in the processing of bone marrow grafts are discussed, and detailed attention is devoted to the indications and rationale for therapeutic apheresis procedures, with individual chapters focusing on therapeutic plasma exchange and immunoadsorption, red cell exchange, and extracorporeal photopheresis. Finally, the applications of apheresis in pediatric donors and in resource-limiting environments are considered. This book, featuring numerous helpful tables, algorithms, and figures, will be of high practical value for residents, fellows, faculty members and other healthcare personnel involved in hematopoietic cell transplantation.
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